Nanomedicine, Год журнала: 2023, Номер 18(11), С. 849 - 854
Опубликована: Май 1, 2023
Язык: Английский
Advanced Functional Materials, Год журнала: 2023, Номер 33(33)
Опубликована: Май 1, 2023
Abstract Activation of cuproptosis pathway has been reported to hold great potential in the application tumor treatment. But efficacy seriously limited by insufficient accumulation sites. Therefore, herein based on strong stabilization effects metalloid element selenium (Se) copper (Cu), a photothermic Cu 2‐ x Se nanoparticle encapsulated with bioresponsive dimethyl maleic anhydride (DMMA@Cu Se) as copper‐carrier improve is constructed, thus achieving cuproptosis‐driven enhancement thermotherapy. This nanosystem exhibits cellular uptake weak acid‐triggered charge‐switching ability. Next step, exposed oxidized and releases divalent high‐level oxide. Then, abundant induces more dihydrolipoamide S ‐acetyltransferase oligomerization down‐regulate FDX1 tricarboxylic acid cycle‐related proteins, which leads inhibiting aerobic respiration. Cuproptosis‐induced mitochondrial damage further improves thermotherapy up‐regulating reactive oxygen species (ROS). In addition, generated ROS also promotes release strengthen cuproptosis, eventually turn. general, DMMA@Cu sequentially triggered copper‐release, efficient appropriate photothermal self‐enhanced nanoplatform for
Язык: Английский
Процитировано
44
Chemical Science, Год журнала: 2022, Номер 13(32), С. 9128 - 9146
Опубликована: Янв. 1, 2022
Nature has inspired the creation of artificial micro- and nanomotors that self-propel converting chemical energy into mechanical action. These tiny machines have appeared as promising biomedical tools for treatment diagnosis also been used environmental, antimicrobial or sensing applications. Among possible catalytic engines, enzymes emerged an alternative to inorganic catalysts due their biocompatibility variety bioavailability fuels. Although field enzyme-powered nano-motors a trajectory more than decade, comprehensive framework on how rationally design, control optimize motion is still missing. With this purpose, herein we performed thorough bibliographic study key parameters governing propulsion these devices, namely chassis shape, material composition, motor size, enzyme type, method incorporate enzymes, distribution product released, mechanism, media technique detection. In conclusion, from library options each parameter offers there needs be rational selection intelligent design enzymatic motors based specific application envisioned.
Язык: Английский
Процитировано
51
Advanced Functional Materials, Год журнала: 2023, Номер 33(15)
Опубликована: Янв. 25, 2023
Abstract Untethered mobile micro‐/nanomotors (MNMs), as newly‐emerging attractive and versatile nanotechnologies, are expected to be the next‐generation disease treatment tools, for breaking through limitations of conventional passive drug delivery manner. However, advances in these fascinating platforms have been hampered by complexity biological environment particularity microenvironment. Consequently, specific design strategies clinical imaging techniques essential ensure high‐efficiency biomedical MNMs on actuation, targeting, localization, therapy when performing assigned vivo tasks. This review thus comprehensively addresses three aspects MNMs, including design, imaging, treatment, highlighting intelligent with biomimetic functionality chemotactic capability, emphasizing applicability different techniques, focusing various proof‐of‐concept studies based physiological characteristics major diseases. In addition, key challenges current addressed, which may inspire future research facilitate translation toward treatment.
Язык: Английский
Процитировано
33
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3375 - 3375
Опубликована: Фев. 8, 2023
Gene therapy has attracted much attention because of its unique mechanism action, non-toxicity, and good tolerance, which can kill cancer cells without damaging healthy tissues. siRNA-based gene downregulate, enhance, or correct expression by introducing some nucleic acid into patient Routine treatment hemophilia requires frequent intravenous injections missing clotting protein. The high cost combined causes most patients to lack the best resources. siRNA potential lasting even curing diseases. Compared with traditional surgery chemotherapy, fewer side effects less damage normal cells. available therapies for degenerative diseases only alleviate symptoms patients, while drugs upregulate expression, modify epigenetic changes, stop disease. In addition, also plays an important role in cardiovascular diseases, gastrointestinal hepatitis B. However, free is easily degraded nuclease a short half-life blood. Research found that be delivered specific through appropriate vector selection design improve therapeutic effect. application viral vectors limited their immunogenicity low capacity, non-viral are widely used immunogenicity, production cost, safety. This paper reviews common recent years introduces advantages disadvantages, as well latest examples.
Язык: Английский
Процитировано
30
Nanoscale, Год журнала: 2023, Номер 15(19), С. 8491 - 8507
Опубликована: Янв. 1, 2023
Untethered robots in the size range of micro/nano-scale offer unprecedented access to hard-to-reach areas body. In these challenging environments, autonomous task completion capabilities micro/nanorobots have been subject research recent years. However, most studies presented preliminary vitro results that can significantly differ under vivo settings. Here, we focus on conducted with animal models reveal current status micro/nanorobotic applications real-world conditions. By a categorization based target locations, highlight main strategies employed organs and other body parts. We also discuss key challenges require interest before successful translation clinic.
