Applied Materials Today, Journal Year: 2022, Volume and Issue: 26, P. 101350 - 101350
Published: Jan. 2, 2022
Language: Английский
Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518
Published: May 14, 2022
Language: Английский
Citations
360
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)
Published: Feb. 25, 2023
Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.
Language: Английский
Citations
223
Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 4279 - 4293
Published: Feb. 6, 2023
How to optimize the enzyme-like catalytic activity of nanozymes improve their applicability has become a great challenge. Herein, we present an l-cysteine (l-Cys) coordination-driven self-assembly strategy activate polyvinylpyrrolidone (PVP)-modified Cu single-atom MoOx-Cu-Cys (denoted as MCCP SAzymes) aiming at tumor-specific therapy. The single atom content can be rationally modulated 10.10 wt %, which activates catalase (CAT)-like MoOx nanoparticles catalyze decomposition H2O2 in acidic microenvironments increase O2 production. Excitingly, maximized CAT-like efficiency is 138-fold higher than that typical MnO2 and exhibits 14.3-fold affinity natural catalase, demonstrated by steady-state kinetics. We verify well-defined l-Cys-Cu···O active sites match through l-Cys bridge-accelerated electron transfer from Cys-Cu disclosed density functional theory calculations. Simultaneously, high loading atoms also enable generation •OH via Fenton-like reaction. Moreover, under X-ray irradiation, converts 1O2 for cascading radiodynamic therapy, thereby facilitating multiple reactive oxygen species (ROS) radiosensitization achieve substantial antitumor.
Language: Английский
Citations
175
ACS Nano, Journal Year: 2021, Volume and Issue: 15(10), P. 15645 - 15655
Published: Oct. 8, 2021
Enzymes have catalytic turnovers. The field of nanozyme endeavors to engineer nanomaterials as enzyme mimics. However, a discrepancy in the definition "nanozyme concentration" has led an unrealistic calculation To date, most reported works considered either atomic concentration or nanoparticle (NP) concentration. These assumptions can lead significant under- overestimation activity nanozymes. In this article, we review some classic nanozymes including Fe3O4, CeO2, and gold nanoparticles (AuNPs) with focus on activities. We argue that only surface atoms should be active sites, then turnover numbers rates were recalculated based atoms. According calculations, peroxidase Fe3O4 NPs is validated. AuNPs are self-limited when performing glucose-oxidase like activity, but they also true catalysts. For CeO2 NPs, behavior observed for both oxidase- phosphatase-like activities due adsorption reaction products. Moreover, single-atom discussed. Finally, few suggestions future research proposed.
Language: Английский
Citations
145
Exploration, Journal Year: 2022, Volume and Issue: 2(1)
Published: Jan. 25, 2022
Abstract Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared enzymes, they have numerous advantages, including higher physiochemical stability, versatility, and suitability for mass production. In the past decade, synthesis of nanozymes their mechanisms advanced beyond simple replacement allowing fascinating applications in various fields such as biosensing disease treatment. particular, exploration powerful toolkits diagnostic viral testing antiviral therapy has attracted growing attention. It can address great challenges faced by current enzyme‐based technologies, high cost storage difficulties. Therefore, nanozyme provide a novel nanozyme‐based therapeutic regime broader availability generalizability that keys fighting pandemic COVID‐19. Herein, we timely review state‐of‐the‐art regarding activities, well focused discussion on recent research into use therapy. The remaining future perspectives will also be outlined. Ultimately, this inform readers knowledge inspire more innovative studies push forward frontier field.
Language: Английский
Citations
133
International Journal of Biological Macromolecules, Journal Year: 2021, Volume and Issue: 194, P. 676 - 687
Published: Nov. 20, 2021
Language: Английский
Citations
130
Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 473, P. 214784 - 214784
Published: Sept. 13, 2022
Language: Английский
Citations
98
Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121687 - 121687
Published: July 19, 2022
Language: Английский
Citations
80
Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)
Published: Nov. 21, 2023
Since the discovery of enzyme-like activity Fe
Language: Английский
Citations
74
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150612 - 150612
Published: March 21, 2024
Language: Английский
Citations
63