Journal of Internal Medicine,
Год журнала:
2022,
Номер
292(6), С. 858 - 869
Опубликована: Июль 12, 2022
Abstract
Antibiotics
are
recognised
as,
on
occasion,
producing
psychiatric
side
effects,
most
notably
depression
and
anxiety.
Apart
from
antimicrobial
activity,
antibiotics
have
multiple
off‐target
effects.
The
brain–gut–microbiota
axis
has
sites
for
which
may
produce
either
positive
or
negative
antibiotic
Here
we
review
how
impact
mental
health
by
acting
through
the
axis.
Microbes
in
gut
influence
brain
function
vagus
nerve
altering
production
of
short‐chain
fatty
acids
amino
acid
tryptophan,
building
block
serotonin.
Not
all
actions
a
impact.
first
antidepressant
discovered
was
actually
an
antibiotic:
isoniazid
is
antibacterial
drug
developed
treating
tuberculosis.
Minocycline,
enters
mediates
its
effects
microglia,
shows
activity.
Some
bring
about
significant
decrease
microbial
diversity,
this
viewed
as
risk
factor
depression.
Other
factors
induced
include
altered
barrier
function,
activation
hypothalamic–pituitary–adrenal
axis,
reducing
levels
brain‐derived
neurotrophic
oxytocin
alteration
vagal
tone.
Although
patients
taking
do
not
suffer
iatrogenic
disorder,
some
do.
As
clinicians,
need
to
keep
mind.
development
new
primarily
focused
resistance,
but
efforts
should
be
made
reduce
resulting
problems.
Molecules,
Год журнала:
2021,
Номер
26(19), С. 6076 - 6076
Опубликована: Окт. 8, 2021
Probiotics
are
beneficial
active
microorganisms
that
colonize
the
human
intestines
and
change
composition
of
flora
in
particular
parts
host.
Recently,
use
probiotics
to
regulate
intestinal
improve
host
immunity
has
received
widespread
attention.
Recent
evidence
shown
play
significant
roles
gut
microbiota
composition,
which
can
inhibit
colonization
pathogenic
bacteria
intestine,
help
build
a
healthy
mucosa
protective
layer,
enhance
immune
system.
Based
on
close
relationship
between
immunity,
it
become
an
extremely
effective
way
by
regulating
microbiome
with
probiotics.
In
this
review,
we
discussed
influence
probiotics,
microbiota,
life
quality.
We
further
emphasized
regulation
microflora
through
thereby
enhancing
improving
people’s
lives.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Окт. 5, 2022
Prebiotics
and
probiotics
play
a
positive
role
in
promoting
human
nutrition
health.
are
compounds
that
cannot
be
digested
by
the
host,
but
can
used
fermented
probiotics,
so
as
to
promote
reproduction
metabolism
of
intestinal
for
health
body.
It
has
been
confirmed
have
clinical
or
care
functions
preventing
controlling
intestinal,
respiratory,
urogenital
infections,
allergic
reaction,
inflammatory
bowel
disease,
irritable
syndrome
other
aspects.
However,
there
few
systematic
summaries
these
types,
mechanisms
action
promotion
relationship
between
prebiotics
probiotic.
Therefore,
we
summarized
various
types
their
individual
mechanisms,
mechanism
tract.
is
hoped
this
review
provide
new
ideas
application
future.
The
gut
microbiota
and
its
homeostasis
play
a
crucial
role
in
human
health.
However,
for
some
diseases
related
to
the
microbiota,
current
traditional
medicines
can
only
relieve
symptoms,
it
is
difficult
solve
root
causes
or
even
cause
side
effects
like
disturbances
microbiota.
Increasing
clinical
studies
evidences
have
demonstrated
that
probiotics,
prebiotics,
postbiotics
prevent
treat
various
diseases,
but
currently
they
be
used
as
dietary
supplements
rather
than
medicines,
which
restricts
application
of
probiotics
field
medicine.
Here,
this
review
analyzes
importance
health
problems
systematically
summarizes
effectiveness
mechanisms
maintaining
treating
based
on
animal
models
trials.
And
research
outcomes
development
trends
field,
challenges
prospects
their
health,
alleviating
are
analyzed.
It
hoped
promote
disease
treatment
open
up
new
frontiers
probiotic
research.
Journal of Gastrointestinal Surgery,
Год журнала:
2021,
Номер
26(3), С. 671 - 683
Опубликована: Ноя. 3, 2021
Hepatosteatosis
is
the
earliest
stage
in
pathogenesis
of
nonalcoholic
fatty
(NAFLD)
and
alcoholic
liver
disease
(ALD).
As
NAFLD
affecting
10–24%
general
population
approximately
70%
obese
patients,
it
carries
a
large
economic
burden
becoming
major
reason
for
transplantation
worldwide.
ALD
cause
morbidity
mortality
causing
50%
cirrhosis
10%
cancer
related
death.
Increasing
evidence
has
accumulated
that
gut-derived
factors
play
crucial
role
development
progression
chronic
diseases.
A
selective
literature
search
was
conducted
Medline
PubMed,
using
terms
"nonalcoholic
disease,"
"alcoholic
"lipopolysaccharide,"
"gut
barrier,"
"microbiome."
Gut
dysbiosis
gut
barrier
dysfunction
both
contribute
to
by
abnormal
regulation
gut-liver
axis.
Thereby,
lipopolysaccharides
(LPS)
are
key
factor
inducing
inflammatory
response
tissue.
The
review
further
underlines
endotoxemia
observed
patients.
LPS
plays
an
important
conducting
damage
through
LPS-TLR4
signaling
pathway.
Treatments
targeting
microbiome
such
as
fecal
microbiota
(FMT),
probiotics,
prebiotics,
synbiotics,
intestinal
alkaline
phosphatase
(IAP)
represent
potential
treatment
modalities
ALD.
axis
disease.
have
shown
beneficial
effects
attenuating
inflammation
need
be
investigated.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Март 23, 2023
Test
anxiety
is
a
common
issue
among
college
students,
which
can
affect
their
physical
and
psychological
health.
However,
effective
interventions
or
therapeutic
strategies
are
still
lacking.
This
study
aims
to
evaluate
the
potential
effects
of
Microorganisms,
Год журнала:
2022,
Номер
10(7), С. 1368 - 1368
Опубликована: Июль 7, 2022
There
is
increasing
evidence
that
diet
influences
the
relationship
between
gut
microbiota
and
individual
health
outcomes.
Nutrient
intake
affects
composition
of
microbial
community
provides
metabolites
influence
host
physiology.
Dietary
patterns,
including
macronutrient
balance
feeding/fasting
cycles
which
may
be
manipulated
with
dietary
regimens
based
on
caloric
restriction
periods,
homeostasis
through
its
impact
ecosystem.
Along
same
line,
prebiotic
probiotic
ingredients
additives
in
foods,
as
well
degree
food
processing
have
consequences
related
immune
metabolic
response
human
host.
Acquiring
knowledge
these
aspects,
especially
an
-omics-integral
approach,
might
provide
basis
for
personalized
nutritional
interventions
directed
to
avoid
dysbiosis
contribute
prevention
major
chronic
degenerative
diseases.
Despite
vast
scientific
supporting
factors
function,
underlying
mechanisms
their
potential
are
far
from
clear.
a
lack
well-designed
longitudinal
studies
performed
target
population
groups
whose
patterns
can
particularly
relevant
future
health,
case
infants,
pregnant
women,
or
athletes.
