Hydrogel Microsphere‐Encapsulated Bimetallic Nanozyme for Promoting Diabetic Bone Regeneration via Glucose Consumption and ROS Scavenging DOI

Yujian Hui,

Jiannan Mao,

Rui Min

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Abstract The healing of bone defects among diabetic patients presents a critical challenge due to the pathological microenvironment, characterized by hyperglycemia, excessive reactive oxygen species (ROS) production, and inflammation. Herein, multifunctional composite microspheres, termed GMAP are developed, using microfluidic technique incorporating Au@Pt nanoparticles (NPs) GelMA hydrogel modulate microenvironment for promoting regeneration. enables sustained release NPs, which function as bimetallic nanozymes with dual enzyme‐like activities involving glucose oxidase catalase. synergistic effect allows efficient consumption ROS elimination concurrently. Thus, effectively protects proliferation marrow mesenchymal stem cells (BMSCs) under adverse high‐glucose conditions. Furthermore, it also promotes osteogenic differentiation paracrine capabilities BMSCs, subsequently inhibits inflammation enhances angiogenesis. In vivo rats defect model, is demonstrated that microspheres significantly improve regeneration, verified micro‐computed tomography histological examinations. This study provides novel strategy regeneration modulating presenting promising approach addressing complex challenges associated in patients.

Язык: Английский

Modulating macrophage phenotype for accelerated wound healing with chlorogenic acid-loaded nanocomposite hydrogel DOI
Shuangqing Wang, Yanhong Liu, Xusheng Wang

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 369, С. 420 - 443

Опубликована: Апрель 5, 2024

Язык: Английский

Процитировано

33
Bioinspired soft-hard combined system with mild photothermal therapeutic activity promotes diabetic bone defect healing via synergetic effects of immune activation and angiogenesis DOI Creative Commons
Minhao Wu, Huifan Liu, Yufan Zhu

и другие.

Theranostics, Год журнала: 2024, Номер 14(10), С. 4014 - 4057

Опубликована: Янв. 1, 2024

Background:The comprehensive management of diabetic bone defects remains a substantial clinical challenge due to the hostile regenerative microenvironment characterized by aggravated inflammation, excessive reactive oxygen species (ROS), bacterial infection, impaired angiogenesis, and unbalanced homeostasis.Thus, an advanced multifunctional therapeutic platform capable simultaneously achieving immune regulation, elimination, tissue regeneration is urgently designed for augmented under pathological milieu.Methods Results: Herein, photoactivated soft-hard combined scaffold system (PGCZ) was engineered introducing polydopamine-modified zeolitic imidazolate framework-8-loaded double-network hydrogel (soft matrix component) into 3D-printed poly(ε-caprolactone) (PCL) (hard component).The versatile PGCZ based on PCL thus prepared features highly extracellular matrix-mimicking microstructure, suitable biodegradability mechanical properties, excellent photothermal performance, allowing long-term structural stability support regeneration.Under periodic near-infrared (NIR) irradiation, localized effect triggers on-demand release Zn 2+ , which, together with repeated mild hyperthermia, collectively accelerates proliferation osteogenic differentiation preosteoblasts potently inhibits growth biofilm formation.Additionally, also presents outstanding immunomodulatory ROS scavenging capacities, which regulate M2 polarization macrophages drive functional cytokine secretion, leading pro-regenerative in situ enhanced vascularization.In vivo experiments further demonstrated that conjunction activity remarkably attenuated local inflammatory cascade, initiated endogenous stem cell recruitment neovascularization, orchestrated osteoblast/osteoclast balance, ultimately accelerating regeneration. Ivyspring

Язык: Английский

Процитировано

28
Design of a Zn-based nanozyme injectable multifunctional hydrogel with ROS scavenging activity for myocardial infarction therapy DOI Open Access
Yiming Zhong, Yi Yang, Yuze Xu

и другие.

Acta Biomaterialia, Год журнала: 2024, Номер 177, С. 62 - 76

Опубликована: Янв. 21, 2024

Язык: Английский

Процитировано

27
Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease DOI Creative Commons

Zhangpeng Shi,

Xiaohong Li,

Jufeng Chen

и другие.

Bioactive Materials, Год журнала: 2024, Номер 35, С. 167 - 180

Опубликована: Янв. 28, 2024

Reactive oxygen species (ROS), immune dysregulation-induced inflammatory outbreaks and microbial imbalance play critical roles in the development of bowel disease (IBD). Herein, a novel enzyme-like biomimetic oral-agent ZnPBA@YCW has been developed, using yeast cell wall (YCW) as outer shell zinc-doped Prussian blue analogue (ZnPBA) nanozyme inside. When orally administered, is able to adhere

Язык: Английский

Процитировано

24
CRISPR/Cas12a-derived ratiometric fluorescence sensor for high-sensitive Pb2+ detection based on CDs@ZIF-8 and DNAzyme DOI

Chuanyu Yang,

Caiyi Du,

Feiyu Yuan

и другие.

Biosensors and Bioelectronics, Год журнала: 2024, Номер 251, С. 116089 - 116089

Опубликована: Фев. 3, 2024

Язык: Английский

Процитировано

22
A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: Antibacterial, hemostasis, immune reprogramming, pro-osteo-/angiogenesis and recruitment DOI Creative Commons

Shi-Yuan Yang,

Yan Zhu,

Chunxiao Ji

и другие.

