Advanced Materials,
Год журнала:
2022,
Номер
34(23)
Опубликована: Фев. 23, 2022
Abstract
Bio‐hybrid
technologies
aim
to
replicate
the
unique
capabilities
of
biological
systems
that
could
surpass
advanced
artificial
technologies.
Soft
bio‐hybrid
robots
consist
synthetic
and
living
materials
have
potential
self‐assemble,
regenerate,
work
autonomously,
interact
safely
with
other
species
environment.
Cells
require
a
sufficient
exchange
nutrients
gases,
which
is
guaranteed
by
convection
diffusive
transport
through
liquid
media.
The
functional
development
long‐term
survival
tissues
in
vitro
can
be
improved
dynamic
flow
culture,
but
only
microfluidic
control
develop
tissue
fine
structuring
regulation
at
microscale.
Full
growth
microscale
will
eventually
lead
macroscale
constructs,
are
needed
as
component
soft
This
review
summarizes
recent
progress
techniques
engineer
tissues,
focusing
on
use
muscle
cells
for
robotic
bio‐actuation.
Moreover,
instances
bio‐actuation
greatly
benefit
from
fusion
microfluidics
highlighted,
include:
microfabrication
matrices,
biomimicry
cell
microenvironments,
maturation,
perfusion,
vascularization.
Tissue
damage
and
organ
failure
are
major
problems
that
many
people
face
worldwide.
Most
of
them
benefit
from
treatment
related
to
modern
technology’s
tissue
regeneration
process.
engineering
is
one
the
booming
fields
widely
used
replace
damaged
tissue.
Scaffold
a
base
material
in
which
cells
growth
factors
embedded
construct
substitute
Various
materials
have
been
develop
scaffolds.
Bio-based
natural
biocompatible,
safe,
do
not
release
toxic
compounds
during
biodegradation.
Therefore,
it
highly
recommendable
fabricate
scaffolds
using
such
materials.
To
date,
there
no
singular
fulfill
all
features
scaffold.
Hence,
combining
two
or
more
encouraged
obtain
desired
characteristics.
design
reliable
scaffold
by
different
materials,
need
choose
good
fabrication
technique.
In
this
review
article,
bio-based
fine
techniques
currently
developing
for
applications,
along
with
number
articles
published
on
each
material,
briefly
discussed.
It
envisaged
gain
explicit
knowledge
applications.
Marine Drugs,
Год журнала:
2023,
Номер
21(3), С. 189 - 189
Опубликована: Март 18, 2023
Today,
with
the
salient
advancements
of
modern
and
smart
technologies
related
to
tissue
engineering
regenerative
medicine
(TE-RM),
use
sustainable
biodegradable
materials
biocompatibility
cost-effective
advantages
have
been
investigated
more
than
before.
Alginate
as
a
naturally
occurring
anionic
polymer
can
be
obtained
from
brown
seaweed
develop
wide
variety
composites
for
TE,
drug
delivery,
wound
healing,
cancer
therapy.
This
renewable
biomaterial
displays
several
fascinating
properties
such
high
biocompatibility,
low
toxicity,
cost-effectiveness,
mild
gelation
by
inserting
divalent
cations
(e.g.,
Ca2+).
In
this
context,
challenges
still
exist
in
relation
solubility
viscosity
high-molecular
weight
alginate,
density
intra-
inter-molecular
hydrogen
bonding,
polyelectrolyte
nature
aqueous
solution,
lack
suitable
organic
solvents.
Herein,
TE-RM
applications
alginate-based
are
deliberated,
focusing
on
current
trends,
important
challenges,
future
prospects.
Bioactive Materials,
Год журнала:
2023,
Номер
28, С. 511 - 536
Опубликована: Июнь 27, 2023
Bioinks
are
formulations
of
biomaterials
and
living
cells,
sometimes
with
growth
factors
or
other
biomolecules,
while
extrusion
bioprinting
is
an
emerging
technique
to
apply
deposit
these
bioinks
biomaterial
solutions
create
three-dimensional
(3D)
constructs
architectures
mechanical/biological
properties
that
mimic
those
native
human
tissue
organs.
