Ultrasonics Sonochemistry,
Journal Year:
2024,
Volume and Issue:
107, P. 106928 - 106928
Published: May 27, 2024
Rheumatoid
arthritis
(RA)
is
a
chronic
systemic
inflammatory
disease
characterized
by
infiltration
of
cells,
hyperplasia
synovium,
and
destruction
the
joint
cartilage.
Owing
to
low
drug
delivery
efficiency
limited
immunosuppression
effect,
complete
cure
for
RA
remains
formidable
challenge.
Here,
we
show
that
live
macrophages
(Mφs)
carrying
protoporphyrin-loaded
Fe
BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 4, 2024
Abstract
Nanomedicine‐assisted
sonodynamic
therapy
(SDT)
has
emerged
as
one
of
the
most
promising
cancer
therapies
due
to
its
unique
advantages
high
penetration,
non‐radiation,
and
excellent
oxidative
stress
effect,
but
always
suffered
from
self‐protection
mechanism
apoptosis
resistance
characteristics
evolutionarily
mutated
cells.
Regulated
cell
death
(RCD)
received
increasing
attention
in
precision
treatments
because
significant
role
synergistically
sensitizing
reversing
immunosuppressive
microenvironment
during
SDT
nanomedicine‐triggered
immunogenic
death.
Herein,
paradigmatic
research
RCD‐augmented
tumor
immunotherapeutics
are
typically
introduced,
such
autophagy
blockade,
ferroptosis
targeting,
pyroptosis
induction,
necroptosis
initiation,
cuproptosis
actuation,
PANoptosis
trigger,
coordinated
anti‐tumor
mechanisms
discussed
detail.
Multiple
analysis
focusing
on
currently
unsolved
problems
future
development
prospects
RCD‐based
nano‐oncology
medicine
also
prospected
further
strengthen
expand
scope
therapeutic
applications.
Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Feb. 24, 2025
Abstract
Sonodynamic
therapy
(SDT)
as
an
emerging
modality
for
malignant
tumors
mainly
involves
in
sonosensitizers
and
low-intensity
ultrasound
(US),
which
can
safely
penetrate
the
tissue
without
significant
attenuation.
SDT
not
only
has
advantages
including
high
precision,
non-invasiveness,
minimal
side
effects,
but
also
overcomes
limitation
of
low
penetration
light
to
deep
tumors.
The
cytotoxic
reactive
oxygen
species
be
produced
by
utilization
combined
with
US
kill
tumor
cells.
However,
underlying
mechanism
been
elucidated,
its
unsatisfactory
efficiency
retards
further
clinical
application.
Herein,
we
shed
on
main
mechanisms
types
sonosensitizers,
organic
inorganic
sonosensitizers.
Due
development
nanotechnology,
many
novel
nanoplatforms
are
utilized
this
arisen
field
solve
barriers
enable
continuous
innovation.
This
review
highlights
potential
nanosonosensitizers
focus
enhanced
based
monotherapy
or
synergistic
that
difficult
reach
traditional
treatment,
especially
orthotopic
cancers.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 23, 2024
Low-intensity
ultrasound-mediated
sonodynamic
therapy
(SDT),
which,
by
design,
integrates
sonosensitizers
and
molecular
oxygen
to
generate
therapeutic
substances
(e.g.,
toxic
hydroxyl
radicals,
superoxide
anions,
or
singlet
oxygen)
at
disease
sites,
has
shown
enormous
potential
for
the
effective
treatment
of
a
variety
diseases.
Nanoscale
play
crucial
role
in
SDT
process
because
their
structural,
compositional,
physicochemical,
biological
characteristics
are
key
determinants
efficacy.
In
particular,
advances
materials
science
nanotechnology
have
invigorated
series
optimization
strategies
augmenting
efficacy
nanosonosensitizers.
This
comprehensive
review
systematically
summarizes,
discusses,
highlights
state-of-the-art
studies
on
current
achievements
nanosonosensitizer
enhanced
treatment,
with
an
emphasis
general
design
principles
nanosonosensitizers
strategies,
mainly
including
organic
inorganic
Additionally,
recent
advancements
optimized
applications
aimed
treating
various
diseases,
such
as
cancer,
bacterial
infections,
atherosclerosis,
autoimmune
clarified
detail.
Furthermore,
effects
improved
versatile
thoroughly
discussed.
The
concludes
highlighting
challenges
future
opportunities
this
rapidly
evolving
research
field
expedite
its
practical
clinical
translation
application.
Small,
Journal Year:
2024,
Volume and Issue:
20(44)
Published: July 6, 2024
Abstract
Sonodynamic
therapy
(SDT),
featuring
noninvasive,
deeper
penetration,
low
cost,
and
repeatability,
is
a
promising
approach
for
deep‐seated
tumors.
