ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(30), С. 38852 - 38879
Опубликована: Июль 23, 2024
Biophysical
and
clinical
medical
studies
have
confirmed
that
biological
tissue
lesions
trauma
are
related
to
the
damage
of
an
intrinsic
electret
(i.e.,
endogenous
electric
field),
such
as
wound
healing,
embryonic
development,
occurrence
various
diseases,
immune
regulation,
regeneration,
cancer
metastasis.
As
exogenous
electrical
signals,
conductivity,
piezoelectricity,
ferroelectricity,
pyroelectricity,
bioelectroactives
can
regulate
field,
thus
controlling
function
cells
promoting
repair
regeneration
tissues.
Materials,
once
polarized,
harness
their
inherent
polarized
static
fields
generate
field
through
direct
stimulation
or
indirect
interactions
facilitated
by
physical
friction,
ultrasound,
mechanical
stimulation.
The
interaction
with
microenvironment
allows
for
regulation
compensation
signals
in
damaged
microenvironments,
leading
repair.
technique
shows
great
promise
applications
regeneration.
In
this
paper,
generation
change
electroactive
substances
expounded,
latest
research
progress
its
effects
include
bone
repair,
nerve
drug
penetration
promotion,
etc.
Finally,
opportunities
challenges
materials
were
summarized.
Exploring
development
new
mechanism
regulating
changes
may
provide
insights
innovative
methods
disease
treatment
applications.
Abstract
The
emergence
of
drug‐resistant
bacteria
poses
a
significant
threat
to
people's
lives
and
health
as
bacterial
infections
continue
persist.
Currently,
antibiotic
therapy
remains
the
primary
approach
for
tackling
infections.
However,
escalating
rates
drug
resistance
coupled
with
lag
in
development
novel
drugs
have
led
diminishing
effectiveness
conventional
treatments.
Therefore,
nonantibiotic‐dependent
therapeutic
strategies
has
become
imperative
impede
rise
resistance.
chemodynamic
(CDT)
opened
up
new
possibility
due
CDT
can
convert
H
2
O
into
•OH
via
Fenton/Fenton‐like
reaction
treatment.
efficacy
is
limited
by
variety
practical
factors.
To
overcome
this
limitation,
sterilization
efficiency
be
enhanced
introducing
therapeutics
inherent
antimicrobial
capability.
In
addition,
researchers
explored
CDT‐based
combined
therapies
augment
its
effects
mitigate
potential
toxic
side
toward
normal
tissues.
This
review
examines
research
progress
field,
explores
various
enhance
presents
synergistic
combination
other
modalities.
And
last,
current
challenges
faced
future
directions
are
discussed.
Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Июнь 22, 2024
Bioelectricity
provides
electrostimulation
to
regulate
cell/tissue
behaviors
and
functions.
In
the
human
body,
bioelectricity
can
be
generated
in
electromechanically
responsive
tissues
organs,
as
well
biomolecular
building
blocks
that
exhibit
piezoelectricity,
with
a
phenomenon
known
piezoelectric
effect.
Inspired
by
natural
bio-piezoelectric
phenomenon,
efforts
have
been
devoted
exploiting
high-performance
synthetic
biomaterials,
including
molecular
materials,
polymeric
ceramic
composite
materials.
Notably,
biomaterials
polarize
under
mechanical
strain
generate
electrical
potentials,
which
used
fabricate
electronic
devices.
Herein,
review
article
is
proposed
summarize
design
research
progress
of
devices
toward
bionanotechnology.
First,
functions
regulating
electrophysiological
activity
from
cellular
tissue
level
are
introduced.
Next,
recent
advances
structure-property
relationship
various
provided
detail.
following
part,
applications
engineering,
drug
delivery,
biosensing,
energy
harvesting,
catalysis
systematically
classified
discussed.
Finally,
challenges
future
prospects
presented.
