Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122845 - 122845
Published: Sept. 20, 2024
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10625 - 10641
Published: April 2, 2024
Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN size 268 nm are stable under physiological conditions, be specifically taken up by macrophages through FN-mediated targeting, dissociated in oxidative microenvironment. dendrimer having intrinsic anti-inflammatory property FN both antioxidative properties display integrated functions ROS scavenging, hypoxia attenuation, macrophage M2 polarization, thus protecting from apoptosis creating designed bone immune microenvironment stem cell osteogenic differentiation. These characteristics lead to their effective treatment an OA model vivo reduce pathological changes joints including synovitis inhibition cartilage matrix degradation simultaneously promote differentiation repair. developed combining advantages bioactive treat may immunomodulatory therapy different diseases.
Language: Английский
Citations
20
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 472, P. 144911 - 144911
Published: July 19, 2023
Language: Английский
Citations
30
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(5)
Published: Nov. 22, 2023
Abstract Osteoarthritis (OA) is a prevalent, chronic degenerative disease that affects people worldwide. It characterized by the destruction of cartilage and inflammatory reactions. High levels reactive oxygen species (ROS) cause oxidative stress, which damages lipids, proteins, DNA, leading to cell damage death. Furthermore, ROS also induces production cytokines chemotaxis, further worsening response damaging resulted in limited movement. Herein, this work reports dual‐functional injectable hydrogel, can help inhibit inflammation scavenging provide lubrication reduce wear tear on joints. To create 3‐aminophenylboronic acid modified hyaluronic synthesized, then crosslinked with hydroxyl‐containing polyvinyl alcohol (PVA) construct dual dynamic covalent hydrogel oHA‐PBA‐PVA gel, Gel (HPP). The mentioned here possesses unique bond structure allows it be injected, self‐heal, lubrication. This innovative approach offers new possibility for treating osteoarthritis combining anti‐inflammatory effects.
Language: Английский
Citations
27
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215431 - 215431
Published: Sept. 4, 2023
Language: Английский
Citations
25
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 14, 2024
In the past 11 years, there has been a surge in studies exploring regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, significant gap persists comprehensive scientometric analysis and scientific mapping research, especially tracking evolution, primary contributors, emerging research focal points. This study aims to comprehensively update advancements targeting ferroptosis with various TCMs during previous years. The data, covering period from 1 January 2012, 30 November 2023, were retrieved Web Science database. For in-depth visualized analyses, series advanced analytical instruments employed. findings highlight China’s predominant role, accounting for 71.99% total publications significantly shaping this domain. Noteworthy productivity was observed at institutions, including Guangzhou University Medicine, Chengdu Zhejiang University. Thomas Efferth emerged as foremost author within field, while Frontiers Pharmacology boasted highest publication count. pinpointed hepatocellular carcinoma, chemical drug-induced liver injury, mitochondrial diseases, acute kidney failure most critical disorders addressed realm. offers bibliometric evaluation, enhancing our understanding present status TCM therapy managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers newcomers by accelerating access vital information fostering innovative concept extraction specialized field.
Language: Английский
Citations
10
Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 169, P. 107867 - 107867
Published: Dec. 20, 2023
Language: Английский
Citations
15
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7099 - 7121
Published: July 1, 2024
Abstract: Introduction of exogenous genes into target cells to overcome various tumor diseases caused by genetic defects or abnormalities and gene therapy, a new treatment method, provides promising strategy for treatment. Over the past decade, therapy has made exciting progress; however, it still faces challenge low nucleic acid delivery release efficiencies. The emergence nonviral vectors, primarily nanodelivery systems (NDRS), resulted in historic breakthrough application therapy. NDRS, especially stimulus-responsive NDRS that can respond timely manner changes internal external microenvironment (eg, pH, high concentration glutathione/reactive oxygen species, overexpressed enzymes, temperature, light, ultrasound, magnetic field), shown excellent loading advantages precision efficiency been widely applied. only disadvantage is poor transfection limits in-depth clinical practice, owing presence biological barriers body. Therefore, this review first introduces development history current obstacles faced delivery, strategies these obstacles, conventional then focuses on latest research progress improving efficiency. Finally, future challenges prospects may face transformation are discussed provide references enhancing Keywords: treatment, efficiency, microenvironment, physiological barrier, efficacy improvement
Language: Английский
Citations
6
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: Dec. 5, 2024
Abstract Bioactive peptides and proteins (BAPPs) are promising therapeutic agents for tissue repair with considerable advantages, including multifunctionality, specificity, biocompatibility, biodegradability. However, the high complexity of microenvironments their inherent deficiencies such as short half-live susceptibility to enzymatic degradation, adversely affect efficacy clinical applications. Investigating fundamental mechanisms by which BAPPs modulate microenvironment developing rational delivery strategies essential optimizing administration in distinct repairs facilitating translation. This review initially focuses on through influence via reactive oxygen species, blood lymphatic vessels, immune cells, cells. Then, a variety platforms, scaffolds hydrogels, electrospun fibers, surface coatings, assisted particles, nanotubes, two-dimensional nanomaterials, nanoparticles engineered summarized incorporate effective repair, modification aimed at enhancing loading efficiencies release kinetics also reviewed. Additionally, can be precisely regulated endogenous stimuli (glucose, enzymes, pH) or exogenous (ultrasound, heat, light, magnetic field, electric field) achieve on-demand tailored specific needs. Furthermore, this potential across various types, bone, cartilage, intervertebral discs, muscle, tendons, periodontal tissues, skin, myocardium, nervous system (encompassing brain, spinal cord, peripheral nerve), endometrium, well ear ocular tissue. Finally, current challenges prospects discussed.
Language: Английский
Citations
6
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(10)
Published: Nov. 27, 2023
Abstract Precision medicine requires precise regulation of drugs in terms time, space, and dosage. Exogenous control systems, such as electrical responsiveness, have made great progress. However, wearable or implantable controlled drug release devices still face major challenges due to limitations including limited battery life, large size, fixed power supply. To overcome these limitations, the fabrication autonomous is available endure extended periods without reliance on external sources. As a promising strategy, nanogenerators (NGs) turn body mechanical energy into electricity, powering long‐term release. In this review, current status delivery systems (DDS) briefly outlined importance self‐driven emphasized. The main types operational mechanisms various are introduced. This review also focuses summarizing latest progress self‐powered based (NG‐based CDRs). Additionally, their applications field introduced detail. Finally, existing future trends NG‐based CDRs discussed from perspectives clinical needs practical translation.
Language: Английский
Citations
12
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(24), P. 5769 - 5786
Published: Jan. 1, 2024
Neuromodulation aims to modulate the signaling activity of neurons or neural networks by precise delivery electrical stimuli chemical agents and is crucial for understanding brain function treating disorders. Conventional approaches, such as direct physical stimulation through acoustic methods, confront challenges stemming from their invasive nature, dependency on wired power sources, unstable therapeutic outcomes. The emergence stimulus-responsive systems harbors potential revolutionize neuromodulation strategies controlled release neurochemicals in a specific region. This review comprehensively examines biological barriers may encounter vivo recent advances applications these neuromodulation. We elucidate intricate interplay between molecular structure response mechanisms furnish insights material selection design. Additionally, contemplates prospects associated with overarching objective propel application technology analyzing functions, disorders, providing insightful perspectives exploiting new biomedical applications.
Language: Английский
Citations
5