Supramolecular Polyzwitterionic Nanoparticles with Engineered pH‐Responsiveness and Cartilage‐Penetration for Osteoarthritis Therapy DOI

Shaopei Ding,

Peng Yu, Peng Xu

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Abstract Abnormal friction forces, compact matrix structure, and dynamic acidic microenvironment in osteoarthritis (OA) make it difficult to remodel cartilage regeneration by integrating prominent inflammatory responses anabolism. Here, pH‐responsive PSBMA‐ b ‐PColBP@KGN nanoparticles (PSPK NPs) are developed a simple supramolecular assembly process. PSPK NPs found reduce the coefficient of (0.028) under high loading pressure (10.41 MPa). The synergistic effect KGN release coupling deep penetration promotes generation microenvironment. Further, vivo studies confirm potential restoring homeostasis, as evidenced reduced osteophyte volume, aligned structures, abundant matrix. This study provides novel insights into effects release, penetration, hydration lubrication on OA treatment, offering strategy for design tissue‐adaptive promote tissue inflammation‐related diseases.

Language: Английский

Nanoparticle-Mediated Multiple Modulation of Bone Microenvironment To Tackle Osteoarthritis DOI
Mengsi Zhan, Huxiao Sun, Zhiqiang Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10625 - 10641

Published: April 2, 2024

Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN size 268 nm are stable under physiological conditions, be specifically taken up by macrophages through FN-mediated targeting, dissociated in oxidative microenvironment. dendrimer having intrinsic anti-inflammatory property FN both antioxidative properties display integrated functions ROS scavenging, hypoxia attenuation, macrophage M2 polarization, thus protecting from apoptosis creating designed bone immune microenvironment stem cell osteogenic differentiation. These characteristics lead to their effective treatment an OA model vivo reduce pathological changes joints including synovitis inhibition cartilage matrix degradation simultaneously promote differentiation repair. developed combining advantages bioactive treat may immunomodulatory therapy different diseases.

Language: Английский

Citations

19

Biomimetic redox-responsive prodrug micelles with diselenide linkage for platinum nanozymes augmented sonodynamic/chemo combined therapy of colon cancer DOI

Yuanru Zhao,

Jingwen Xu, Yuanyuan Zhang

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 472, P. 144911 - 144911

Published: July 19, 2023

Language: Английский

Citations

30

Dual‐Functional Injectable Hydrogel for Osteoarthritis Treatments DOI
Lei Lei, Rui Cong,

Yifei Ni

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(5)

Published: Nov. 22, 2023

Abstract Osteoarthritis (OA) is a prevalent, chronic degenerative disease that affects people worldwide. It characterized by the destruction of cartilage and inflammatory reactions. High levels reactive oxygen species (ROS) cause oxidative stress, which damages lipids, proteins, DNA, leading to cell damage death. Furthermore, ROS also induces production cytokines chemotaxis, further worsening response damaging resulted in limited movement. Herein, this work reports dual‐functional injectable hydrogel, can help inhibit inflammation scavenging provide lubrication reduce wear tear on joints. To create 3‐aminophenylboronic acid modified hyaluronic synthesized, then crosslinked with hydroxyl‐containing polyvinyl alcohol (PVA) construct dual dynamic covalent hydrogel oHA‐PBA‐PVA gel, Gel (HPP). The mentioned here possesses unique bond structure allows it be injected, self‐heal, lubrication. This innovative approach offers new possibility for treating osteoarthritis combining anti‐inflammatory effects.

Language: Английский

Citations

26

Responsive metal–organic framework nanocarrier delivery system: An effective solution against bacterial infection DOI
Yi Liu, Jinmei Wu, Weihui Li

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215431 - 215431

Published: Sept. 4, 2023

Language: Английский

Citations

25

Targeting ferroptosis unveils a new era for traditional Chinese medicine: a scientific metrology study DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 14, 2024

In the past 11 years, there has been a surge in studies exploring regulatory effect of Traditional Chinese Medicine (TCM) on ferroptosis. However, significant gap persists comprehensive scientometric analysis and scientific mapping research, especially tracking evolution, primary contributors, emerging research focal points. This study aims to comprehensively update advancements targeting ferroptosis with various TCMs during previous years. The data, covering period from 1 January 2012, 30 November 2023, were retrieved Web Science database. For in-depth visualized analyses, series advanced analytical instruments employed. findings highlight China’s predominant role, accounting for 71.99% total publications significantly shaping this domain. Noteworthy productivity was observed at institutions, including Guangzhou University Medicine, Chengdu Zhejiang University. Thomas Efferth emerged as foremost author within field, while Frontiers Pharmacology boasted highest publication count. pinpointed hepatocellular carcinoma, chemical drug-induced liver injury, mitochondrial diseases, acute kidney failure most critical disorders addressed realm. offers bibliometric evaluation, enhancing our understanding present status TCM therapy managing ferroptosis-related diseases. Consequently, it aids both seasoned researchers newcomers by accelerating access vital information fostering innovative concept extraction specialized field.

Language: Английский

Citations

10

A bibliometric and visualized analysis of nanoparticles in musculoskeletal diseases (from 2013 to 2023) DOI
Siyang Cao, Yihao Wei, Zhi Yao

et al.

