Abstract
Spider
silk,
possessing
exceptional
combination
properties,
is
classified
as
a
bio‐gel
fiber.
Thereby,
it
serves
valuable
origin
of
inspiration
for
the
advancement
various
artificial
gel
fiber
materials
with
distinct
functionalities.
Gel
fibers
exhibit
promising
potential
utilization
in
diverse
fields,
including
smart
textiles,
muscle,
tissue
engineering,
and
strain
sensing.
However,
there
are
still
numerous
challenges
improving
performance
functionalizing
applications
spider
silk‐inspired
fibers.
Thus,
to
gain
penetrating
insight
into
bioinspired
fibers,
this
review
provided
comprehensive
overview
encompassing
three
key
aspects:
fundamental
design
concepts
implementing
strategies
properties
strengthening
functionalities
application
prospects
In
particular,
multiple
toughening
mechanisms
were
introduced
at
micro,
nano,
molecular‐level
structures
Additionally,
existing
summarized.
This
aims
offer
significant
guidance
development
inspire
further
research
field
high‐performance
Polymers for Advanced Technologies,
Год журнала:
2022,
Номер
34(2), С. 520 - 530
Опубликована: Ноя. 15, 2022
Abstract
Wound
healing
has
always
been
a
great
challenge
throughout
human
history.
Today,
with
substantial
rise
in
chronic
diseases
and
surgical
operations,
there
is
more
demand
for
wound
dressings
to
facilitate
the
process.
Modern
come
different
forms
offer
significant
advantages
over
traditionally
used
passive
bandages
by
inhibiting
microbial
activity
providing
suitable
moist
environment
wound.
Despite
their
widespread
clinical
usage
successful
results
treatment,
even
modern
cannot
promote
as
expected
since
they
are
not
responsive
conditions.
On
other
hand,
smart
can
interact
through
built‐in
sensors
respond
needs.
They
monitor
changes
stages
provide
insightful
information
that
could
affect
treatment
direction.
The
current
manuscript
reviews
evolution
of
from
ancient,
traditional
presents
advanced
class
future
trend
field.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Авг. 26, 2023
Bacterial
infections,
especially
those
caused
by
drug-resistant
bacteria,
have
seriously
threatened
human
life
and
health.
There
is
urgent
to
develop
new
antibacterial
agents
reduce
the
problem
of
antibiotics.
Biomedical
materials
with
good
antimicrobial
properties
been
widely
used
in
applications.
Among
them,
hydrogels
become
focus
research
field
biomedical
due
their
unique
three-dimensional
network
structure,
high
hydrophilicity,
biocompatibility.
In
this
review,
latest
progresses
about
recent
years
were
summarized,
mainly
including
preparation
methods
According
different
mechanisms,
several
representative
introduced,
such
as
antibiotics
loaded
hydrogels,
antibiotic-free
metal-based
peptide
polymers,
stimuli-responsive
smart
light-mediated
hydrogels.
addition,
we
also
discussed
applications
challenges
biomedicine,
which
are
expected
provide
directions
ideas
for
application
clinical
therapy.
Materials & Design,
Год журнала:
2023,
Номер
237, С. 112623 - 112623
Опубликована: Дек. 30, 2023
The
treatment
of
tenacious
diabetic
wounds
still
remains
an
enormous
challenge
in
clinics,
originated
from
the
complicated
pathological
microenvironment
wound
sites.
Therefore,
it's
urgently
required
to
develop
one
type
innovative
dressing
patch
with
appropriate
microstructure
and
multifunctions
regulate
promote
regeneration
wounds.
In
this
study,
novel
gelatin
(Gel)/poly
(L-lactic
acid)
(PLLA)
nanofibrous
yarns
loading
or
without
Salvia
miltiorrhiza
Bunge-Radix
Puerariae
herbal
compound
(SRHC)
are
fabricated
by
using
our
modified
electrospinning
strategy,
which
further
interlaced
into
woven
fabrics
respectively,
serving
as
biofunctional
patches
for
potential
application.
actual
photographs
SEM
images
confirm
that
all
different
textiles
SRHC
exhibited
a
uniform
interwoven
structure
warp
weft,
internal
nanofibers
present
bead-free
morphology
uniaxially
oriented
along
longitudinal
axis
yarns.
Moreover,
demonstrated
possess
strong
mechanical
properties
great
surface
wettability.
vitro
cell
characterization
shows
addition
can
significantly
attachment
proliferation
human
dermal
fibroblasts
(HDFs),
also
dramatically
inhibit
secretion
levels
proinflammatory
factors
M1
macrophages.
vivo
mouse
full-thickness
skin
model
experiments
reveal
as-developed
SRHC-loaded
Gel/PLLA
textile
best
performances
referring
short
healing
time
(100
%
closure
after
18
days
treatment)
high-quality
(i.e.,
enhance
collagen
deposition,
improve
re-epithelialization
neovascularization,
increase
hair
follicles),
assuredly
finds
interests
hard-to-heal
ACS Nano,
Год журнала:
2024,
Номер
18(5), С. 4269 - 4286
Опубликована: Янв. 25, 2024
The
repair
of
diabetic
wounds
remains
challenging,
primarily
due
to
the
high-glucose-derived
immune
inhibition
which
often
leads
excessive
inflammatory
response,
impaired
angiogenesis,
and
heightened
susceptibility
infection.
