Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 9, 2024
The
excessive
use
of
fungicides
in
agriculture
causes
challenges
like
pathogen
resistance,
soil
and
water
contamination,
potential
health
risks.
Sustainable
options
Pseudomonas
spp.
yeast
are
being
explored
as
bioinoculants
to
promote
plant
growth
inhibit
fungal
proliferation.
87
isolates,
comprising
36
fluorescent
51
isolates
were
obtained
from
healthy
fruits
vegetables.
Yeast
(YFSL)
(PFSL)
significantly
(p
<
0.05)
inhibited
the
in-vitro
Fusarium
solani
Drechslera
sp.
Experiments
a
screen
house
for
90
days
used
randomized
block
design
study
effects
on
fruit
health.
Moreover,
plants
treated
with
these
showed
increased
levels
salicylic
acid
(66.14%),
total
phenolic
content
(59.67%),
chlorophyll
(24.31%),
carbohydrates
(40.38%),
phosphorus
(0.24%),
antioxidant
activity
(90%).
treatments
displayed
higher
defensive
enzymes,
chitinase
(0.09
mg/h/protein)
β-1-3-glucanase
(0.093
mg/h/protein).
concentrations
enzymes
SOD
(0.07
U/L),
POD
(0.23
APX
(0.24
U/L)
also
observed
bio-inoculated
plants.
However.,
difference
results
was
non-significant
(P
≤
0.05).
This
demonstrates
Efficacy
improving
growth,
compositional
characteristics,
activities
while
reducing
losses
tomato
fruits.
Cancers,
Год журнала:
2023,
Номер
15(18), С. 4548 - 4548
Опубликована: Сен. 14, 2023
Post-oropharyngeal
cancer
treatment
complications
include
a
multitude
of
oral
side
effects
that
impact
overall
survival
and
quality
life.
These
acute
chronic
conditions
affecting
the
cavity
head
neck,
such
as
mucositis,
infection,
xerostomia,
dysgeusia,
radiation
caries,
osteonecrosis,
trismus.
This
review
will
summarize
most
common
from
oropharyngeal
therapy.
The
authors
would
like
to
point
out
literature
cited
frequently
combines
neck
results.
If
recommendations
are
made
strictly
related
cancers,
this
be
highlighted.
Experimental & Molecular Medicine,
Год журнала:
2023,
Номер
55(12), С. 2498 - 2507
Опубликована: Дек. 1, 2023
Our
understanding
of
host-microbe
interactions
has
broadened
through
numerous
studies
over
the
past
decades.
However,
most
investigations
primarily
focus
on
dominant
members
within
ecosystems
while
neglecting
low-abundance
microorganisms.
Moreover,
laboratory
animals
usually
do
not
have
microorganisms
beyond
bacteria.
The
phenotypes
observed
in
animals,
including
immune
system,
displayed
notable
discrepancies
when
compared
to
real-world
observations
due
diverse
microbial
community
natural
environments.
Interestingly,
recent
unveiled
beneficial
roles
played
by
Despite
their
rarity,
these
keystone
taxa
play
a
pivotal
role
shaping
composition
and
fulfilling
specific
functions
host.
Consequently,
become
imperative
unravel
true
commensalism.
In
this
review,
we
provide
comprehensive
overview
important
findings
how
commensal
microorganisms,
bacteria,
fungi,
archaea,
protozoa,
interact
with
host
contribute
phenotypes,
emphasis
system.
Indeed,
vital
development
host's
influence
disease
status,
key
communities
niches.
Understanding
microbes
is
will
lead
better
relationships.
Fungal Diversity,
Год журнала:
2024,
Номер
128(1), С. 1 - 165
Опубликована: Окт. 15, 2024
Abstract
Fungi
are
one
of
the
most
diverse
groups
organisms
with
an
estimated
number
species
in
range
2–3
million.
The
higher-level
ranking
fungi
has
been
discussed
framework
molecular
phylogenetics
since
Hibbett
et
al.,
and
definition
higher
ranks
(e.g.,
phyla)
‘true
fungi’
have
revised
several
subsequent
publications.
