A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Год журнала: 2024, Номер 20(25)

Опубликована: Янв. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Язык: Английский

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Metformin-Mediated Fast Charge-Reversal Nanohybrid for Deep Penetration Piezocatalysis-Augmented Chemodynamic Immunotherapy of Cancer

ACS Nano, Год журнала: 2024, Номер 18(8), С. 6314 - 6332

Опубликована: Фев. 12, 2024

Immune checkpoint blockade (ICB) therapy still suffers from insufficient immune response and adverse effect of ICB antibodies. Chemodynamic (CDT) has been demonstrated to be an effective way synergize with therapy. However, a low generation rate reactive oxygen species poor tumor penetration CDT platforms decline the effects. Herein, charge-reversal nanohybrid Met@BF containing both Fe3O4 BaTiO3 nanoparticles in core Metformin (Met) on surface was fabricated for microenvironment (TME)- ultrasound (US)-activated piezocatalysis-chemodynamic immunotherapy cancer. Interestingly, had negative charge blood circulation, which rapidly changed into positive when exposed acidic TME attributed quaternization tertiary amine Met, facilitating deep penetration. Subsequently, US irradiation, produced H2O2 based piezocatalysis BaTiO3, greatly enhanced Fenton reaction Fe3O4, thus boosting robust antitumor response. Furthermore, PD-L1 expression inhibited by local released Met further augment effect, achieving inhibitions primary metastatic tumors. Such combination piezocatalysis-enhanced chemodynamic Met-mediated downregulation provides promising strategy cancer immunotherapy.

Язык: Английский

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A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous H2O2- and O2-independent ROS generation

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 20, 2025

Язык: Английский

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Piezoelectrical Hydrogel Containing Cationic Vacancies Bismuth Sulfide with Enhanced Sonodynamic/Nanozyme Activity for Synergistic Killing Bacteria and Boosting Osteoblast Differentiation

Journal of Materials Chemistry B, Год журнала: 2025, Номер 13(10), С. 3420 - 3436

Опубликована: Янв. 1, 2025

A piezoelectric nanozyme is a novel biomaterial with the integration of piezoelectricity and activity that has capability killing bacteria promoting cell responses under mechanical stimulus exhibits great prospects in tissue regeneration. Herein, bismuth sulfide (BS) cationic vacancies (VBS) was synthesized, which enhanced activities compared BS. Moreover, hydrogel VBS phenylboronic acid grafted sodium alginate-arginine (VBS-PSA) prepared. Triggered by ultrasound (US) high power (>0.5 W cm-2), VBS-PSA produces large amount reactive oxygen species (ROS) through both piezoelectricity-enhanced sonodynamic efficiency peroxidase-like (POD-like) activity, thereby displaying powerful antibacterial capability. However, low-power US (≤0.5 effect generates electrical signals significantly stimulate osteoblast (proliferation differentiation) enhance catalase-like (CAT-like) for scavengers ROS generation oxygen, creating favorable microenvironment growth. Our study presents strategy to apply hydrogels enhancing synergistically kill responses. The would have potential repair infected bone defects.

Язык: Английский

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Nanotheranostics with Radionuclides for Cancer Diagnosis and Therapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Abstract Anti‐tumor theranostic radionuclide nanosystems have gained significant attention as an emerging therapeutic strategy. This review systematically elucidates the concept and recent advances of anti‐tumor nanotheranostic systems with radionuclides, a focus on design nanocarriers, precise selection their advantages limitations in clinical translation. also explores integration imaging various treatment modalities, including photodynamic therapy, photothermal sonodynamic immunotherapy. Furthermore, combination therapy fluorescence magnetic resonance technologies, which broadens application nanotheranostics, is discussed. Finally, outlooks future development nanotheranostics radionuclides proposes key research focus.

