Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(7), С. 2901 - 2926
Опубликована: Март 11, 2024
Despite
the
considerable
advancements
in
chemotherapy
as
a
cornerstone
modality
cancer
treatment,
prevalence
of
complications
and
pre-existing
diseases
is
on
rise
among
patients
along
with
prolonged
survival
aging
population.
The
relationships
between
these
disorders
are
intricate,
bearing
significant
influence
quality
life
individuals
presenting
challenges
for
prognosis
outcomes
malignancies.
Herein,
we
review
prevailing
comorbidities
that
often
accompany
summarize
lessons
to
learn
from
inadequate
research
management
this
scenario,
an
emphasis
possible
strategies
reducing
potential
alleviating
comorbidities,
well
overview
current
preclinical
models
practical
advice
establishing
bio-faithful
such
complex
context.
Molecules,
Год журнала:
2022,
Номер
27(23), С. 8367 - 8367
Опубликована: Ноя. 30, 2022
Natural
products
have
been
an
invaluable
and
useful
source
of
anticancer
agents
over
the
years.
Several
compounds
synthesized
from
natural
by
modifying
their
structures
or
using
naturally
occurring
as
building
blocks
in
synthesis
these
for
various
purposes
different
fields,
such
biology,
medicine,
engineering.
Multiple
modern
costly
treatments
applied
to
combat
cancer
limit
its
lethality,
but
results
are
not
significantly
refreshing.
products,
which
a
significant
new
therapeutic
drugs,
currently
being
investigated
potential
cytotoxic
shown
positive
trend
preclinical
research
prompted
numerous
innovative
strategies
order
expedite
clinical
research.
becoming
increasingly
important
drug
discovery
due
high
molecular
diversity
novel
biofunctionality.
Furthermore,
can
provide
superior
efficacy
safety
unique
properties.
The
objective
current
review
is
overview
emergence
treatment
prevention
cancer,
chemosensitizers,
immunotherapeutics,
combinatorial
therapies
with
other
formulations
mechanisms
underlying
Acta Pharmaceutica Sinica B,
Год журнала:
2023,
Номер
13(11), С. 4391 - 4416
Опубликована: Май 20, 2023
Owing
to
the
inherent
shortcomings
of
traditional
therapeutic
drugs
in
terms
inadequate
efficacy
and
toxicity
clinical
treatment,
nanomedicine
designs
have
received
widespread
attention
with
significantly
improved
reduced
non-target
side
effects.
Nanomedicines
hold
tremendous
theranostic
potential
for
treating,
monitoring,
diagnosing,
controlling
various
diseases
are
attracting
an
unfathomable
amount
input
research
resources.
Against
backdrop
exponentially
growing
number
publications,
it
is
imperative
help
audience
get
a
panorama
image
activities
field
nanomedicines.
Herein,
this
review
elaborates
on
development
trends
nanomedicines,
emerging
nanocarriers,
vivo
fate
safety
their
extensive
applications.
Moreover,
challenges
obstacles
hindering
translation
nanomedicines
also
discussed.
The
elaboration
aspects
may
enlighten
readers
set
route
future
endeavors.
ACS Materials Letters,
Год журнала:
2023,
Номер
5(2), С. 466 - 472
Опубликована: Янв. 13, 2023
Metal–organic
frameworks
are
smart
carriers
for
controlled
drug
delivery
due
to
large
surface
area
and
adjustable
pore
size.
Current
approaches
can
hardly
utilize
the
space
of
MOFs
thoroughly,
greatly
causing
waste
space.
Here,
Pore
Space
Partition
(PSP)
approach
was
employed
achieve
effective
encapsulation
pH-controlled
codelivery
two
guest
molecules.
The
ZIF-8
partitioned
by
molecule
ursolic
acid
(UA),
remaining
filled
with
small
5-fluorouracil
(5-FU),
obtaining
5-FU&UA@ZIF-8
high
loading
capacity
UA
(12.80
wt
%)
5-FU
(11.20
%).
Accompanied
collapse
in
acidic
surroundings,
exhibited
delivery.
To
our
surprise,
also
showed
pH
responsive
delivery,
which
did
not
exist
before
partition
UA.
Codelivery
enable
have
good
anticancer
performance
against
4T1
cells.
Polymers,
Год журнала:
2023,
Номер
15(13), С. 2928 - 2928
Опубликована: Июль 1, 2023
The
limitations
associated
with
the
conventional
treatment
of
cancer
have
necessitated
design
and
development
novel
drug
delivery
systems
based
mainly
on
nanotechnology.
These
include
various
kinds
nanoparticles,
such
as
polymeric
solid
lipid
nanostructured
carriers,
hydrogels,
micelles.
Among
systems,
chitosan-based
nanoparticles
attracted
attention
researchers
to
treat
cancer.
Chitosan
is
a
polycationic
polymer
generated
from
chitin
characteristics
biocompatibility,
biodegradability,
non-toxicity,
mucoadhesiveness,
making
it
an
ideal
fabricate
systems.
However,
chitosan
poorly
soluble
in
water
acidic
aqueous
solutions.
Furthermore,
owing
presence
reactive
amino
groups,
can
be
chemically
modified
improve
its
physiochemical
properties.
derivatives
employed
which
are
used
most
frequently
pharmaceutical
sector
due
their
possession
nanosize,
appropriate
pharmacokinetic
pharmacodynamic
properties,
non-immunogenicity,
improved
stability,
loading
capacity.
capable
delivering
nucleic
acids,
chemotherapeutic
medicines,
bioactives
using
chitosan.
derivative-based
targeted
specific
sites
via
active
passive
mechanisms.
