World Journal of Stem Cells,
Год журнала:
2021,
Номер
13(10), С. 1360 - 1381
Опубликована: Окт. 26, 2021
With
developments
in
the
field
of
tissue
engineering
and
regenerative
medicine,
use
biological
products
for
treatment
various
disorders
has
come
into
limelight
among
researchers
clinicians.
Among
all
available
tissues,
research
exploration
adipose
have
become
more
robust.
Adipose
aims
to
develop
by-products
their
substitutes
immunomodulatory
potential.
The
biodegradable
scaffolds
along
with
a
major
role
cellular
growth,
proliferation,
differentiation.
tissue,
apart
from
being
powerhouse
energy
storage,
also
functions
as
largest
endocrine
organ,
release
adipokines.
progenitor
cells
heterogeneous
population
are
paramount
importance
they
determine
capacity
regeneration
these
tissues.
results
adipose-derived
stem-cell
assisted
fat
grafting
provide
numerous
growth
factors
adipokines
that
improve
vasculogenesis,
graft
integration,
survival
within
recipient
promote
promising.
gives
rise
upon
processing.
This
article
highlights
significance
usage
by-products,
individual
characteristics,
clinical
applications.
Stem Cell Research & Therapy,
Год журнала:
2022,
Номер
13(1)
Опубликована: Июль 28, 2022
Abstract
The
multipotency
property
of
mesenchymal
stem
cells
(MSCs)
has
attained
worldwide
consideration
because
their
immense
potential
for
immunomodulation
and
therapeutic
function
in
tissue
regeneration.
MSCs
can
migrate
to
injury
areas
contribute
immune
modulation,
secrete
anti-inflammatory
cytokines
hide
themselves
from
the
system.
Certainly,
various
investigations
have
revealed
anti-inflammatory,
anti-aging,
reconstruction,
wound
healing
potentials
many
vitro
vivo
models.
Moreover,
current
progresses
field
biology
facilitated
progress
particular
guidelines
quality
control
approaches,
which
eventually
lead
clinical
application
MSCs.
In
this
literature,
we
provided
a
brief
overview
immunoregulatory
characteristics
immunosuppressive
activities
addition,
discussed
enhancement,
utilization,
responses
neural,
liver,
kidney,
bone,
heart
diseases,
healing.
Cells,
Год журнала:
2021,
Номер
10(9), С. 2241 - 2241
Опубликована: Авг. 29, 2021
Intervertebral
disc
degeneration
(IVDD)
occurs
as
a
result
of
an
imbalance
the
anabolic
and
catabolic
processes
in
intervertebral
disc,
leading
to
alteration
composition
extracellular
matrix
(ECM),
loss
nucleus
pulposus
(NP)
cells,
excessive
oxidative
stress
inflammation.
Degeneration
IVD
naturally
with
age,
but
mechanical
trauma,
lifestyle
factors
certain
genetic
abnormalities
can
increase
likelihood
symptomatic
disease
progression.
IVDD,
often
referred
degenerative
(DDD),
poses
increasingly
substantial
financial
burden
due
aging
population
increasing
incidence
obesity
United
States.
Current
treatments
for
IVDD
include
pharmacological
surgical
interventions,
these
lack
ability
stop
progression
restore
functionality
IVD.
Biological
therapies
have
been
evaluated
show
varying
degrees
efficacy
reversing
long-term.
Stem
cell-based
shown
promising
results
regeneration
IVD,
face
both
biological
ethical
limitations.
Exosomes
play
important
role
intercellular
communication,
stem
cell-derived
exosomes
maintain
therapeutic
benefit
their
origin
cells
without
associated
risks.
This
review
highlights
current
state
research
on
use
stem-cell
derived
treatment
IVDD.
Biomarker Research,
Год журнала:
2022,
Номер
10(1)
Опубликована: Май 12, 2022
Abstract
Exosomes,
ranging
in
size
from
30
to
150
nm
as
identified
initially
via
electron
microscopy
1946,
are
one
of
the
extracellular
vesicles
(EVs)
produced
by
many
cells
and
have
been
subject
studies;
initially,
they
were
considered
cell
wastes
with
belief
that
exosomes
maintain
homeostasis.
Nowadays,
it
has
found
EVs
secreted
different
play
a
vital
role
cellular
communication
usually
both
physiological
pathological
conditions.
Due
presence
markers
ligands
on
surface
exosomes,
paracrine,
endocrine
autocrine
effects
some
cases.
Immune
cells,
like
other
can
secrete
interact
surrounding
these
vesicles.
system
cells-derived
(IEXs)
induce
responses,
such
increasing
decreasing
transcription
various
genes
regulating
cytokine
production.
