Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Авг. 28, 2023

Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD multifactorial and results from complex interplay between mucosal immunity, environmental factors, host genetics. Future therapeutics for GI disorders, including IBD, that are driven oxidative stress require greater understanding the cellular molecular mechanisms mediated reactive oxygen species (ROS). In tract, stressors include infections pro-inflammatory responses, which boost ROS generation promoting production cytokines. Nuclear factor kappa B (NF-κB) nuclear erythroid 2–related 2 (Nrf2) represent two important signaling pathways in immune cells regulate numerous physiological processes, anti-inflammatory antioxidant activities. Natural compounds exhibit scavenging increase defense capacity to inhibit pro-oxidative enzymes, may be useful treatment. this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phenethyl ester, luteolin, xanthohumol, genistein, alpinetin, proanthocyanidins, anthocyanins, silymarin), phenolic thymol, alkaloids such berberine, storage polysaccharides tamarind xyloglucan, other phytochemicals represented isothiocyanate sulforaphane food/spices ginger, flaxseed oil), well hormones like melatonin target reduce inflammation occurring with IBD.

Язык: Английский

---

Role of Natural and Synthetic Compounds in Modulating NRF2/KEAP1 Signaling Pathway in Prostate Cancer

Cancers, Год журнала: 2023, Номер 15(11), С. 3037 - 3037

Опубликована: Июнь 2, 2023

Prostate cancer is the second most common in men worldwide. can be treated by surgery or active surveillance when early diagnosed but, at an advanced metastatic stage, radiation therapy androgen-deprivation needed to reduce progression. However, both of these therapies cause prostate resistance treatment. Several studies demonstrated that oxidative stress involved occurrence, development, progression and treatment resistance. The nuclear factor erythroid 2-related 2 (NRF2)/KEAP1 (Kelch-Like ECH-Associated Protein 1) pathway plays important role protecting cells against damage. Reactive oxygen species (ROS) levels NRF2 activation determine cell fate. In particular, toxic ROS lead physiological death tumor suppression, while lower are associated with carcinogenesis On contrary, a high level promotes survival related activating adaptive antioxidant response. this review, we analyzed current literature regarding natural synthetic compounds modulating NRF2/KEAP1 signaling cancer.

Язык: Английский

---

Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Март 6, 2024

Sepsis is a potentially fatal condition characterized by organ dysfunction caused an imbalanced immune response to infection. Although increased inflammatory significantly contributes the pathogenesis of sepsis, several molecular mechanisms underlying progression sepsis are associated with cellular reactive oxygen species (ROS) generation and exhausted antioxidant pathways. This review article provides comprehensive overview involvement ROS in pathophysiology potential application antioxidants antimicrobial properties as adjunct primary therapies (fluid antibiotic therapies) against sepsis. delves into advantages disadvantages utilization therapeutic approach which has been explored variety animal models clinical trials. While suggested therapy suppress cases where intensified reaction occurs, use multiple agents can be beneficial they act additively or synergistically on different pathways, thereby enhancing defense. Furthermore, immunoadjuvant therapy, specifically septic patients displaying immunosuppressive tendencies, represents promising advancement therapy.

Язык: Английский

---

Oxidative stress in critically ill neonatal foals

Journal of Veterinary Internal Medicine, Год журнала: 2025, Номер 39(1)

Опубликована: Янв. 1, 2025

Abstract Background Oxidative injury occurs in septic people, but the role of oxidative stress and antioxidants has rarely been evaluated foals. Objectives/Hypothesis To measure reactive oxygen species (ROS), biomarkers injury, neonatal We hypothesized that ill foals would have higher blood concentrations ROS lower compared to healthy Animals Seventy‐two hospitalized 21 Methods Prospective cohort study. Reactive (hydrogen peroxide [H 2 O ]), (malondialdehyde [MDA], protein carbonyl), (superoxide dismutase [SOD], catalase [CAT], glutathione, glutathione reductase [GR] peroxidase [GPx]) were measured from at admission. Measured variables between using a 1‐way ANOVA by Tukey's multiple comparisons test. Results Ill (n = 51) had significantly mean H (healthy 2.6 ± 1.4 nmol/mL, 6.8 4.6 L nmol/mL; 95% CI), MDA 31.2 14.4 114.3 94.0 carbonyl 0.07 0.01 nmol/mg protein, 0.12 0.02 CI). Significant CAT 0.4 0.3 mU/mg 238.5 101.9 μg/mL, 110.7 37.8 CI; P < .0001), GR 1.6 1.8 0.5 GPx 0.003 0.007 0.002 CI) also noted. Conclusions Clinical Importance antioxidant occur bacteremic These should be considered during treatment

Язык: Английский

---

Postbiotic production: harnessing the power of microbial metabolites for health applications

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Дек. 19, 2023

Postbiotics, which are bioactive substances derived from the metabolic processes of beneficial microbes, have received considerable attention in field microbiome science recent years, presenting a promising path for exploration and innovation. This comprehensive analysis looks into multidimensional terrain postbiotic production, including an extensive examination diverse classes, revealing their sophisticated mechanisms action highlighting future applications that might significantly affect human health. The authors thoroughly investigate various support ranging conventional fermentation procedures to cutting-edge enzyme conversion synthetic biology approaches. review, as acknowledgment field’s developing nature, not only highlights current achievements but also navigates through problems inherent production. In order successfully include postbiotics therapeutic interventions production functional food ingredients, emphasis is given critical elements, improving yields, bolstering stability, assuring safety. knowledge presented herein sheds light on expanding potential revolutionize development novel therapeutics ingredients.

