International Immunopharmacology, Год журнала: 2025, Номер 147, С. 114056 - 114056
Опубликована: Янв. 11, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2415 - 2415
Опубликована: Янв. 26, 2023
The progressive loss of skeletal muscle mass and concomitant reduction in contractile strength plays a central role frailty syndrome. Age-related neuronal impairments are closely associated with sarcopenia the elderly, which is characterized by severe muscular atrophy that can considerably lessen overall quality life at old age. Mass-spectrometry-based proteomic surveys senescent human muscles, as well animal models sarcopenia, have decisively improved our understanding molecular cellular consequences fiber-type shifting during aging. This review outlines spectrometric identification proteome-wide changes atrophying focus on proteins potential markers distribution patterns. observed trend fast-to-slow transitions individual muscles aging process most likely linked to preferential susceptibility fast-twitching fibers atrophy. Studies models, including mostly aged rodent confirmed shifting. analysis fast versus slow isoforms key proteins, such myosin heavy chains, light actins, troponins tropomyosins, suggests them suitable bioanalytical tools
Язык: Английский
Процитировано
46
Frontiers in Endocrinology, Год журнала: 2023, Номер 14
Опубликована: Март 1, 2023
Background Elderly people with low lean and high fat mass, are diagnosed sarcopenic obesity (SO), often have poor clinical outcomes. This study aimed to explore the relationship between sarcopenia, optimal proportion of muscle for old individuals. Methods Participants aged 60 years or above were instructed perform bioelectrical impedance analysis obtain indicators, handgrip strength was also performed. Sarcopenia according predicted appendicular skeletal mass function. Body index (BMI) body percentage (BF%) used define obesity. The association indicators analyzed by Pearson’s correlation coefficient. Pearson Chi-Square test utilized estimate odds ratios (OR) 95% confidence intervals (CI) on risk sarcopenia status. Results 1637 subjects (74.8 ± 7.8 years) participated in this study. Not only but positively correlated BMI weight (p < 0.05). Absolute different positions had positive associations Muscle negatively related When defined (OR = 0.69, CI [0.56, 0.86]; p 0.001), a protective factor whilst it when using BF% 1.38, [1.13, 1.69]; 0.002) as definition. reduced increase both genders. It increased raised males displayed U-shaped curve females. 26.0–34.6% females lower than 23.9% recommended prevention. Conclusion Skeletal strong absolute negative mass. Obesity instead BMI. management can accurately help elderly prevent against
Язык: Английский
Процитировано
42
BMC Geriatrics, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 29, 2025
Most existing studies focus on either the relationship between sarcopenia and depressive symptoms or cognitive functions. Few have examined functions simultaneously. This study aimed to analyze both in elderly by introducing activities of daily living explore mediating role mental health. used data from 2015 2018 China Health Retirement Longitudinal Study, including a total 3,552 older adults aged 60 above. We conducted descriptive statistical analysis correlation seemingly unrelated regression examine sarcopenia, symptoms, adults. Bootstrap mediation was further elderly. After adjusting for confounding factors, positively correlated with (β = 0.663, p < 0.001) negatively (β=-0.748, 0.001), indicating negative impact Activities mediated health, stronger effect (18.77%, β 0.125, 95%CI (0.035, 0.222)) than (12.82%, β=-0.099, (-0.162, -0.035)). partially health status Chinese Interventions targeting may be an effective way prevent improve
Язык: Английский
Процитировано
3
Experimental Gerontology, Год журнала: 2022, Номер 164, С. 111823 - 111823
Опубликована: Апрель 30, 2022
Язык: Английский
Процитировано
64
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(22), С. 14006 - 14006
Опубликована: Ноя. 13, 2022
Multisystem derangements encompassing musculoskeletal, stress, and metabolic response have been described in older adults with physical frailty sarcopenia (PF&S). Whether PF&S is also associated markers of cellular senescence has yet to be explored. To address this research question, we quantified the serum levels selected inflammatory, mitochondrial, senescence-associated secretory phenotype (SASP)-related factors 22 (mean age 75.5 ± 4.7 years; 81.8% women) 27 nonPF&S controls 75.0 4.4 62.9% evaluated their association PF&S. Markers inflammation (interleukin (IL)1-
Язык: Английский
Процитировано
48
Ageing Research Reviews, Год журнала: 2023, Номер 91, С. 102082 - 102082
Опубликована: Окт. 4, 2023
Frailty is an age-related clinical condition characterised by increased susceptibility to stressors and elevated risk of adverse outcomes such as mortality. In the light global population ageing, prevalence frailty expected soar in coming decades. This narrative review provides critical insights into recent developments emerging practices research regarding identification, management, factors, prevention. We searched journals top two quartiles geriatrics gerontology (from Clarivate Journal Citation Reports) for articles published between 01 January 2018 20 December 2022. Several were identified, including new biomarkers biomarker panels screening diagnosis, using artificial intelligence identify frailty, investigating altered response medications older adults with frailty. Other areas novel included exercise (including technology-based exercise), multidimensional interventions, person-centred integrated care, assistive technologies, analysis transitions, risk-factors, guidelines, COVID-19, potential future treatments. identified a strong need implementation evaluation cost-effective, community-based interventions manage prevent Our findings highlight better support involve those shared decision-making their care.