It
believed
this
will
provide
inspiration
for
development
innovative
fields
biomedicine
nanotechnology.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(44)
Опубликована: Июнь 19, 2024
Abstract
Piezocatalysis
and
piezo‐photocatalysis
technology
is
a
continuously
developing
catalytic
based
on
the
piezoelectric
effect
of
catalysts,
which
breaks
barrier
between
mechanical
chemical
energy.
The
polarization
field
formed
by
deformation
materials
proven
to
effectively
manipulate
band
structures,
improve
separation
electron‐hole
pairs
enhance
activity,
thus
alleviating
energy
crises
environmental
issues.
Herein,
this
review
first
introduces
piezocatalysis
piezo‐photocatalysis,
comprehensively
summarizes
synthesis
methods
piezo(photo)catalysis
materials,
analyzes
discusses
measures
optimize
performance
piezo(photo)catalysts.
following
systematically
characteristics
development
current
main
piezo(photo)catalytic
systems,
application
principles
calculations
in
combination
with
practical
researches.
Subsequently,
progress
remediation,
conversion,
biomedical
therapy
fields
presented.
In
end,
challenges,
direction,
future
prospects
are
prospected.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Severe
bone
and
cartilage
defects
caused
by
trauma
are
challenging
to
treat,
often
resulting
in
poor
outcomes.
An
endogenous
electric
field
(EnEF)
is
crucial
for
regeneration,
making
electrical
materials
a
promising
therapy.
This
review
provides
comprehensive
overview
of
the
role
bioelectric
signals
cells,
alongside
recent
advancements
biomaterials,
with
particular
emphasis
on
nanogenerators,
piezoelectric
materials,
triboelectric
scaffolds,
zwitterionic
hydrogels.
It
further
investigates
impact
these
biomaterials
as
well
applications
both
exogenous
stimulation
(ES)
mechanisms
underlying
ES‐induced
cellular
molecular
responses.
Finally,
underscores
future
directions
ES
systems
tissue
engineering,
emphasizing
critical
importance
integrating
structural
integrity,
mechanical
properties,
signal
delivery
into
intelligent
implantable
scaffolds.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 8, 2025
Sonodynamic
therapy
(SDT)
represents
a
promising
approach
for
cancer
treatment.
Compared
to
photodynamic
therapy,
SDT
offers
increased
penetration
depth
and
higher
precision.
However,
the
practical
application
of
is
constrained
by
low
water
solubility,
poor
tumor
specificity,
metabolic
susceptibility
most
sonosensitizers.
Recent
research
has
explored
use
piezoelectric
materials
as
sonosensitizers
in
treatment
inhibition
bacterial
growth.
Upon
ultrasound
excitation,
separation
electron-hole
(e--h+)
pairs
occurs
within
material.
By
improving
crystal
structure
material
or
incorporating
other
nanoparticles
prevent
rapid
recombination
e--h+
pairs,
accumulates
charges
conduction
band
valence
band,
achieving
redox
potential
O2/·O2
-.
This
enables
serve
sonosensitizer,
leading
concept
termed
Sono-Piezo
Dynamic
Therapy
(SPDT).
review
aims
define
SPDT,
provide
systematic
overview
historical
development
SDT,
elucidate
mechanisms
which
act
Importantly,
various
will
be
discussed
terms
their
feasibility,
advantages,
disadvantages
sonosensitizers,
offering
new
perspectives
identifying
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
Metal‐protein
hybrid
materials
represent
a
novel
class
of
functional
that
exhibit
exceptional
physicochemical
properties
and
tunable
structures,
rendering
them
remarkable
applications
in
diverse
fields,
including
engineering,
biocatalysis,
biosensing,
biomedicine.
The
design
development
multifunctional
biocompatible
metal‐protein
have
been
the
subject
extensive
research
key
aspiration
for
practical
clinical
settings.
This
review
provides
comprehensive
analysis
strategies,
intrinsic
properties,
biomedical
these
materials,
with
specific
emphasis
on
their
potential
cancer
therapy,
drug
vaccine
delivery,
antibacterial
treatments,
tissue
regeneration.