Based
many
anticancer
drugs
now
better
effectiveness,
potency,
cytotoxicity,
or
biocompatibility.
tailored
derivatives,
well
use
therapy,
will
examined
this
review.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 115976 - 115976
Опубликована: Дек. 3, 2023
T
helper
(Th)
cells
have
received
extensive
attention
owing
to
their
indispensable
roles
in
anti-tumor
immune
responses.
Th1
and
Th2
are
two
key
subsets
of
Th
that
exist
relative
equilibrium
through
the
secretion
cytokines
suppress
respective
response.
When
type
cytokine
tumor
microenvironment
is
altered,
this
may
be
disrupted,
leading
a
shift
from
Th1/Th2
imbalance
one
decisive
factors
development
malignant
tumors.
Therefore,
focusing
on
balance
responses
enable
future
breakthroughs
cancer
immunotherapy.
Polysaccharides
can
regulate
between
characteristic
profiles,
thereby
improving
microenvironment.
To
our
knowledge,
study
most
comprehensive
assessment
regulation
by
polysaccharides.
Herein,
we
systematically
summarized
intrinsic
molecular
mechanisms
polysaccharides
provide
new
perspective
potential
target
drugs
for
improved
immunity
delayed
progression.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 889 - 889
Опубликована: Март 9, 2023
Anticancer
drugs
in
monotherapy
are
ineffective
to
treat
various
kinds
of
cancer
due
the
heterogeneous
nature
cancer.
Moreover,
available
anticancer
possessed
hurdles,
such
as
drug
resistance,
insensitivity
cells
drugs,
adverse
effects
and
patient
inconveniences.
Hence,
plant-based
phytochemicals
could
be
a
better
substitute
for
conventional
chemotherapy
treatment
properties:
lesser
effects,
action
via
multiple
pathways,
economical,
etc.
Various
preclinical
studies
have
demonstrated
that
combination
with
is
more
efficacious
than
individually
because
plant-derived
compounds
lower
efficacy
drugs.
suffer
from
poor
aqueous
solubility
reduced
bioavailability,
which
must
resolved
Therefore,
nanotechnology-based
novel
carriers
employed
codelivery
These
include
nanoemulsion,
nanosuspension,
nanostructured
lipid
carriers,
solid
nanoparticles,
polymeric
micelles,
dendrimers,
metallic
carbon
nanotubes
provide
benefits
improved
solubility,
higher
efficacy,
dose,
dosing
frequency,
bioavailability
compliance.
This
review
summarizes
cancer,
therapy
deliver
Nanoscale Advances,
Год журнала:
2024,
Номер
6(7), С. 1800 - 1821
Опубликована: Янв. 1, 2024
Here,
we
explored
the
recent
development
of
MOF-based
nanomaterials
for
biomedical
applications.
not
only
show
excellent
bio-imaging
and
biosensing
performance
but
also
can
be
well
designed
as
bio-carriers
in
drug
delivery.
Abstract
Photothermal
therapy
(PTT)
has
garnered
significant
attention
in
recent
years,
but
the
standalone
application
of
PTT
still
faces
limitations
that
hinder
its
ability
to
achieve
optimal
therapeutic
outcomes.
Nitric
oxide
(NO),
being
one
most
extensively
studied
gaseous
molecules,
presents
itself
as
a
promising
complementary
candidate
for
PTT.
In
response,
various
nanosystems
have
been
developed
enable
simultaneous
utilization
and
NO‐mediated
gas
(GT),
with
integration
photothermal
agents
(PTAs)
thermally‐sensitive
NO
donors
prevailing
approach.
This
combination
seeks
leverage
synergistic
effects
GT
while
mitigating
potential
risks
associated
toxicity
through
use
single
laser
irradiation.
Furthermore,
additional
internal
or
external
stimuli
employed
trigger
release
when
combined
different
types
PTAs,
thereby
further
enhancing
efficacy.
comprehensive
review
aims
summarize
advancements
gas‐assisted
cancer
treatment.
It
commences
by
providing
an
overview
precursors,
including
those
sensitive
photothermal,
light,
ultrasound,
reactive
oxygen
species,
glutathione.
These
precursors
are
discussed
context
dual‐modal
PTT/GT.
Subsequently,
incorporation
other
treatment
modalities
such
chemotherapy
(CHT),
photodynamic
(PDT),
alkyl
radical
therapy,
radiation
immunotherapy
(IT)
creation
triple‐modal
nanoplatforms
is
presented.
The
explores
tetra‐modal
therapies,
PTT/GT/CHT/PDT,
PTT/GT/CHT/chemodynamic
(CDT),
PTT/GT/PDT/IT,
PTT/GT/starvation
(ST)/IT,
PTT/GT/Ca
2+
overload/IT,
PTT/GT/ferroptosis
(FT)/IT,
PTT/GT/CDT/IT.
Finally,
challenges
future
perspectives
concerning
these
novel
paradigms
discussed.
anticipated
serve
valuable
resource
studies
focused
on
development
innovative
photothermal/NO‐based
nanotheranostics.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 13339 - 13355
Опубликована: Дек. 1, 2024
Hepatocellular
carcinoma
(HCC)
is
a
serious
global
health
concern,
accounting
for
about
90%
of
all
liver
cancer
instances.
Surgical
treatment
fundamental
aspect
HCC
management;
however,
the
challenge
postoperative
recurrence
significantly
impacts
mortality
rates.
ACS Nano,
Год журнала:
2024,
Номер
18(17), С. 10979 - 11024
Опубликована: Апрель 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