However,
means
reduce
immunosuppression
regulate
conversion
M2
phenotype
macrophages
under
a
high-glucose
microenvironment
using
advanced
biomaterials
for
are
not
yet
fully
understood.
Herein,
we
report
two-dimensional
carbide
(MXene)-M2
macrophage
exosome
(Exo)
nanohybrids
(FM-Exo)
promoting
wound
by
overcoming
inhibition.
FM-Exo
showed
sustained
release
macrophage-derived
exosomes
(M2-Exo)
up
7
days
exhibited
broad-spectrum
antibacterial
activity.
In
microenvironment,
relative
single
Exo,
could
significantly
induce
optimized
M2a/M2c
polarization
ratio
activating
PI3K/Akt
signaling
pathway,
proliferation,
migration
fibroblasts,
angiogenic
ability
endothelial
cells.
full-thickness
model,
effectively
regulated
status
promoted
their
transition
phenotype,
thereby
inhibiting
inflammation,
angiogenesis
through
VEGF
secretion,
improving
proper
collagen
deposition.
As
result,
healing
process
was
accelerated,
leading
better
outcome
with
reduced
scarring.
Therefore,
this
study
introduced
promising
approach
address
developing
bioactive
nanomaterials
in
environment.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(11), С. 13563 - 13572
Опубликована: Март 7, 2024
Antibacterial
hydrogels
have
emerged
as
a
promising
approach
for
effective
wound
treatment.
However,
despite
extensive
research
on
the
fabrication
of
antibacterial
hydrogels,
it
remains
challenging
to
develop
injectable,
biocompatible,
transparent,
and
mass-producible
with
properties.
In
this
study,
we
successfully
fabricated
an
drug-loaded
composite
hydrogel,
named
CC45/OKG40/HS,
through
Schiff
base
reaction
between
carboxymethyl
chitosan
(CC)
oxidized
konjac
glucomannan
(OKG),
followed
by
encapsulation
stevioside-stabilized
honokiol
(HS)
micelles.
The
CC45/OKG40/HS
hydrogel
exhibited
several
favorable
properties,
including
short
gel
time
(<10
min),
high
water
content
(>92%),
injectability,
good
adhesiveness,
self-healing
ability,
transparency.
vitro
experiments
confirmed
its
excellent
antioxidant
activities,
biocompatibility
(no
cytotoxicity,
hemolysis
ratio
<5%).
Furthermore,
in
vivo
evaluation
demonstrated
that
CC45/OKG40/HS0.5
accelerated
healing
relieving
inflammatory
responses
enhancing
re-epithelization.
Given
feasibility
mass
production,
findings
showed
has
potential
advanced
dressing
commercial
use.
Pharmaceutics,
Год журнала:
2024,
Номер
16(1), С. 93 - 93
Опубликована: Янв. 10, 2024
Wounds
and
chronic
wounds
can
be
caused
by
bacterial
infections
lead
to
discomfort
in
patients.
To
solve
this
problem,
scientists
are
working
create
modern
wound
dressings
with
antibacterial
additives,
mainly
because
traditional
materials
cannot
meet
the
general
requirements
for
complex
promote
healing.
This
demand
is
met
material
engineering,
through
which
we
electrospun
dressings.
Electrospun
dressings,
as
well
those
based
on
hydrogels
incorporated
compounds,
these
requirements.
manuscript
reviews
recent
used
discussing
their
formation,
application,
functionalization.
The
focus
presenting
hydrogels.
In
contrast,
advancements
care
have
highlighted
potential
of
thermoresponsive
dynamic
These
contain
adaptable
polymers
that
offer
targeted
drug
delivery
show
promise
managing
various
types
while
addressing
infections.
way,
article
intended
serve
a
compendium
knowledge
researchers,
medical
practitioners,
biomaterials
engineers,
providing
up-to-date
information
state
art,
possibilities
innovative
solutions,
challenges
area
Molecules,
Год журнала:
2023,
Номер
28(15), С. 5931 - 5931
Опубликована: Авг. 7, 2023
Diffusion
is
one
of
the
key
nature
processes
which
plays
an
important
role
in
respiration,
digestion,
and
nutrient
transport
cells.
In
this
regard,
present
article
aims
to
review
various
diffusion
approaches
used
fabricate
different
functional
materials
based
on
hydrogels,
unique
examples
that
control
diffusion.
They
have
found
applications
fields
such
as
drug
encapsulation
delivery,
delivery
agriculture,
developing
for
regenerative
medicine,
creating
stimuli-responsive
soft
robotics
microrobotics.
addition,
mechanisms
release
kinetics
tools
material
design
are
discussed.