Язык: Английский
Процитировано
29
Materials & Design, Год журнала: 2023, Номер 231, С. 112036 - 112036
Опубликована: Май 25, 2023
As the population ages, cancer has become a major health concern. Although surgical treatment, chemoradiotherapy, and other clinical treatments have dominant, their strong invasiveness intolerable toxic side effects seriously affect patients' quality of life. Therefore, developing non-invasive optical therapy with high safety is great significance. In last two decades development, progress been made in lanthanide doped nanoparticles on biomedical applications under near-infrared (NIR) light due to unique properties. These nanomaterials used wide range applications, including bioluminescence marker detection, vitro vivo imaging, photodynamic (PDT), photothermal (PTT), therapeutic applications. therapies rapidly developed profession involving oncology non-invasive, spatiotemporal controllability, efficiency. For this key review, based listed as follows: bioimaging, biosensors, PDT PTT. Some emerging biological lanthanide-doped currently at forefront nano/biological interface are also discussed. Finally, review summarizes future opportunities challenges nanotechnology research nanoparticles.
Язык: Английский
Процитировано
27
Small, Год журнала: 2022, Номер 19(13)
Опубликована: Авг. 12, 2022
Abstract Drug‐coated balloons (DCB) intervention is an important approach for the treatment of atherosclerosis (AS). However, this therapeutic has drawbacks poor drug retention and penetration at lesion site. Here, a lipophilic drug‐loaded nanomotor as modified balloon coating AS reported. First, PMA‐TPP/PTX loaded with PTX triphenylphosphine (TPP) compounds synthesized. The nanomotors use nitric oxide (NO) driving force, which produced from reaction between arginine on motor substrate excess reactive oxygen species (ROS) inducible synthase (iNOS) in microenvironment. final vitro vivo experimental results confirm that introduction technology can greatly enhance permeability atherosclerotic lesions. In particular, NO also play anti‐AS role improving endothelial cell function reducing oxidative stress. chemotherapeutic onto inhibit division proliferation, thereby exerting effect inhibiting vascular intimal hyperplasia, helpful multiple therapies AS. Using to solve cardiovascular diseases may be promising research direction.
Язык: Английский
Процитировано
30
Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 619 - 647
Опубликована: Июнь 29, 2024
In recent years, enzyme therapy strategies have rapidly evolved to catalyze essential biochemical reactions with therapeutic potential. These approaches hold particular promise in addressing rare genetic disorders, cancer treatment, neurodegenerative conditions, wound healing, inflammation management, and infectious disease control, among others. There are several primary reasons for the utilization of enzymes as therapeutics: their substrate specificity, biological compatibility, ability generate a high number product molecules per unit. features encouraged application replacement where serves agent rectify abnormal metabolic physiological processes, prodrug initiates clinical effect by activating prodrugs, dynamic or starving acts upon host molecules. Currently, there >20 commercialized products based on enzymes, but approval rates considerably lower than other biologicals. This has stimulated nanobiotechnology last years develop nanoparticle-based solutions that integrate enzymes. approach aims enhance stability, prevent rapid clearance, reduce immunogenicity, even enable spatio-temporal activation catalyst. comprehensive review delves into emerging trends emphasis synergistic opportunities presented incorporating nanomaterials. Such integration holds enhancing existing therapies paving way innovative nanotherapeutic approaches.
Язык: Английский
Процитировано
7
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(6), С. 5745 - 5760
Опубликована: Март 4, 2024
Micro/nanomotors can convert different forms of energy into mechanical motion according to the controllable direction by mechanisms. This new nanodevice is widely used in biomedical applications such as targeted drug delivery, biological imaging, diagnosis, and detection. Although practical medical these small devices are still initial stage, nanomotors manifest their great potential applications. In particular, micro/nanomotors driven magnetic force have advantages biomedicine because movement direction. this review, classified, recent medicine reviewed. Finally, problems existing possibilities for future development discussed.
Язык: Английский
Процитировано
5
ACS Omega, Год журнала: 2024, Номер unknown
Опубликована: Март 10, 2024
With the rapid development of nanotechnology, nanomaterials have shown immense potential for antitumor applications. Nanosized calcium carbonate (CaCO3) materials exhibit excellent biocompatibility and degradability, been utilized to develop platform technologies cancer therapy. These can be engineered carry anticancer drugs functional groups that specifically target cells tissues, thereby enhancing therapeutic efficacy. Additionally, their physicochemical properties tailored enable stimuli-responsive therapy precision drug delivery. This Review consolidates recent literatures focusing on synthesis, properties, multimodal therapies CaCO3-based nanoplatforms (CBN). We also explore current challenges breakthroughs in CBN applications, providing a valuable reference researchers field.
Язык: Английский
Процитировано
5