Through
rational
design,
stable
can
be
synthesized
using
straightforward
methods,
enabling
therapeutic,
immunomodulatory,
other
desired
functionalities.
Finally,
outlines
existing
limitations
challenges
associated
evaluates
translation,
providing
insights
into
implementation
within
applications.
Ultrasonics Sonochemistry,
Год журнала:
2023,
Номер
100, С. 106617 - 106617
Опубликована: Сен. 23, 2023
The
rapid
spread
and
uncontrollable
evolution
of
antibiotic-resistant
bacteria
have
already
become
urgent
global
to
treat
bacterial
infections.
Sonodynamic
therapy
(SDT),
a
noninvasive
effective
therapeutic
strategy,
has
broadened
the
way
toward
dealing
with
biofilms,
which
base
on
ultrasound
(US)
sonosensitizer.
Sonosensitizer,
based
small
organic
molecules
or
inorganic
nanoparticles,
is
essential
SDT
process.
Thus,
it
meaningful
design
sonosensitizer-loaded
nanoplatform
synthesize
an
efficient
effect.
In
this
review,
we
initially
summarize
probable
SDT-based
antibacterial
mechanisms
systematically
discuss
current
advancement
in
different
(including
for
small-molecule
sonosensitizer
delivery
as
sonosensitizer)
infection
therapy.
addition,
biomedical
applications
SDT-involved
multifunctional
nanoplatforms
are
also
discussed.
We
believe
innovative
would
highly
next-generation
tool
combating
infection.
Abstract
Endogenous
electric
field
is
ubiquitous
in
a
multitude
of
important
living
activities
such
as
bone
repair,
cell
signal
transduction,
and
nerve
regeneration,
signifying
that
regulating
the
organisms
highly
beneficial
to
maintain
organism
health.
As
an
emerging
promising
research
direction,
piezoelectric
nanomedicine
materdicine
precisely
activated
by
ultrasound
with
synergetic
advantages
deep
tissue
penetration,
remote
spatiotemporal
selectivity,
mechanical‐electrical
energy
interconversion,
have
been
progressively
utilized
for
disease
treatment
repair
participating
modulation
endogenous
field.
This
specific
utilizing
effect
typically
regarded
“sonopiezoelectric
nanomedicine”.
comprehensive
review
summarizes
discusses
substantially
employed
sonopiezoelectric
nanomaterials
nanotherapies
provide
insight
into
internal
mechanism
corresponding
biological
behavior/effect
biomaterials
versatile
treatments.
primarily
focuses
on
biosensing,
drug
delivery,
tumor
therapy,
antimicrobia,
further
illuminates
underlying
mechanism.
In
addition,
challenges
developments/prospects
are
analyzed
promoting
clinical
translation.
It
earnestly
expected
this
kind
nanomedicine/biomaterials‐enabled
technology
will
provoke
investigation
promote
development
next‐generation
multifunctional
materdicine.
Materials Today Bio,
Год журнала:
2023,
Номер
22, С. 100740 - 100740
Опубликована: Июль 20, 2023
The
imbalance
between
life
expectancy
and
quality
of
is
increasing
due
to
the
raising
prevalence
chronic
diseases.
Musculoskeletal
disorders
wounds
affect
a
growing
percentage
people
demand
more
efficient
tools
for
regenerative
medicine.
Scaffolds
that
can
better
mimic
natural
physical
stimuli
tissues
receive
under
healthy
conditions
during
healing
may
significantly
aid
regeneration
process.
Shape,
mechanical
properties,
pore
size
interconnectivity
have
already
been
demonstrated
be
relevant
scaffold
features
determine
cell
adhesion
differentiation.
Much
less
attention
has
paid
scaffolds
deliver
dynamic
stimuli,
such
as
electrical
signals.
Recent
developments
in
precise
measurement
fields
