Journal of Biomolecular Structure and Dynamics,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Фев. 22, 2024
Resistance
to
chemotherapeutics
is
an
eminent
cause
that
leads
search
for
options
help
in
diminution
of
pancreatic
ductal
adenocarcinoma
(PDAC)
by
overcoming
resistance
issues.
Caffeic
acid
(CFA),
a
polyphenol
occurring
many
dietary
foods,
known
show
antidiabetic
and
anticancer
properties
potential.
To
unveil
the
effect
CFA
on
PDAC,
we
carried
out
this
research
PDAC
cells,
following
which
checked
combination
pre-sensitization
effects
CFA.
Multitudinous
web-based
approaches
were
applied
identifying
targets
then
getting
their
interconnections.
Subsequently,
manifested
in-vitro
analysis
showing
IC50
concentrations
37.37
15.06
µM
Panc-1
Mia-PaCa-2,
respectively.
The
index
with
different
drugs
was
explored
showed
antagonistic
treatment
leading
further
investigation
pre-sensitizing
effects.
reduced
concentration
doxorubicin
both
cell
lines
also
triggered
ROS
generation
determined
2′,7′-dichlorofluorescin
diacetate
assay.
differential
gene
expression
after
discrete
genes
affected
i.e.
N-Cad
Cas9
Pi3K/AkT/mTOR
along
p53
Mia-PaCa-2.
Collectively,
study
investigated
role
as
therapeutics
mechanism
mitigating
sensitizing
chemotherapeutics.
Nutrients,
Год журнала:
2022,
Номер
14(21), С. 4637 - 4637
Опубликована: Ноя. 3, 2022
Nutraceuticals
are
the
nourishing
components
(hybrid
of
nutrition
and
pharmaceuticals)
that
biologically
active
possess
capability
for
maintaining
optimal
health
benefits.
These
products
play
a
significant
role
in
human
care
its
endurance,
most
importantly
future
therapeutic
development.
have
received
recognition
due
to
their
nutritional
benefits
along
with
effects
safety
profile.
globally
growing
field
services
such
as
promotion,
disease
reduction,
etc.
Various
drug
nutraceutical
interactions
also
been
elaborated
various
examples
this
review.
Several
patents
on
nutraceuticals
agricultural
applications
diseases
stated
last
section
review,
which
confirms
exponential
growth
nutraceuticals’
market
value.
used
not
only
but
support
therapy
prevention
treatment
diseases,
reduce
side
cancer
chemotherapy
radiotherapy.
Diverse
novel
nanoformulation
approaches
tend
overcome
challenges
involved
formulation
development
nutraceuticals.
Prior
information
drugs
may
help
preventing
any
deleterious
products.
Nanotechnology
leads
generation
micronized
dietary
other
supplements
improved
In
review
article,
latest
key
findings
(clinical
studies)
show
action
nutraceutical’s
bioactive
molecules
discussed.
Applied Sciences,
Год журнала:
2025,
Номер
15(1), С. 380 - 380
Опубликована: Янв. 3, 2025
This
study
evaluated
Maltodextrin
(MD),
Gum
Arabic
(GA),
and
Carboxymethylcellulose
(CMC)
in
different
ratios
as
coating
materials
to
encapsulate
citrus
pomace
phenolic
compounds.
Citrus
encapsulates
were
obtained
by
ultrasound-assisted
extraction
followed
the
freeze-drying
process
characterized
regarding
microencapsulation
efficiency,
physical,
chemical
properties.
Carrier
material
choice
reflected
a
significant
effect
on
encapsulation
compounds
retention,
reconstitution
properties
of
encapsulated
extract.
The
efficiency
prepared
ranked
from
50.909%
84.000%,
it
was
strongly
dependent
upon
CMC
addition.
A
wide
range
parameters
(water
absorption
index-WAI
water
solubility
index-WSI)
suggested
possible
release
mechanism
modifications.
HPLC
analysis
revealed
presence
three
main
compounds,
namely
Hesperidin,
Naringin,
Rutin.
wall
mixture
MD,
GA,
same
proportions
optimal
for
freeze-drying.
combination
resulted
with
low
moisture
content
(1.936
±
0.012%)
activity
(0.110
0.001),
indicating
prolonged
stability.
Based
results,
an
technique
should
be
considered
promising
solution
recover
industry
byproducts
protect
them
environmental
gastrointestinal
circumstances.
