International Journal of Applied Pharmaceutics,
Год журнала:
2023,
Номер
unknown, С. 30 - 36
Опубликована: Дек. 18, 2023
Objective:
Proper
wound
care
is
essential
to
prevent
complications
and
worsening
of
the
injured
patient.
Everyone
in
family
needs
possess
knowledge,
especially
mother,
who
plays
a
role
making
decisions
about
health
behaviors.
This
study
aims
evaluate
mothers'
knowledge
towards
Greater
Bandung
Area.
Methods:
cross-sectional
involved
100
participants
with
varied
backgrounds
had
met
inclusion
criteria.
The
was
conducted
using
questionnaires
distributed
online
mother
community
living
Area,
West
Java,
then
data
processing
analysis
were
carried
out.
Results:
results
showed
that
mothers
Area
good
level
(27%),
average
(52%),
less
(21%).
In
addition,
plasters
solutions
still
main
choice
care.
Nevertheless,
there
are
many
choices
pharmaceutical
dosage
forms
for
have
been
developed
today
optimize
healing
process.
Conclusion:
Most
already
an
good.
However,
quite
lot
lack
related
Therefore,
educational
programs
must
be
raise
awareness
management,
as
well
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Transdermal
drug
delivery
presents
a
promising
noninvasive
approach,
bypassing
first-pass
metabolism
and
gastrointestinal
degradation.
However,
the
stratum
corneum
(SC)
barrier
limits
absorption,
necessitating
development
of
effective
systems.
Microneedles,
particularly
polymer-based
ones,
offer
solution
by
penetrating
SC
while
avoiding
critical
nerves
capillaries.
These
microneedles
are
biodegradable,
nontoxic,
easily
manufacturable,
making
them
highly
attractive
platform
for
transdermal
delivery.
their
clinical
application
remains
limited
due
to
suboptimal
therapeutic
efficacy
slow
release
rates.
Recent
advancements
have
introduced
incorporation
nanodrugs,
such
as
nanoparticles
encapsulated
drugs,
into
enhance
efficiency.
Among
materials
explored,
graphene
its
derivatives,
including
oxide
(GO)
reduced
(rGO),
garnered
significant
attention.
Their
exceptional
mechanical
strength,
electrical
conductivity,
antibacterial
properties
not
only
improve
performance
but
also
rates
biocompatibility.
This
review
synthesizes
current
state
microneedle
technologies,
focusing
on
materials,
fabrication
techniques,
challenges.
It
examines
potential
graphene-based
microneedles,
comparing
traditional
in
terms
efficiency
stability.
The
highlights
key
challenges,
scalability,
biocompatibility,
complexity,
suggests
future
research
directions
address
these
issues.
quantum
dots
(GQDs)
is
identified
avenue
improving
profiles,
stability,
real-time
tracking
diffusion.
Finally,
outlines
emerging
applications,
smart
systems,
biosensing,
monitoring,
urging
further
exploration
unlock
full
graphene-enhanced
settings.
Abstract
The
use
of
photothermal
therapy
(PTT)
with
the
near‐infrared
II
region
(NIR‐II:
1000–1700
nm)
is
expected
to
be
a
powerful
cancer
treatment
strategy.
It
retains
noninvasive
nature
and
excellent
temporal
spatial
controllability
traditional
PTT,
offers
significant
advantages
in
terms
tissue
penetration
depth,
background
noise,
maximum
permissible
exposure
standards
for
skin.
MXenes,
transition‐metal
carbides,
nitrides,
carbonitrides
are
emerging
inorganic
nanomaterials
natural
biocompatibility,
wide
spectral
absorption,
high
conversion
efficiency.
PTT
MXenes
NIR‐II
not
only
provides
valuable
reference
exploring
agents
that
respond
2D
nanomaterials,
but
also
considered
as
promising
biomedical
therapy.
First,
synthesis
methods
briefly
summarized,
laser
light
source,
mechanism
conversion,
evaluation
criteria
performance
introduced.