Rapid
accumulation
novel
genomic
data
advancements
now
facilitate
a
robust
precise
foundation
for
classification
within
kingdom.
This
study
provides
updated
kingdom
,
drawing
upon
comprehensive
phylogenomic
analysis
Holomycota
which
we
outline
well-supported
nodes
fungal
tree
explore
more
contentious
groupings.
We
accept
19
phyla
Fungi,
viz
.
Aphelidiomycota
Ascomycota
Basidiobolomycota
Basidiomycota
Blastocladiomycota
Calcarisporiellomycota
Chytridiomycota
Entomophthoromycota
Entorrhizomycota
Glomeromycota
Kickxellomycota
Monoblepharomycota
Mortierellomycota
Mucoromycota
Neocallimastigomycota
Olpidiomycota
Rozellomycota
Sanchytriomycota,
Zoopagomycota
In
phylogenies,
Caulochytriomycota
resides
;
thus,
former
is
regarded
as
synonym
latter,
while
Caulochytriomycetes
viewed
class
provide
description
each
phylum
followed
by
its
classes.
A
new
subphylum,
Sanchytriomycotina
Karpov
introduced
only
subphylum
Sanchytriomycota
subclass
Pneumocystomycetidae
Kirk
al.
Pneumocystomycetes
invalid
thus
validated.
Placements
fossil
classes
also
discussed,
providing
examples.
Infectious Diseases and Therapy,
Год журнала:
2023,
Номер
12(12), С. 2631 - 2648
Опубликована: Ноя. 8, 2023
Candida
albicans,
a
ubiquitous
opportunistic
fungal
pathogen,
plays
pivotal
role
in
human
health
and
disease.
As
commensal
organism,
it
normally
resides
harmlessly
within
the
microbiota.
However,
under
certain
conditions,
C.
albicans
can
transition
into
pathogenic
state,
leading
to
various
infections
collectively
known
as
candidiasis.
With
increasing
prevalence
of
immunocompromised
individuals
widespread
use
invasive
medical
procedures,
candidiasis
has
become
significant
public
concern.
The
emergence
drug-resistant
strains
further
complicates
treatment
options,
highlighting
urgent
need
for
alternative
therapeutic
strategies.
Antifungal
peptides
(AFPs)
have
gained
considerable
attention
potential
candidates
combating
spp.
infections.
These
naturally
occurring
possess
broad-spectrum
antimicrobial
activity,
including
specific
efficacy
against
albicans.
AFPs
exhibit
several
advantageous
properties,
such
rapid
killing
kinetics,
low
propensity
resistance
development,
diverse
mechanisms
action,
making
them
promising
alternatives
conventional
antifungal
agents.
In
recent
years,
extensive
research
focused
on
discovering
developing
novel
with
improved
selectivity
species.
Advances
biotechnology
synthetic
peptide
design
enabled
modification
optimization
natural
peptides,
enhancing
their
stability,
bioavailability,
potential.
Nevertheless,
challenges
must
be
addressed
before
widely
implemented
clinical
practice.
include
optimizing
delivery
methods,
overcoming
toxicity
concerns,
conducting
comprehensive
preclinical
studies.
This
commentary
presents
short
overview
candidemia
AFP;
articles
reviews
published
last
10
years
were
searched
National
Library
Medicine
(National
Center
Biotechnology
Information–NIH–PubMed).
terms
used
infections,
treatments
guidelines,
challenges,
trials
main
ones.
Older
publications
cited
if
they
brought
some
relevant
concept
or
helped
bring
perspective
our
narrative.
Articles
older
than
20
those
that
appeared
PubMed
but
did
not
match
goal
updated
information
about
using
an
considered.
American Journal of Reproductive Immunology,
Год журнала:
2025,
Номер
93(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Problem
Recurrent
vulvovaginal
candidiasis
(RVVC)
affects
5%−10%
of
all
women,
negatively
impacting
their
reproductive
health
and
quality
life.