Язык: Английский

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Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Год журнала: 2023, Номер 303, С. 122391 - 122391

Опубликована: Ноя. 15, 2023

Язык: Английский

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2D Piezoelectric BiVO₄ Artificial Nanozyme with Adjustable Vanadium Vacancy for Ultrasound Enhanced Piezoelectric/Sonodynamic Therapy

Small, Год журнала: 2023, Номер 19(36)

Опубликована: Май 1, 2023

Increasing the yield of reactive oxygen species (ROS) to enhance oxidative stress in cells is an eternal goal cancer therapy. In this study, BiVO4 artificial nanozyme developed with adjustable vanadium vacancy for ultrasound (US) enhanced piezoelectric/sonodynamic Under US excitation, vacancy-rich nanosheets (abbreviated Vv -r NSs) facilitate generation a large number electrons improve ROS yield. Meanwhile, mechanical strain imposed by irradiation makes NSs display typical piezoelectric response, which tilts conduction band be more negative and valance positive than redox potentials O2 /O2•- H2 O/·OH, boosting efficiency generation. Both density functional theory calculations experiments confirm that introduction cationic can sonodynamic effect. As expected, have better peroxidase enzyme catalytic glutathione depletion activities, resulting increased intracellular stress. This triple amplification strategy induced substantially inhibits growth cells. The work may open avenue achieve synergetic therapy introducing vacancy, broadening biomedical use materials.

Язык: Английский

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Cornea‐Inspired Ultrasound‐Responsive Adhesive Hydrogel Patches for Keratitis Treatment

Advanced Functional Materials, Год журнала: 2023, Номер 34(12)

Опубликована: Дек. 12, 2023

Abstract Biomedical patches offer significant potential for keratitis treatment. Building on advances in multifunctionality and biomimicry, an innovative, multifunctional hydrogel patch with high therapeutic efficacy, inspired by the native architecture functions of cornea, is introduced. By engineering a composite comprising recombinant human collagen (RHC) hydrogel, near‐field electrospinning (NFES) microfibers, gold‐nanoparticle‐decorated tetragonal barium titanates (BTO@Au), structural mimicry, mechanical reinforcement, tissue‐specific adhesion, bacterial inhibition are achieved. The RHC recreates three‐dimensional (3D) microenvironment that emulates natural structure corneal tissue, demonstrating excellent tissue adhesion. Integrated within this NFES designed to emulate orthogonal arrangement stroma, not only reinforce strength but also act as scaffolds guide aligned growth keratocytes. A unique aspect advanced incorporation BTO@Au nanoparticles, which generate reactive oxygen species effective eradication when subjected ultrasound stimulation. Through vivo studies rat models infected wounds, exhibits superior efficacy compared current It posited these cornea‐inspired ultrasound‐responsive adhesive represent scientific advancement clinical applications.

Язык: Английский

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2D Ultrathin Iron Doped Bismuth Oxychloride Nanosheets with Rich Oxygen Vacancies for Enhanced Sonodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(30)

Опубликована: Июнь 7, 2023

Sonodynamic therapy (SDT) combines ultrasound and sonosensitizers to produce toxic reactive oxygen species (ROS) for cancer cell killing. Due the high penetration depth of (US), SDT breaks barrier conventional photodynamic treatment deeply seated tumors. A key point enhance therapeutic efficiency is development novel with promoted ability ROS production. Herein, ultrathin Fe-doped bismuth oxychloride nanosheets rich vacancies bovine serum albumin coating on surface are designed as piezoelectric (BOC-Fe NSs) enhanced SDT. The BOC-Fe NSs provide electron trapping sites promote separation e

Язык: Английский

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Lattice expansion in ruthenium nanozymes improves catalytic activity and electro-responsiveness for boosting cancer therapy

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 16, 2024

Nanozymes have been attracting widespread interest for the past decade, especially in field of cancer therapy, due to their intrinsic catalytic activities, strong stability, and ease synthesis. However, enhancing activity tumor microenvironment (TME) remains a major challenge. Herein, we manipulate activities Ru nanozymes via modulating lattice spacing nanocrystals supported on nitrogen-doped carbon support, achieve improvement multiple enzyme-like that can form cascade reactions boost cell killing. In addition, expansion improve responsiveness self-powered electric field, achieving maximized therapeutic outcome. Under electrical stimulation provided by human self-propelled triboelectric device, Ru-based nanozyme (Ru1000) with 5.99% realizes optimal performance outcome breast female tumor-bearing mice. Through theoretical calculations, uncover promote reaction, simultaneously, reducing electron density shifting d-band center active sites. This work provides opportunities improving development nanozymes.

Язык: Английский

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