The Impressive Anti-Inflammatory Activity of Cerium Oxide Nanoparticles: More than Redox? DOI Creative Commons
Francesca Corsi, Greta Deidda Tarquini,

Marta Urbani

и другие.

Nanomaterials, Год журнала: 2023, Номер 13(20), С. 2803 - 2803

Опубликована: Окт. 21, 2023

Cerium oxide nanoparticles (CNPs) are biocompatible nanozymes exerting multifunctional biomimetic activities, including superoxide dismutase (SOD), catalase, glutathione peroxidase, photolyase, and phosphatase. SOD- catalase-mimesis depend on Ce3+/Ce4+ redox switch nanoparticle surface, which allows scavenging the most noxious reactive oxygen species in a self-regenerating, energy-free manner. As oxidative stress plays pivotal roles pathogenesis of inflammatory disorders, CNPs have recently attracted attention as potential anti-inflammatory agents. A careful survey literature reveals that CNPs, alone or constituents implants scaffolds, strongly contrast chronic inflammation (including neurodegenerative autoimmune diseases, liver steatosis, gastrointestinal disorders), infections, trauma, thereby ameliorating/restoring organ function. By general consensus, inhibit cues while boosting pro-resolving signaling pathways. The mechanism CNPs' effects has hardly been investigated, being rather deductively attributed to CNP-induced ROS scavenging. However, multi-functional exert additional bioactivities independent from switch, such phosphatase activity, could conceivably mediate some reported, suggesting fight via pleiotropic actions. Since CNP activity is potentially pharmacological breakthrough, it important precisely attribute described one another their nanozyme functions, thus achieving therapeutic credibility.

Язык: Английский

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application DOI
Jingyi Sheng,

Yuehuang Wu,

He Ding

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Фев. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Язык: Английский

Процитировано

223

“Electron Transport Chain Interference” Strategy of Amplified Mild-Photothermal Therapy and Defect-Engineered Multi-Enzymatic Activities for Synergistic Tumor-Personalized Suppression DOI
Shuming Dong, Yushan Dong, Zhiyu Zhao

и другие.

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(17), С. 9488 - 9507

Опубликована: Март 31, 2023

Arming activatable mild-photothermal therapy (PTT) with the property of relieving tumor thermotolerance holds great promise for overcoming traditional mild PTT limitations such as thermoresistance, insufficient therapeutic effect, and off-target heating. Herein, a mitochondria-targeting, defect-engineered AFCT nanozyme enhanced multi-enzymatic activity was elaborately designed microenvironment (TME)-activatable phototheranostic agent to achieve remarkable anti-tumor via "electron transport chain (ETC) interference synergistic adjuvant therapy". Density functional theory calculations revealed that effect among multi-enzyme active centers endows nanozymes excellent catalytic activity. In TME, open sources H2O2 can be achieved by superoxide dismutase-mimicking nanozymes. response dual stimuli acidity, peroxidase-mimicking not only catalyzes accumulation generate ·OH but also converts loaded 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) into its oxidized form strong near-infrared absorption, specifically unlocking photothermal photoacoustic imaging properties. Intriguingly, undesired thermoresistance cells greatly alleviated owing reduced expression heat shock proteins enabled NADH POD-mimicking AFCT-mediated depletion consequent restriction ATP supply. Meanwhile, accumulated facilitate both apoptosis ferroptosis in cells, resulting outcomes combination TME-activated PTT.

Язык: Английский

Процитировано

178

Nanocatalytic Biofunctional MOF Coating on Titanium Implants Promotes Osteoporotic Bone Regeneration through Cooperative Pro-osteoblastogenesis MSC Reprogramming DOI
Maowen Chen, Dong Wang,

Menghuan Li

и другие.

ACS Nano, Год журнала: 2022, Номер 16(9), С. 15397 - 15412

Опубликована: Сен. 15, 2022

An elevated bone microenvironmental reactive oxygen species (ROS) level is a hallmark of osteoporosis that often leads to the dysfunction bone-related mesenchymal stem cells (MSCs), which would induce MSC senescence and severely undermine their osteoblastic potential. Herein, we report in situ construction microenvironment-responsive biofunctional metal-organic framework (bio-MOF) coating on titanium surface through coordination between p-xylylenebisphosphonate (PXBP) Ce/Sr ions by hydrothermal method. Taking advantage anchored Ce Sr ions, AHT-Ce/SrMOF implants demonstrate on-demand superoxide dismutase catalase-like catalytic activities decompose ROS MSCs restore mitochondrial functions. In vitro analysis showed substantially activated AMP-activated protein kinase (AMPK) signaling pathway reduced levels. Meanwhile, grown displayed significantly higher expressions fission marker (DRP1), fusion (MFN2 OPA1), mitophagy (PINK1 LC3) than those AHT-CeMOF AHT-SrMOF groups, indicated bio-MOF could amend function reverse senescence. vivo evaluations bio-MOF-coated Ti implant site promote new formation, leading improved osteointegration osteoporotic rat. This study may improve implant-mediated fracture healing clinics.