Printed
have
found
wide
applications
in
engineering
for
repairing
treating
tissue/organ
injuries,
as
well
vitro
modelling
testing
validating
newly
developed
therapeutics
vaccines
prior
their
use
humans.
Successful
printing
subsequent
rely
on
the
formulated
bioinks,
including
rheological,
mechanical,
biological
properties,
process.
This
article
critically
reviews
latest
developments
bioprinting,
focusing
bioink
synthesis
characterization,
influence
Key
issues
challenges
also
discussed
along
recommendations
future
research.
Materials Advances,
Год журнала:
2022,
Номер
3(4), С. 1849 - 1873
Опубликована: Янв. 1, 2022
Preparation,
characterization
and
applications,
particularly
for
signal-stimulated
molecule
release,
of
Fe
3+
-cross-linked
alginate
hydrogels
are
critically
overviewed.
Journal of Biomedical Materials Research Part B Applied Biomaterials,
Год журнала:
2022,
Номер
111(1), С. 220 - 233
Опубликована: Авг. 12, 2022
The
skin
is
the
largest
organ
in
human
body
and
its
physical
integrity
must
be
maintained
for
homeostasis
to
prevent
entry
of
pathogenic
microorganisms.
Sodium
alginate
(SA)
polyvinyl
alcohol
(PVA)
are
two
polymers
widely
used
films
wound
dressing
applications.
Furthermore,
blends
between
SA
PVA
improve
physical,
mechanical
biological
properties
final
healing
material
when
compared
individual
polymers.
Different
drugs
have
been
incorporated
into
SA/PVA-based
activity.
It
noteworthy
that
SA/PVA
can
crosslinked
with
Ca2+
or
other
agents,
which
improves
physicochemical
properties.
Thus,
associations
promising
biomedical
field,
as
a
potential
alternative
treatment.
This
review
focuses
on
main
techniques
obtaining
films,
their
physical-chemical
characterization,
drug
incorporation,
advantages
challenges
these
healing.
Pharmaceutics,
Год журнала:
2022,
Номер
14(2), С. 464 - 464
Опубликована: Фев. 21, 2022
Skin
tissue
engineering
and
regeneration
aim
at
repairing
defective
skin
injuries
progress
in
wound
healing.
Until
now,
even
though
several
developments
are
made
this
field,
it
is
still
challenging
to
face
the
complexity
of
with
current
methods
fabrication.
In
review,
short,
state-of-the-art
on
using
3D
bioprinting
as
a
new
tool
described.
The
summary
bioink
formulations,
parameters,
properties
discussed.
Finally,
representative
number
examples
advances
field
together
limitations
future
needs
provided.
Materials,
Год журнала:
2024,
Номер
17(2), С. 456 - 456
Опубликована: Янв. 18, 2024
Biomaterials
embody
a
groundbreaking
paradigm
shift
in
the
field
of
drug
delivery
and
human
applications.
Their
versatility
adaptability
have
not
only
enriched
therapeutic
outcomes
but
also
significantly
reduced
burden
adverse
effects.
This
work
serves
as
comprehensive
overview
biomaterials,
with
particular
emphasis
on
their
pivotal
role
delivery,
classifying
them
terms
biobased,
biodegradable,
biocompatible
nature,
highlighting
characteristics
advantages.
The
examination
delves
into
extensive
array
applications
for
biomaterials
encompassing
diverse
medical
fields
such
cancer
therapy,
cardiovascular
diseases,
neurological
disorders,
vaccination.
explores
actual
challenges
within
this
domain,
including
potential
toxicity
complexity
manufacturing
processes.
These
emphasize
necessity
thorough
research
continuous
development
regulatory
frameworks.
second
aim
review
is
to
navigate
through
compelling
terrain
recent
advances
prospects
envisioning
healthcare
landscape
where
they
empower
precise,
targeted,
personalized
delivery.
transform
staggering,
promise
treatments
tailored
individual
patient
needs,
offering
hope
improved
efficacy,
fewer
side
effects,
brighter
future
practice.
