Placenta, Год журнала: 2023, Номер 132, С. 38 - 43
Опубликована: Янв. 5, 2023
Язык: Английский
Translational research, Год журнала: 2022, Номер 251, С. 84 - 95
Опубликована: Авг. 12, 2022
Язык: Английский
Процитировано
48
Antioxidants, Год журнала: 2022, Номер 11(2), С. 184 - 184
Опубликована: Янв. 18, 2022
COVID-19 has reached pandemic proportions worldwide, with considerable consequences for both health and the economy. In pregnant women, can alter metabolic environment, iron metabolism, oxygen supply of trophoblastic cells, therefore have a negative influence on essential mechanisms fetal development. The purpose this study was to investigate, first time, effects infection during pregnancy regard oxidative/antioxidant status in mothers' serum placenta, together placental metabolism. Results showed no differences superoxide dismutase activity antioxidant capacity. However, capacity decreased infected mothers. Catalase group, while an increase 8-hydroxy-2'-deoxyguanosine, hydroperoxides, 15-FT-isoprostanes, carbonyl groups were recorded group. Placental vitamin D, E, Coenzyme-Q10 also be increased As iron-related proteins, up-regulation DMT1, ferroportin-1, ferritin expression women. Due potential role metabolism oxidative stress function complications, further research is needed explain pathogenic mechanism that may affect pregnancy, so as assess short-term long-term outcomes infants' health.
Язык: Английский
Процитировано
47
Neuroscience & Biobehavioral Reviews, Год журнала: 2021, Номер 127, С. 520 - 530
Опубликована: Май 13, 2021
Язык: Английский
Процитировано
47
Viruses, Год журнала: 2021, Номер 13(9), С. 1877 - 1877
Опубликована: Сен. 20, 2021
The COVID-19 pandemic has hugely impacted global public health and economy. also shown potential impacts on maternal perinatal neonatal outcomes. This systematic review aimed to summarize the evidence from existing reviews about effects of SARS-CoV-2 infections We searched PubMed, MEDLINE, Embase, Web Science in accordance with PRISMA guidelines, 1 December 2019 7 July 2021, for published studies that included case reports, primary studies, clinical practice overviews, case-control observational studies. Systematic reported plausibility mother-to-child transmission (also known as vertical transmission), outcomes, addressed effect infection during pregnancy were included. identified 947 citations, which 69 further analysis. Most (>70%) was likely due environmental exposure, although a significant proportion (about 20%) attributable SARS-CoV-2. Further results indicated mode delivery pregnant women infected could not increase or decrease risk newborns (outcomes), thereby emphasizing significance breastfeeding. issue outcomes continues worsen ongoing pandemic, increasing mortality, stillbirth, ruptured ectopic pregnancies, depression. Based this study, we observed rates cesarean mothers infection. found be potentially transmitted vertically gestation period. However, more data are needed investigate follow-up, especially reports SARS-CoV-2, order examine possible long-term adverse effect.
Язык: Английский
Процитировано
43
Archives of Gynecology and Obstetrics, Год журнала: 2022, Номер 306(6), С. 1939 - 1948
Опубликована: Март 7, 2022
Язык: Английский
Процитировано
31
The Pediatric Infectious Disease Journal, Год журнала: 2022, Номер 41(6), С. 466 - 472
Опубликована: Апрель 1, 2022
The vertical transmission of severe acute respiratory coronavirus-2 (SARS-CoV-2) remains highly debated. Here, we evaluated SARS-CoV-2-transmission in newborns with intrauterine conditions.This was a prospective, observational and multicentric study involving 13 Spanish hospitals included the GEStational NEOnatal-COVID cohort. Pregnant women microbiologically confirmed SARS-CoV-2 infection during any trimester pregnancy or delivery their were from March to November 2020. Demographic, clinical microbiological data also obtained. Viral loads analyzed different maternal newborn biological samples (placenta, breast milk blood; urine, meconium blood).A total 177 exposed included. Newborns tested by reverse transcriptase-polymerase chain reaction using nasopharyngeal swabs within first 24-48 hours life at 14 days life. In 5.1% considered have neonatal period, 1.7% 3.4% intrapartum early postnatal cases. There no differences demographic characteristics pregnant newborns' susceptibility infections perinatal history background.Intrauterine is possible, although rare, occurring more frequently. Most infected remained asymptomatic had mild symptoms that evolved well follow-up. We did not find predisposing infants infection. All mothers delivery.Although there presence SARS-CoV2 cord blood samples, viral load detected urine newborns.
Язык: Английский
Процитировано
30
Medicina, Год журнала: 2021, Номер 57(8), С. 796 - 796
Опубликована: Авг. 1, 2021
Background and Objectives: The ongoing pandemic proved to be a tremendous challenge all economic layers, healthcare, people safety. As more than one year elapsed since the beginning of COVID-19 pandemic, multitude medical studies involving SARS-CoV-2 virus helped researchers practitioners in understanding effects it has on sorts patients until effective vaccines were finally developed distributed for mass vaccination. Still, its new variants remain potential threat towards categories patients, including delicate group represented by pregnant women. Thus, current study aims investigate obstetrical outcomes after positive infection. Materials Methods: This single-center prospective cohort investigated pregnancy total 1039 eligible women between 30 August 2020 January 2021. Multiple patient characteristics tested analyzed multivariate regression model establish risks determined COVID-19-positive mother newborn. Results: In sample, there 938 pregnancies included without 101 identified with was significantly associated 2-fold increase risk premature rupture membranes 1.5 times higher preterm birth emergency c-sections lower APGAR scores. Also, newborns given prematurely, scores mothers infected SARS-CoV-2. Conclusions: A third-trimester infection is significant factor via an cesarean section, membranes, score newborns, as compared where not identified.
