Metal N-heterocyclic carbene complexes as potential metallodrugs in antitumor therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 514, P. 215941 - 215941

Published: May 18, 2024

Language: Английский

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N -Heterocyclic Carbene-Metal Complexes as Bio-Organometallic Antimicrobial and Anticancer Drugs, an Update (2015–2020)

Future Medicinal Chemistry, Journal Year: 2020, Volume and Issue: 12(24), P. 2239 - 2275

Published: Nov. 24, 2020

N-heterocyclic carbenes (NHCs) are organic compounds that typically mimic the chemical properties of phosphines. NHCs have made a significant impact on field coordination and organometallic chemistry because they easy to prepare handle their versatility stability. Importantly, physicochemical can be easily fine-tuned by simple variation substituents nitrogen atoms. Over past few years, various NHC-metal complexes been extensively used as metal-based drug candidates catalysts (homogeneous or heterogeneous) for applications. To help assist future work with these compounds, this review provides thorough latest information involving some biomedical applications complexes. Specifically, article focuses recent advances in design, synthesis, characterization (e.g., antimicrobial anticancer activity) (metal: silver, gold, palladium, rhodium, ruthenium, iridium platinum) covering published from 2015 2020. It is hoped promising discoveries date will accelerate studies encouraging potential class effective therapeutic agents.

Language: Английский

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Silver Complexes as Anticancer Agents: A Perspective Review

German Journal of Pharmaceuticals and Biomaterials, Journal Year: 2022, Volume and Issue: 1(1), P. 06 - 28

Published: April 27, 2022

Metal complexes gained more attention in the medical field, particularly cancer treatment, due to their enhanced potential and redox ability. These exhibited significant antiproliferation by triggering generation of reactive oxygen species (ROS), altering cell membrane, changing DNA replication inhibition. Platinum-based metal complex Cisplatin was prepared. It widely used treating lung, breast, ovarian testicular cancers; however, these showed many adverse effects such as renal insufficiency electrolyte abnormalities, neurotoxicity, ototoxicity, nausea, vomiting drug resistance. To overcome side resistance mechanisms, silver is highly employed a cytotoxic agent binding through formation disulphide bonds. Moreover, cytotoxicity with lowest toxicity. This review highlighted complexes' anticancer various bioactive ligands.

Language: Английский

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Second and third-row transition metal compounds containing benzimidazole ligands: An overview of their anticancer and antitumour activity

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 472, P. 214790 - 214790

Published: Sept. 6, 2022

Language: Английский

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Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(12), P. 6595 - 6595

Published: June 13, 2022

Developing new, smart drugs with the anticancer activity is crucial, especially for cancers, which cause highest mortality in humans. In this paper we describe a series of coordination compounds element health, zinc, and bioactive ligands, benzimidazole derivatives. By way synthesis have obtained four named C1, C2, C4 C4. Analytical analyses (elemental analysis (EA), flame atomic absorption spectrometry (FAAS)), spectroscopic (Fourier transform infrared spectroscopy (FT-IR), mass (MS)) thermogravimetric (TG) methods definition crystal structures were used to explore nature bonding elucidate chemical structures. The collected analytical data allowed determination stoichiometry compounds, thermal stability, structure bonding. cytotoxicity effect new as potential antitumor agent on glioblastoma (T98G), neuroblastoma (SK-N-AS) lung adenocarcinoma (A549) cell lines human normal skin fibroblasts (CCD-1059Sk) was also determined. Cell viability determined by MTT assay. results confirmed that conversion ligands into respective metal complexes significantly improved their properties. screened antibacterial antifungal activities. ADME technique determine physicochemical biological

Language: Английский

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Effect of fluorination on the cytotoxic potentials of benzimidazolium-based N-heterocyclic carbene ligands and their silver(I) complexes

Inorganica Chimica Acta, Journal Year: 2024, Volume and Issue: 567, P. 122040 - 122040

Published: March 27, 2024

Language: Английский

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Synthesis of aryl linked binuclear silver N-heterocyclic carbene complexes, DNA interaction study and biological potentials

Inorganic Chemistry Communications, Journal Year: 2020, Volume and Issue: 119, P. 108077 - 108077

Published: June 30, 2020

Language: Английский

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N‐Heterocyclic Carbene (NHC) Silver Complexes as Versatile Chemotherapeutic Agents Targeting Human Topoisomerases and Actin

ChemMedChem, Journal Year: 2022, Volume and Issue: 17(18)

Published: July 29, 2022

In recent years, the number of people suffering from cancer has risen rapidly and World Health Organization U.S. European governments have identified this pathology as a priority issue. It is known that most bioactive anticancer molecules do not target single protein but exert pleiotropic effects, simultaneously affecting multiple pathways. our study, we designed synthesized new series silver N-heterocyclic carbene (NHC) complexes [(NHC)

Language: Английский

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In Vitro Cytotoxic Activity, Cells Staining, DFT Computation, Docking, MD Simulation of Silver N-Heterocyclic Carbene Complexes

Journal of the Indian Chemical Society, Journal Year: 2025, Volume and Issue: unknown, P. 101602 - 101602

Published: Jan. 1, 2025

Language: Английский

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Cytotoxicity, Cell Line Selectivity and Proapoptotic Activity of New Anticancer Agents Derived From N,N’‐Functionalised Benzimidazolium Salts and Their Silver(I)‐N‐Heterocyclic Carbene Complexes

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(3)

Published: May 1, 2025

ABSTRACT A new series of N ‐decyl‐ ’‐benzylbenzimidazolium ‐heterocyclic carbene (NHC) precursors and their mononuclear silver(I)‐NHC complexes were synthesised characterised. The benzyl group was functionalised with various para substituents (H, CH 3 , F, Cl, Br, CN, NO 2 ). effect these on cytotoxicity cell line selectivity against human cervical cancer (HeLa), oestrogen‐positive breast (MCF‐7), normal skin fibroblasts (Hs‐27) investigated. All compounds exhibited significant growth inhibition the tested lines. activity influenced by type line. electron‐donating methylated NHC precursor its silver complex generally demonstrated higher potentials than analogues electron‐withdrawing groups, except in two cases where fluorinated more potent Hs‐27 HeLa, while chlorinated active MCF‐7. Notably, all compounds, particularly complexes, towards MCF‐7 but less toxic Hs‐27. methyl‐, bromo‐, cyano‐containing broadened safety windows (selectivity indices ≥ 3). most selective (against MCF‐7) ROS‐mediated proapoptotic activity, which indicated that promoted death inducing intracellular ROS formation accumulation. Our findings highlight potential use design development safe anticancer agents.

Language: Английский

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