Gas
detection
has
become
a
popular
research
topic
in
the
field
of
environmental
protection
and
disease
because
concerning
increase
pollution
human
health
problems.
2D
MXenes
are
promising
candidates
for
room-temperature
gas
sensors
their
flexible
adjustable
material
compositions,
high
conductivities,
signal-to-noise
ratios,
surface
terminations.
This
paper
presents
prospects
sensors,
structure
MXenes,
potential
sensing
mechanisms
MXenes-based
sensors.
Applications
Ti3C2Tx,
V2CTx,
Nb2CTx,
Mo2CTx
different
gases
reviewed,
challenges
directions
applying
discussed.
review
provides
ideas
designing
novel
sensitive
materials
by
analyzing
value
sensor
field.
With
the
advantages
of
diverse
structures,
tunable
enzymatic
activity,
and
high
stability,
nanozymes
are
widely
used
in
medicine,
chemistry,
food,
environment,
other
fields.
As
an
alternative
to
traditional
antibiotics,
attract
more
attention
from
scientific
researchers
recent
years.
Developing
nanozymes-based
antibacterial
materials
opens
up
a
new
avenue
for
bacterial
disinfection
sterilization.
In
this
review,
classification
their
mechanisms
discussed.
The
surface
composition
critical
efficacy,
which
can
be
tailored
enhance
both
binding
activity.
On
one
hand,
modification
enables
targeting
bacteria
that
improves
performance
including
biochemical
recognition,
charge,
topography.
modulated
achieve
enhanced
single
nanozyme-mediated
synergistic
multiple
nanozymes-mediated
cascade
catalytic
applications.
addition,
current
challenges
future
prospects
tailoring
applications
This
review
provide
insights
into
design
treatments.
Advanced Materials,
Год журнала:
2023,
Номер
35(22)
Опубликована: Март 25, 2023
Reactive
oxygen
species
(ROS)-mediated
tumor
catalytic
therapy
is
typically
hindered
by
gap
junction
proteins
that
form
cell-to-cell
channels
to
remove
cytotoxic
ROS,
thereby
protecting
cells
from
oxidative
damage.
In
this
work,
a
multifunctional
nanozyme,
FePGOGA,
designed
and
prepared
Fe(III)-mediated
polymerization
(FeP),
followed
glucose
oxidase
(GOx)
GAP19
peptides
co-loading
through
electrostatic
π-π
interactions.
The
FePGOGA
nanozyme
exhibits
excellent
cascade
peroxidase-
glutathione-oxidase-like
activities
efficiently
catalyze
hydrogen
peroxide
conversion
hydroxyl
radicals
convert
reduced
glutathione
oxidized
disulfide.
loaded
GOx
starves
the
tumors
aggravates
stress
decomposition,
while
block
hemichannels
inducing
degradation
of
Cx43,
thus
increasing
accumulation
intracellular
decreasing
transport
glucose.
Furthermore,
ROS
reacts
with
primary
amines
heat
shock
destroy
their
structure
function,
enabling
photothermal
at
widely
sought-after
mild
temperature
(mildPTT,
≤45
°C).
vivo
experiments
demonstrate
significant
antitumor
effectof
on
cal27
xenograft
under
near-infrared
light
irradiation.
This
study
demonstrates
successful
ablation
overcome
resistance
ROS-mediated
therapy,
providing
regulator
suppress
self-preservation
during
starvation,
mildPTT.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Фев. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(5), С. 2298 - 2316
Опубликована: Янв. 26, 2024
Bacterial
infection
hampers
wound
repair
by
impeding
the
healing
process.
Concurrently,
inflammation
at
site
triggers
production
of
reactive
oxygen
species
(ROS),
causing
oxidative
stress
and
damage
to
proteins
cells.
This
can
lead
chronic
wounds,
posing
severe
risks.
Therefore,
eliminating
bacterial
reducing
ROS
levels
are
crucial
for
effective
healing.
Nanozymes,
possessing
enzyme-like
catalytic
activity,
convert
endogenous
substances
into
highly
toxic
substances,
such
as
ROS,
combat
bacteria
biofilms
without
inducing
drug
resistance.