Язык: Английский
Процитировано
40
Biomedicines, Год журнала: 2022, Номер 10(8), С. 1775 - 1775
Опубликована: Июль 22, 2022
Since its discovery in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread over the world, having a huge impact on people’s lives and health. The system is often targeted people with disease 2019 (COVID-19). virus can also infect many organs tissues body, including reproductive system. consequences of SARS-CoV-2 infection fertility pregnancy hosts are poorly documented. Available data other coronaviruses, such as (SARS-CoV) Middle Eastern Respiratory Syndrome (MERS-CoV) identified pregnant women vulnerable group increased pregnancy-related complications. COVID-19 was shown to pregnancy, which be seen either mother or fetus. Pregnant more likely require intensive care treatment than non-pregnant women, they susceptible giving birth prematurely their newborns admitted neonatal unit. Angiotensin converting enzyme (ACE2), key player ubiquitous renin-angiotensin (RAS), principal host cellular receptor for spike protein. ACE2 involved regulation both male female systems, suggesting that associated RAS dysfunction could affect reproduction. Herein, we review current knowledge about fertility, fetuses. Furthermore, describe effects vaccination
Язык: Английский
Процитировано
20
Актуальні питання педіатрії акушерства та гінекології, Год журнала: 2025, Номер 2, С. 65 - 69
Опубликована: Янв. 22, 2025
Мета дослідження – вивчити вплив постковідного синдрому на перебіг вагітності та стан новонародженого. Матеріали методи. У дослідженні взяли участь 60 вагітних жінок (основна група) із перенесеним SARS-CoV-2, позитивним ІgA, ІgM чи ІgG до SARS-CoV-2 у термін 30–34 тижні період листопада 2020 січня 2022 р. Контрольну групу склали 30 фізіологічною вагітністю. Було досліджено частоту виявлених ускладнень під час особливості перебігу поєднаною патологією. Стан плода оцінювали за даними ультразвукового вагітної, визначенням біофізичного профілю результатами доплерометрії. Результати їх обговорення. Серед усіх ускладнень, які спостерігали гострим респіраторним захворюванням вагітності, були такі: передчасні пологи 5 випадків (8,8 %), олігогідроамніон 2 випадки (3,5 загострення хронічного пієлонефриту гострий пієлонефрит, вперше виявлений 1 випадок (1,7 полігідроамніон прееклампсія середнього ступеня тяжкості тяжкого передчасне відшарування нормально розташованої плаценти %). 15 (26,3 %) пацієнток (OR=7,1; 95 % CI: 1,21–13,2; P<0,01) мали тяжкі порушення фетоплацентарного кровотоку в пупковій артерії (порівняно з контрольною групою). Затримку росту діагностовано 26 (45,6 (OR=20,4; ДІ: 2,56−16,3; P<0,01). шести (10,5 (OR=1,5; 1,01–3,12; спостережено високорезистентний кровотік без діастолічного компонента, що вказує загрозливий і дистрес-синдром плода, допомогою Наявність патологічних процесів фетоплацентарному комплексі негативно впливала призводила затримки підвищення ризику перинатальної смертності. За дослідження, затримку розвитку становить 45,6 відсотка серед обстежених основної групи, 43 (75,4 виявлено ті інші патологічні зміни плаценти. Висновки. дітей, народжених від матерів постковідним синдромом, було зафіксовано збільшення частоти патологічного раннього неонатального періоду. COVID-19 був пов’язаний підвищенням материнської захворюваності неонатальних ускладнень. Спостережено фетальний постковідний синдром, супроводжувався синдромом росту, дистресом, антенатальною загибеллю посиленням тромбоутворення судинах й пуповини.
Процитировано
0
Infection and Drug Resistance, Год журнала: 2025, Номер Volume 18, С. 1393 - 1403
Опубликована: Март 1, 2025
Background: Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by SARS-CoV-2 (severe acute syndrome coronavirus 2). The pandemic potential of the virus along with its severity posed threat to all individuals particularly pregnant women. Multiple studies suggested possibility vertical transmission COVID-19 variable findings. Aim: This study aims assess frequency and identify maternal neonatal complications. Materials Methods: A retrospective 17 months for women attending delivery who tested positive using polymerase chain reaction (PCR) (n = 80) their neonates 81) were both SARS-CoV2 PCR viral IgG IgM antibodies detection immunochromatography. matched control group negative mothers 51) was included. All testing done within 24– 48 hours, immediately completely separated from as per hospital policy. Results: total 263 included in study. Out 80 mothers, 4 (5%) had one (1.3%) neonates. commonest presentation cough (11.4%) dyspnea (10%). In addition, need ICU admission antibiotics usage significantly higher (p value 0.042, 0.003 respectively). On other hand, risk low birth weight NICU < 0.001). Conclusion: study, unique infection protocol managing PCR-positive use immunological neonates, provides evidence in-utero transmission, interpretation results should be conjunction WHO categorization timing mother-to-fetal transmission. Further are needed impact genetic evolution on maternal–fetal Keywords: SARS-CoV-2, in-utero, IgM,
Язык: Английский
Процитировано
0