A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges

Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4637 - 4637

Published: Nov. 3, 2022

Nutraceuticals are the nourishing components (hybrid of nutrition and pharmaceuticals) that biologically active possess capability for maintaining optimal health benefits. These products play a significant role in human care its endurance, most importantly future therapeutic development. have received recognition due to their nutritional benefits along with effects safety profile. globally growing field services such as promotion, disease reduction, etc. Various drug nutraceutical interactions also been elaborated various examples this review. Several patents on nutraceuticals agricultural applications diseases stated last section review, which confirms exponential growth nutraceuticals’ market value. used not only but support therapy prevention treatment diseases, reduce side cancer chemotherapy radiotherapy. Diverse novel nanoformulation approaches tend overcome challenges involved formulation development nutraceuticals. Prior information drugs may help preventing any deleterious products. Nanotechnology leads generation micronized dietary other supplements improved In review article, latest key findings (clinical studies) show action nutraceutical’s bioactive molecules discussed.

Language: Английский

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Polyphenol-Protein Particles: A Nutraceutical Breakthrough in Nutrition and Food Science

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101641 - 101641

Published: Jan. 1, 2025

Language: Английский

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Valorization of Underutilized Mandarin Juice Byproduct Through Encapsulation of Flavonoids Using Freeze-Drying Technique

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(1), P. 380 - 380

Published: Jan. 3, 2025

This study evaluated Maltodextrin (MD), Gum Arabic (GA), and Carboxymethylcellulose (CMC) in different ratios as coating materials to encapsulate citrus pomace phenolic compounds. Citrus encapsulates were obtained by ultrasound-assisted extraction followed the freeze-drying process characterized regarding microencapsulation efficiency, physical, chemical properties. Carrier material choice reflected a significant effect on encapsulation compounds retention, reconstitution properties of encapsulated extract. The efficiency prepared ranked from 50.909% 84.000%, it was strongly dependent upon CMC addition. A wide range parameters (water absorption index-WAI water solubility index-WSI) suggested possible release mechanism modifications. HPLC analysis revealed presence three main compounds, namely Hesperidin, Naringin, Rutin. wall mixture MD, GA, same proportions optimal for freeze-drying. combination resulted with low moisture content (1.936 ± 0.012%) activity (0.110 0.001), indicating prolonged stability. Based results, an technique should be considered promising solution recover industry byproducts protect them environmental gastrointestinal circumstances.

Language: Английский

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Cardiovascular health in perspective: a comprehensive five-year geodatabase of hospitalizations and environmental factors in Mashhad, Iran

BMC Research Notes, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

This data note presents a comprehensive geodatabase of cardiovascular disease (CVD) hospitalizations in Mashhad, Iran, alongside key environmental factors such as air pollutants, built environment indicators, green spaces, and urban density. Using spatiotemporal dataset over 52,000 hospitalized CVD patients collected five years, the study supports approaches like advanced modeling, artificial intelligence, machine learning to predict high-risk areas guide public health interventions. includes detailed epidemiologic geospatial information on from January 1, 2016, December 31, 2020. It contains 52,176 confirmed cases demographic age, gender, admission date, ICD-10 codes, occurrence death, length hospital stay. The median age was 64 with 54.44% male. A notable 9.41% died during hospitalization. In addition hospitalization case file its shape created by joining 1301 census tracts, this quality indicators (SO2, PM2.5, CO, etc.). also incorporates socio-economic variables (population density, illiteracy, unemployment rates), infrastructure, data, providing view Mashhad.

Language: Английский

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Phytochemical insights and antioxidant capabilities of rose cultivars: implications for traditional medicine and modern industry

Discover Agriculture, Journal Year: 2025, Volume and Issue: 3(1)

Published: Feb. 13, 2025

Rose is a commercially important flower and has been an part of traditional medicine cuisines around the world with its unique flavor potential health benefits. This study aimed at examining phytochemical properties antioxidant different dehydrated petal samples rose cultivars underscoring versatility significance these natural resources. The cultivars, 'Pusa Pitamber' 'Summer Snow' displayed elevated phenolic content, rendering them versatile for applications in skincare products, culinary enhancements, medicine, aesthetic colorants. Among Gaurav' 'IHT' exhibited highest tannin content which can be insight industries seeking colorant textile dyeing, leather industry, pharmaceuticals cosmetics. Mohit' Abhishek' promising potential, capturing interest food sectors. carotenoids viz., β-carotene, Neoxanthin Antheraxanthin were identified as biomarkers based on Partial Least Squares Discriminant Analysis (PLS-DA) from diverse carotenoid profiles obtained cultivars. PLS-DA emphasized phenols flavonoids biomarker differentiating terms potential. cluster analysis could divide four distinct groups their composition, giving summarized information to breeder improvement varieties. Principal Component unveiled intricate relationships between phytochemicals combined effects properties. enhances our understanding dynamic interactions compounds collective role augmenting overall

Language: Английский

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Tea polyphenols: extraction techniques and its potency as a nutraceutical

