Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies DOI Creative Commons
Emanuele F. Osimo, Luke Baxter, Jan Štochl

и другие.

Schizophrenia, Год журнала: 2021, Номер 7(1)

Опубликована: Май 28, 2021

Abstract Meta-analyses of cross-sectional studies suggest that patients with psychosis have higher circulating levels C-reactive protein (CRP) compared healthy controls; however, cause and effect is unclear. We examined the prospective association between CRP subsequent risk developing a psychotic disorder by conducting systematic review meta-analysis population-based cohort studies. Databases were searched for psychosis. obtained unpublished results, including adjustment age, sex, body mass index, smoking, alcohol use, socioeconomic status suspected infection (CRP > 10 mg/L). Based on random 89,792 participants (494 incident cases at follow-up), pooled odds ratio (OR) high (>3 mg/L), as to low (≤3 mg/L) baseline was 1.50 (95% confidence interval [CI], 1.09–2.07). Evidence this remained after adjusting potential confounders (adjusted OR [aOR] = 1.31; 95% CI, 1.03–1.66). After excluding infection, 1.36 1.06–1.74), but attenuated controlling (aOR 1.23; 0.95–1.60). Using continuous variable, per standard deviation increase in log(CRP) 1.11 0.93–1.34), further 1.07; 0.90–1.27) 0.92–1.24). There no using categorical variable (low, medium or high). While we provide some evidence longitudinal psychosis, larger are required enable definitive conclusions.

Язык: Английский

The IL-2A receptor pathway and its role in lymphocyte differentiation and function DOI

Yuqian Li,

Xue Li,

Xiaokun Geng

и другие.

Cytokine & Growth Factor Reviews, Год журнала: 2022, Номер 67, С. 66 - 79

Опубликована: Июль 2, 2022

Язык: Английский

Процитировано

31
Applications of Mendelian randomization in psychiatry: a comprehensive systematic review DOI Creative Commons
Luigi F. Saccaro,

Simone Gasparini,

Grazia Rutigliano

и другие.

Psychiatric Genetics, Год журнала: 2022, Номер 32(6), С. 199 - 213

Опубликована: Окт. 20, 2022

Psychiatric diseases exact a heavy socioeconomic toll, and it is particularly difficult to identify their risk factors causative mechanisms due multifactorial nature, the limited physiopathological insight, many confounding factors, potential reverse causality between psychiatric diseases. These characteristics make Mendelian randomization (MR) precious tool for studying these disorders. MR an analytical method that employs genetic variants linked certain factor, assess if observational association factor health outcome compatible with causal relationship. We report first systematic review of all existing applications findings in disorders, aiming at facilitating identification may be common different diseases, paving way transdiagnostic studies psychiatry, which are currently lacking. searched Web Knowledge, Scopus, Pubmed databases (until 3 May 2022) articles on psychiatry. The protocol was preregistered PROSPERO (CRD42021285647). included methodological details results from 50 articles, mainly schizophrenia, major depression, autism spectrum bipolar disorder. While this shows how can offer unique opportunities unraveling links etiological elements specific transdiagnostically, some flaws literature limit reliability probably underlie heterogeneity. highlight perspectives recommendations future works

Язык: Английский

Процитировано

31
Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review DOI Creative Commons
Javier Quintero,

José Ramón Gutiérrez-Casares,

Cecilio Álamo

и другие.

Neurology and Therapy, Год журнала: 2022, Номер 11(4), С. 1489 - 1517

Опубликована: Авг. 11, 2022

Attention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset neurodevelopmental characterised by persistent inattention, hyperactivity and impulsivity. Moreover, ADHD commonly associated with other comorbid diseases (depression, anxiety, bipolar disorder, etc.). The symptomatology interferes subject function development. treatment of requires multidisciplinary approach based on combination non-pharmacological pharmacological treatments the aim ameliorating symptomatology; among first-line are stimulants [such as methylphenidate (MPH) lisdexamfetamine dimesylate (LDX)]. In this review we explored recent ADHD- stimulants-related literature, compiling available descriptions molecular pathways altered in ADHD, mechanisms current MPH LDX. While conducting narrative review, applied structured search strategies covering PubMed/MEDLINE database performed handsearching reference lists results those searches. aetiology pathophysiology incompletely understood; both genetic environmental factors have been its grade burden, also relationship between their clinical implications. lack comprehensive understanding underlying pathology makes diagnosis difficult. Few published studies evaluating data mechanism action (MoA) LDX most them animal models. Further necessary to improve knowledge how MoAs differentially modulate control symptomatology.

