Time-Restricted Eating as a Nutrition Strategy for Individuals with Type 2 Diabetes: A Feasibility Study

Nutrients, Год журнала: 2020, Номер 12(11), С. 3228 - 3228

Опубликована: Окт. 22, 2020

Individuals with type 2 diabetes (T2D) require a long-term dietary strategy for blood glucose management and may benefit from time-restricted eating (TRE, where the duration between first last energy intake is restricted to 8–10 h/day). We aimed determine feasibility of TRE individuals T2D. Participants T2D (HbA1c >6.5 <9%, window >12 h/day) were recruited pre-post, non-randomised intervention consisting 2-week Habitual period establish baseline intake, followed by 4-weeks during which they instructed limit all occasions 10:00 19:00 h on as many days each week possible. Recruitment, retention, acceptability, safety recorded throughout study indicators feasibility. Dietary glycaemic control, psychological well-being, cognitive outcomes, physiological measures explored secondary outcomes. From 594 interested persons, 27 eligible individuals, 24 participants enrolled 19 (mean ± SD; age: 50 9 years, BMI: 34 5 kg/m2, HbA1c: 7.6 1.1%) completed 6-week study. Overall daily did not change (~8400 kJ/d; 35% carbohydrate, 20% protein, 41% fat, 1% alcohol) periods (~8500 19% 42% alcohol). Compliance was 72 24% 28 (i.e., ~5 days/week), varied adherence (range: 4–100%). Comparisons adherent vs. non-adherent showed that 9-h reduced through lower absolute carbohydrate alcohol intakes. Overall, significantly improve control −0.2 0.4%; p = 0.053) or reduce body mass. impair variable effects function. described hunger, stressors, emotions main barriers adherence. demonstrate feasible achievable these adhere at least days/week. The degree strongly influenced intake. Future trials supporting incorporate in regular life overcome

Язык: Английский

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The Effects of Intermittent Fasting on Brain and Cognitive Function

Nutrients, Год журнала: 2021, Номер 13(9), С. 3166 - 3166

Опубликована: Сен. 10, 2021

The importance of diet and the gut-brain axis for brain health cognitive function is increasingly acknowledged. Dietary interventions are tested their potential to prevent and/or treat disorders. Intermittent fasting (IF), abstinence or strong limitation calories 12 48 h, alternated with periods regular food intake, has shown promising results on neurobiological in animal models. In this review article, we discuss benefits IF possible effects prevention progress brain-related disorders animals humans. We do so by summarizing which through metabolic, cellular, circadian mechanisms lead anatomical functional changes brain. Our shows that there no clear evidence a positive short-term effect cognition healthy subjects. Clinical studies show epilepsy, Alzheimer's disease, multiple sclerosis disease symptoms progress. Findings from Parkinson's ischemic stroke, autism spectrum disorder, mood anxiety could benefit IF. Future research should disentangle whether hold true regardless age presence obesity. Moreover, variations patterns, total caloric intake specific nutrients may be relevant components success. Longitudinal randomized clinical trials (RCTs) will provide window into long-term development diseases.

Язык: Английский

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Time-Restricted Eating and Metabolic Syndrome: Current Status and Future Perspectives

Nutrients, Год журнала: 2021, Номер 13(1), С. 221 - 221

Опубликована: Янв. 14, 2021

Metabolic syndrome (MetS) occurs in ~30% of adults and is associated with increased risk cardiovascular disease diabetes mellitus. MetS reflects the clustering individual cardiometabolic factors including central obesity, elevated fasting plasma glucose, dyslipidemia, blood pressure. Erratic eating patterns such as over a prolonged period per day irregular meal timing are common patients MetS. Misalignment between daily rhythms food intake circadian system can contribute to rhythm disruption which results abnormal metabolic regulation adversely impacts health. Novel approaches aim at restoring robust through modification duration represent promising strategy for Restricting during (time-restricted eating, TRE) aid mitigating improving outcomes. Previous pilot TRE study showed feasibility improvements body weight fat, abdominal atherogenic lipids, pressure, were observed despite no overt attempt change diet quantity quality or physical activity. The present article aims giving an overview human studies individuals its components, summarizing current clinical evidence health intervention these populations, presenting future perspectives implementation treat prevent trials laid groundwork indicate need further research large-scale controlled determine efficacy reducing long-term risk, providing tools sustained lifestyle changes and, ultimately, overall

Язык: Английский

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Intermittent fasting: from calories to time restriction

GeroScience, Год журнала: 2021, Номер 43(3), С. 1083 - 1092

Опубликована: Март 9, 2021

Язык: Английский

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Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

AJP Heart and Circulatory Physiology, Год журнала: 2021, Номер 320(5), С. H2080 - H2100

Опубликована: Апрель 9, 2021

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of death America. Advancing age is a major risk factor for CVD. Recent plateaus CVD-related mortality rates high-income countries after decades decline highlight critical need to identify novel therapeutic targets strategies mitigate manage CVD development progression. Vascular dysfunction, characterized by endothelial dysfunction large elastic artery stiffening, independently associated with an increased incidence therefore attractive target prevention management. mitochondria have emerged as important player maintaining vascular homeostasis. As such, age- disease-related impairments mitochondrial function contribute consequent increases risk. This review outlines role discusses ramifications on health setting disease. The adverse consequences mitochondrial-derived reactive oxygen species, impaired quality control, defective calcium cycling are emphasized, particular. Current evidence both lifestyle pharmaceutical mitochondrial-targeted improve also presented.

