Central Nicotinic and Muscarinic Receptors in Health and Disease DOI Creative Commons
Yousef Tizabi, Bruk Getachew, Vassiliy Tsytsarev

и другие.

IntechOpen eBooks, Год журнала: 2023, Номер unknown

Опубликована: Авг. 14, 2023

Without acetylcholine (ACh) no skeletal muscle contraction, preganglionic sympathetic or parasympathetic activity can be obtained. This result in dysregulation of cardiac, respiratory, gastrointestinal, and renal functions as well disruption fluid secretion from various glands such tears, saliva, digestive juices, sweat, milk. Importantly, ACh deficiency the brain have severe cognitive consequences. The action is mediated by two distinct classes receptors, namely muscarinic (mAChRs), which are G-protein coupled (metabotropic) receptors nicotinic (nAChRs), ligand-gated ion channels (ionotropic receptors). focus this chapter on interaction these receptor its implication health disease. Thus, following a brief description actions central circuitry, an update mAChRs nAChRs how their may impact neuropsychiatric/neurodegenerative diseases will provided. Moreover, potential novel therapeutic intervention based interactions, particularly relationship to Alzheimer’s Parkinson’s touched upon.

Язык: Английский

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease DOI Creative Commons
Érica Novaes Soares, Ana Carla dos Santos Costa,

Gabriel de Jesus Ferrolho

и другие.

Cells, Год журнала: 2024, Номер 13(6), С. 474 - 474

Опубликована: Март 7, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types, including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells and, specifically, their pathology treatment.

Язык: Английский

Процитировано

11
trans-4-Fluoro-l-proline: A Sensitive 19F NMR Probe for the Rapid Simultaneous Enantiomeric Analysis of Multicomponent Amines DOI
Biling Huang, Lihua Xu, Ning Wang

и другие.

Analytical Chemistry, Год журнала: 2022, Номер 94(3), С. 1867 - 1873

Опубликована: Янв. 13, 2022

Simultaneous enantiomeric analysis is especially important for medicine, food security, and life science. Chiral of multicomponent amine mixtures still faces many challenges. Here, our work demonstrates the first time that a novel chiral derivatizing agent CDApro based on trans-4-fluoro-l-proline (trans4Fpro) has been successfully used rapid simultaneous 22 nonamino acid (non-AA) amines, l/d-AAs, or mirror-image dipeptides in mixture, as well amines with centers several carbons remote to amino group. Furthermore, determination purity quantification can be made using CDApro, which serves robust powerful reagent differentiation amines.

Язык: Английский

Процитировано

30
Nicotinic Acetylcholine Receptor Dysfunction in Addiction and in Some Neurodegenerative and Neuropsychiatric Diseases DOI Creative Commons

Ana Sofía Vallés,

Francisco J. Barrantes

Cells, Год журнала: 2023, Номер 12(16), С. 2051 - 2051

Опубликована: Авг. 11, 2023

The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. focuses on the nicotinic acetylcholine (nAChR) its addiction neurodegenerative neuropsychiatric diseases epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly involvement of α7 nAChRs expressed peripheral immune cells. Evidence suggests these neuroinflammatory trigger aggravate pathological states. We discuss preclinical evidence demonstrating therapeutic potential nAChR ligands Alzheimer disease, Parkinson schizophrenia spectrum disorders, autosomal dominant sleep-related hypermotor PubMed Google Scholar bibliographic databases were searched keywords indicated below.

Язык: Английский

Процитировано

20
Nicotine alleviates MPTP-induced nigrostriatal damage through modulation of JNK and ERK signaling pathways in the mice model of Parkinson’s disease DOI Creative Commons

Sisi Ruan,

Jiqing Xie, Linhai Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Фев. 2, 2023

Introduction: Nicotine (Nic) has previously been proven to reduce neurodegeneration in the models of Parkinson's disease (PD). The present study is intended investigate detailed mechanisms related potential neuroprotective effects Nic vivo. Methods: We established a PD model using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced C57BL6 mice (25 mg/kg/d, 5 d, i.p.) neuropharmacological modulation pretreatment (2.5 i.p., 30 min before MPTP injection) from perspectives neurobehavioral assessment, pathological alterations, microglial cell inflammation and MAPK signaling pathways specific brain regions. Results: open field test, elevated plus maze, rotarod traction test suggested that could significantly improve MPTP-induced motor impairment had an anxiolytic effect. was found neuroapoptosis, enhance tyrosine hydroxylase activity, accumulation phosphorylated α-synuclein substantia nigra striatal regions by TUNEL immunohistochemical assays. Immuno-fluorescent method for labeling Iba1 CD68 indicated remarkably alleviates activation microglia which represents M1 polarization state under stimulation. No significant difference expression p38/MAPK pathway nigrostriatal regions, while inhibit p-JNK/JNK ratio increase declined p-ERK/ERK MPTP-exposed brains, further confirmed CYP2A5 inhibitor decline metabolic activity Nic. Discussion: molecular mechanism exerts its against may be achieved regulating JNK ERK nigra-striatum