Язык: Английский

Процитировано

28
Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells DOI Creative Commons
Amalie C.M. Couch, Shiden Solomon, Rodrigo R. R. Duarte

и другие.

Brain Behavior and Immunity, Год журнала: 2023, Номер 110, С. 43 - 59

Опубликована: Фев. 11, 2023

Prenatal exposure to elevated interleukin (IL)-6 levels is associated with increased risk for psychiatric disorders a putative neurodevelopmental origin, such as schizophrenia (SZ), autism spectrum condition (ASC) and bipolar disorder (BD). Although rodent models provide causal evidence this association, we lack detailed understanding of the cellular molecular mechanisms in human model systems. To close gap, characterized response induced pluripotent stem cell (hiPSC-)derived microglia-like cells (MGL) neural progenitor (NPCs) IL-6 monoculture. We observed that forebrain NPCs did not respond acute monoculture at both protein transcript due absence IL6R expression soluble (s)IL6Ra secretion. By contrast, resulted STAT3 phosphorylation IL6, JMJD3 IL10 MGL, confirming activation canonical IL6Ra signaling. Bulk RNAseq identified 156 up-regulated genes (FDR < 0.05) MGL following exposure, including IRF8, REL, HSPA1A/B OXTR, which significantly overlapped an gene set from post-mortem brain tissue individuals schizophrenia. Acute stimulation motility, consistent ontology pathways highlighted data replicating indications IRF8 regulates microglial motility. Finally, induces MGLs secrete CCL1, CXCL1, MIP-1α/β, IL-8, IL-13, IL-16, IL-18, MIF Serpin-E1 after 3h 24h. Our specific effects system, ultimately suggesting microglia-NPC co-culture are required study how influences cortical development vitro.

Язык: Английский

Процитировано

20
Associations between plasma inflammatory markers and psychotic disorder, depressive disorder and generalised anxiety disorder in early adulthood: A nested case-control study DOI Creative Commons
David Mongan, Subash Raj Susai, Melanie Föcking

и другие.

Brain Behavior and Immunity, Год журнала: 2023, Номер 111, С. 90 - 100

Опубликована: Март 31, 2023

Low-grade inflammation may occur in association with several mental disorders of early adulthood, though associations markers chronic such as soluble urokinase plasminogen activator receptor (suPAR) are less well-established. We aimed to examine between acute and inflammatory disorders, well psychiatric co-morbidity, young adults aged 24 years the Avon Longitudinal Study Parents Children.Included were 781 participants (of 4019 who attended at age years) completed assessments provided plasma samples. Of these, 377 met criteria for psychotic disorder, depressive disorder or generalised anxiety 404 did not. Plasma concentrations IFN-γ, IL-6, IL-8, IL-10, TNF-α, CRP, sVCAM1, sICAM1, suPAR alpha-2-macroglobulin measured using immunoassays. Logistic regression compared standardised marker levels cases controls. Negative binomial evaluated co-morbidity (number disorders). Models adjusted sex, body mass index, cigarette smoking, cannabis use employment status, then additionally childhood trauma.For there was evidence IL-6 (odds ratio[OR] 1.68, 95 %CI 1.20-2.34) (OR 1.74, 1.17-2.58). There weaker an 1.31, 1.05-1.62). little disorder. weak (β 0.10, 0.01-0.19). additional confounding by trauma.There that 24-year-olds had raised These findings have implications regarding role adulthood.

