Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(47)
Published: Sept. 4, 2023
Abstract
Oxygen
as
one
of
the
most
critical
substances
in
living
organisms
has
attracted
ever‐increasing
attention
disease
treatment,
which
is
important
regulating
metabolic
activities.
However,
hypoxia
arising
from
a
prevalent
problem,
leading
to
observably
reduced
therapeutic
effectiveness
photodynamic
therapy,
radiotherapy,
sonodynamic
etc.
Therefore,
reversion
becomes
basis
for
enhancing
treatment.
Thanks
development
nanotechnology,
various
nanomaterials
with
oxygen‐production
capacity
are
explored
recover
function
oxygen
tissue,
but
there
still
some
limitations.
The
photosynthetic
microorganisms
(PSMs)
extensively
applied
improving
diseases
due
their
highly
efficient
photocatalytic
production
efficacy
and
desirable
biocompatibility.
In
this
review,
up‐to‐date
research
progress
on
modalities
microbial‐based
oxygenation
(e.g.,
cancer
wound
healing,
tissue
engineering)
summarized
highlighted.
addition,
key
issue
biocompatibility/biosafety
treatment
that
fundamental
apply
vivo
further
emphasized
clarified.
Finally,
present
issues
discussed
future
evolution
based
predicted,
promoting
clinical
applications.
Exploration,
Journal Year:
2023,
Volume and Issue:
3(1)
Published: Jan. 5, 2023
Nanomaterials
are
promising
carriers
to
improve
the
bioavailability
and
therapeutic
efficiency
of
drugs
by
providing
preferential
drug
accumulation
at
their
sites
action,
but
delivery
efficacy
is
severely
limited
a
series
biological
barriers,
especially
mononuclear
phagocytic
system
(MPS)-the
first
major
barrier
encountered
systemically
administered
nanomaterials.
Herein,
current
strategies
for
evading
MPS
clearance
nanomaterials
summarized.
First,
engineering
methods
including
surface
modification,
cell
hitchhiking,
physiological
environment
modulation
reduce
explored.
Second,
disabling
blockade,
suppression
macrophage
phagocytosis,
macrophages
depletion
examined.
Last,
challenges
opportunities
in
this
field
further
discussed.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 4751 - 4778
Published: Aug. 1, 2023
Abstract:
Exosomes,
as
natural
nanocarriers,
characterized
with
low
immunogenicity,
non-cytotoxicity
and
targeted
delivery
capability,
which
have
advantages
over
synthetic
nanocarriers.
Recently,
exosomes
shown
great
potential
diagnostic
markers
for
diseases
are
also
considered
a
promising
cell-free
therapy.
Engineered
significantly
enhanced
the
efficacy
precision
of
delivering
therapeutic
agents,
currently
being
extensively
employed
in
investigations
various
ailments,
including
oncology,
inflammatory
disorders,
degenerative
conditions.
Particularly,
engineered
enable
agent
loading,
modification,
evasion
MPS
phagocytosis,
intelligent
control,
bioimaging,
been
developed
multifunctional
nano-delivery
platforms
recent
years.
The
utilization
bioactive
scaffolds
that
loaded
exosome
has
to
substantially
augment
retention,
extend
release,
enhance
efficacy.
This
approach
advanced
from
conventional
hydrogels
nanocomposite
hydrogels,
nanofiber
3D
printing,
resulting
superior
physical
biological
properties
effectively
address
limitations
scaffolds.
Additionally,
plant-derived
exosomes,
can
participate
gut
flora
remodeling
via
oral
administration,
an
ideal
platform
treatment
intestinal
diseases.
Consequently,
there
is
interest
nanocarriers
applications.
comprehensive
review
provides
overview
biogenesis,
composition,
isolation
methods
exosomes.
it
examines
pathological
mechanisms
diseases,
tumors,
Furthermore,
this
highlights
significance
microbial-derived
Strategies
specific
applications
scaffold-loaded
further
summarized,
especially
some
new
techniques
such
large-scale
loading
technique,
macromolecular
development
nano-scaffold-loaded
delivery.
benefits
using
gut-related
discussed.
challenges,
opportunities,
prospects
exosome-based
disease
diagnosis
summarized
both
preclinical
clinical
viewpoints.
Keywords:
diagnosis,
Quantitative Imaging in Medicine and Surgery,
Journal Year:
2024,
Volume and Issue:
14(8), P. 5460 - 5472
Published: Feb. 23, 2024
Non-small
cell
lung
cancer
(NSCLC)
patients
with
epidermal
growth
factor
receptor-sensitizing
(EGFR-sensitizing)
mutations
exhibit
a
positive
response
to
tyrosine
kinase
inhibitors
(TKIs).
Given
the
limitations
of
current
clinical
predictive
methods,
it
is
critical
explore
radiomics-based
approaches.
In
this
study,
we
leveraged
deep-learning
technology
multimodal
radiomics
data
more
accurately
predict
EGFR-sensitizing
mutations.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: May 22, 2024
Abstract
Rapid
uptake
of
nanoparticles
by
mononuclear
phagocyte
system
(MPS)
significantly
hampers
their
therapeutic
efficacy.
Temporal
MPS
blockade
is
one
the
few
ways
to
overcome
this
barrier
–
approach
rediscovered
many
times
under
different
names
but
never
extensively
used
in
clinic.