Язык: Английский

Процитировано

19
Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease DOI Creative Commons
Sandro Huenchuguala, Juan Segura‐Aguilar

Neural Regeneration Research, Год журнала: 2023, Номер 19(3), С. 529 - 535

Опубликована: Июль 28, 2023

Abstract The positive effect of levodopa in the treatment Parkinson’s disease, although it is limited time and has severe side effects, encouraged scientific community to look for new drugs that can stop neurodegenerative process or even regenerate neuromelanin-containing dopaminergic nigrostriatal neurons. Successful preclinical studies with coenzyme Q10, mitoquinone, isradipine, nilotinib, TCH346, neurturin, zonisamide, deferiprone, prasinezumab, cinpanemab prompted clinical trials. However, these failed after more than 50 years continues be key drug despite its effects 4–6 chronic treatment. lack translated successful results obtained investigations based on use neurotoxins do not exist human body as disease a big problem. In our opinion, cause failures lies experimental animal models involving body, such 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine, induce very fast, massive expansive process, which contrasts extremely slow one exceedingly progress neurons idiopathic patients due (i) degenerative model neurotoxic an endogenous neurotoxin affects single neuron, (ii) event (iii) fact triggers produced inside fits this neuron at aminochrome, since generated within neurons, does all mechanisms involved disease. conclusion, hypothesis corresponds single-neuron neurodegeneration model, we must search molecules increase expression neuroprotective enzymes DT-diaphorase glutathione transferase M2-2. It been observed activation Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 pathway associated transcriptional genes.

Язык: Английский

Процитировано

18
Iron toxicity, ferroptosis and microbiota in Parkinson’s disease: Implications for novel targets DOI
Fernanda V. Carvalho,

Harold E. Landis,

Bruk Getachew

и другие.

Advances in neurotoxicology, Год журнала: 2024, Номер unknown, С. 105 - 132

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

9
HAT and HDAC: Enzyme with Contradictory Action in Neurodegenerative Diseases DOI
Richa Singh, Aaina Singh Rathore, Hagera Dilnashin

и другие.

Molecular Neurobiology, Год журнала: 2024, Номер 61(11), С. 9110 - 9124

Опубликована: Апрель 8, 2024

Язык: Английский

Процитировано

9
Neuroprotective and Immunomodulatory Effects of Probiotics in a Rat Model of Parkinson’s Disease DOI
Irving Parra, Isabel Martínez‐Alcalá, Lizbeth Vásquez-Celaya

и другие.

Neurotoxicity Research, Год журнала: 2023, Номер 41(2), С. 187 - 200

Опубликована: Янв. 20, 2023

Язык: Английский

Процитировано

15
An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices DOI Creative Commons

Carmen Tesoro,

Filomena Lelario, Rosanna Ciriello

и другие.

Separations, Год журнала: 2022, Номер 9(8), С. 224 - 224

Опубликована: Авг. 17, 2022

L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most isolated either synthesized chemically or from natural sources, but only some plants belonging to Fabaceae family contain significant amounts L-dopa. Due its low stability, unambiguous determination in plant matrices requires appropriate technologies. Several analytical methods have been developed different plants. The quantification are mainly based on capillary electrophoresis chromatographic methods, i.e., high-performance liquid chromatography (HPLC), coupled ultraviolet-visible mass spectrometric detection. HPLC often used. This paper aims give information latest developments chemical study L-dopa, emphasizing extraction, separation and characterization this compound by chromatographic, electrochemical spectral techniques. can help select best possible strategy determining using advanced methods.

Язык: Английский

Процитировано

23
Tricin promoted ATG-7 dependent autophagic degradation of α-synuclein and dopamine release for improving cognitive and motor deficits in Parkinson's disease DOI Creative Commons
Xingxia Wang, Wei Hu, Liqun Qu

и другие.

Pharmacological Research, Год журнала: 2023, Номер 196, С. 106874 - 106874

Опубликована: Авг. 14, 2023

Tricin, a natural nontoxic flavonoid distributed in grasses and euphorbia plants, has been reported to scavenge free radicals, possess anti-inflammatory antioxidative effects. However, its autophagic effect on Parkinson's disease (PD) not elucidated. By adopting cellular C. elegans models of PD, the tricin was identified based level autophagy markers (LC3-II p62). Besides, pharmacological effects neurotransmitters (tyrosine hydroxylase dopamine), inflammatory cytokines (IFN γ, TNFα, MCP-1, IL-10, IL-6 IL-17A), histology (hematoxylin & eosin Nissl staining) behavioural pathology (open-field test, hindlimb clasping, Y-maze, Morris water-maze nest building test) were also confirmed A53T-α-transgenic PD mouse model. Further experiments demonstrated that induced flux lowered α-synuclein through AMPK-p70s6K- ATG7-dependent mechanism. Compared existing clinical drugs, mitigated pathogenesis symptoms with no observable side In summary, is proposed as potential adjuvant remedy or nutraceutical for prevention treatment PD.

Язык: Английский

Процитировано

9