BMC Research Notes,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 13, 2025
This
data
note
presents
a
comprehensive
geodatabase
of
cardiovascular
disease
(CVD)
hospitalizations
in
Mashhad,
Iran,
alongside
key
environmental
factors
such
as
air
pollutants,
built
environment
indicators,
green
spaces,
and
urban
density.
Using
spatiotemporal
dataset
over
52,000
hospitalized
CVD
patients
collected
five
years,
the
study
supports
approaches
like
advanced
modeling,
artificial
intelligence,
machine
learning
to
predict
high-risk
areas
guide
public
health
interventions.
includes
detailed
epidemiologic
geospatial
information
on
from
January
1,
2016,
December
31,
2020.
It
contains
52,176
confirmed
cases
demographic
age,
gender,
admission
date,
ICD-10
codes,
occurrence
death,
length
hospital
stay.
The
median
age
was
64
with
54.44%
male.
A
notable
9.41%
died
during
hospitalization.
In
addition
hospitalization
case
file
its
shape
created
by
joining
1301
census
tracts,
this
quality
indicators
(SO2,
PM2.5,
CO,
etc.).
also
incorporates
socio-economic
variables
(population
density,
illiteracy,
unemployment
rates),
infrastructure,
data,
providing
view
Mashhad.
Frontiers in Sustainable Food Systems,
Год журнала:
2023,
Номер
7
Опубликована: Май 24, 2023
Usually,
polyphenols
help
address
numerous
health
issues
caused
by
oxidative
stress.
Tea
is
a
popular
beverage
(rich
in
polyphenols)
with
abundant
promoting
and
disease
prevention
great
health-promoting
disease-prevention
attributes,
originating
from
the
delicate,
dried
leaves
of
Camellia
sinensis
plant.
has
been
proven
to
have
health-boosting
impacts
like
anti-inflammatory,
anti-cancerous,
anti-diabetic,
aids
weight
loss.
Cognitive
impairment,
also
known
as
cognitive
decline
aging
or
other
neurological
disorders,
become
an
emerging
concern.
polyphenols,
especially
phenolic
acids,
havegained
enormous
attention
due
their
link
improved
function
preventing
decline.
This
review
summarizes
recent
studies
on
benefits
tea.
Additionally,
effective
traditional
modern
techniques
extract
effects
various
diseases
described.
Journal of Physiology and Biochemistry,
Год журнала:
2024,
Номер
80(3), С. 603 - 625
Опубликована: Авг. 1, 2024
A
diet
rich
in
polyphenols
and
other
types
of
phytonutrients
can
reduce
the
occurrence
chronic
diseases.
However,
a
well-established
cause-and-effect
association
has
not
been
clearly
demonstrated
several
issues
will
need
to
be
fully
understood
before
general
recommendations
carried
out
In
present
review,
some
future
challenges
that
research
on
phenolic
compounds
have
face
next
years
are
discussed:
toxicological
aspects
safety
risk
assessment;
synergistic
effects
between
different
polyphenols;
metabotype-based
nutritional
advice
based
differential
gut
microbial
metabolism
(precision
nutrition);
combination
with
bioactive
compounds;
innovative
formulations
improve
bioavailability
sports
nutrition
recovery.Other
related
polyphenol
boost
are:
microbiota
crosstalk,
including
prebiotic
biotransformation
into
metabolites
by
microorganisms;
molecular
docking,
dynamics
simulation,
quantum
mechanics
studies
protein-polyphenol
complexes;
polyphenol-based
coating
films,
nanoparticles,
hydrogels
facilitate
delivery
drugs,
nucleic
acids
proteins.In
summary,
this
article
provides
constructive
inspirations
for
advancing
applications,
assessment
metabolic
dietary
humans.
Discover Agriculture,
Год журнала:
2025,
Номер
3(1)
Опубликована: Фев. 13, 2025
Rose
is
a
commercially
important
flower
and
has
been
an
part
of
traditional
medicine
cuisines
around
the
world
with
its
unique
flavor
potential
health
benefits.
This
study
aimed
at
examining
phytochemical
properties
antioxidant
different
dehydrated
petal
samples
rose
cultivars
underscoring
versatility
significance
these
natural
resources.
The
cultivars,
'Pusa
Pitamber'
'Summer
Snow'
displayed
elevated
phenolic
content,
rendering
them
versatile
for
applications
in
skincare
products,
culinary
enhancements,
medicine,
aesthetic
colorants.
Among
Gaurav'
'IHT'
exhibited
highest
tannin
content
which
can
be
insight
industries
seeking
colorant
textile
dyeing,
leather
industry,
pharmaceuticals
cosmetics.
