The History of Electrospinning: Past, Present, and Future Developments

Advanced Materials Technologies, Год журнала: 2023, Номер 8(11)

Опубликована: Май 5, 2023

Abstract Electrospinning has rapidly progressed over the past few decades as an easy and versatile way to fabricate fibers with diameters ranging from micrometers tens of nanometers that present unique intricate morphologies. This led conception new technologies diverse methods exploit basic electrohydrodynamic phenomena electrospinning process, which in turn invention novel apparatuses have reshaped field. Research on revamping conventional principally focused achieving three key objectives: upscaling process while retaining consistent morphological traits, developing 3D nanofibrous macrostructures, formulating fiber configurations. review introduces extensive group techniques presents a comperative study based apparatus type output. Then, each process's advantages limitations are critically assessed identify bona fide practicability relevance technological breakthrough. Finally, outlook future developments advanced is outlined, emphasis upscaling, translational research, sustainable manufacturing prospective solutions current shortcomings.

Язык: Английский

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Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Ноя. 14, 2022

Epidermal growth factor is an excellent drug for promoting wound healing; however, its conventional administration strategies are associated with pharmacodynamic challenges, such as low transdermal permeability, reduction, and receptor desensitization. Here, we develop a microneedle-based self-powered transcutaneous electrical stimulation system (mn-STESS) by integrating sliding free-standing triboelectric nanogenerator microneedle patch to achieve improved epidermal pharmacodynamics. We show that the mn-STESS facilitates penetration utilization using microneedles pierce stratum corneum. More importantly, find it converts mechanical energy of finger into electricity mediates through microneedles. demonstrate applied acts "adjuvant" suppresses reduction glutathione upregulates expression in keratinocyte cells, successfully compensating Collectively, this work highlights promise adjuvants improving pharmacodynamics, creating combinatorial therapeutic traditional drugs.

Язык: Английский

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Developing natural polymers for skin wound healing

Bioactive Materials, Год журнала: 2023, Номер 33, С. 355 - 376

Опубликована: Ноя. 26, 2023

Natural polymers are complex organic molecules that occur in the natural environment and have not been subjected to artificial synthesis. They frequently encountered various creatures, including mammals, plants, microbes. The aforementioned commonly derived from renewable sources, possess a notable level of compatibility with living organisms, limited adverse effect on environment. As result, they hold considerable significance development sustainable environmentally friendly goods. In recent times, there has advancement investigation potential uses field biomedicine, specifically relation biomaterials exhibit antibacterial antioxidant characteristics. This review provides comprehensive overview prevalent utilized biomedical domain throughout preceding two decades. this paper, we present examination components typical methods for preparation based polymers. Furthermore, summarize application polymer materials each stage skin wound repair. Finally, key findings insights into limitations current elucidate prospects their future field.

Язык: Английский

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Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1829 - 1829

Опубликована: Июнь 26, 2023

Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, well spatial structure which mimics the extracellular matrix. However, use of nanofibers achieve controlled loading release still presents many challenges, with ongoing research exploring how load drugs onto nanofiber without loss activity control in specific spatiotemporal manner. This comprehensive study systematically reviews applications recent advances related drug-laden skin-wound management. First, we introduce commonly used methods preparation, electrostatic spinning, sol-gel, molecular self-assembly, thermally induced phase separation, 3D-printing techniques. Next, summarize polymers preparation utilizing scaffolds. We then review application drug-loaded considering different stages healing acts. Finally, briefly describe stimulus-responsive schemes scaffolds, other exciting systems.

Язык: Английский

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Advances in wound dressing based on electrospinning nanofibers

Journal of Applied Polymer Science, Год журнала: 2023, Номер 141(1)

Опубликована: Окт. 3, 2023

Abstract In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity permeability air water, effective barrier properties against external pathogens, excellent resemblance the extracellular matrix wound healing skin regeneration. This article reviews advancements in application of electrospinning healing. The review begins with an overview process methods. It then explores advantages disadvantages different synthetic natural polymers used preparation dressings. discussed this include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, sodium alginate. Additionally, delves into commonly like polyvinyl alcohol, chloride, polyethylene lactone, polylactide, polyurethane applications. Furthermore, examines blending create high‐performance also incorporation functional additives, such as antimicrobial agents, growth factors, extracts, expedite tissue repair. conclusion, is emerging technology that provides unique opportunities designing more care products.

Язык: Английский

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Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds

Advanced Functional Materials, Год журнала: 2024, Номер 34(24)

Опубликована: Фев. 16, 2024

Abstract Diabetic wounds are difficult to heal, and the key wound healing is exudate management effective disinfection. Inspired by asymmetric wettability of Janus‐structured lotus leaves, herein study has presented design a biomimetic Janus membrane that integrates unidirectional biofluid drainage photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic healing. This prepared electrospinning polyacrylonitrile (PAN) nanofiber containing polydopamine (PDA) on surface polypropylene (PP) nonwoven membrane. Such PP/PAN x%PDA enables antigravity “pumping” water from hydrophobic PP layer hydrophilic PAN within 22 s through contact points interface. The incorporation 30 wt% PDA in imparts high photoabsorption photothermal responsiveness, facilitating continuous volatilization exudate, achieving twice displacement water, causing irreversible damage bacteria. As result, it effectively alleviates inflammation cellular fibrosis while promoting collagen deposition due its structure antibacterial properties. Impressively, such achieves an impressive closure rate 96.7% wounds, better than (59.8%) conventional bandages. Therefore, this offers promising alternative chronic wounds.

Язык: Английский

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Noncancerous disease-targeting AIEgens

Chemical Society Reviews, Год журнала: 2023, Номер 52(3), С. 1024 - 1067

Опубликована: Янв. 1, 2023

Schematic diagram of noncancerous disease-targeting AIEgens.

Язык: Английский

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Luminescent MOF-Based Nanofibers with Visual Monitoring and Antibacterial Properties for Diabetic Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(7), С. 9110 - 9119

Опубликована: Фев. 8, 2023

Diabetic wound healing remains as a serious challenge for medical circles that required continuous monitoring and effective management. Herein, the glucose oxidase/carbon dots@copper-metal–organic framework-based nanofibers (GOx/CDs@MOF NFs) were proposed multifunctional dressing, aiming to visually monitor pH inhibit bacterial infection. In diabetic microenvironment, GOx/CDs@MOF NFs could convert endogenous into hydroxyl radial (•OH) through cascade catalytic reaction. vivo vitro experimental results confirmed efficiently kill bacteria promote healing. Additionally, CDs fluorescent indicator endowed with sensitive reversible sensing behavior pH, these visual images also be captured by smartphones transformed RGB color mode (red, green, blue) values, allowing onsite evaluation of status. This dressing provides smart solution management takes an immeasurable step toward development next generation digitally visualized dressings.

Язык: Английский

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Multifunctional dressings for wound exudate management

Progress in Materials Science, Год журнала: 2024, Номер 146, С. 101328 - 101328

Опубликована: Июнь 14, 2024

Язык: Английский

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On-Site Electrospinning Nanofiber Membranes Incorporating V-Shaped Organic Semiconductors for Multifunctional Diabetic Wound Dressing

Advanced Fiber Materials, Год журнала: 2024, Номер 6(5), С. 1413 - 1427

Опубликована: Май 7, 2024

Язык: Английский

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