Butyrate protects and synergizes with nicotine against iron- and manganese-induced toxicities in cell culture: Implications for neurodegenerative diseases DOI Creative Commons
Yousef Tizabi, Bruk Getachew, Michael Aschner

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 5, 2023

Abstract Toxic exposures to heavy metals, such as iron (Fe) and manganese (Mn), can result in long-range neurological diseases are therefore of significant environmental medical concerns. We have previously reported that damage neuroblastoma-derived dopaminergic cells (SH-SY5Y) by both Fe Mn could be prevented pre-treatment with nicotine. Moreover, butyrate, a short chain fatty acid (SCFA) provided protection against salsolinol, selective toxin, the same cell line. Here, we broadened investigation determine whether butyrate might also protect and/or Mn, whether, if combined nicotine, an additive or synergistic effect observed. Both nicotine concentration-dependently blocked toxicities. The ineffective concentrations when combined, full Mn. effects but not mecamylamine, non-selective nicotinic antagonist. On other hand, beta-hydroxy acid-3 receptor These results only provide further support for neuroprotective indicate distinct mechanisms action each one. Furthermore, potential utility combination metal toxicities is suggested.

Language: Английский

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease DOI Creative Commons
Érica Novaes Soares, Ana Carla dos Santos Costa,

Gabriel de Jesus Ferrolho

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 474 - 474

Published: March 7, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types, including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells and, specifically, their pathology treatment.

Language: Английский

Citations

11
HAT and HDAC: Enzyme with Contradictory Action in Neurodegenerative Diseases DOI
Richa Singh, Aaina Singh Rathore, Hagera Dilnashin

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(11), P. 9110 - 9124

Published: April 8, 2024

Language: Английский

Citations

9
trans-4-Fluoro-l-proline: A Sensitive 19F NMR Probe for the Rapid Simultaneous Enantiomeric Analysis of Multicomponent Amines DOI
Biling Huang, Lihua Xu, Ning Wang

et al.

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(3), P. 1867 - 1873

Published: Jan. 13, 2022

Simultaneous enantiomeric analysis is especially important for medicine, food security, and life science. Chiral of multicomponent amine mixtures still faces many challenges. Here, our work demonstrates the first time that a novel chiral derivatizing agent CDApro based on trans-4-fluoro-l-proline (trans4Fpro) has been successfully used rapid simultaneous 22 nonamino acid (non-AA) amines, l/d-AAs, or mirror-image dipeptides in mixture, as well amines with centers several carbons remote to amino group. Furthermore, determination purity quantification can be made using CDApro, which serves robust powerful reagent differentiation amines.

Language: Английский

Citations

30
Nicotinic Acetylcholine Receptor Dysfunction in Addiction and in Some Neurodegenerative and Neuropsychiatric Diseases DOI Creative Commons

Ana Sofía Vallés,

Francisco J. Barrantes

Cells, Journal Year: 2023, Volume and Issue: 12(16), P. 2051 - 2051

Published: Aug. 11, 2023

The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. focuses on the nicotinic acetylcholine (nAChR) its addiction neurodegenerative neuropsychiatric diseases epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly involvement of α7 nAChRs expressed peripheral immune cells. Evidence suggests these neuroinflammatory trigger aggravate pathological states. We discuss preclinical evidence demonstrating therapeutic potential nAChR ligands Alzheimer disease, Parkinson schizophrenia spectrum disorders, autosomal dominant sleep-related hypermotor PubMed Google Scholar bibliographic databases were searched keywords indicated below.

Language: Английский

Citations

20
Nicotine alleviates MPTP-induced nigrostriatal damage through modulation of JNK and ERK signaling pathways in the mice model of Parkinson’s disease DOI Creative Commons

Sisi Ruan,

Jiqing Xie, Linhai Wang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 2, 2023

