Future Medicinal Chemistry,
Год журнала:
2020,
Номер
12(24), С. 2239 - 2275
Опубликована: Ноя. 24, 2020
N-heterocyclic
carbenes
(NHCs)
are
organic
compounds
that
typically
mimic
the
chemical
properties
of
phosphines.
NHCs
have
made
a
significant
impact
on
field
coordination
and
organometallic
chemistry
because
they
easy
to
prepare
handle
their
versatility
stability.
Importantly,
physicochemical
can
be
easily
fine-tuned
by
simple
variation
substituents
nitrogen
atoms.
Over
past
few
years,
various
NHC-metal
complexes
been
extensively
used
as
metal-based
drug
candidates
catalysts
(homogeneous
or
heterogeneous)
for
applications.
To
help
assist
future
work
with
these
compounds,
this
review
provides
thorough
latest
information
involving
some
biomedical
applications
complexes.
Specifically,
article
focuses
recent
advances
in
design,
synthesis,
characterization
(e.g.,
antimicrobial
anticancer
activity)
(metal:
silver,
gold,
palladium,
rhodium,
ruthenium,
iridium
platinum)
covering
published
from
2015
2020.
It
is
hoped
promising
discoveries
date
will
accelerate
studies
encouraging
potential
class
effective
therapeutic
agents.
German Journal of Pharmaceuticals and Biomaterials,
Год журнала:
2022,
Номер
1(1), С. 06 - 28
Опубликована: Апрель 27, 2022
Metal
complexes
gained
more
attention
in
the
medical
field,
particularly
cancer
treatment,
due
to
their
enhanced
potential
and
redox
ability.
These
exhibited
significant
antiproliferation
by
triggering
generation
of
reactive
oxygen
species
(ROS),
altering
cell
membrane,
changing
DNA
replication
inhibition.
Platinum-based
metal
complex
Cisplatin
was
prepared.
It
widely
used
treating
lung,
breast,
ovarian
testicular
cancers;
however,
these
showed
many
adverse
effects
such
as
renal
insufficiency
electrolyte
abnormalities,
neurotoxicity,
ototoxicity,
nausea,
vomiting
drug
resistance.
To
overcome
side
resistance
mechanisms,
silver
is
highly
employed
a
cytotoxic
agent
binding
through
formation
disulphide
bonds.
Moreover,
cytotoxicity
with
lowest
toxicity.
This
review
highlighted
complexes'
anticancer
various
bioactive
ligands.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(12), С. 6595 - 6595
Опубликована: Июнь 13, 2022
Developing
new,
smart
drugs
with
the
anticancer
activity
is
crucial,
especially
for
cancers,
which
cause
highest
mortality
in
humans.
In
this
paper
we
describe
a
series
of
coordination
compounds
element
health,
zinc,
and
bioactive
ligands,
benzimidazole
derivatives.
By
way
synthesis
have
obtained
four
named
C1,
C2,
C4
C4.
Analytical
analyses
(elemental
analysis
(EA),
flame
atomic
absorption
spectrometry
(FAAS)),
spectroscopic
(Fourier
transform
infrared
spectroscopy
(FT-IR),
mass
(MS))
thermogravimetric
(TG)
methods
definition
crystal
structures
were
used
to
explore
nature
bonding
elucidate
chemical
structures.
The
collected
analytical
data
allowed
determination
stoichiometry
compounds,
thermal
stability,
structure
bonding.
cytotoxicity
effect
new
as
potential
antitumor
agent
on
glioblastoma
(T98G),
neuroblastoma
(SK-N-AS)
lung
adenocarcinoma
(A549)
cell
lines
human
normal
skin
fibroblasts
(CCD-1059Sk)
was
also
determined.
Cell
viability
determined
by
MTT
assay.
results
confirmed
that
conversion
ligands
into
respective
metal
complexes
significantly
improved
their
properties.
screened
antibacterial
antifungal
activities.
ADME
technique
determine
physicochemical
biological
In
recent
years,
the
number
of
people
suffering
from
cancer
has
risen
rapidly
and
World
Health
Organization
U.S.
European
governments
have
identified
this
pathology
as
a
priority
issue.
It
is
known
that
most
bioactive
anticancer
molecules
do
not
target
single
protein
but
exert
pleiotropic
effects,
simultaneously
affecting
multiple
pathways.
our
study,
we
designed
synthesized
new
series
silver
N-heterocyclic
carbene
(NHC)
complexes
[(NHC)
Reviews in Inorganic Chemistry,
Год журнала:
2020,
Номер
40(4), С. 193 - 232
Опубликована: Авг. 7, 2020
Abstract
In
wake
of
emerging
applications
organotellurium
compounds
in
biological
and
material
science
avenues,
the
current
review
describes
their
key
synthetic
methodologies
while
focusing
synthesis
through
five
ligand-to-metal
linkages
including
carbon;
carbon-oxygen;
carbon-nitrogen;
carbon-metal;
carbon-sulfur
to
tellurium.
all
these
whether
tellurium
links
with
ligands
a
complicated
or
simple
pathways,
it
is
often
governed
electrophilic
substitution
reactions.
The
present
study
encompasses
major
routes
so
as
acquire
comprehensive
understanding
compounds.
