Clinical and Experimental Pharmacology and Physiology,
Год журнала:
2024,
Номер
51(12)
Опубликована: Окт. 30, 2024
Senescence
impairs
liver
physiology,
mitochondrial
function
and
circadian
regulation,
resulting
in
systemic
metabolic
dysregulation.
Given
the
limited
research
on
effects
of
combined
exercise
an
ageing
liver,
this
study
aimed
to
evaluate
its
impact
metabolism,
rhythms
senescence-accelerated
mouse-prone
8
(SAMP8)
mouse-resistant
1
(SAMR1)
mice.
Histological,
reverse
transcription
quantitative
polymerase
chain
reaction
(RT-qPCR)
immunoblotting
analyses
were
conducted,
supplemented
by
transcriptomic
data
sets
AML12
hepatocyte
studies.
Sedentary
SAMP8
mice
exhibited
decreased
muscle
strength,
reduced
complex
I
levels
increased
lipid
droplet
accumulation.
In
contrast,
mitigated
strength
loss,
upregulated
proteins
involved
complexes
(CIII,
CIV,
CV)
Bmal1
messenger
RNA
(mRNA)
expression
liver.
These
molecular
adaptations
are
associated
with
healthier
phenotypes
may
influence
cellular
longevity.
Notably,
elevated
content
aged
was
post-exercise,
indicating
benefits
even
after
a
relatively
short
intervention.
The
regimen
did
not
improve
aerobic
capacity,
likely
due
low
volume
brief
duration
running.
Moreover,
no
significant
observed
SAMR1
mice,
possibly
because
training
intensity
insufficient
for
younger,
animals.
findings
underscore
potential
endurance
attenuate
age-related
dysfunction,
particularly
populations.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Март 1, 2024
Abstract
Peroxisome
proliferator-activated
receptor
gamma
coactivator-1
(PGC-1)
family
(PGC-1s),
consisting
of
three
members
encompassing
PGC-1α,
PGC-1β,
and
PGC-1-related
coactivator
(PRC),
was
discovered
more
than
a
quarter-century
ago.
PGC-1s
are
essential
coordinators
many
vital
cellular
events,
including
mitochondrial
functions,
oxidative
stress,
endoplasmic
reticulum
homeostasis,
inflammation.
Accumulating
evidence
has
shown
that
implicated
in
diseases,
such
as
cancers,
cardiac
diseases
cardiovascular
neurological
disorders,
kidney
motor
system
metabolic
disorders.
Examining
the
upstream
modulators
co-activated
partners
identifying
critical
biological
events
modulated
by
downstream
effectors
contribute
to
presentation
elaborate
network
PGC-1s.
Furthermore,
discussing
correlation
between
well
summarizing
therapy
targeting
helps
make
individualized
precise
intervention
methods.
In
this
review,
we
summarize
basic
knowledge
regarding
molecular
regulatory
network,
discuss
physio-pathological
roles
human
review
application
PGC-1s,
diagnostic
prognostic
value
several
therapies
pre-clinical
studies,
suggest
directions
for
future
investigations.
This
presents
immense
potential
treatment
hopefully
facilitates
promotion
new
therapeutic
targets.
GeroScience,
Год журнала:
2023,
Номер
45(6), С. 3211 - 3239
Опубликована: Июль 26, 2023
Abstract
Physical
activity,
including
walking,
has
numerous
health
benefits
in
older
adults,
supported
by
a
plethora
of
observational
and
interventional
studies.
Walking
decreases
the
risk
or
severity
various
outcomes
such
as
cardiovascular
cerebrovascular
diseases,
type
2
diabetes
mellitus,
cognitive
impairment
dementia,
while
also
improving
mental
well-being,
sleep,
longevity.
Dose-response
relationships
for
walking
duration
intensity
are
established
adverse
outcomes.
Walking’s
favorable
effects
on
factors
attributed
to
its
impact
circulatory,
cardiopulmonary,
immune
function.
Meeting
current
physical
activity
guidelines
briskly
30
min
per
day
5
days
can
reduce
several
age-associated
diseases.
Additionally,
low-intensity
exercise,
exerts
anti-aging
helps
prevent
age-related
making
it
powerful
tool
promoting
healthy
aging.