Mohit'
Abhishek'
promising
potential,
capturing
interest
food
sectors.
carotenoids
viz.,
β-carotene,
Neoxanthin
Antheraxanthin
were
identified
as
biomarkers
based
on
Partial
Least
Squares
Discriminant
Analysis
(PLS-DA)
from
diverse
carotenoid
profiles
obtained
cultivars.
PLS-DA
emphasized
phenols
flavonoids
biomarker
differentiating
terms
potential.
cluster
analysis
could
divide
four
distinct
groups
their
composition,
giving
summarized
information
to
breeder
improvement
varieties.
Principal
Component
unveiled
intricate
relationships
between
phytochemicals
combined
effects
properties.
enhances
our
understanding
dynamic
interactions
compounds
collective
role
augmenting
overall
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 7146 - 7146
Опубликована: Апрель 12, 2023
Polyphenols
have
attracted
tremendous
attention
due
to
their
pro-health
properties,
including
antioxidant,
anti-inflammatory,
antibacterial
and
neuroprotective
activities.
Atherosclerosis
is
a
vascular
disorder
underlying
several
CVDs.
One
of
the
main
risk
factors
causing
atherosclerosis
type
quality
food
consumed.
Therefore,
polyphenols
represent
promising
agents
in
prevention
treatment
atherosclerosis,
as
demonstrated
by
vitro,
animal,
preclinical
clinical
studies.
However,
most
cannot
be
absorbed
directly
small
intestine.
Gut
microbiota
play
crucial
role
converting
dietary
into
absorbable
bioactive
substances.
An
increasing
understanding
field
has
confirmed
that
specific
GM
taxa
strains
mediate
gut
microbiota–atherosclerosis
axis.
The
present
study
explores
anti-atherosclerotic
properties
associated
mechanisms
polyphenols.
Moreover,
it
provides
basis
for
better
relationship
between
polyphenols,
microbiota,
cardiovascular
benefits.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(11), С. 9581 - 9581
Опубликована: Май 31, 2023
The
intestine
is
critically
crucial
for
nutrient
absorption
and
host
defense
against
exogenous
stimuli.
Inflammation-related
intestinal
diseases,
including
enteritis,
inflammatory
bowel
disease
(IBD),
colorectal
cancer
(CRC),
are
heavy
burdens
human
beings
due
to
their
high
incidence
devastating
clinical
symptoms.
Current
studies
have
confirmed
that
responses,
along
with
oxidative
stress
dysbiosis
as
critical
pathogenesis,
involved
in
most
diseases.
Polyphenols
secondary
metabolites
derived
from
plants,
which
possess
convincible
anti-oxidative
anti-inflammatory
properties,
well
regulation
of
microbiome,
indicating
the
potential
applications
enterocolitis
CRC.
Actually,
accumulating
based
on
biological
functions
polyphenols
been
performed
investigate
functional
roles
underlying
mechanisms
over
last
few
decades.
Based
mounting
evidence
literature,
objective
this
review
outline
current
research
progress
regarding
category,
functions,
metabolism
within
intestine,
prevention
treatment
might
provide
ever-expanding
new
insights
utilization
natural
polyphenols.
Plants,
Год журнала:
2023,
Номер
12(14), С. 2652 - 2652
Опубликована: Июль 14, 2023
Basil
is
a
great
source
of
phytochemicals
such
as
polyphenols,
vitamin
C,
anthocyanin,
and
flavonoids.
In
this
work,
the
biochemical
compounds,
antioxidant
capacity,
leaf
color
profile,
yield
21
cultivars
genotypes
basil
microgreen
were
investigated.
Results
showed
that
highest
potential
composite
index
(APCI)
was
measured
in
Persian
Ablagh
genotype
(70.30).
Twenty-one
classified
into
four
clusters,
including
cluster
1
(lowest
capacity
total
phenolic
compounds),
2
C
APCI
index),
3
(highest
4
levels
anthocyanin).
The
principal
components
analysis
(PCA)
diversity
terms
phytochemical
components,
F1,
F2,
F3,
F4
explained
variation
at
rate
78.12%.
average
annual
temperature
origin
seeds
plays
an
important
role
synthesis
content.
Most
with
moderate
had
higher
index.
genotype,
Violeto,
Kapoor
can
be
recommended,
according
to
their
yield.
These
used
individually
or
different
ratios
produce
substances
concentrations
for
various
purposes.