However,
the
general
or
only
utilization
of
SDT
shows
efficiency
unsatisfactory
treatment
outcomes
due
to
complicated
tumor
microenvironment
(TME)
process.
To
circumvent
issues,
three
feasible
approaches
enhancing
SDT‐based
therapeutic
effects,
including
sonosensitizer
optimization,
strategies
conquering
hypoxia
TME,
combinational
are
summarized,
with
particular
focus
on
combination
other
modalities,
chemodynamic
therapy,
photodynamic
photothermal
chemotherapy,
starvation
gas
immunotherapy.
In
end,
current
challenges
in
tumors
discussed
enhanced
effects
provided.
It
envisioned
that
this
review
will
provide
new
insight
into
strategic
design
high‐efficiency
sonosensitizer‐derived
nanotheranostics,
thereby
augmenting
accelerating
potential
clinical
transformation.
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(5)
Published: Jan. 29, 2025
Cancer
immunotherapies
rely
on
CD8
+
cytolytic
T
lymphocytes
(CTLs)
in
recognition
and
eradication
of
tumor
cells
via
antigens
presented
major
histocompatibility
complex
class
I
(MHC-I)
molecules.
However,
we
observe
MHC-I
deficiency
human
murine
urologic
tumors,
posing
daunting
challenges
for
successful
immunotherapy.
We
herein
report
an
unprecedented
nanosonosensitizer
one-dimensional
bamboo-like
multisegmented
manganese
dioxide@manganese–bismuth
vanadate
(BMMBV)
to
boost
multiple
branches
immune
responses
targeting
MHC-I–deficient
tumors.
BMMBV
markedly
augments
sonodynamic
activity
contributed
by
heteroatoms
the
lattice
bismuth
with
narrowing
bandgaps.
Under
sonoirradiation,
enhances
antigen
spreading
emission
adjuvant
signals,
which
potentiate
dendritic
cell
maturation,
thereby
eliciting
high
aptitude
CTLs.
This
therapy
substantially
up-regulates
MHC
expression
cells,
are
reversely
sensitive
Alongside,
extensive
innate
complement
CTLs
eliminating
mouse
study
offers
a
reinforced
strategy
against
antigen-loss
immune-evasive
tumor.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 9549 - 9574
Published: Sept. 1, 2024
Molecular
imaging
is
an
advanced
technology
that
utilizes
specific
probes
or
markers
in
conjunction
with
cutting-edge
techniques
to
observe
and
analyze
the
localization,
distribution,
activity,
interactions
of
biomolecules
within
living
organisms.
Tumor
molecular
imaging,
by
enabling
visualization
quantification
characteristics
tumor
cells,
facilitates
a
deeper
more
comprehensive
understanding
tumors,
providing
valuable
insights
for
early
diagnosis,
treatment
monitoring,
cancer
biology
research.
However,
image
quality
still
requires
improvement,
nanotechnology
has
significantly
propelled
advancement
imaging.
Currently,
nanoparticle-based
technologies
encompass
radionuclide
fluorescence
magnetic
resonance
ultrasound
photoacoustic
multimodal
among
others.
As
our
microenvironment
deepens,
design
nanoparticle
also
evolved,
offering
new
perspectives
expanding
applications
Beyond
diagnostics,
there
marked
trend
towards
integrated
diagnosis
therapy,
image-guided
playing
pivotal
role.
This
includes
surgery,
photodynamic
chemodynamic
therapy.
Despite
continuous
advancements
innovative
developments
many
these
remain
experimental
stage
require
breakthroughs
before
they
can
be
fully
into
clinical
practice.
Recent
insights
into
covalent
organic
frameworks
(COFs)
provide
an
opportunity
for
developing
new
sonosensitizers
with
the
advantages
of
both
small
molecules
and
inorganic
nanoagents.
Herein,
we
synthesize
two
benzotrithiophene-based
imine-linked
COFs
(BTT-DPh-COF
BTT-DPy-COF)
through
density-functional-theory-guided
structure
editing.
The
tailored
donor-acceptor
(D-A)
structures
optimize
band
position
endow
them
good
intrinsic
sonodynamic
activity,
which
can
efficiently
kill
cancer
cells,
showing
excellent
therapeutic
effect.
Particularly,
because
enhanced
D-A
effect
that
promotes
charge
separation
transfer
behavior,
BTT-DPy-COF
exhibits
superior
ultrasound-triggered
reactive
oxygen
species
(ROS)
generation
capability
than
BTT-DPh-COF.
Therefore,
these
studies
highlight
great
potential
elaborate
editing
configurations
as
suitable
candidates
advanced
sonosensitizers.