Язык: Английский
Процитировано
34
Ageing Research Reviews, Год журнала: 2023, Номер 92, С. 102111 - 102111
Опубликована: Окт. 29, 2023
Frailty and sarcopenia are age-related diseases, exhibit a concomitant relationship, as they share many common clinical features etiological factors. Transitions within frailty status would be influenced by the presence of sarcopenia. Investigating their association to devise efficacious intervention management strategies for geriatric patients is imperative, given potentially unfavorable outcomes. In this study, literature on was screened in Web Science core collection database over past 30 years ascertain link between them through bibliometric analysis exploration disease-related molecular pathways GeneCards OMIM databases conducted. Per inclusion exclusion criteria, 3889 sources were selected subsequent analysis. Keywords, including "cirrhosis" "postoperative complications," represent current potential future research trends focal points field. Moreover, 63 targets two diseases identified. Their pathogenesis involved cellular aging endocrine metabolism regulation pathways, AMPK, cell senescence, resistance pathway. This study identified an intimate correlation pathogenesis, prevention, treatment measures, establishing foundation exploring shared prevention these disorders.
Язык: Английский
Процитировано
30
Experimental Gerontology, Год журнала: 2023, Номер 179, С. 112253 - 112253
Опубликована: Июль 13, 2023
Frailty is a common geriatric syndrome characterized by increased vulnerability and associated with adverse clinical events such as falls, hospitalization, death. Early diagnosis early intervention can delay or reverse frailty ensure the healthy aging of older individuals. At present, there are no gold standard biomarkers for frailty, which mainly relies on scale to assess has shortcomings lagging assessment, subjectivity, poor consistency. help in frailty. The purpose this review summarize existing inflammatory markers focus novel that be used identify explore potential targets.
Язык: Английский
Процитировано
28
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115147 - 115147
Опубликована: Июль 18, 2023
With global population aging, age-related diseases, especially sarcopenia, have attracted much attention in recent years. Characterized by low muscle strength, quantity or quality and physical performance, sarcopenia is one of the major factors associated with an increased risk falls disability. Much effort has been made to understand cellular biological physiological mechanisms underlying sarcopenia. Autophagy important self-protection mechanism that relies on lysosomes degrade misfolded proteins damaged organelles. Research designed obtain new insight into human diseases from autophagic aspect carried out progress, which encourages relevant studies relationship between autophagy plays a protective role modulating regenerative capability satellite cells, relieving oxidative stress suppressing inflammatory response. This review aims reveal specific interaction explore possible therapies hopes encouraging more research need unlocking novel promising ameliorate
Язык: Английский
Процитировано
24
Immunity & Ageing, Год журнала: 2024, Номер 21(1)
Опубликована: Янв. 6, 2024
Abstract Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and considered an important indicator of adverse events in older population. Therefore, there growing interest early diagnosis intervention frailty, but cellular mechanisms responsible for frailty are still not completely understood. Chronic inflammation related to function increased disease risk. Additionally, multiple human animal studies suggest that probably plays largest role contributing frailty. Some inflammatory markers have been proposed predict However, large gaps knowledge clinical application these frail patients. understanding biological processes identifying recognized reliable urgent pivotal tasks geriatricians. In present review, we broadly summarize may potential diagnostic therapeutic use, thereby translating them into people near future.
Язык: Английский
Процитировано
15