Frontiers in Sustainable Food Systems, Journal Year: 2023, Volume and Issue: 7

Published: May 24, 2023

Usually, polyphenols help address numerous health issues caused by oxidative stress. Tea is a popular beverage (rich in polyphenols) with abundant promoting and disease prevention great health-promoting disease-prevention attributes, originating from the delicate, dried leaves of Camellia sinensis plant. has been proven to have health-boosting impacts like anti-inflammatory, anti-cancerous, anti-diabetic, aids weight loss. Cognitive impairment, also known as cognitive decline aging or other neurological disorders, become an emerging concern. polyphenols, especially phenolic acids, havegained enormous attention due their link improved function preventing decline. This review summarizes recent studies on benefits tea. Additionally, effective traditional modern techniques extract effects various diseases described.

Language: Английский

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The Influence of Polyphenols on Atherosclerosis Development

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7146 - 7146

Published: April 12, 2023

Polyphenols have attracted tremendous attention due to their pro-health properties, including antioxidant, anti-inflammatory, antibacterial and neuroprotective activities. Atherosclerosis is a vascular disorder underlying several CVDs. One of the main risk factors causing atherosclerosis type quality food consumed. Therefore, polyphenols represent promising agents in prevention treatment atherosclerosis, as demonstrated by vitro, animal, preclinical clinical studies. However, most cannot be absorbed directly small intestine. Gut microbiota play crucial role converting dietary into absorbable bioactive substances. An increasing understanding field has confirmed that specific GM taxa strains mediate gut microbiota–atherosclerosis axis. The present study explores anti-atherosclerotic properties associated mechanisms polyphenols. Moreover, it provides basis for better relationship between polyphenols, microbiota, cardiovascular benefits.

Language: Английский

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New Insights of Biological Functions of Natural Polyphenols in Inflammatory Intestinal Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9581 - 9581

Published: May 31, 2023

The intestine is critically crucial for nutrient absorption and host defense against exogenous stimuli. Inflammation-related intestinal diseases, including enteritis, inflammatory bowel disease (IBD), colorectal cancer (CRC), are heavy burdens human beings due to their high incidence devastating clinical symptoms. Current studies have confirmed that responses, along with oxidative stress dysbiosis as critical pathogenesis, involved in most diseases. Polyphenols secondary metabolites derived from plants, which possess convincible anti-oxidative anti-inflammatory properties, well regulation of microbiome, indicating the potential applications enterocolitis CRC. Actually, accumulating based on biological functions polyphenols been performed investigate functional roles underlying mechanisms over last few decades. Based mounting evidence literature, objective this review outline current research progress regarding category, functions, metabolism within intestine, prevention treatment might provide ever-expanding new insights utilization natural polyphenols.

Language: Английский

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Polyphenols and metabolism: from present knowledge to future challenges

Journal of Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: 80(3), P. 603 - 625

Published: Aug. 1, 2024

A diet rich in polyphenols and other types of phytonutrients can reduce the occurrence chronic diseases. However, a well-established cause-and-effect association has not been clearly demonstrated several issues will need to be fully understood before general recommendations carried out In present review, some future challenges that research on phenolic compounds have face next years are discussed: toxicological aspects safety risk assessment; synergistic effects between different polyphenols; metabotype-based nutritional advice based differential gut microbial metabolism (precision nutrition); combination with bioactive compounds; innovative formulations improve bioavailability sports nutrition recovery.Other related polyphenol boost are: microbiota crosstalk, including prebiotic biotransformation into metabolites by microorganisms; molecular docking, dynamics simulation, quantum mechanics studies protein-polyphenol complexes; polyphenol-based coating films, nanoparticles, hydrogels facilitate delivery drugs, nucleic acids proteins.In summary, this article provides constructive inspirations for advancing applications, assessment metabolic dietary humans.

Language: Английский

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Role of Driving Force on Engineering Layer-by-Layer Protein/Polyphenol Coating with Flexible Structures and Properties

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(16), P. 20551 - 20562

Published: April 13, 2023

Protein-based coatings are of immense interest due to their rich biological functions. Layer-by-layer (LbL) assembly, as a powerful means transferring protein functions the material surface, has received widespread attention. However, assembly mechanism protein-based LbL is still far from being explained, not only because structure and function diversity but also characterization limitations. Herein, we monitored in situ process tannic acid (TA) lysozyme (Lyz), classic pair polyphenol protein, by combining quartz crystal microbalance with dissipation monitoring (QCM-D) spectroscopic ellipsometry (SE). The water content, morphology, mechanical properties, antioxidant activity, driving force TA-Lyz coating engineered under different pH values were analyzed detail various techniques. key factor coatings, increased increasing assembled values, which resulted porous inhomogeneous distribution, faster growth, better activity both acellular cellular levels. In addition, high content unfavorable entropy enthalpy changes, thermodynamic TA Lyz mainly comes change brought noncovalent interaction between Lyz. These results provide new insights into engineering structure, function, mechanisms coatings.

Language: Английский

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