Bioactive Materials, Год журнала: 2024, Номер 41, С. 239 - 256

Опубликована: Июль 24, 2024

Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues, resulting in tooth loss. Poor eradication of pathogenic microorganisms, persistent malignant inflammation and impaired osteo-/angiogenesis are currently primary challenges to control progression rebuild damaged bone. However, existing treatments for periodontitis fail comprehensively address these issues. Herein, an injectable composite hydrogel (SFD/CS/ZIF-8@QCT) encapsulating quercetin-modified zeolitic imidazolate framework-8 (ZIF-8@QCT) developed. This possesses thermo-sensitive adhesive properties, which can provide excellent flowability post-injection stability, resist oral fluid washout as well achieve effective tissue adhesion. Inspirationally, it observed SFD/CS/ZIF-8@QCT exhibits rapid localized hemostatic effect following implantation, then virtue sustained release zinc ions quercetin exerts collective functions including antibacterial, immunomodulation, pro-osteo-/angiogenesis pro-recruitment, ultimately facilitating regeneration. Notably, our study also demonstrates inhibition PDLSCs under due strong energy metabolism powerful activation oxidative stress autophagy, whereas synergistic effects released reversing biological processes. Overall, presents innovative insights into advancement biomaterials regenerate periodontitis.

Язык: Английский

Процитировано

18
Biomaterials for diabetic bone repair: Influencing mechanisms, multi-aspect progress and future prospects DOI
Bingbing Wang, Yong Huang,

Qiang Cai

и другие.

Composites Part B Engineering, Год журнала: 2024, Номер 274, С. 111282 - 111282

Опубликована: Фев. 5, 2024

Язык: Английский

Процитировано

17
Adaptive Nanoparticle-Mediated Modulation of Mitochondrial Homeostasis and Inflammation to Enhance Infected Bone Defect Healing DOI
Xu Chen, Qingqing He,

Qiming Zhai

и другие.

ACS Nano, Год журнала: 2023, Номер 17(22), С. 22960 - 22978

Опубликована: Ноя. 6, 2023

Infected bone defects (IBDs) exhibit impaired healing due to excessive inflammation triggered by pathogen-associated molecular patterns (PAMPs) from bacteria. As a vital factor in orchestrating immune responses, mitochondrial homeostasis maintenance is central blockade. This research developed chameleon-like nanoplatform covering hydroxyapatite nanoparticles with cerium ion coordinated tannic acid supramolecular network (HA@Ce-TA), which adaptively functions regulate based on intra- and extracellular environments. Extracellularly, acidic conditions activate HA@Ce-TA's peroxidase/oxidase-mimicking activity produce reactive oxygen species (ROS), external near-infrared (NIR) irradiation excites nanoscale Ce-TA hyperthermia, found explained chemical computation. ROS production photothermal therapy can eliminate bacteria effectively reduce stress. Intracellularly, HA@Ce-TA remodels dynamics upregulating fusion genes eliminates mimicking superoxidase/catalase. Consequently, this comprehensive modulation of inhibits inflammasome overactivation. In vitro vivo studies showed modulate the mitochondria-centered inflammatory cascade enhance IBD treatment, highlighting potential engineering nanotherapeutics recalibrate as an infected disease-modifying intervention.

Язык: Английский

Процитировано

28
Activating Macrophage Continual Efferocytosis via Microenvironment Biomimetic Short Fibers for Reversing Inflammation in Bone Repair DOI
Haoran Wang, Yu Zhang,

Yipu Zhang

и другие.

Advanced Materials, Год журнала: 2024, Номер 36(30)

Опубликована: Май 6, 2024

Abstract Efferocytosis‐mediated inflammatory reversal plays a crucial role in bone repairing process. However, refractory defects, the macrophage continual efferocytosis may be suppressed due to disrupted microenvironment homeostasis, particularly loss of apoptotic signals and overactivation intracellular oxidative stress. In this study, polydopamine‐coated short fiber matrix containing biomimetic “apoptotic signals” reconstruct reactivate for defect repair is presented. The (AM/CeO 2 ) are prepared using CeO nanoenzymes with neutrophil membrane coating recognition stress regulation. Additionally, “biomimetic matrix” utilized loading AM/CeO via abundant adhesion sites involving π – stacking hydrogen bonding interactions. Ultimately, implantable apoptosis‐mimetic nanoenzyme/short‐fiber matrixes (PFS@AM/CeO ), integrating matrixes, constructed facilitate reestablish pro‐efferocytosis microenvironment. vitro vivo data indicate that fibers can activate efferocytosis, leading suppression overactivated inflammation. enhanced rat femoral further demonstrates osteogenic potential strategy. It believed regulation through materials provide new perspective tissue repair.

Язык: Английский

Процитировано

14
Metal–Organic Framework‐Based Nanomaterials for Regulation of the Osteogenic Microenvironment DOI

Wenzhuo Zheng,

Zihan Meng, Zhou Zhu

и другие.

Small, Год журнала: 2024, Номер 20(29)

Опубликована: Фев. 20, 2024

As the global population ages, bone diseases have become increasingly prevalent in clinical settings. These conditions often involve detrimental factors such as infection, inflammation, and oxidative stress that disrupt homeostasis. Addressing these disorders requires exogenous strategies to regulate osteogenic microenvironment (OME). The regulation of OME can be divided into four processes: induction, modulation, protection, support, each serving a specific purpose. To this end, metal-organic frameworks (MOFs) are an emerging focus nanomedicine, which show tremendous potential due their superior delivery capability. MOFs play numerous roles metal ion donors, drug carriers, nanozymes, photosensitizers, been extensively explored recent studies. This review presents comprehensive introduction by MOF-based nanomaterials. By discussing various functional MOF composites, work aims inspire guide creation sophisticated efficient nanomaterials for disease management.

Язык: Английский

Процитировано

12