Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5085 - 5085

Опубликована: Май 7, 2024

The brain is the central organ of adaptation to stress because it perceives and determines threats that induce behavioral, physiological, molecular responses. In humans, chronic manifests as an enduring consistent feeling pressure being overwhelmed for extended duration. This can result in a persistent proinflammatory response peripheral nervous system (CNS), resulting cellular, behavioral effects. Compounding stressors may increase risk chronic-stress-induced inflammation, which yield serious health consequences, including mental disorders. review summarizes current knowledge surrounding neuroinflammatory rodent models stress—a relationship continually defined. Many studies investigating effects on neuroinflammation have identified significant changes inflammatory modulators, nuclear factor-κB (NF-κB) toll-like receptors (TLRs), cytokines, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6. suggests these are key factors response, contribute establishment anxiety depression-like symptoms. neurological modulating through gene knockdown (KD) knockout (KO), conventional alternative medicine approaches, discussed.

Язык: Английский

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Transcutaneous auricular vagus nerve stimulation as a novel therapy connecting the central and peripheral systems: a review

International Journal of Surgery, Год журнала: 2024, Номер unknown

Опубликована: Май 9, 2024

Currently, clinical practice and scientific research mostly revolve around a single disease or system, but the disease-oriented diagnostic therapeutic paradigm needs to be revised. This review describes how transcutaneous auricular vagus nerve stimulation (taVNS), novel non-invasive neuromodulation approach, connects central peripheral systems of body. Through widely distributed from head abdominal cavity, this therapy can improve treat system disorders, central-peripheral comorbidities caused by autonomic dysfunction. In past, on taVNS has focused treatment disorders modulating brain nerve. As innervates heart, lungs, liver, pancreas, gastrointestinal tract, spleen other organs, could have an overall modulatory effect region body where is widespread. Based physiological basis, authors summarize existing evidence ability regulate cardiac function, adiposity, glucose levels, immune among others, diseases, complex diseases with comorbidities. shows successful examples progress using mechanisms more perspectives, demonstrating expanded scope value provide new ideas approaches for holistic both perspectives.

Язык: Английский

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Stimulation of Auricular Vagus Nerve Ameliorates Chronic Stress induced Metabolic Syndrome via Activation of Sirtuin-6

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 756, С. 151567 - 151567

Опубликована: Март 5, 2025

Язык: Английский

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Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis

International Immunopharmacology, Год журнала: 2023, Номер 125, С. 111046 - 111046

Опубликована: Окт. 23, 2023

Язык: Английский

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Transcutaneous vagus nerve stimulation: a bibliometric study on current research hotspots and status

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Авг. 16, 2024

Background Transcutaneous Vagal Nerve Stimulation (tVNS) has been used as a promising noninvasive neuromodulation technique for the treatment of various systems.The aim this study was to analyze research hotspots and future directions tVNS in 21st century by using bibliometric methods. Methods The object literature related from Web Science database 2000 May 2024. In order measure number issuance, institutions, authors, countries, keywords, co-citations, journals publication, we VOSviewer, Citespace, Bibliometrix R-package, Scimago Graphica software. A narrative review current content conducted gain better understanding state field. Results total 569 papers were included study. results show that 2024, publications shows an increasing trend year year, involving 326 institutions. United States, China, Germany are major centers. identified 399 which roughly formed 11 natural clusters, revealing mainly reflected 3 areas: intervention efficacy on nervous system diseases, mechanism action tVNS, stimulation mode tVNS. top 10 most cited references focus into Conclusion safety have confirmed previous studies, but standardized protocol not yet developed, clinical studies small sample sizes lack multicenter multidisciplinary collaboration. Currently, is neurological psychiatric cardiovascular some autoimmune diseases. It expected field will continue application central diseases exploration mechanisms, at same time, with rise non-invasive technology, other also great potential development.

Язык: Английский

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Vitamin D alleviates chronic stress-induced testicular steroidogenesis disruption in Wistar rats

Tissue and Cell, Год журнала: 2025, Номер unknown, С. 102910 - 102910

Опубликована: Апрель 1, 2025

Язык: Английский

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Probiotics as a Treatment of Chronic Stress Associated Abnormalities

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Язык: Английский

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Effects of multisession prefrontal cortex tDCS or taVNS on stress, perceived stress and sleep quality: a double-blind, randomized controlled study

Frontiers in Psychology, Год журнала: 2024, Номер 15

Опубликована: Сен. 13, 2024

Chronic stress is a condition characterized by prolonged stimulation, leading to mental and physical weakness. It can have detrimental effects on individuals' health cognitive function, potentially causing various issues. This article explores the potential of non-invasive neuromodulation techniques, specifically transcranial direct current stimulation (tDCS) transcutaneous auricular vagus nerve (taVNS), in managing chronic improving sleep quality.

Язык: Английский

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Inflammation as a shared mechanism of chronic stress related disorders with potential novel therapeutic targets

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 8, 2024

Язык: Английский

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Chronic stress-mediated dysregulations in inflammatory, immune and oxidative circuitry impairs the therapeutic response of methotrexate in experimental autoimmune disease models

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Язык: Английский

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