ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(15), С. 19472 - 19479
Опубликована: Апрель 4, 2024
Nanomedicine-enhanced
immunogenic
cell
death
(ICD)
has
attracted
considerable
attention
for
its
great
potential
in
cancer
treatment.
Even
though
polyethylene
glycol
(PEG)
is
widely
recognized
as
the
gold
standard
surface
modification
of
nanomedicines,
some
shortcomings
associated
with
this
PEGylation,
such
hindered
endocytosis
and
accelerated
blood
clearance
phenomenon,
have
been
revealed
recent
years.
Notably,
polysarcosine
(PSar)
a
highly
biocompatible
polymer
can
be
finely
synthesized
by
mild
ring-opening
polymerization
(ROP)
sarcosine
N-carboxyanhydrides
(Sar-NCAs)
exhibit
an
alternative
to
PEG.
In
article,
PSar-b-polycamptothecin
block
copolymers
are
sequential
ROP
camptothecin-based
NCAs
(CPT-NCAs)
Sar-NCAs.
Then,
detailed
systematic
comparison
between
PEGylation
PSarylation
against
4T1
tumor
model
indicates
that
PSar
decoration
facilitate
endocytosis,
greatly
enhancing
ICD
effects
antitumor
efficacy.
Therefore,
it
believed
well-developed
technique
will
achieve
effective
precise
treatment
near
future.
The
polarization
of
tumor-associated
macrophages
(TAMs)
from
M2
to
M1
phenotype
demonstrates
great
potential
for
remodeling
the
immunosuppressive
tumor
microenvironment
(TME)
hepatocellular
carcinoma
(HCC).
d-lactate
(DL;
a
gut
microbiome
metabolite)
acts
as
an
endogenous
immunomodulatory
agent
that
enhances
Kupffer
cells
clearance
pathogens.
In
this
study,
DL
transformation
TAMs
was
confirmed,
and
mechanisms
underlying
such
were
mainly
due
modulation
phosphatidylinositol
3-kinase/protein
kinase
B
pathway.
A
poly(lactide-co-glycolide)
nanoparticle
(NP)
used
load
DL,
DL-loaded
NP
modified
with
HCC
membrane
macrophage-binding
peptide
(M2pep),
forming
nanoformulation
(DL@NP-M-M2pep).
DL@NP-M-M2pep
transformed
remodeled
TME
in
mice,
promoting
efficacy
anti-CD47
antibody
long-term
animal
survival.
These
findings
reveal
TAM
modulatory
function
provide
combinatorial
strategy
immunotherapy.
Bioengineering,
Год журнала:
2023,
Номер
10(7), С. 760 - 760
Опубликована: Июнь 25, 2023
Nano-oncology
is
a
branch
of
biomedical
research
and
engineering
that
focuses
on
using
nanotechnology
in
cancer
diagnosis
treatment.
Nanomaterials
are
extensively
employed
the
field
oncology
because
their
minute
size
ultra-specificity.
A
wide
range
nanocarriers,
such
as
dendrimers,
micelles,
PEGylated
liposomes,
polymeric
nanoparticles
used
to
facilitate
efficient
transport
anti-cancer
drugs
at
target
tumor
site.
Real-time
labeling
monitoring
cells
quantum
dots
essential
for
determining
level
therapy
needed
The
drug
targeted
site
either
by
passive
or
active
means.
Passive
targeting
makes
use
microenvironment
enhanced
permeability
retention
effect,
while
involves
ligand-coated
nanoparticles.
Nanotechnology
being
diagnose
early
stage
detecting
cancer-specific
biomarkers
imaging.
implication
employs
photoinduced
nanosensitizers,
reverse
multidrug
resistance,
enabling
delivery
CRISPR/Cas9
RNA
molecules
therapeutic
applications.
However,
despite
recent
advancements
nano-oncology,
there
need
delve
deeper
into
domain
designing
applying
improved
diagnostics.
Abstract
Photothermal
therapy
(PTT)
has
garnered
significant
attention
in
recent
years,
but
the
standalone
application
of
PTT
still
faces
limitations
that
hinder
its
ability
to
achieve
optimal
therapeutic
outcomes.
Nitric
oxide
(NO),
being
one
most
extensively
studied
gaseous
molecules,
presents
itself
as
a
promising
complementary
candidate
for
PTT.
In
response,
various
nanosystems
have
been
developed
enable
simultaneous
utilization
and
NO‐mediated
gas
(GT),
with
integration
photothermal
agents
(PTAs)
thermally‐sensitive
NO
donors
prevailing
approach.
This
combination
seeks
leverage
synergistic
effects
GT
while
mitigating
potential
risks
associated
toxicity
through
use
single
laser
irradiation.
Furthermore,
additional
internal
or
external
stimuli
employed
trigger
release
when
combined
different
types
PTAs,
thereby
further
enhancing
efficacy.
comprehensive
review
aims
summarize
advancements
gas‐assisted
cancer
treatment.
It
commences
by
providing
an
overview
precursors,
including
those
sensitive
photothermal,
light,
ultrasound,
reactive
oxygen
species,
glutathione.
These
precursors
are
discussed
context
dual‐modal
PTT/GT.
Subsequently,
incorporation
other
treatment
modalities
such
chemotherapy
(CHT),
photodynamic
(PDT),
alkyl
radical
therapy,
radiation
immunotherapy
(IT)
creation
triple‐modal
nanoplatforms
is
presented.
The
explores
tetra‐modal
therapies,
PTT/GT/CHT/PDT,
PTT/GT/CHT/chemodynamic
(CDT),
PTT/GT/PDT/IT,
PTT/GT/starvation
(ST)/IT,
PTT/GT/Ca
2+
overload/IT,
PTT/GT/ferroptosis
(FT)/IT,
PTT/GT/CDT/IT.