This
is
exemplified
lifestyles
individuals
Blue
Zones,
regions
world
with
highest
concentration
centenarians.
other
activities
contribute
significantly
longevity
these
regions,
being
an
integral
part
their
daily
lives.
Thus,
incorporating
into
routines
encouraging
walking-based
interventions
be
effective
strategy
aging
all
populations.
The
goal
this
review
provide
overview
vast
consistent
evidence
supporting
specific
focus
discuss
outcomes,
prevention
Furthermore,
will
delve
molecular
cellular
mechanisms
aging,
providing
insights
underlying
biological
through
which
beneficial
effects.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 17, 2024
Mitochondria
plays
an
essential
role
in
regulating
cellular
metabolic
homeostasis,
proliferation/differentiation,
and
cell
death.
Mitochondrial
dysfunction
is
implicated
many
age-related
pathologies.
Evidence
supports
that
the
of
mitochondria
decline
mitochondrial
DNA
copy
number
negatively
affect
ovarian
aging.
However,
mechanism
aging
still
unclear.
Treatment
methods,
including
antioxidant
applications,
transplantation,
emerging
biomaterials,
advanced
technologies,
are
being
used
to
improve
function
restore
oocyte
quality.
This
article
reviews
key
evidence
research
updates
on
damage
pathogenesis
aging,
emphasizing
may
accelerate
lead
senescence
as
well
exploring
potential
methods
for
using
mechanisms
slow
down
Abstract
Cardiorespiratory
fitness
(CRF)
not
only
reflects
an
individual’s
capacity
to
perform
physical
activities
but
also
encapsulates
broader
effects
on
the
basic
biology
of
aging.
This
review
aims
summarize
evidence
influence
CRF
overall
and
site-specific
cancer
risks.
It
delves
into
biological
mechanisms
through
which
may
exert
its
effects,
explores
clinical
implications
these
findings,
identifies
gaps
in
current
base,
suggests
directions
for
future
research.
The
synthesis
findings
reveals
that
higher
levels
(general
threshold
>
7
METs)
are
consistently
associated
with
a
reduced
risk
range
cancers,
including
head
neck,
lung,
breast,
gastrointestinal,
particularly
pancreatic
colorectal,
bladder,
incidence
mortality,
potentially
stomach
liver,
bile
duct,
gall
bladder
cancers.
These
inverse
associations
between
do
generally
differ
across
age
groups,
sex,
race,
or
adiposity,
suggesting
universal
protective
effect
CRF.
Nonetheless,
linking
skin,
mouth
pharynx,
kidney,
endometrial
cancers
is
limited
inconclusive.
Conversely,
be
linked
increased
prostate
hematological
malignancies,
such
as
leukemia
myeloma,
although
still
conclusive.
appears
play
significant
role
reducing
several
various
mechanisms,
inflammation
reduction,
immune
system
enhancement,
hormonal
regulation,
metabolic
improvements.
Overall,
enhancing
regular
activity
offers
vital,
accessible
strategy
extending
health
span.
Future
research
should
aim
fill
existing
regarding
specific
elucidate
detailed
dose–response
relationships
risk.
Studies
needed
causal
mechanistic
pathways
outcomes.
Frontiers in Reproductive Health,
Год журнала:
2024,
Номер
6
Опубликована: Июль 18, 2024
On
a
global
scale,
15%
of
couples
experience
infertility.
Approximately
50%
these
cases
refer
to
male
This
literature
review
investigated
the
effects
exercise
activities
on
fertility
and
reproductive
health.
subject
was
explored
using
studies
conducted
human
animal
models.
Physical
activity
is
widely
recognized
improve
overall
well-being,
but
engaging
in
excessive
might
potentially
lead
infertility
due
negative
impact
hypothalamic-pituitary-testicular
(HPT)
function,
increased
oxidative
stress,
presence
chronic
inflammation.
Infertility
result
from
fundamental
factors
that
induce
decline
testosterone
production
semen
quality.
has
potential
strategy
enhance
caused
by
obesity
diabetes.
Exercise
enhances
spermatogenesis
quality
lifestyle-induced
increasing
testicular
antioxidant
defense,
reducing
pro-inflammatory
cytokines,
promoting
steroidogenesis.
