Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

MedComm, Год журнала: 2023, Номер 4(4)

Опубликована: Июль 14, 2023

Nanoparticles (NPs) have become one of the most popular objects scientific study during past decades. However, despite wealth reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding NPs risk effects. In this review, we first present comprehensive landscape applications on health, especially addressing role medical diagnosis, therapy. Then, toxicity systems introduced. We describe detail effects various systems, including respiratory, nervous, endocrine, immune, reproductive carcinogenicity NPs. Furthermore, unravels mechanisms ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA cell cycle, epigenetic regulation. addition, classical such as lines mice emerging 3D organoids used for evaluating or are both Overall, review presents critical summary state NPs, giving readers more better remedy key gaps knowledge techniques.

Язык: Английский

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A Gas/phototheranostic Nanocomposite Integrates NIR‐II‐Peak Absorbing Aza‐BODIPY with Thermal‐Sensitive Nitric Oxide Donor for Atraumatic Osteosarcoma Therapy

Advanced Materials, Год журнала: 2023, Номер 35(35)

Опубликована: Апрель 20, 2023

Photothermal therapy (PTT) has received increasing interest in cancer therapeutics owing to its excellent efficacy and controllability. However, there are two major limitations PTT applications, which the tissue penetration depth of lasers within absorption range photothermal agents unavoidable empyrosis induced by high-energy lasers. Herein, a gas/phototheranostic nanocomposite (NA1020-NO@PLX) is engineered that integrates second near-infrared-peak (NIR-II-peak) absorbing aza-boron-dipyrromethenes (aza-BODIPY,NA1020) with thermal-sensitive nitric oxide (NO) donor (S-nitroso-N-acetylpenicillamine, SNAP). An enhanced intramolecular charge transfer mechanism proposed achieve NIR-II-peak absorbance (λmax = 1020 nm) on NA1020, thereby obtaining deep depth. The NA1020 exhibits remarkable conversion, making it feasible for deep-tissue orthotopic osteosarcoma providing favorable NIR-II emission precisely pinpoint tumor visible process. simultaneously investigated atraumatic therapeutic process an cell apoptosis indicates feasibility synergistic NO/low-temperature osteosarcoma. this strategy optimizes existing present repeatable tumors, validating potential clinical applications.

Язык: Английский

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A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy

Carbohydrate Polymers, Год журнала: 2024, Номер 329, С. 121795 - 121795

Опубликована: Янв. 9, 2024

Язык: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Язык: Английский

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Copper-Based Biomaterials for Anti-Tumor Therapy: Recent Advances and Perspectives

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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The applications of nanozymes in cancer therapy: based on regulating pyroptosis, ferroptosis and autophagy of tumor cells

Nanoscale, Год журнала: 2023, Номер 15(29), С. 12137 - 12156

Опубликована: Янв. 1, 2023

Nanozymes are nanomaterials with catalytic properties similar to those of natural enzymes, and they have recently been collectively identified as a class innovative artificial enzymes.

Язык: Английский

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A Paramagnetic Metal‐Organic Framework Enhances Mild Magnetic Hyperthermia Therapy by Downregulating Heat Shock Proteins and Promoting Ferroptosis via Aggravation of Two‐Way Regulated Redox Dyshomeostasis

Advanced Science, Год журнала: 2023, Номер 11(11)

Опубликована: Дек. 31, 2023

Abstract Mild magnetic hyperthermia therapy (MMHT) holds great potential in treating deep‐seated tumors, but its efficacy is impaired by the upregulation of heat shock proteins (HSPs) during treatment process. Herein, Lac‐FcMOF, a lactose derivative (Lac‐NH 2 ) modified paramagnetic metal‐organic framework (FcMOF) with property and thermal stability, has been developed to enhance MMHT therapeutic efficacy. In vitro studies showed that Lac‐FcMOF aggravates two‐way regulated redox dyshomeostasis (RDH) via magnetothermal‐accelerated ferricenium ions‐mediated consumption glutathione ferrocene‐catalyzed generation ∙OH induce oxidative damage inhibit protein 70 (HSP70) synthesis, thus significantly enhancing anti‐cancer MMHT. Aggravated RDH promotes peroxidase 4 inactivation lipid peroxidation promote ferroptosis, which further synergizes H22‐tumor‐bearing mice treated under alternating field (AMF) demonstrated 90.4% inhibition tumor growth. This work therefore provides new strategy for simple construction agent enables efficient downregulating HSPs promoting ferroptosis through aggravation RDH.

Язык: Английский

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Advances and Prospects in the Treatment of Pancreatic Cancer

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 3973 - 3988

Опубликована: Июль 1, 2023

Abstract: Pancreatic cancer is a highly malignant and incurable disease, characterized by its aggressive nature high fatality rate. The most common type pancreatic ductal adenocarcinoma (PDAC), which has poor prognosis mortality Current treatments for mainly encompass surgery, chemotherapy, radiotherapy, targeted therapy, combination regimens. However, despite efforts to improve prognosis, the 5-year survival rate remains very low. Therefore, it's urgent explore novel therapeutic approaches. With rapid development of strategies in recent years, new ideas have been provided treating cancer. This review expositions advancements nano drug delivery system, molecular drugs, photo-thermal treatment combined with nanotechnology It comprehensively analyzes prospects cancer, aiming at deeper understanding existing drugs approaches, promoting attempting enhance effect patients this disease. Keywords:

Язык: Английский

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The bioengineered and multifunctional nanoparticles in pancreatic cancer therapy: Bioresponisive nanostructures, phototherapy and targeted drug delivery

Environmental Research, Год журнала: 2023, Номер 233, С. 116490 - 116490

Опубликована: Июнь 22, 2023

Язык: Английский

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MXene-Based Dual Functional Nanocomposite with Photothermal Nanozyme Catalytic Activity to Fight Bacterial Infections

ACS Materials Letters, Год журнала: 2023, Номер 5(3), С. 762 - 774

Опубликована: Фев. 6, 2023

Bacterial infections are common complications for diabetic wounds and represent a considerable challenge wound therapy. Diabetic differ from those of normal wounds. Owing to the special microenvironment around them, more susceptible infection difficult heal. Nanozymes great significance treat bacterial through unique catalytic activities, particularly controlling drug-resistant bacteria. However, their intrinsically low activity largely restricts bactericidal function. Therefore, it is crucial design develop novel antibacterial modalities with multiple mechanisms action. In this study, we synthesize CeO2/Nb2C nanocomposite dual functions peroxidase an excellent near-infrared (NIR) photothermal property. Under 808 nm laser irradiation, produced effect simultaneously displayed synergistic enzyme property, thereby killing bacteria in sustained manner than 80% sterilization ratio. The could accelerate recovery when skin lesions infected methicillin-resistant Staphylococcus aureus (MRSA) were irradiated mouse model. An RNA sequencing assay was used profile dynamic transcriptome MRSA. data set reveals that experience dysfunction energy metabolism, cell morphology, oxidative stress systems during treatment under NIR which further affects survival. Moreover, exhibits good biosafety vitro vivo, indicates potency as agents. This study provides strategy by combination nanozymes effective MRSA-related infection.

Язык: Английский

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