Finally,
challenges
future
perspectives
concerning
these
novel
paradigms
discussed.
anticipated
serve
valuable
resource
studies
focused
on
development
innovative
photothermal/NO‐based
nanotheranostics.
Cancer
immunotherapy
has
achieved
tremendous
successful
clinical
results
and
obtained
historic
victories
in
tumor
treatments.
However,
great
limitations
associated
with
feeble
immune
responses
serious
adverse
effects
still
cannot
be
neglected
due
to
the
complicated
multifactorial
etiology
pathologic
microenvironment
tumors.
The
rapid
development
of
nanomedical
science
material
facilitated
advanced
progress
engineering
biomaterials
tackle
critical
issues.
supramolecular
flexible
modular
structures
have
exhibited
unparalleled
advantages
high
cargo-loading
efficiency,
excellent
biocompatibility,
diversiform
immunomodulatory
activity,
thereby
providing
a
powerful
weapon
for
cancer
immunotherapy.
In
past
decades,
were
extensively
explored
as
versatile
delivery
platforms
immunotherapeutic
agents
or
designed
interact
key
moleculars
system
precise
controllable
manner.
this
review,
we
focused
on
crucial
role
modulation
pivotal
steps
during
immunotherapy,
including
antigen
presentation,
T
lymphocyte
activation,
tumor-associated
macrophage
elimination
repolarization,
myeloid-derived
suppressor
cell
depletion.
Based
extensive
research,
current
prospects
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(7), С. 3224 - 3252
Опубликована: Янв. 1, 2024
Neoantigens
play
a
pivotal
role
in
the
field
of
tumour
therapy,
encompassing
stimulation
anti-tumour
immune
response
and
enhancement
targeting
capability.
Nonetheless,
numerous
factors
directly
influence
effectiveness
neoantigens
bolstering
responses,
including
neoantigen
quantity
specificity,
uptake
rates
by
antigen-presenting
cells
(APCs),
residence
duration
within
microenvironment
(TME),
their
ability
to
facilitate
maturation
APCs
for
activation.
Nanotechnology
assumes
significant
several
aspects,
facilitating
release,
promoting
delivery
cells,
augmenting
dendritic
shielding
from
protease
degradation,
optimizing
interactions
between
system.
Consequently,
development
nanotechnology
synergistically
enhances
efficacy
cancer
theranostics.
In
this
review,
we
provide
an
overview
sources,
mechanisms
neoantigen-induced
evolution
precision
neoantigen-based
nanomedicine.
This
encompasses
various
therapeutic
modalities,
such
as
immunotherapy,
phototherapy,
radiotherapy,
chemotherapy,
chemodynamic
other
strategies
tailored
augment
therapeutics.
We
also
discuss
current
challenges
prospects
application
nanomedicine,
aiming
expedite
its
clinical
translation.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(5), С. 5683 - 5695
Опубликована: Янв. 23, 2024
Photosensitizers
have
been
widely
used
to
cause
intratumoral
generation
of
reactive
oxygen
species
(ROS)
for
cancer
therapy,
but
they
are
easily
disturbed
by
the
autophagy
pathway,
a
self-protective
mechanism
mitigating
oxidative
damage.
Hereby,
we
reported
simple
and
effective
strategy
construct
carrier-free
nanodrug,
Ce6@CQ
namely,
based
on
self-assembly
photosensitizer
chlorin
e6
(Ce6)
inhibitor
chloroquine
(CQ).
Specifically,
avoided
unexpected
toxicity
caused
regular
nanocarrier
also
ameliorated
its
stability
in
different
conditions.
Light-activated
Ce6
generated
cytotoxic
ROS
elicited
part
immunogenic
cell
death
(ICD).
Moreover,
CQ
induced
dysfunction,
which
hindered
self-healing
tumor
cells
enhanced
photodynamic
therapy
(PDT)
exert
more
potent
killing
effect
efficient
ICD.
Also,
could
effectively
accumulate
xenograft
breast
site
mouse
model
through
permeability
retention
(EPR)
effect,
growth
tumors
was
inhibited
with
light.
Such
nanodrug
provided
new
improve
efficacy
PDT
via
suppression
digest
ROS-induced
toxic
substances.
Sono-immunotherapy
faces
challenges
from
poor
immunogenicity
and
low
response
rate
due
to
complex
biological
barriers.
Herein,
we
prepared
MCTH
nanocomposites
(NCs)
consisting
of
disulfide
bonds
(S-S)
doped
mesoporous
organosilica
(MONs),
Cu-modified
protoporphyrin
(CuPpIX),
mitochondria-targeting
triphenylphosphine
(TPP),
CD44-targeting
hyaluronic
acid
(HA).
NCs
efficiently
accumulate
at
the
tumor
site
overexpressed
CD44
receptors
on
membrane
cancer
cells.
Under
function
HAase
glutathione
(GSH),
degrades
exposes
TPP
deliver
CuPpIX
mitochondrial
induce
a
reactive
oxygen
species
(ROS)
burst
in
situ
under
ultrasound
irradiations,
thereby
causing
severe
mitochondria
dysfunction.
This
cascade-targeting
ability
not
only
reinforces
oxidative
stress
cells
but
also
amplifies
immunogenic
cell
death
(ICD)
stimulate
body's
immune
alleviate
immunosuppressive
microenvironment.
These
significantly
enhance
infiltration
into
tumor,
particularly
CD8+
T
cells,
for
powerful
antitumor
sono-immunotherapy.
The
proposed
strategy
holds
promise
strengthening
sono-immunotherapy
prostate
treatment
overcoming
limitations
traditional
immunotherapy.
