Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Abstract
Electrospinning
is
a
significant
manufacturing
strategy
to
create
micro/nanofiber
platforms
that
can
be
considered
biomedical
scaffold
for
tissue
engineering
repair
and
regeneration.
In
recent
years
researchers
have
continuously
broadened
the
equipment
design
materials
development
of
electrospinning
nanofiber
(ENPs),
which
evolved
from
single‐needle
multi‐needle
creating
3D
ENPs,
diversify
their
application
including
drugs/cell/growth
factors
release,
anti‐bacterial
anti‐inflammatory,
hemostasis,
wound
healing,
Herein,
multifunctional
ENPs
with
bioactive
polymer
fabricated
via
in
terms
novel
material
design,
construction
various
structures,
requirements
different
regeneration
are
reviewed.
Furthermore,
this
review
delves
into
advancements
facilitated
by
highlighting
effectiveness
versatility
across
types
such
as
bone,
cartilage,
tendons,
cardiac
tissue,
nerves.
The
discussion
comprehensively
addresses
ongoing
challenges
selection,
biodegradation
mechanisms,
bioactivation
strategies,
techniques
specific
applications.
Moreover,
outlines
potential
future
research
avenues
aimed
at
enhancing
ENPs‐based
approaches
engineering.
This
in‐depth
analysis
aims
provide
nuanced
insights
technical
recommendations
propel
field
forward
Advanced Materials Technologies,
Год журнала:
2023,
Номер
8(11)
Опубликована: Май 5, 2023
Abstract
Electrospinning
has
rapidly
progressed
over
the
past
few
decades
as
an
easy
and
versatile
way
to
fabricate
fibers
with
diameters
ranging
from
micrometers
tens
of
nanometers
that
present
unique
intricate
morphologies.
This
led
conception
new
technologies
diverse
methods
exploit
basic
electrohydrodynamic
phenomena
electrospinning
process,
which
in
turn
invention
novel
apparatuses
have
reshaped
field.
Research
on
revamping
conventional
principally
focused
achieving
three
key
objectives:
upscaling
process
while
retaining
consistent
morphological
traits,
developing
3D
nanofibrous
macrostructures,
formulating
fiber
configurations.
review
introduces
extensive
group
techniques
presents
a
comperative
study
based
apparatus
type
output.
Then,
each
process's
advantages
limitations
are
critically
assessed
identify
bona
fide
practicability
relevance
technological
breakthrough.
Finally,
outlook
future
developments
advanced
is
outlined,
emphasis
upscaling,
translational
research,
sustainable
manufacturing
prospective
solutions
current
shortcomings.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Ноя. 14, 2022
Epidermal
growth
factor
is
an
excellent
drug
for
promoting
wound
healing;
however,
its
conventional
administration
strategies
are
associated
with
pharmacodynamic
challenges,
such
as
low
transdermal
permeability,
reduction,
and
receptor
desensitization.
Here,
we
develop
a
microneedle-based
self-powered
transcutaneous
electrical
stimulation
system
(mn-STESS)
by
integrating
sliding
free-standing
triboelectric
nanogenerator
microneedle
patch
to
achieve
improved
epidermal
pharmacodynamics.
We
show
that
the
mn-STESS
facilitates
penetration
utilization
using
microneedles
pierce
stratum
corneum.
More
importantly,
find
it
converts
mechanical
energy
of
finger
into
electricity
mediates
through
microneedles.
demonstrate
applied
acts
"adjuvant"
suppresses
reduction
glutathione
upregulates
expression
in
keratinocyte
cells,
successfully
compensating
Collectively,
this
work
highlights
promise
adjuvants
improving
pharmacodynamics,
creating
combinatorial
therapeutic
traditional
drugs.
Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 355 - 376
Опубликована: Ноя. 26, 2023
Natural
polymers
are
complex
organic
molecules
that
occur
in
the
natural
environment
and
have
not
been
subjected
to
artificial
synthesis.
They
frequently
encountered
various
creatures,
including
mammals,
plants,
microbes.
The
aforementioned
commonly
derived
from
renewable
sources,
possess
a
notable
level
of
compatibility
with
living
organisms,
limited
adverse
effect
on
environment.
As
result,
they
hold
considerable
significance
development
sustainable
environmentally
friendly
goods.
In
recent
times,
there
has
advancement
investigation
potential
uses
field
biomedicine,
specifically
relation
biomaterials
exhibit
antibacterial
antioxidant
characteristics.