Язык: Английский

Процитировано

17
Gut microbiota decreased inflammation induced by chronic unpredictable mild stress through affecting NLRP3 inflammasome DOI Creative Commons

Li Huang,

Zewei Ma,

Xiaolei Ze

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Май 24, 2023

Dysbiosis of the gut microbiota is associated with development depression, but underlying mechanism remains unclear. The aim this study was to determine relationship between and NLRP3 inflammasome induced by chronic unpredictable mild stress (CUMS). Fecal transplantation (FMT) experiment conducted elucidate potential mechanism. Levels inflammasome, microbiota, inflammatory factors tight junction proteins were measured. CUMS stimulation significantly increased levels NLRP3, Caspase-1 ASC in brain colon( p &lt;0.05), decreased Occludin ZO-1 ( &lt;0.05). Interestingly, cytokines found antibiotic-treated (Abx) rats received rat fecal transplantation. Furthermore, altered Abx rats, which partially overlapped that donor rats. Importantly, probiotic administration amended alteration treatment, then reduced factors. In conclusion, these findings suggested depression-like behaviors related broke intestinal barrier, promoted expression elevated inflammation. Therefore, improving composition via can attenuate inflammation amending suppressing activation considered as a novel therapeutic strategy for depression.

Язык: Английский

Процитировано

17
Effect of statins on sepsis and inflammatory factors: A Mendelian randomization study DOI Creative Commons
Kai Zhang, Wei Liu, H M Liang

и другие.

European Journal of Clinical Investigation, Год журнала: 2024, Номер 54(5)

Опубликована: Янв. 16, 2024

Abstract Background As inhibitors of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR), statins can reduce the synthesis low‐density lipoptrotein cholesterol (LDL‐C), and are clinically used as first‐line lipid‐lowering drugs to prevent cardiovascular diseases. However, effect on sepsis is controversial. Therefore, we intend explore effects inflammatory factors through Mendelian randomization (MR). Method We obtained sepsis, factors, LDL‐C data from open free genome‐wide association study (GWAS) for subsequent analysis. Inverse‐variance weighted (IVW) was main method, MR‐Egger, MR‐PRESSO Cochrane's Q ‐test were sensitive analysis evaluate robustness MR results. Results Statins associated with a reduced risk under 75 (sepsis in individuals years old) (OR: .716, 95% CI: .572–.896, p = .003), elevated circulating IL‐18 .762, .643–.903, .002) CCL2 .416, .279–.620, 1.685e −5 ). Conclusion may have protective this provide new idea treatment sepsis.

Язык: Английский

Процитировано

7
Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain DOI Creative Commons
Linn Sofie Sæther, Attila Szabó, Ibrahim A. Akkouh

и другие.

Brain Behavior and Immunity, Год журнала: 2024, Номер 118, С. 287 - 299

Опубликована: Март 8, 2024

Recent findings link cognitive impairment and inflammatory-immune dysregulation in schizophrenia (SZ) bipolar (BD) spectrum disorders. However, heterogeneity translation between the periphery central (blood-to-brain) mechanisms remains a challenge. Starting with large SZ, BD healthy control cohort (n = 1235), we aimed to i) identify candidate peripheral markers 25) associated domains 9) elucidate heterogenous immune-cognitive patterns, ii) evaluate regulation of using human induced pluripotent stem cell (iPSC)-derived astrocytes neural progenitor cells 10), iii) marker messenger RNA expression leukocytes microarray available data from subsample main 776), RNA-sequencing deconvolution analysis postmortem brain samples 474) CommonMind Consortium (CMC). We identified transdiagnostic subgroups based on covariance (measures speed verbal learning) reflecting inflammatory response (CRP, sTNFR1, YKL-40), innate immune activation (MIF) extracellular matrix remodelling (YKL-40, CatS). Of there was considerable variance secretion YKL-40 iPSC-derived SZ compared HC. Further, provide evidence dysregulated genes encoding related signalling pathways high neuroinflammatory subgroup samples. Our suggest relationship activity impairment, highlight as potential functioning individuals severe mental illness.

Язык: Английский

Процитировано

7
Immuno-metabolic depression: from concept to implementation DOI Creative Commons
Brenda W.J.H. Penninx, Femke Lamers, Rick Jansen

и другие.

The Lancet Regional Health - Europe, Год журнала: 2024, Номер 48, С. 101166 - 101166

Опубликована: Дек. 18, 2024

Язык: Английский

Процитировано

6
Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes DOI Creative Commons
Paris Alexandros Lalousis, Lianne Schmaal, Stephen J. Wood

и другие.

Biological Psychiatry, Год журнала: 2022, Номер 92(7), С. 552 - 562

Опубликована: Апрель 12, 2022

Язык: Английский

Процитировано

27