Язык: Английский

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Early time‐restricted eating compared with daily caloric restriction: A randomized trial in adults with obesity

Obesity, Год журнала: 2022, Номер 30(5), С. 1027 - 1038

Опубликована: Апрель 26, 2022

This trial aimed to evaluate the acceptability and efficacy of early time-restricted eating plus daily caloric restriction (E-TRE+DCR) compared with DCR alone within a behavioral weight-loss intervention.Participants (n = 81, 69 women, mean [SD] age: 38.0 [7.8] years, BMI: 34.1 [5.7] kg/m2 ) were randomized E-TRE (10-hour window starting 3 hours waking) or (~35% DCR) for 39 weeks. The primary outcome was body weight (measured digital scale) at week 12. Secondary outcomes measured 12 included hemoglobin A1c, lipids, energy intake (photographic food records), physical activity (accelerometry), dietary adherence (questionnaires), composition (dual-energy x-ray absorptiometry). Weight also assessed 39.Mean loss not different between groups (E-TRE+DCR: -6.2 [4.1] kg vs. DCR: -5.1 [3.2] kg) (E-TRE: -4.9 [5.3] -4.3 kg). There no between-group differences in changes composition, adherence, intake, activity, lipids 12.E-TRE+DCR found be an acceptable strategy, resulting similar levels alone.

Язык: Английский

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Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases

Nutrients, Год журнала: 2022, Номер 15(1), С. 47 - 47

Опубликована: Дек. 22, 2022

An increasing number of studies suggest that diet plays an important role in regulating aging processes and modulates the development most age-related diseases.The aim this review is to provide overview relationship between nutrition critical age-associated diseases.A literature was conducted survey recent pre-clinical clinical findings related nutritional factors modulation fundamental cellular molecular mechanisms their prevention genesis diseases aging.Studies show cardiovascular cerebrovascular diseases, neurodegenerative cognitive impairment dementia can be slowed down or prevented by certain diets with anti-aging action. The protective effects diets, at least part, may mediated beneficial macro- (protein, fat, carbohydrate) micronutrient (vitamins, minerals) composition.Certain such as Mediterranean diet, play a significant healthy preventing onset improving process itself. This latter strengthened incorporating fasting elements into diet. As dietary recommendations change age, should taken consideration well, when developing tailored needs elderly individuals. Future ongoing on complex interventions translating results preclinical investigations are expected lead novel guidelines for older adults near future.

Язык: Английский

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Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease

Acta Pharmaceutica Sinica B, Год журнала: 2021, Номер 12(2), С. 511 - 531

Опубликована: Июнь 30, 2021

Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging AD are associated with apparent metabolic alterations. As developing effective therapeutic interventions to treat clearly in urgent need, impact of modulating whole-body intracellular metabolism preclinical models human patients, on pathogenesis, have been explored. There also an increasing awareness differential potential targeting strategies related biological sex, microbiome, circadian regulation. a major part metabolism, mitochondrial bioenergetics, quality-control mechanisms, mitochondria-linked inflammatory responses considered interventions. This review summarizes highlights these efforts.

Язык: Английский

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The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

Free Radical Biology and Medicine, Год журнала: 2022, Номер 182, С. 206 - 218

Опубликована: Фев. 24, 2022

Язык: Английский

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Randomized controlled trial for time-restricted eating in overweight and obese young adults

iScience, Год журнала: 2022, Номер 25(9), С. 104870 - 104870

Опубликована: Авг. 5, 2022

Time-restricted eating (TRE) is known to improve metabolic health, whereas very few studies have compared the effects of early and late TRE (eTRE lTRE) on health. Overweight obese young adults were randomized 6-h eTRE (eating from 7 a.m. 1 p.m.) (n = 21), lTRE 12 p.m. 6 20), or a control group (ad libitum intake in day) 19). After 8 weeks, produced comparable body weight loss with controls. Compared control, reduced systolic blood pressure, mean glucose, fasting insulin, insulin resistance, leptin, thyroid axis activity, only leptin. These findings shed light promise for loss. Larger are needed assess yield better modulation overall cardiometabolic health improvement.

Язык: Английский

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