Using
meta-analysis
published
data
we
prove
efficacy
technique
for
enhancing
particle
circulation
blood
and
delivery
tumours,
describe
a
century
its
evolution
potential
combined
mechanism
behind
it.
Finally,
discuss
future
directions
research
focusing
on
features
essential
successful
clinical
translation
method.
Exploration,
Journal Year:
2023,
Volume and Issue:
4(3)
Published: Dec. 7, 2023
Abstract
Atherosclerosis,
a
chronic
disease
associated
with
metabolism,
poses
significant
risk
to
human
well‐being.
Currently,
existing
treatments
for
atherosclerosis
lack
sufficient
efficiency,
while
the
utilization
of
surface‐modified
nanoparticles
holds
potential
deliver
highly
effective
therapeutic
outcomes.
These
can
target
and
bind
specific
receptors
that
are
abnormally
over‐expressed
in
atherosclerotic
conditions.
This
paper
reviews
recent
research
(2018–present)
advances
various
ligand‐modified
nanoparticle
systems
targeting
by
specifically
signature
molecules
hope
precise
treatment
at
molecular
level
concludes
discussion
challenges
prospects
this
field.
The
intention
review
is
inspire
novel
concepts
design
advancement
targeted
nanomedicines
tailored
atherosclerosis.
Nano TransMed,
Journal Year:
2024,
Volume and Issue:
3, P. 100042 - 100042
Published: July 11, 2024
Novel
drug
delivery
systems
comprise
sophisticated
technology
merged
into
systems.
These
are
created
with
the
aim
of
addressing
limitations
conventional
For
instance,
inefficient
in
tackling
challenging
human
diseases
such
as
cancer.
thus
formed
materials
to
enhance
permeation
target
cells.
They
improve
patients'
compliance
and
efficacy.
include
self-powered
microelectromechanical
Nanotechnology
is
a
rapidly
growing
promising
field,
especially
system
development
disease
therapy.
often
utilise
nanocarriers
due
their
numerous
advantages.
One
benefits
ability
manipulate
size
surface
functionalisation
achieve
site-specific
targeting.
Many
researchers
have
reported
controlled
targeted
release
profiles.
Nanocarriers
propelled
tissues,
where
entrapped
drugs
released,
prolonging
therapeutic
efficacy
decreasing
undesired
side
effects.
Hence,
these
offer
delivery,
low
toxicity,
high
bioavailability
improved
efficiency.
It
essential
understand
mechanisms
toxicity
order
develop
efficient
safe
This
review
describes
utilisation
novel
also
dwells
on
loading,
targeting
from
nanocarriers.
The
primary
concerns
clinical
applications
potential
presented.
expected
that
this
will
be
helpful
formulation
seeking
solutions
cancer
cardiovascular
diseases.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: April 2, 2024
Atherosclerotic
plaque
formation
is
considered
the
primary
pathological
mechanism
underlying
atherosclerotic
cardiovascular
diseases,
leading
to
severe
events
such
as
stroke,
acute
coronary
syndromes,
and
even
sudden
cardiac
death.
Early
detection
timely
intervention
of
plaques
are
challenging
due
lack
typical
symptoms
in
initial
stages.
Therefore,
precise
early
play
a
crucial
role
risk
stratification
achieving
favorable
post-interventional
outcomes.
The
continuously
advancing
nanoplatforms
have
demonstrated
numerous
advantages
including
high
signal-to-noise
ratio,
enhanced
bioavailability,
specific
targeting
capabilities
for
imaging
agents
therapeutic
drugs,
enabling
effective
visualization
management
plaques.
Motivated
by
these
superior
properties,
various
noninvasive
modalities
recognition
preliminary
stage
atherosclerosis
comprehensively
summarized.
Additionally,
several
strategies
proposed
enhance
efficacy
treating
Finally,
existing
challenges
promising
prospects
accelerating
clinical
translation
nanoplatform-based
molecular
therapy
discussed.
In
conclusion,
this
review
provides
an
insightful
perspective
on
diagnosis
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(19)
Published: March 13, 2024
Abstract
Efferocytosis,
an
intrinsic
regulatory
mechanism
to
eliminate
apoptotic
cells,
will
be
suppressed
due
the
delayed
apoptosis
process
in
aging‐related
diseases,
such
as
osteoarthritis
(OA).
In
this
study,
cartilage
lesion‐localized
hydrogel
microspheres
are
developed
remodel
situ
efferocytosis
reverse
senescence
and
recruit
endogenous
stem
cells
accelerate
repair.
Specifically,
aldehyde‐
methacrylic
anhydride
(MA)‐modified
hyaluronic
acid
(AHM),
loaded
with
pro‐apoptotic
liposomes
(liposomes
encapsulating
ABT263,
A‐Lipo)
PDGF‐BB,
namely
A‐Lipo/PAHM,
prepared
by
microfluidic
photo‐cross‐linking
techniques.
By
a
degraded
porcine
explant
OA
model,
lesion
location
experiment
illustrated
that
aldehyde‐functionalized
promote
affinity
for
cartilage.
vitro
data
showed
A‐Lipo
induced
of
senescent
chondrocytes
(Sn‐chondrocytes),
which
can
then
phagocytosed
macrophages,
remodeling
facilitated
protection
normal
maintained
chondrogenic
differentiation
capacity
MSCs.
vivo
experiments
confirmed
localized
reversed
promoted
repair
OA.
It
is
believed
strategy
great
significance
tissue
regeneration
diseases.
