Selenization of Small Molecule Drugs: A New Player on the Board

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(10), С. 7759 - 7787

Опубликована: Май 8, 2024

There is an urgent need to develop safer and more effective modalities for the treatment of a wide range pathologies due increasing rates drug resistance, undesired side effects, poor clinical outcomes, etc. Throughout years, selenium (Se) has attracted great deal attention its important role in human health. Besides, growing body work unveiled that inclusion Se motifs into number molecules promising strategy obtaining novel therapeutic agents. In current Perspective, we have gathered most recent literature related incorporation different moieties scaffolds known drugs their feasible pharmaceutical applications. addition, highlight representative examples as well provide our perspective on possible future directions, promises, opportunities, challenges this ground-breaking area research.

Язык: Английский

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Nutritional Management of Thyroiditis of Hashimoto

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 5144 - 5144

Опубликована: Май 5, 2022

Since the thyroid gland is one of organs most affected by autoimmune processes, many patients with thyroiditis Hashimoto (TH) seek medical advice on lifestyle variance and dietary modifications to improve maintain their hyroid function. In this review, we aim present discuss some challenges associated nutritional management TH, focusing environmental deficits, inflammatory toxic nutrients, cyanotoxins, etc. We relationships among different diets, chronic inflammation, microbiota, impact development exacerbation TH in detail. share novel insights into role vitamin D melatonin for preserving function during inflammation predisposed subjects. A comprehensive overview provided anti-inflammatory nutrients ecological including foods cleansing detoxification, which represent strategies prevent relapses achieve overall improvement life quality. conclusion, data from biomedical clinical studies provide evidence that an appropriate lighting regimen could significantly reduce reactivity autoantibodies TH. Compliance guidelines may help need medicines.

Язык: Английский

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The protective role of nutritional antioxidants against oxidative stress in thyroid disorders

Frontiers in Endocrinology, Год журнала: 2023, Номер 13

Опубликована: Янв. 4, 2023

An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific. Although OxS a consequence of normal body organ physiology, severely impaired homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, apoptosis, ultimately compromising cells’ function viability. The thyroid gland an that exhibits both processes. In terms severity, the gland’s response could physiological (i.e. hormone production secretion) pathological development diseases, such as goitre, cancer, thyroiditis). Protective nutritional antioxidants benefit defensive systems resolving dominance redox imbalance, preventing delaying chronic diseases. This review provides information on their protective roles against various pathologies. We also novel findings related to connection gut microbiome analyze effects probiotics with antioxidant properties

Язык: Английский

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Radioiodine therapy in advanced differentiated thyroid cancer: Resistance and overcoming strategy

Drug Resistance Updates, Год журнала: 2023, Номер 68, С. 100939 - 100939

Опубликована: Фев. 8, 2023

Thyroid cancer is the most prevalent endocrine tumor and its incidence fast-growing worldwide in recent years. Differentiated thyroid (DTC) common pathological subtype which typically curable with surgery Radioactive iodine (RAI) therapy (approximately 85%). first-line treatment for patients metastatic Papillary Cancer (PTC). However, 60% of aggressive metastasis DTC developed resistance to RAI had a poor overall prognosis. The molecular mechanisms include gene mutation fusion, failure transport into cells, interference microenvironment (TME). it unclear whether above are main drivers inability benefit from therapy. With development new biological technologies, strategies that bolster function TKI-targeted therapy, cell Redifferentiation, Improved Drug Delivery via Extracellular Vesicles (EVs) have emerged. Despite some promising data early success, survival was not prolonged majority patients, disease continued progress. It still necessary understand genetic landscape signaling pathways leading enhance effectiveness safety sensitization approach. This review will summarize resistance, predictive biomarkers current strategies.