Herein,
we
investigated
the
molecular
effects
RVVC
on
vaginal
mucosa
otherwise
healthy
women.
Method
Study
Gene
expression
analysis
was
performed
tissue
biopsies
from
women
with
RVVC,
including
those
a
current
episode
(VVC,
n
=
19)
between
infections
(culture
negative
[CNR],
8);
asymptomatically
colonized
Candida
albicans
(asymptomatic
[AS],
7);
controls
(
18).
profiles
were
compared
groups
correlated
clinical
data
retrieved
questionnaires
gynecologic
examinations.
Results
Of
20
171
genes
identified
in
biopsies,
6506
differentially
expressed
group,
to
controls.
pathway
revealed
an
association
pathways
inflammatory
responses,
especially
involved
neutrophil
recruitment
activation.
Expression
inflammation
increased
increasing
severity
VVC,
whereas
some
epithelial
integrity
decreased
infection.
both
CNR
AS
comparable
Conclusions
The
during
active
infection
correlates
activation
mucosa.
lack
differences
who
acute
indicates
that
observed
group
are
only
present
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 24, 2025
The
human
fungal
pathobiont
Candida
albicans
displays
extensive
genomic
plasticity,
including
large-scale
chromosomal
changes
such
as
aneuploidy.
Chromosome
trisomy
appears
frequently
in
natural
and
laboratory
strains
of
C.
.
Trisomy
specific
chromosomes
has
been
linked
to
large
phenotypic
effects,
increased
murine
gut
colonization
by
trisomic
for
chromosome
7
(Chr7).
However,
studies
whole-chromosome
aneuploidy
are
generally
limited
the
SC5314
genome
reference
strain,
making
it
unclear
whether
imparted
phenotypes
conserved
across
genetic
backgrounds.
Here,
we
report
presence
a
Chr7
"commensal-like"
oral
candidiasis
529L,
dissect
contribution
virulence
529L
SC5314.
These
experiments
show
that
strain
background
homolog
identity
(i.e.,
AAB
vs
ABB)
interact
with
alter
commensal
multiple
host
niches.
In
vitro
filamentation
was
only
phenotype
altered
similar
ways
two
Oral
mice
but
not
SC5314;
conversely,
during
systemic
infection
reduced
529L.
Strikingly,
rendered
this
avirulent
infection.
Increased
dosage
NRG1
failed
reproduce
most
phenotypes.
Our
results
demonstrate
interacts
variation
produce
complex
patterns
deviate
from
our
current
understanding
strain.
is
clinically
important
fungus
humans
also
part
microbiota
typically
colonizes
bodies.
Changes
number
copies
(Chr7)
enhances
colonization.
We
identified
third
copy
classified
good
colonizer
doesn't
cause
disease,
mimicking
alters
differently
between
these
strains,
three
does
universally
better
Additionally,
which
diploid
species
exists
influences
pathogen
Therefore,
same
different
have
substantially
effects.
The
occurrence
and
distribution
of
new
re-emerging
fungal
pathogens,
along
with
rates
antifungal
resistance,
are
rising
across
the
globe,
correspondingly,
so
our
awareness
call
for
action
to
address
this
public
health
concern.
To
effectively
detect,
monitor,
treat
infections,
biological
insights
into
mechanisms
that
regulate
pathogenesis,
influence
survival,
promote
resistance
urgently
needed.
Mass
spectrometry-based
proteomics
is
a
high-resolution
technique
enables
identification
quantification
proteins
diverse
systems
better
understand
biology
driving
phenotypes.
In
review,
we
highlight
dynamic
innovative
applications
characterize
three
critical
pathogens
(i.e.,
Candida
spp.,
Cryptococcus
Aspergillus
spp.)
causing
disease
in
humans.
We
present
strategies
investigate
host-pathogen
interface,
virulence
factor
production,
protein-level
drivers
resistance.
Through
these
studies,
opportunities
biomarker
development,
drug
target
discovery,
immune
system
remodeling
discussed,
supporting
use
combat
plethora
diseases
threatening
global
health.