However,
current
nanozyme
model
with
single
enzyme
activity
falls
short
meeting
complex
requirements
antimicrobial
therapy.
Thus,
developing
nanozymes
multiple
enzymatic
activities
is
essential.
Herein,
we
engineered
a
novel
metalloenzyme
called
Ru-procyanidin
nanoparticles
(Ru-PC
NPs)
diverse
aid
infections.
Under
acidic
conditions,
due
their
glutathione
(GSH)
depletion
peroxidase
(POD)-like
Ru-PC
NPs
combined
H2O2
exhibit
excellent
antibacterial
effects.
in
neutral
environment,
NPs,
catalase
(CAT)
decompose
O2,
alleviating
hypoxia
ensuring
sufficient
supply.
Furthermore,
possess
exceptional
antioxidant
capacity
through
superior
superoxide
dismutase
(SOD)
effectively
scavenging
excess
nitrogen
(RNS)
environment.
maintains
balance
system
prevents
inflammation.
also
promote
polarization
macrophages
from
M1
M2,
facilitating
More
importantly,
show
good
biosafety
negligible
toxicity.
In
vivo
models
have
confirmed
efficacy
inhibiting
promoting
The
focus
this
work
highlights
quadruple
its
potential
reduce
bacteria-infected
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 13, 2024
Abstract
As
nanoscale
materials
with
the
function
of
catalyzing
substrates
through
enzymatic
kinetics,
nanozymes
are
regarded
as
potential
alternatives
to
natural
enzymes.
Compared
protein‐based
enzymes,
exhibit
attractive
characteristics
low
preparation
cost,
robust
activity,
flexible
performance
adjustment,
and
versatile
functionalization.
These
advantages
endow
them
wide
use
from
biochemical
sensing
environmental
remediation
medical
theranostics.
Especially
in
biomedical
diagnosis,
feature
catalytic
signal
amplification
provided
by
makes
emerging
labels
for
detection
biomarkers
diseases,
rapid
developments
observed
recent
years.
To
provide
a
comprehensive
overview
progress
made
this
dynamic
field,
here
an
diagnosis
enabled
is
provided.
This
review
first
summarizes
synthesis
nanozyme
then
discusses
main
strategies
applied
enhance
their
activity
specificity.
Subsequently,
representative
utilization
combined
biological
elements
disease
reviewed,
including
related
metabolic,
cardiovascular,
nervous,
digestive
diseases
well
cancers.
Finally,
some
development
trends
nanozyme‐enabled
highlighted,
corresponding
challenges
also
pointed
out,
aiming
inspire
future
efforts
further
advance
promising
field.
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
11(29), С. 6746 - 6761
Опубликована: Янв. 1, 2023
The
slow
healing
of
diabetic
wounds
has
seriously
affected
human
health.
Meanwhile,
the
open
are
susceptible
to
bacterial
infection.
Clinical
therapeutic
methods
such
as
antibiotic
therapy,
insulin
treatment,
and
surgical
debridement
have
made
great
achievements
in
treatment
wounds.
However,
drug-resistant
bacteria
will
develop
after
long-term
use
antibiotics,
resulting
decreased
efficacy.
To
improve
effect,
increasing
drug
concentration
is
a
common
strategy
clinical
practice,
but
it
also
brings
serious
side
effects.
In
addition,
hyperglycemia
control
or
can
easily
bring
negative
effects
patients,
hypoglycemia
damage
normal
tissue.
Therefore,
essential
novel
strategies
effectively
promote
wound
healing.
recent
years,
nanozyme-based
systems
received
extensive
attention
because
they
possess
advantages
nanomaterials
natural
enzymes.
For
example,
nanozymes
small
size
high
surface
area
volume
ratio,
which
enhance
tissue
penetration
increase
reactive
active
sites.
Moreover,
compared
with
enzymes,
more
stable
catalytic
activity,
lower
production
cost,
stronger
operability.
this
review,
we
first
reviewed
basic
characteristics
then
elaborated
on
mechanism
action
principle
different
types
from
three
aspects:
controlling
infection,
hyperglycemia,
relieving
inflammation.
Finally,
challenges,
prospects
future
implementation
for
outlined.
