Neuron, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Neuroscience Bulletin, Год журнала: 2023, Номер 39(6), С. 994 - 1008
Опубликована: Янв. 25, 2023
Язык: Английский
Процитировано
11
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Сен. 30, 2023
To localize objects during active sensing, animals must differentiate stimuli caused by volitional movement from real-world object motion. determine a neural basis for this ability, we examined the mouse superior colliculus (SC), which contains multiple egocentric maps of sensorimotor space. By placing mice in whisker-guided virtual reality, discovered rapidly adapting tactile response that transiently emerged externally generated gains whisker contact. Responses to self-generated touch matched history were significantly attenuated, revealing transient magnitude is controlled predictions. The gradually decreased with repetitions external motion, slow habituation based on history. direction motion was accurately encoded firing rates responsive neurons. These data reveal whisker-specific adaptation and predictions SC neurons enhance localization unexpected, changes
Язык: Английский
Процитировано
11
Neuroscience Bulletin, Год журнала: 2023, Номер 39(12), С. 1749 - 1761
Опубликована: Март 15, 2023
Язык: Английский
Процитировано
10
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Июль 24, 2023
Abstract The brain continuously anticipates the energetic needs of body and prepares to meet those before they arise, called allostasis. In support allostasis, continually models sensory state body, interoception. We replicated extended a large-scale system supporting allostasis interoception in human using ultra-high precision 7 Tesla functional magnetic resonance imaging (fMRI) ( N = 90), improving subgenual pregenual anterior cingulate topography combined with extensive brainstem nuclei mapping. observed over 90% anatomical connections published tract-tracing studies non-human animals. also included regions dense intrinsic connectivity broadly throughout system, some which were identified previously as part backbone neural communication across brain. These results strengthen previous evidence for whole-brain modeling regulation internal milieu body.
Язык: Английский
Процитировано
10
Brain, Год журнала: 2023, Номер 147(2), С. 390 - 405
Опубликована: Окт. 17, 2023
Abstract The sense of body ownership (i.e. the feeling that our or its parts belong to us) plays a key role in bodily self-consciousness and is believed stem from multisensory integration. Experimental paradigms such as rubber hand illusion have been developed allow controlled manipulation laboratory settings, providing effective tools for investigating malleability boundaries distinguish self other. Neuroimaging studies converge on involvement several cortical regions, including premotor cortex posterior parietal cortex. However, relatively less attention has paid subcortical structures may also contribute perception, cerebellum putamen. Here, basis neuroimaging neuropsychological observations, we provide an overview relevant regions consider their potential generating maintaining over body. We suggest novel avenues future research targeting making own.
Язык: Английский
Процитировано
9
iScience, Год журнала: 2024, Номер 27(2), С. 109009 - 109009
Опубликована: Янв. 26, 2024
The avian optic tectum (OT) has been studied for its diverse functions, yet a comprehensive molecular landscape at the cellular level lacking. In this study, we applied spatial transcriptome sequencing and single-nucleus RNA (snRNA-seq) to explore organization characteristics of OT from two species:
Язык: Английский
Процитировано
3
Journal of Neuroscience, Год журнала: 2024, Номер 44(10), С. e1655232024 - e1655232024
Опубликована: Фев. 7, 2024
The inferior colliculus (IC) represents a crucial relay station in the auditory pathway, located midbrain's tectum and primarily projecting to thalamus. Despite identification of distinct cell classes based on various biomarkers IC, their specific contributions organization tectothalamic pathways have remained poorly understood. In this study, we demonstrate that IC neurons expressing parvalbumin (IC
Язык: Английский
Процитировано
3
iScience, Год журнала: 2024, Номер 27(6), С. 109886 - 109886
Опубликована: Май 3, 2024
The neural computations for looming detection are strikingly similar across species. In mammals, information about approaching threats is conveyed from the retina to midbrain superior colliculus, where approach variables computed enable defensive behavior. Although neuroscientific theories posit that representations contribute emotion through connectivity with distributed brain systems, it remains unknown whether a computational system can predict both behavior and phenomenal experience in humans. Here, we show shallow convolutional network based on
Язык: Английский
Процитировано
3
Cell Reports, Год журнала: 2024, Номер 43(7), С. 114383 - 114383
Опубликована: Июнь 25, 2024
Alcohol is the most widely used addictive substance, potentially leading to brain damage and genetic abnormalities. Despite its prevalence associated risks, current treatments have yet identify effective methods for reducing cravings preventing relapse. In this study, we find that 4-Hz alternating bilateral sensory stimulation (ABS) effectively reduces ethanol-induced conditioned place preference (CPP) in male mice, while flash light does not exhibit therapeutic effects. Whole-brain c-Fos mapping demonstrates ABS triggers notable activation superior colliculus GABAergic neurons (SC
Язык: Английский
Процитировано
3
Current Biology, Год журнала: 2024, Номер 34(16), С. 3616 - 3631.e5
Опубликована: Июль 16, 2024
Язык: Английский
Процитировано
3