Chemico-Biological Interactions, Год журнала: 2021, Номер 351, С. 109768 - 109768
Опубликована: Дек. 3, 2021
Язык: Английский
Journal of Chemistry, Год журнала: 2024, Номер 2024, С. 1 - 21
Опубликована: Май 31, 2024
Absorption of free radicals in the body cannot be done by antioxidant compounds originating from human body, so exogenous antioxidants are required to help their natural action. Oxidative stress can caused an imbalance radical inhibitors and accumulation that enter cellular structures. Synthetic found external not primary choice because they harmful carcinogenic. Therefore, using ingredients provides a necessary alternative constructing novel antioxidants. Recent studies have highlighted critical analysis evaluation flavonoids unique class secondary metabolites plants used communities as traditional therapeutics with proven bioactivity. This could support new discoveries based on various herbal medicines addition, functional effectiveness against radicals. In this review, there several strengths discussion. First, study takes comprehensive approach covering aspects, including properties sources radicals, oxidative relation different diseases, defense mechanisms, specific mechanisms flavonoids. Second, focus antioxidants, especially flavonoids, also discussion about clinical applications studies, limitations, global perspectives, future research directions become references selection medicines. But, constraints should considered when interpreting findings review. mechanism is only discussed general one example compound (flavonoid) has potential antioxidant. lack regarding relationship between diseases Third, limited number investigated some discussed.
Язык: Английский
Процитировано
29
Nutrients, Год журнала: 2025, Номер 17(2), С. 275 - 275
Опубликована: Янв. 13, 2025
Type 2 diabetes mellitus (T2DM), a serious metabolic disorder, is worldwide health problem due to the alarming rise in prevalence and elevated morbidity mortality. Chronic hyperglycemia, insulin resistance, ineffective effect secretion are hallmarks of T2DM, leading many secondary complications. These include, particular, cardiovascular disorders, diabetic neuropathy, nephropathy retinopathy, foot, osteoporosis, liver damage, susceptibility infections some cancers. Polyphenols such as flavonoids, phenolic acids, stilbenes, tannins, lignans constitute an extensive heterogeneous group phytochemicals fresh fruits, vegetables their products. Various vitro studies, animal model studies available clinical trials revealed that flavonoids (e.g., quercetin, kaempferol, rutin, epicatechin, genistein, daidzein, anthocyanins), acids chlorogenic, caffeic, ellagic, gallic curcumin), stilbenes resveratrol), tannins procyanidin B2, seaweed phlorotannins), pinoresinol) have ability lower enhance sensitivity improve secretion, scavenge reactive oxygen species, reduce chronic inflammation, modulate gut microbiota, alleviate complications T2DM. The interaction between polyphenols conventional antidiabetic drugs offers promising strategy management treatment especially advanced disease stages. Synergistic effects with been documented, but also antagonistic interactions may impair drug efficacy. Therefore, additional research required clarify mutual order use knowledge applications. Nevertheless, dietary can be successfully applied part supportive for they both obvious symptoms
Язык: Английский
Процитировано
2
Antioxidants, Год журнала: 2025, Номер 14(2), С. 200 - 200
Опубликована: Фев. 10, 2025
Polyphenols (PPs) are recognized as bioactive compounds and antimicrobial agents, playing a critical role in enhancing food safety, preservation, extending shelf life. The effectiveness of PPs has different molecular biological reasons, predominantly linked to their hydroxyl groups electron delocalization, which interact with microbial cell membranes, proteins, organelles. These interactions may reduce the efficiency metabolic pathways, cause destructive damage membrane, or they harm proteins nucleic acids foodborne bacteria. Moreover, exhibit distinctive ability form complexes metal ions, further amplifying activity. This narrative review explores complex multifaceted between pathogens, underlying correlation chemical structures mechanisms action. Such insights shed light on potential innovative natural preservatives within systems, presenting an eco-friendly sustainable alternative synthetic additives.
Язык: Английский
Процитировано
2
Journal of Agricultural and Food Chemistry, Год журнала: 2021, Номер 69(26), С. 7285 - 7302
Опубликована: Июнь 23, 2021
Flavones are an important class of bioactive constituents in foods, and their structural diversity enables them to interact with different targets. In particular, flavones known for anti-inflammatory activity. Herein, we summarized commonly applied vitro, vivo, clinical models testing activity flavones. The structure–activity relationship was systematically mapped supported cross comparisons that flavanones, flavanols, isoflavones. Hydroxyl groups (−OH) indispensable the function flavones, −OH at C-5 C-4′ positions enhance while C-6, C-7, C-8, C-3′ attenuate Moreover, C2–C3 single bond, C-3 B-ring undermine flavone aglycones' Most aglycones through NF-κB, MAPK, JNK-STAT pathways, possible cell binding targets kinase, aryl hydrocarbon receptor (AhR), G-protein coupled receptors, estrogen receptors. However, structure were unclear, further research shall be conducted close gap order guide development evidence-based functional foods.