This
review
provides
comprehensive
overview
prevalent
utilized
biomedical
domain
throughout
preceding
two
decades.
this
paper,
we
present
examination
components
typical
methods
for
preparation
based
polymers.
Furthermore,
summarize
application
polymer
materials
each
stage
skin
wound
repair.
Finally,
key
findings
insights
into
limitations
current
elucidate
prospects
their
future
field.
Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1829 - 1829
Опубликована: Июнь 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Journal of Applied Polymer Science,
Год журнала:
2023,
Номер
141(1)
Опубликована: Окт. 3, 2023
Abstract
In
recent
years,
there
has
been
a
significant
focus
on
bioactive
dressings
suitable
for
treating
chronic
and
acute
wounds.
Electrospinning
nanofibers
are
considered
advanced
dressing
options
due
to
their
high
porosity
permeability
air
water,
effective
barrier
properties
against
external
pathogens,
excellent
resemblance
the
extracellular
matrix
wound
healing
skin
regeneration.
This
article
reviews
advancements
in
application
of
electrospinning
healing.
The
review
begins
with
an
overview
process
methods.
It
then
explores
advantages
disadvantages
different
synthetic
natural
polymers
used
preparation
dressings.
discussed
this
include
collagen,
gelatin,
silk
fibroin,
chitosan,
hyaluronic
acid,
sodium
alginate.
Additionally,
delves
into
commonly
like
polyvinyl
alcohol,
chloride,
polyethylene
lactone,
polylactide,
polyurethane
applications.
Furthermore,
examines
blending
create
high‐performance
also
incorporation
functional
additives,
such
as
antimicrobial
agents,
growth
factors,
extracts,
expedite
tissue
repair.
conclusion,
is
emerging
technology
that
provides
unique
opportunities
designing
more
care
products.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(24)
Опубликована: Фев. 16, 2024
Abstract
Diabetic
wounds
are
difficult
to
heal,
and
the
key
wound
healing
is
exudate
management
effective
disinfection.
Inspired
by
asymmetric
wettability
of
Janus‐structured
lotus
leaves,
herein
study
has
presented
design
a
biomimetic
Janus
membrane
that
integrates
unidirectional
biofluid
drainage
photothermal‐enhanced
evaporation/sterilization
capabilities
for
accelerating
diabetic
healing.
This
prepared
electrospinning
polyacrylonitrile
(PAN)
nanofiber
containing
polydopamine
(PDA)
on
surface
polypropylene
(PP)
nonwoven
membrane.
Such
PP/PAN
x%PDA
enables
antigravity
“pumping”
water
from
hydrophobic
PP
layer
hydrophilic
PAN
within
22
s
through
contact
points
interface.
The
incorporation
30
wt%
PDA
in
imparts
high
photoabsorption
photothermal
responsiveness,
facilitating
continuous
volatilization
exudate,
achieving
twice
displacement
water,
causing
irreversible
damage
bacteria.
As
result,
it
effectively
alleviates
inflammation
cellular
fibrosis
while
promoting
collagen
deposition
due
its
structure
antibacterial
properties.
Impressively,
such
achieves
an
impressive
closure
rate
96.7%
wounds,
better
than
(59.8%)
conventional
bandages.
Therefore,
this
offers
promising
alternative
chronic
wounds.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(7), С. 9110 - 9119
Опубликована: Фев. 8, 2023
Diabetic
wound
healing
remains
as
a
serious
challenge
for
medical
circles
that
required
continuous
monitoring
and
effective
management.
Herein,
the
glucose
oxidase/carbon
dots@copper-metal–organic
framework-based
nanofibers
(GOx/CDs@MOF
NFs)
were
proposed
multifunctional
dressing,
aiming
to
visually
monitor
pH
inhibit
bacterial
infection.
In
diabetic
microenvironment,
GOx/CDs@MOF
NFs
could
convert
endogenous
into
hydroxyl
radial
(•OH)
through
cascade
catalytic
reaction.
vivo
vitro
experimental
results
confirmed
efficiently
kill
bacteria
promote
healing.
Additionally,
CDs
fluorescent
indicator
endowed
with
sensitive
reversible
sensing
behavior
pH,
these
visual
images
also
be
captured
by
smartphones
transformed
RGB
color
mode
(red,
green,
blue)
values,
allowing
onsite
evaluation
of
status.
This
dressing
provides
smart
solution
management
takes
an
immeasurable
step
toward
development
next
generation
digitally
visualized
dressings.