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 169, P. 107867 - 107867

Published: Dec. 20, 2023

Language: Английский

Citations

15

Stimulus-Responsive Nanodelivery and Release Systems for Cancer Gene Therapy: Efficacy Improvement Strategies DOI Creative Commons
Huamin Zeng, Yiran Zhang, Ningyi Liu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7099 - 7121

Published: July 1, 2024

Abstract: Introduction of exogenous genes into target cells to overcome various tumor diseases caused by genetic defects or abnormalities and gene therapy, a new treatment method, provides promising strategy for treatment. Over the past decade, therapy has made exciting progress; however, it still faces challenge low nucleic acid delivery release efficiencies. The emergence nonviral vectors, primarily nanodelivery systems (NDRS), resulted in historic breakthrough application therapy. NDRS, especially stimulus-responsive NDRS that can respond timely manner changes internal external microenvironment (eg, pH, high concentration glutathione/reactive oxygen species, overexpressed enzymes, temperature, light, ultrasound, magnetic field), shown excellent loading advantages precision efficiency been widely applied. only disadvantage is poor transfection limits in-depth clinical practice, owing presence biological barriers body. Therefore, this review first introduces development history current obstacles faced delivery, strategies these obstacles, conventional then focuses on latest research progress improving efficiency. Finally, future challenges prospects may face transformation are discussed provide references enhancing Keywords: treatment, efficiency, microenvironment, physiological barrier, efficacy improvement

Language: Английский

Citations

6

Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential DOI Creative Commons
Zhuowen Hao, Zheyuan Zhang,

Ze-Pu Wang

et al.

Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)

Published: Dec. 5, 2024

Abstract Bioactive peptides and proteins (BAPPs) are promising therapeutic agents for tissue repair with considerable advantages, including multifunctionality, specificity, biocompatibility, biodegradability. However, the high complexity of microenvironments their inherent deficiencies such as short half-live susceptibility to enzymatic degradation, adversely affect efficacy clinical applications. Investigating fundamental mechanisms by which BAPPs modulate microenvironment developing rational delivery strategies essential optimizing administration in distinct repairs facilitating translation. This review initially focuses on through influence via reactive oxygen species, blood lymphatic vessels, immune cells, cells. Then, a variety platforms, scaffolds hydrogels, electrospun fibers, surface coatings, assisted particles, nanotubes, two-dimensional nanomaterials, nanoparticles engineered summarized incorporate effective repair, modification aimed at enhancing loading efficiencies release kinetics also reviewed. Additionally, can be precisely regulated endogenous stimuli (glucose, enzymes, pH) or exogenous (ultrasound, heat, light, magnetic field, electric field) achieve on-demand tailored specific needs. Furthermore, this potential across various types, bone, cartilage, intervertebral discs, muscle, tendons, periodontal tissues, skin, myocardium, nervous system (encompassing brain, spinal cord, peripheral nerve), endometrium, well ear ocular tissue. Finally, current challenges prospects discussed.

Language: Английский

Citations

6

Self‐Powered Electrically Controlled Drug Release Systems Based on Nanogenerator DOI Open Access
Weikang Luo,

Ruizeng Luo,

Jingjing Liu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(10)

Published: Nov. 27, 2023

Abstract Precision medicine requires precise regulation of drugs in terms time, space, and dosage. Exogenous control systems, such as electrical responsiveness, have made great progress. However, wearable or implantable controlled drug release devices still face major challenges due to limitations including limited battery life, large size, fixed power supply. To overcome these limitations, the fabrication autonomous is available endure extended periods without reliance on external sources. As a promising strategy, nanogenerators (NGs) turn body mechanical energy into electricity, powering long‐term release. In this review, current status delivery systems (DDS) briefly outlined importance self‐driven emphasized. The main types operational mechanisms various are introduced. This review also focuses summarizing latest progress self‐powered based (NG‐based CDRs). Additionally, their applications field introduced detail. Finally, existing future trends NG‐based CDRs discussed from perspectives clinical needs practical translation.

Language: Английский

Citations

12

Advancements in pH-Responsive nanoparticles for osteoarthritis treatment: Opportunities and challenges DOI Creative Commons

Shuai Liao,

Shicheng Jia, Yaohang Yue

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: July 1, 2024

Osteoarthritis (OA) is a degenerative disease linked to aging and obesity. The global population has led an increasing number of OA patients, imposing significant economic burden on society. Traditional drugs treatment methods often fail achieve satisfactory outcomes. With the rapid advancement nanomaterial delivery systems, numerous studies have focused utilizing nanomaterials as carriers efficient by effectively loading delivering bioactive ingredients (e.g., drugs, nucleic acids) tailored unique pathological conditions, such weakly acidic microenvironment synovial fluid in patients. This review highlights latest advancements use pH-responsive nanoparticles for treatment, emphasizing principle targeted drug leveraging inflamed joints. It further discusses composition, synthesis, response mechanism, target selection, application, recent research findings nanoparticles, while also addressing challenges future directions this promising field.

Language: Английский

Citations

5