This
review
deliberate
function
innate
acquired
immune
derived
their
pathogenesis
diseases,
therapeutic
appliances.
Inflammation and Regeneration,
Год журнала:
2023,
Номер
43(1)
Опубликована: Май 25, 2023
Abstract
Aging
of
the
global
population
increases
incidence
osteoporosis
and
associated
fragility
fractures,
significantly
impacting
patient
quality
life
healthcare
costs.
The
acute
inflammatory
reaction
is
essential
to
initiate
healing
after
injury.
However,
aging
with
“inflammaging”,
referring
presence
systemic
low-level
chronic
inflammation.
Chronic
inflammation
impairs
initiation
bone
regeneration
in
elderly
patients.
This
review
examines
current
knowledge
process
potential
immunomodulatory
therapies
facilitate
inflammaging.
Aged
macrophages
show
increased
sensitivity
responsiveness
signals.
While
M1
are
activated
during
response,
proper
resolution
phase
involves
repolarizing
pro-inflammatory
an
anti-inflammatory
M2
phenotype
tissue
regeneration.
In
aging,
persistent
resulting
from
failure
repolarization
leads
osteoclast
activation
decreased
osteoblast
formation,
thus
increasing
resorption
decreasing
formation
healing.
Inflammaging
can
impair
ability
stem
cells
support
contributes
decline
mass
strength
that
occurs
aging.
Therefore,
modulating
inflammaging
a
promising
approach
for
improving
health
population.
Mesenchymal
(MSCs)
possess
properties
may
benefit
Preconditioning
MSCs
cytokines
affects
MSCs’
secretory
profile
osteogenic
ability.
cultured
under
hypoxic
conditions
proliferation
rates
secretion
growth
factors.
Resolution
via
local
delivery
also
therapy
Scaffolds
containing
cytokines,
unaltered
MSCs,
genetically
modified
have
therapeutic
potential.
MSC
exosomes
increase
migration
fracture
site
enhance
differentiation
angiogenesis.
conclusion,
elderly.
Modulating
compromised
Stem Cell Research & Therapy,
Год журнала:
2022,
Номер
13(1)
Опубликована: Июль 28, 2022
Abstract
Parkinson's
disease
(PD)
is
the
second
most
predominant
neurodegenerative
worldwide.
It
recognized
clinically
by
severe
complications
in
motor
function
caused
progressive
degeneration
of
dopaminergic
neurons
(DAn)
and
dopamine
depletion.
As
current
standard
treatment
focused
on
alleviating
symptoms
through
Levodopa,
developing
neuroprotective
techniques
critical
for
adopting
a
more
pathology-oriented
therapeutic
approach.
Regenerative
cell
therapy
has
provided
us
with
an
unrivalled
platform
evaluating
potentially
effective
novel
methods
treating
illnesses
over
last
two
decades.
Mesenchymal
stem
cells
(MSCs)
are
promising,
as
they
can
differentiate
into
produce
neurotrophic
substances.
The
precise
process
which
repair
neuronal
injury
unknown,
MSC-derived
exosomes
suggested
to
be
responsible
significant
portion
such
effects.
present
review
discusses
application
mesenchymal
PD
treatment.
Membranes,
Год журнала:
2022,
Номер
12(7), С. 716 - 716
Опубликована: Июль 19, 2022
The
repair
of
critical
bone
defects
is
a
hotspot
orthopedic
research.
With
the
development
tissue
engineering
(BTE),
there
increasing
evidence
showing
that
combined
application
extracellular
vesicles
(EVs)
derived
from
mesenchymal
stem
cells
(MSCs)
(MSC-EVs),
especially
exosomes,
with
hydrogels,
scaffolds,
and
other
bioactive
materials
has
made
great
progress,
exhibiting
good
potential
for
regeneration.
Recent
studies
have
found
miRNAs,
proteins,
cargo
loaded
in
EVs
are
key
factors
promoting
osteogenesis
angiogenesis.
In
BTE,
expression
profile
intrinsic
can
be
changed
by
modifying
gene
MSCs
to
obtain
enhanced
osteogenic
activity
ultimately
enhance
osteoinductive
ability
graft
materials.
However,
current
research
on
MSC-EVs
repairing
still
its
infancy,
underlying
mechanism
remains
unclear.
Therefore,
this
review,
effect
such
as
hydrogels
scaffolds
summarized,
defect
delivering
active
molecules
internal
miRNAs
further
elucidated,
which
provides
theoretical
basis
reference
clinical
defects.