Язык: Английский
Процитировано
100
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 157, С. 114032 - 114032
Опубликована: Дек. 6, 2022
Pinocembrin (5,7-dihydroxyflavone) is a major flavonoid found in many plants, fungi and hive products, mainly honey propolis. Several vitro preclinical studies revealed numerous pharmacological activities of pinocembrin including antioxidant, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective anticancer activities. Here, we comprehensively review critically analyze the carried out on pinocembrin. We also discuss its potential mechanisms action, bioavailability, toxicity, clinical investigations. The wide therapeutic window makes it promising drug candidate for applications. recommend some future perspectives to improve pharmacokinetic pharmacodynamic properties better delivery that may lead new advances.
Язык: Английский
Процитировано
55
Journal of Advanced Research, Год журнала: 2023, Номер 55, С. 103 - 118
Опубликована: Март 4, 2023
Cancer management faces multiple obstacles, including resistance to current therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt metabolically maintain their supply energy and precursor molecules for biosynthesis thus sustain rapid proliferation tumor growth. Among various metabolic adaptations observed in cells, altered glucose metabolism is most widely studied. The aberrant glycolytic modification has been associated with cell division, growth, progression, drug resistance. higher rates glycolysis as a hallmark modulated by transcription factor hypoxia inducible 1 alpha (HIF-1α), downstream target PI3K/Akt signaling, deregulated pathway cancer. We provide detailed overview current, primarily experimental, evidence on potential effectiveness flavonoids combat glycolysis-induced conventional targeted therapies. manuscript focuses reducing via affecting PI3K/Akt, HIF-1α (as critical that regulated pathway), key mediators PI3K/Akt/HIF-1α signaling (glucose transporters enzymes). working hypothesis proposes – an attractive application mitigate Phytochemicals represent source promising substances applicable primary, secondary, tertiary care. However, accurate patient stratification individualized profiling crucial steps paradigm shift from reactive predictive, preventive, personalized medicine (PPPM / 3PM). article focused targeting molecular patterns natural provides evidence-based recommendations 3PM relevant implementation.
Язык: Английский
Процитировано
29
Nature Catalysis, Год журнала: 2024, Номер 7(4), С. 361 - 374
Опубликована: Янв. 29, 2024
Язык: Английский
Процитировано
12
Journal of Separation Science, Год журнала: 2024, Номер 47(9-10)
Опубликована: Май 1, 2024
Deep eutectic solvents (DESs), as a new type of eco‐friendly solvent, have attracted increasing attention on the extraction and separation flavonoid compounds from various samples, owing to their excellent properties such biodegradability ease handling with very low toxicity. This article provides status review applications DESs in flavonoids, including introduction compounds, superiority DESs, methods (ultrasonic‐assisted extraction, heating reflux matrix solid‐phase dispersion, extraction). Finally, prospects challenges application are extensively elucidated critically reviewed.
Язык: Английский
Процитировано
11
Frontiers in Plant Science, Год журнала: 2024, Номер 14
Опубликована: Янв. 16, 2024
Light is one of the important environmental factors affecting growth and development facility vegetables. In this experiment, we investigated effects different light intensities on growth, nutritional quality flavonoid accumulation celery under hydroponic full LED conditions. Four 40, 100, 200, or 300 µmol·m -2 ·s -1 were set up in three harvest periods basis intensities, which 15, 30, 45 d after treatment (labeled as S1, S2, S3, respectively). The results showed that plant height aboveground biomass increased with increase intensity, intensity 200 μmol·m was beneficial to contents chlorophyll, carotenoids, total phenols, vitamin C, cellulose, flavones apigenin celery. During S1-S3 period, activities PAL, CHS, CHI ANS gradually treatments, FNS CHS enzymes highest treatment. expression activity Ag3GT , a key gene for anthocyanin synthesis, reached maximum value at level AgFNS . general, content conclusion, more favorable nutrient synthesis.
Язык: Английский
Процитировано
10
Results in Chemistry, Год журнала: 2025, Номер 13, С. 102028 - 102028
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1