Язык: Английский

Процитировано

80

Nanozyme-based biosensor for organophosphorus pesticide monitoring: Functional design, biosensing strategy, and detection application DOI
Fengnian Zhao, Li Wang, Mengyue Li

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 165, С. 117152 - 117152

Опубликована: Июнь 20, 2023

Язык: Английский

Процитировано

80

Regulating the H2O2 Activation Pathway on a Well-Defined CeO2 Nanozyme Allows the Entire Steering of Its Specificity between Associated Enzymatic Reactions DOI
Bo Yuan, Zicong Tan, Qiang Guo

и другие.

ACS Nano, Год журнала: 2023, Номер 17(17), С. 17383 - 17393

Опубликована: Авг. 14, 2023

Nanozymes are promising alternatives to natural enzymes, but their use remains limited owing poor specificity. For example, CeO2 activates H2O2 and displays peroxidase (POD)-like, catalase (CAT)-like, haloperoxidase (HPO)-like activities. Since they unavoidably compete for H2O2, affecting its utilization in the target application, precise manipulation of reaction specificity is thus imperative. Herein, we showed that one can simply achieve this by manipulating activation pathway on pristine well-defined shapes. This because coordination electronic structures Ce sites vary with surfaces, wherein (100) (111) surfaces display nearly 100% toward POD-/CAT-like HPO-like activities, respectively. The antibacterial results suggest latter surface well-utilize kill bacteria (cf., former), which anti-biofouling applications. work provides atomic insights into synthesis nanozymes improved activity, specificity, utilization.

Язык: Английский

Процитировано

68

Activity Regulating Strategies of Nanozymes for Biomedical Applications DOI
Xiaoteng Ding, Zhen Zhao, Yanfang Zhang

и другие.

Small, Год журнала: 2023, Номер 19(11)

Опубликована: Янв. 17, 2023

Abstract On accounts of the advantages inherent high stability, ease preparation and superior catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical applications as alternatives to natural enzymes. Optimizing activity is significant for widening boosting into practical level. As research regulation strategies boosting, it essential timely review, summarize, analyze advances structure–activity relationships further inspiring ingenious this prosperous area. Herein, methods recent 5 years are systematically summarized, including size morphology, doping, vacancy, surface modification, hybridization, followed by a discussion latest consisting biosensing, antibacterial, tumor therapy. Finally, challenges opportunities rapidly developing field presented more infant yet promising

Язык: Английский

Процитировано

58

Nanoceria: an innovative strategy for cancer treatment DOI Creative Commons
Joyce Tang, Shehzahdi S. Moonshi, Hang T. Ta

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2023, Номер 80(2)

Опубликована: Янв. 19, 2023

Abstract Nanoceria or cerium oxide nanoparticles characterised by the co-existing of Ce 3+ and 4+ that allows self-regenerative, redox-responsive dual-catalytic activities, have attracted interest as an innovative approach to treating cancer. Depending on surface characteristics immediate environment, nanoceria exerts either anti- pro-oxidative effects which regulate reactive oxygen species (ROS) levels in biological systems. mimics ROS-related enzymes protect normal cells at physiological pH from oxidative stress induce ROS production slightly acidic tumour microenvironment trigger cancer cell death. nanozymes also generates molecular relieves hypoxia, leading sensitisation improve therapeutic outcomes photodynamic (PDT), photothermal (PTT) radiation (RT), targeted chemotherapies. has been engineered a nanocarrier drug delivery combination with other drugs produce synergistic anti-cancer effects. Despite reported preclinical successes, there are still knowledge gaps arising inadequate number studies reporting findings based physiologically relevant disease models accurately represent complexities This review discusses activities responding tension gradient microenvironment, highlights recent nanoceria-based platforms be feasible direct indirect agents protective healthy tissues, finally addresses challenges clinical translation therapeutics.

Язык: Английский

Процитировано

52

Tuning oxidant and antioxidant activities of ceria by anchoring copper single-site for antibacterial application DOI Creative Commons
Peng Jiang, Ludan Zhang, Xiaolong Liu

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 3, 2024

Abstract The reaction system of hydrogen peroxide (H 2 O ) catalyzed by nanozyme has a broad prospect in antibacterial treatment. However, the complex catalytic activities nanozymes lead to multiple pathways reacting parallel, causing uncertain results. New approach effectively regulate is urgent need. Herein, Cu single site modified on nanoceria with various activities, such as peroxidase-like activity (POD) and hydroxyl radical antioxidant capacity (HORAC). Benefiting from interaction between coordinated CeO substrate, POD enhanced while HORAC inhibited, which further confirmed density functional theory (DFT) calculations. Cu-CeO + H shows good properties both vitro vivo. In this work, strategy based metal carrier provides general clue for optimizing nanozymes.

Язык: Английский

Процитировано

49

Molecular insights of nanozymes from design to catalytic mechanism DOI Open Access
Yuan Xu, Zhixin Zhou,

Nankai Deng

и другие.

Science China Chemistry, Год журнала: 2023, Номер 66(5), С. 1318 - 1335

Опубликована: Фев. 9, 2023

Язык: Английский

Процитировано

48

Biomedical potential of nanozymes: Harnessing redox enzyme mimicry for theranostic applications DOI
Somaye Shahraki,

Esmaeil Vaziri,

Ali Akbar Saboury

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 517, С. 215937 - 215937

Опубликована: Июнь 15, 2024

Язык: Английский

Процитировано

33