Язык: Английский

---

Evaluating the Effectiveness of a Novel Pongamia pinnata Derived Herbal Mouth‐Dissolving Film for Treating Oral Disorders and Evaluating Its Anticancer Properties

Cell Biochemistry and Function, Год журнала: 2025, Номер 43(2)

Опубликована: Янв. 28, 2025

ABSTRACT The present study aimed to optimize a mouth‐dissolving film (MDF) made from Pongamia pinnata stem bark extract increase patient compliance and accelerate oral disease therapy. Several extracts were prepared, karanjin was used as an herbal marker for the extracts. ethanolic showed maximum yield (12.10% ± 0.09%) cytotoxic activity against human cancer (KB 3‐1) embryonic kidney cell lines. MDF formulation focused on incorporating fixed amount of varying concentrations HPMC E5 polymer, along with evaluating performance plasticizers like PEG 400 propylene glycol (PG). An optimized determined based disintegration time, wetting folding endurance. consisted film‐forming PG superior plasticizer, ascorbic acid antioxidant, other ingredients contributing solubility, dispersion, sweetening, appearance. High‐performance thin‐layer chromatography‐mass spectrometry analysis confirmed higher levels in formulation, ensuring its successful incorporation stability. Taste masking evaluations indicate favorable taste profile high potential compliance. stability displayed no significant changes physical characteristics film, affirming quality. In conclusion, developed herbal‐based presents promising drug delivery system, offering enhanced compliance, masking, holds great effective treatment management diseases, providing convenience improved therapeutic outcomes.

Язык: Английский

---

Reactive oxygen species mediated apoptotic death of colon cancer cells: therapeutic potential of plant derived alkaloids

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Июль 25, 2023

Colorectal cancer (CRC) is one of the most deaths causing diseases worldwide. Several risk factors including hormones like insulin and growth (e.g., IGF-1) have been considered responsible for progression colon cancer. Though there a huge advancement in available screening as well treatment techniques CRC. There no significant decrease mortality patients. Moreover, current approaches CRC are associated with serious challenges drug resistance re-growth. Given severity disease, an urgent need novel therapeutic agents ideal characteristics. pieces evidence suggested that natural products, specifically medicinal plants, derived phytochemicals may serve potential sources discovery various On other hand, cells require high basal level reactive oxygen species (ROS) to maintain its own cellular functions. However, excess production intracellular ROS leads cell death via disturbing redox homeostasis. Therefore, plants phytocompounds can enhance induce apoptotic modulating molecular targets IGF-1 could be agents. Alkaloids form major class such phytoconstituents play key role prevention. several preclinical clinical studies also evidenced these compounds show potent anti-colon effects exhibit negligible toxicity towards normal cells. Hence, present evidence-based study aimed provide update on alkaloids reported ROS-mediated apoptosis targeting components factors, which metastasis, angiogenesis, proliferation, invasion. This provides individual account each alkaloid underwent trials either alone or combination drugs. In addition, classes different kinds cancers discussed.

Язык: Английский

---

The Role of Oxidative Stress in Infertility

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(8), С. 1264 - 1264

Опубликована: Авг. 15, 2023

(1) Background: Oxidative stress markers in the follicular fluid and serum of patient with IVF results (number fertilized oocytes, number embryos, cumulative pregnancy rate) are important establishing causes infertility. (2) Methods: 42 patients were enrolled study over duration 24 months divided into two groups: group female etiology for infertility as a tubal factor, diminished ovarian reserve, endometriosis, unexplained infertility, control consisting male excluding sperm donors no factor cause. On day puncture IVF, collected from patients. (3) Results: Malondialdehyde was higher group. The total antioxidant capacity is positively correlated rate. There statistically significant difference oxidative both groups. (4) Conclusions: environment to contain reactive oxygen species (ROS) leads rate

Язык: Английский

---

Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 30, 2023

Oxidative stress, resulting from dysregulation in the secretion of adrenal hormones, represents a major concern human health. The present review comprehensively examines various categories endocrine within glands, encompassing glucocorticoids, mineralocorticoids, and androgens. Additionally, comprehensive account hormone disorders, including insufficiency, Cushing’s syndrome, tumors, is presented, with particular emphasis on their intricate association oxidative stress. also delves into an examination nutritional antioxidants, namely vitamin C, E, carotenoids, selenium, zinc, polyphenols, coenzyme Q10, probiotics, elucidates role mitigating adverse effects stress arising imbalances levels. In conclusion, harnessing power antioxidants has potential to help caused by imbalance hormones. This could lead new research therapeutic interventions.

Язык: Английский

---

Editorial: Hormonal imbalance-associated oxidative stress and protective benefits of nutritional antioxidants

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Фев. 9, 2024

Editorial: Hormonal imbalance-associated oxidative stress and protective benefits of nutritional antioxidants

Язык: Английский

---