Introduction: Nicotine (Nic) has previously been proven to reduce neurodegeneration in the models of Parkinson's disease (PD). The present study is intended investigate detailed mechanisms related potential neuroprotective effects Nic vivo. Methods: We established a PD model using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced C57BL6 mice (25 mg/kg/d, 5 d, i.p.) neuropharmacological modulation pretreatment (2.5 i.p., 30 min before MPTP injection) from perspectives neurobehavioral assessment, pathological alterations, microglial cell inflammation and MAPK signaling pathways specific brain regions. Results: open field test, elevated plus maze, rotarod traction test suggested that could significantly improve MPTP-induced motor impairment had an anxiolytic effect. was found neuroapoptosis, enhance tyrosine hydroxylase activity, accumulation phosphorylated α-synuclein substantia nigra striatal regions by TUNEL immunohistochemical assays. Immuno-fluorescent method for labeling Iba1 CD68 indicated remarkably alleviates activation microglia which represents M1 polarization state under stimulation. No significant difference expression p38/MAPK pathway nigrostriatal regions, while inhibit p-JNK/JNK ratio increase declined p-ERK/ERK MPTP-exposed brains, further confirmed CYP2A5 inhibitor decline metabolic activity Nic. Discussion: molecular mechanism exerts its against may be achieved regulating JNK ERK nigra-striatum

Language: Английский

Citations

19
Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease DOI Creative Commons
Sandro Huenchuguala, Juan Segura‐Aguilar

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(3), P. 529 - 535

Published: July 28, 2023

Abstract The positive effect of levodopa in the treatment Parkinson’s disease, although it is limited time and has severe side effects, encouraged scientific community to look for new drugs that can stop neurodegenerative process or even regenerate neuromelanin-containing dopaminergic nigrostriatal neurons. Successful preclinical studies with coenzyme Q10, mitoquinone, isradipine, nilotinib, TCH346, neurturin, zonisamide, deferiprone, prasinezumab, cinpanemab prompted clinical trials. However, these failed after more than 50 years continues be key drug despite its effects 4–6 chronic treatment. lack translated successful results obtained investigations based on use neurotoxins do not exist human body as disease a big problem. In our opinion, cause failures lies experimental animal models involving body, such 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine, induce very fast, massive expansive process, which contrasts extremely slow one exceedingly progress neurons idiopathic patients due (i) degenerative model neurotoxic an endogenous neurotoxin affects single neuron, (ii) event (iii) fact triggers produced inside fits this neuron at aminochrome, since generated within neurons, does all mechanisms involved disease. conclusion, hypothesis corresponds single-neuron neurodegeneration model, we must search molecules increase expression neuroprotective enzymes DT-diaphorase glutathione transferase M2-2. It been observed activation Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 pathway associated transcriptional genes.

Language: Английский

Citations

18
Iron toxicity, ferroptosis and microbiota in Parkinson’s disease: Implications for novel targets DOI
Fernanda V. Carvalho,

Harold E. Landis,

Bruk Getachew

et al.

Advances in neurotoxicology, Journal Year: 2024, Volume and Issue: unknown, P. 105 - 132

Published: Jan. 1, 2024

Language: Английский

Citations

9
An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices DOI Creative Commons

Carmen Tesoro,

Filomena Lelario, Rosanna Ciriello

et al.

Separations, Journal Year: 2022, Volume and Issue: 9(8), P. 224 - 224

Published: Aug. 17, 2022

L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most isolated either synthesized chemically or from natural sources, but only some plants belonging to Fabaceae family contain significant amounts L-dopa. Due its low stability, unambiguous determination in plant matrices requires appropriate technologies. Several analytical methods have been developed different plants. The quantification are mainly based on capillary electrophoresis chromatographic methods, i.e., high-performance liquid chromatography (HPLC), coupled ultraviolet-visible mass spectrometric detection. HPLC often used. This paper aims give information latest developments chemical study L-dopa, emphasizing extraction, separation and characterization this compound by chromatographic, electrochemical spectral techniques. can help select best possible strategy determining using advanced methods.

Language: Английский

Citations

23
Neuroprotective and Immunomodulatory Effects of Probiotics in a Rat Model of Parkinson’s Disease DOI
Irving Parra, Isabel Martínez‐Alcalá, Lizbeth Vásquez-Celaya

et al.

Neurotoxicity Research, Journal Year: 2023, Volume and Issue: 41(2), P. 187 - 200

Published: Jan. 20, 2023

Language: Английский

Citations

15
Role of Glial Cells and Receptors in Schizophrenia Pathogenesis DOI
Yousef Tizabi, Marta C. Antonelli,

Daniela Tizabi

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Jan. 27, 2025

Language: Английский

Citations

0