Язык: Английский

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Hormone-linked redox status and its modulation by antioxidants

Vitamins and hormones, Год журнала: 2023, Номер unknown, С. 197 - 246

Опубликована: Янв. 1, 2023

Язык: Английский

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A H2O2-specific fluorescent probe for evaluating oxidative stress in pesticides-treated cells, rice roots and zebrafish

Journal of Hazardous Materials, Год журнала: 2024, Номер 465, С. 133426 - 133426

Опубликована: Янв. 4, 2024

Язык: Английский

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Redox mechanisms in autoimmune thyroid eye disease

Autoimmunity Reviews, Год журнала: 2024, Номер 23(5), С. 103534 - 103534

Опубликована: Март 26, 2024

Thyroid eye disease (TED) is an autoimmune condition affecting the orbit and with its adnexa, often occurring as extrathyroidal complication of Graves' (GD). Orbital inflammatory infiltration stimulation orbital fibroblasts, triggering de novo adipogenesis, overproduction hyaluronan, myofibroblast differentiation, eventual tissue fibrosis are hallmarks disease. Notably, several redox signaling pathways have been shown to intensify inflammation promote fibrogenesis by upregulating potent cytokines, such interleukin (IL)-1β, IL-6, transforming growth factor (TGF)-β. While existing treatment options can manage symptoms potentially halt progression, they come drawbacks relapses, side effects, chronic adverse effects on optic nerve. Currently, studies shed light pathogenetic contributions emerging factors within immunological cascades oxidative stress. This review article provides overview latest advancements in understanding pathophysiology TED, a special focus interplay between stress, mechanisms environmental factors. Furthermore, cutting-edge therapeutic approaches targeting will be presented discussed.

Язык: Английский

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Unveiling Risk Factors for Treatment Failure in Patients with Graves’ Disease: A Nationwide Cohort Study in Korea

Endocrinology and Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

BackgroundAntithyroid drug (ATD) treatment is the preferred initial for Graves' disease (GD) in South Korea, despite higher failure rates than radioactive iodine (RAI) therapy or thyroidectomy. This study aimed to evaluate incidence of associated with primary modalities GD real-world practice. MethodsWe included 452,001 patients diagnosed between 2004 and 2020 from Korean National Health Insurance Service-National Information Database. Treatment was defined as switching ATD, RAI, thyroidectomy treatments, ATD specifically, inability discontinue medication over 2 years. ResultsMean age 46.2 years, females constituting 70.8%. Initial treatments ATDs (98.0%), (1.3%), RAI (0.7%), a noted increment application 96.2% 98.8% 2020. During median follow- up 8.5 were 58.5% ATDs, 21.3% 2.1% Multivariate analysis indicated that hazard ratio 2.81 times RAI. ≥10 mCi had 37% lower doses <10 mCi. ConclusionATDs are most commonly used followed by Although risk therapy, Korea relatively limited compared Western countries. Further studies required cause low Korea.

Язык: Английский

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Bisphenol A exposure enhances proliferation and tumorigenesis of papillary thyroid carcinoma through ROS generation and activation of NOX4 signaling pathways

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117946 - 117946

Опубликована: Фев. 27, 2025

Язык: Английский

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Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist

Journal of Endocrinological Investigation, Год журнала: 2023, Номер 47(1), С. 17 - 33

Опубликована: Сен. 11, 2023

Abstract Purpose The purpose of this review is to examine the current evidence on potential role Mediterranean diet (MD) in prevention and management endocrine disorders highlight importance interdisciplinary collaboration between endocrinologists nutritionists. Methods A literature search was conducted using PubMed Google Scholar databases identify relevant studies published English. Studies were selected based their relevance MD disorders. terms included "Mediterranean diet," "endocrine disorders," "thyroid "gonadal "neuroendocrine tumors". Results reviewed suggest that may have a beneficial effect various disorders, including thyroid gonadal neuroendocrine tumors. has been associated with decreased risk nodular disease cancer, improved male female reproductive health, MD's anti-inflammatory antioxidant properties, as well its high levels phytochemicals, play effects. Conclusion Interdisciplinary nutritionists essential for optimal management. While further research needed, suggests protective against incorporation into dietary recommendations be beneficial.

Язык: Английский

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