Visual looming is a primitive for human emotion DOI Creative Commons
Monica K. Thieu, Vladislav Ayzenberg, Stella F. Lourenco

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109886 - 109886

Published: May 3, 2024

The neural computations for looming detection are strikingly similar across species. In mammals, information about approaching threats is conveyed from the retina to midbrain superior colliculus, where approach variables computed enable defensive behavior. Although neuroscientific theories posit that representations contribute emotion through connectivity with distributed brain systems, it remains unknown whether a computational system can predict both behavior and phenomenal experience in humans. Here, we show shallow convolutional network based on

Language: Английский

Co-Conservation of Synaptic Gene Expression and Circuitry in Collicular Neurons DOI Creative Commons
Yuanming Liu, J McDaniel, Chen Chen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

The superior colliculus (SC), a midbrain sensorimotor hub, is anatomically and functionally similar across vertebrates, but how its cell types have evolved unclear. Using single-nucleus transcriptomics, we compared the SC's molecular cellular organization in mice, tree shrews, humans. Despite over 96 million years of evolutionary divergence, identified ∼30 consensus neuronal subtypes, including Cbln2 + neurons that form SC-pulvinar circuit mice shrews. Synapse-related genes were among most conserved, unlike neocortex, suggesting co-conservation synaptic circuitry. In contrast, cilia-related diverged significantly species, highlighting potential importance primary cilium SC evolution. Additionally, novel inhibitory neuron shrews humans not mice. Our findings reveal has by conserving genes, circuitry, while diversifying ciliary gene expression an subtype.

Language: Английский

Citations

0
The superior colliculus DOI Creative Commons
Jennifer L. Hoy, Karl Farrow

Current Biology, Journal Year: 2025, Volume and Issue: 35(5), P. R164 - R168

Published: March 1, 2025

Language: Английский

Citations

0
Neural dynamics in superior colliculus of freely moving mice DOI Creative Commons
Shelby L. Sharp, Jhoseph Shin, Dylan M. Martins

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract Vision is an active process that depends on head and eye movements to explore the visual environment. Superior colliculus (SC) known for its role in generating these movements, as well processing information, but has not been studied extensively during free movement complex environments. To determine impact of vision, we recorded neural activity across depth SC while simultaneously recording position. We find superficial (sSC) neurons respond input following gaze-shifting saccadic whereas deep (dSC) themselves, demonstrated by their sustained response darkness. Additionally, motor responses dSC are more correlated rather than movements. Furthermore, compared sSC gaze shift primary cortex (V1), finding similarities key types, although temporal sequences shifts differ between regions. Our results demonstrate distinct differences V1 highlighting various roles plays vision. Highlights depths superior freely moving mice measuring Neurons mouse strongly shifts, layers. primarily a movement. generally represent movement, independent input. While share with there unique profiles suggest

Language: Английский

Citations

0
Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions DOI

Liang Shan,

Yuan Liu, Bo Zhang

et al.

Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 39(12), P. 1749 - 1761

Published: March 15, 2023

Language: Английский

Citations

10
Cortical and subcortical mapping of the allostatic-interoceptive system in the human brain: replication and extension with 7 Tesla fMRI DOI Creative Commons
Jiahe Zhang, Danlei Chen, Philip Deming

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 24, 2023

Abstract The brain continuously anticipates the energetic needs of body and prepares to meet those before they arise, called allostasis. In support allostasis, continually models sensory state body, interoception. We replicated extended a large-scale system supporting allostasis interoception in human using ultra-high precision 7 Tesla functional magnetic resonance imaging (fMRI) ( N = 90), improving subgenual pregenual anterior cingulate topography combined with extensive brainstem nuclei mapping. observed over 90% anatomical connections published tract-tracing studies non-human animals. also included regions dense intrinsic connectivity broadly throughout system, some which were identified previously as part backbone neural communication across brain. These results strengthen previous evidence for whole-brain modeling regulation internal milieu body.

Language: Английский

Citations

10
Neural mechanisms for the localization of unexpected external motion DOI Creative Commons
Suma Chinta, Scott R. Pluta

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Sept. 30, 2023

To localize objects during active sensing, animals must differentiate stimuli caused by volitional movement from real-world object motion. determine a neural basis for this ability, we examined the mouse superior colliculus (SC), which contains multiple egocentric maps of sensorimotor space. By placing mice in whisker-guided virtual reality, discovered rapidly adapting tactile response that transiently emerged externally generated gains whisker contact. Responses to self-generated touch matched history were significantly attenuated, revealing transient magnitude is controlled predictions. The gradually decreased with repetitions external motion, slow habituation based on history. direction motion was accurately encoded firing rates responsive neurons. These data reveal whisker-specific adaptation and predictions SC neurons enhance localization unexpected, changes

Language: Английский

Citations

10
Emergent Aspects of the Integration of Sensory and Motor Functions DOI Creative Commons
Tiziana M. Florio

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 162 - 162

Published: Feb. 7, 2025

This article delves into the intricate mechanisms underlying sensory integration in executive control of movement, encompassing ideomotor activity, predictive capabilities, and motor systems. It examines interplay between functions, highlighting role cortical subcortical regions central nervous system enhancing environmental interaction. The acquisition skills, procedural memory, representation actions brain are discussed emphasizing significance mental imagery training function. development this aspect sensorimotor can help to advance our understanding interactions control, mechanisms, consciousness. Bridging theoretical insights with practical applications, it sets stage for future innovations clinical rehabilitation, assistive technology, education. ongoing exploration these domains promises uncover new pathways human capability well-being.

Language: Английский

Citations

0
Single-nucleus profiling decoding the subcortical visual pathway evolution of vertebrates DOI Creative Commons
Kuo Liao,

Ya Xiang,

Youning Lin

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112128 - 112128

Published: Feb. 28, 2025

Language: Английский

Citations

0
Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging DOI Creative Commons

Isaac Clark,

Andrew Heinmiller,

Wei Zhu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Brain connectomes are insightful models that describe the connectivity of different regions throughout brain. These traditionally generated through temporal correlation blood oxygen level dependent (BOLD) signals detected by functional magnetic resonance imaging (fMRI). Photoacoustic ultrasound (PAU) can also detect oxygenation levels while being more accessible and cost effective than fMRI. We propose use PAU to generate brain as an alternative In this study we successfully developed a pipeline for processing data from whole scans mice found it produced were comparable those fMRI, particularly, in detecting connections previously documented literature. Our findings suggest is promising fMRI mapping connectome, offering advantages sensitivity accessibility, making valuable tool future research on connectivity.

Language: Английский

Citations

0
Single-neuron projectome reveals organization of somatosensory ascending pathways in the mouse brain DOI

Wen-Qun Ding,

Wei Song,

Xiaoxue Shi

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0