Second,
latest
progress
based
on
reviewed,
including
titanium
carbide
(Ti
3
C
2
),
niobium
(Nb
C),
molybdenum
(Mo
C).
Finally,
main
problems
application
future
research
directions
discussed.
Plants,
Год журнала:
2023,
Номер
12(14), С. 2661 - 2661
Опубликована: Июль 16, 2023
Transdermal
delivery
devices
and
wound
dressing
materials
are
constantly
improved
upgraded
with
the
aim
of
enhancing
their
beneficial
effects,
biocompatibility,
biodegradability,
cost
effectiveness.
Therefore,
researchers
in
field
have
shown
an
increasing
interest
using
natural
compounds
as
constituents
for
such
systems.
Plants,
important
source
so-called
“natural
products”
enormous
variety
structural
diversity
that
still
exceeds
capacity
present-day
sciences
to
define
or
even
discover
them,
been
part
medicine
since
ancient
times.
However,
benefits
just
at
beginning
being
fully
exploited
modern
dermal
transdermal
Thus,
plant-based
primary
compounds,
without
biological
activity,
contained
gums
mucilages,
traditionally
used
gelling
texturing
agents
food
industry,
now
explored
valuable
cost-effective
components
biomedical
field.
Their
non-toxicity
compensate
local
availability
compositional
variations.
Also,
secondary
metabolites,
classified
based
on
chemical
structure,
intensively
investigated
wide
pharmacological
toxicological
effects.
impact
is
highlighted
detail
through
most
recent
reported
studies.
Innovative
isolation
purification
techniques,
new
drug
systems,
advanced
evaluation
procedures
presented.
Macromolecular Bioscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 28, 2024
Abstract
The
stratum
corneum,
which
acts
as
a
strong
barrier
against
external
agents,
presents
significant
challenge
to
transdermal
drug
delivery.
In
this
regard,
microneedle
(MN)
patches,
designed
modern
systems
for
delivery
via
permeation
through
the
skin
with
ability
pass
are
known
be
convenient,
painless,
and
effective.
fact,
MN
have
shown
breakthroughs
in
delivery,
among
various
types,
hydrogel
(HMNs)
demonstrated
desirable
inherent
properties.
Despite
advancements,
issues
such
limited
loading
capacity,
uncontrolled
release
rates,
non‐uniform
therapeutic
approaches
persist.
Conversely,
nanomaterials
(NMs)
promise
medical
applications,
however,
their
efficacy
applicability
constrained
by
challenges
including
poor
stability,
low
bioavailability,
payload
rapid
clearance
immune
system.
Incorporation
of
NMs
within
HMNs
offers
new
prospects
address
associated
NMs.
This
combination
can
provide
promising
field
research
improved
effective
agents
mitigate
certain
adverse
effects,
addressing
current
clinical
concerns.
review
highlights
use
diagnostic
applications.
Advanced Materials Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 22, 2024
Abstract
Microneedle
(MN)
technology
offers
a
powerful
approach
for
transdermal
delivery
enabling
painless
injection
and
facilitating
self‐administration
without
the
need
professional
assistance.
However,
weak
mechanical
strength
of
MNs
can
lead
to
inefficient
drug
serious
skin
irritation
if
fracture
during
administration
leave
fragments
under
skin.
Thus,
be
mechanically
robust
avoid
penetration
through
while
maintaining
efficient
delivery.
Herein,
polymer‐based
with
layer‐by‐layer
(LbL)
films
silica
(SiO
2
)
nanoparticles
(NPs)
polycation
(poly(diallyldimethylammonium
chloride)
(PDADMAC))
followed
by
hydrothermal
calcination
are
reinforced.
The
is
significantly
improved
after
LbL
assembly
shows
lower
threshold
pressure
penetrate
skins.
Moreover,
their
loading
releasing
properties
enhanced
due
an
increase
in
surface
area
interfacial
interaction.
These
SiO
nanoparticle‐containing
thin
have
great
potential
modification
3D
microstructured
devices
such
as
MNs,
evidenced
coating
efficiency
that
result
promising
MN
model.
