Materials Today Sustainability, Год журнала: 2024, Номер 27, С. 100865 - 100865
Опубликована: Май 27, 2024
Язык: Английский
Small, Год журнала: 2023, Номер 20(5)
Опубликована: Сен. 26, 2023
Abstract Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from worldwide. The prevalence pathogens has led to a significant increase in medical costs poses great threat normal life people. This is an important issue field biomedicine, emergence new antimicrobial materials hydrogels holds promise for solving this problem. Hydrogel material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, controlled release drugs as well structural diversity. Bacteria‐disturbing have applications direction surgical treatment, wound dressing, device coating, tissue engineering. paper reviews classification hydrogels, current status research, potential one application analyzes research biomedical five aspects: metal‐loaded drug‐loaded carbon‐material‐loaded fixed activity biological provides outlook high activity, biodegradability, injectability, clinical applicability future development prospects field.
Язык: Английский
Процитировано
55
Biomaterials, Год журнала: 2024, Номер 312, С. 122718 - 122718
Опубликована: Июль 27, 2024
Functional hydrogels are used for numerous biomedical applications such as tissue engineering, wound dressings, lubricants, contact lenses and advanced drug delivery systems. Most of them based on synthetic or natural polymers forming a three-dimensional network that contains aqueous media. Among polymers, poly(meth)acrylates, polyethyleneglycols, poly(vinylalcohols), poly(vinylpyrrolidones), PLGA poly(urethanes) high relevance, whereas mainly polysaccharides hyaluronic acid, alginate chitosan proteins albumin, collagen elastin. In contrast to most biodegradable. Both often chemically modified in order improve induce favorable properties functions like mechanical strength, stiffness, elasticity, porosity, adhesive properties, situ gelling water binding capacity release controlling properties. Within this review we provide an overview about the broad spectrum functional hydrogels, summarize innovative approaches, discuss concept relevant clinical trials highlight products examples successful developments.
Язык: Английский
Процитировано
50
Bioactive Materials, Год журнала: 2024, Номер 37, С. 206 - 221
Опубликована: Март 21, 2024
With the development of nanomedicine, nanomaterials have been widely used, offering specific drug delivery to target sites, minimal side effects, and significant therapeutic effects. The kidneys filtration reabsorption functions, with various potential cell types a complex structural environment, making strategies for kidney function protection recovery after injury complex. This also lays foundation application nanomedicine in diseases. Currently, evidence preclinical clinical settings supports feasibility targeted therapy diseases using based on nanomaterials. prerequisite treating is use carriers good biocompatibility, including nanoparticles, hydrogels, liposomes, micelles, dendrimer polymers, adenoviruses, lysozymes, elastin-like polypeptides. These precise renal uptake, longer half-life, organ distribution, protecting improving efficacy drugs they carry. Additionally, attention should be paid toxicity solubility carriers. While mentioned above used studies both vivo vitro, extensive trials are still needed ensure short-term long-term effects nano human body. review will discuss advantages limitations nanoscale carrier materials diseases, provide more comprehensive catalog nanocarrier materials, offer prospects their drug-loading applications.
Язык: Английский
Процитировано
39
Bioactive Materials, Год журнала: 2023, Номер 31, С. 315 - 332
Опубликована: Авг. 22, 2023
Surgical resection remains the prefer option for bladder cancer treatment. However, effectiveness of surgery is usually limited high recurrence rate and poor prognosis. Consequently, intravesical chemotherapy synergize with immunotherapy in situ an attractive way to improve therapeutic effect. Herein, a combined strategy based on thermo-sensitive PLEL hydrogel drug delivery system was developed. GEM loaded instilled kill tumor cells directly, then incorporated CpG injected into both groins subcutaneously promote immune responses GEM. The results demonstrated that had sol-gel phase transition behavior response physiological temperature presented sustained release, PLEL-assisted combination therapy could have better suppression effect stronger immunostimulating vivo. Hence, this treatment has great potential suggests clinically-relevant valuable cancer.
Язык: Английский
Процитировано
26
Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(3), С. 100911 - 100911
Опубликована: Апрель 14, 2024
Precision therapy has become the preferred choice attributed to optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse effects. Over past few years, sprayable or injectable thermosensitive hydrogels have exhibited high potential. These can be applied as cell-growing scaffolds drug-releasing reservoirs by simply mixing a free-flowing sol phase at room temperature. Inspired their unique properties, been widely delivery treatment platforms for precision medicine. In this review, state-of-the-art developments are investigated, which covers from thermo-gelling mechanisms main components biomedical applications, including wound healing, anti-tumor activity, osteogenesis, periodontal, sinonasal ophthalmic diseases. The most promising applications trends of also discussed light features.
Язык: Английский
Процитировано
12
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 132671 - 132671
Опубликована: Май 31, 2024
Язык: Английский
Процитировано
12
Journal of Controlled Release, Год журнала: 2024, Номер 370, С. 14 - 42
Опубликована: Апрель 17, 2024
Язык: Английский
Процитировано
11
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
The severe side effects of systemic chemotherapy for cervical cancer encourage the use topical intravaginal drug delivery systems. 5-fluorouracil, 5-FU, is an anticancer accepted in clinical therapy colorectal, gastric, and hepatocellular carcinoma. However, it shows low activity against cells (HeLa) thus requires usage additional drugs to support therapy, which associated with effects. We report on polyglycidol/polyacrylamide-based hydrogel carrier providing effective monotherapy cells, HeLa along a neutral effect normal HMEC-1. hyperbranched polyglycidol modified aryl groups, i.e., phenylurethane, 1,4-biphenylurethane, benzoyl ester, respectively, enhance solubility 5-FU aqueous medium ensured drug's efficacy selectivity Hela after 48 h at dose. Crucially, cross-linking drug-loaded aryl-enriched acrylamide copolymer bearing 2-acrylamidephenylboronic acid induced anticervical reducing time required complete cell death 24 h. An vitro study showed that boronic moieties are responsible promotion 5-FU. Reported hydrogels' structure based reversibly cross-linked HbPGLs provides self-healing properties network crucial formation continuous layer formulation ensuring afflicted area covered tissue. Among tested hydrogels, system constructed from HbPGL linear constitutional units were ester or phenylurethane approximately 45 mol % highest permeability through STRAT-M model membrane. This demonstrates direction synthetic design assuring safe avoiding typical combinatory therapies.
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2023, Номер 10(35)
Опубликована: Окт. 24, 2023
Abstract Patients with colorectal cancer (CRC) and diffuse peritoneal metastasis (PM) are not eligible for surgical intervention. Thus, palliative treatment remains the standard of care in clinical practice. Systemic chemotherapy fails to cause drug accumulation at lesion sites, while intraperitoneal (IPC) is limited by high clearance rates associated complications. Given poor prognosis, a customized OxP/R848@PLEL hydrogel delivery system has been devised improve benefit advanced CRC PM. This distinguished its simplicity, security, efficiency. Specifically, PLEL exhibits excellent injectability thermosensitivity, enabling formation depots within abdominal cavity, rendering it an optimal carrier IPC. Oxaliplatin (OxP), first‐line CRC, cytotoxic enhances immunogenicity tumors inducing immunogenic cell death. Furthermore, OxP resiquimod (R848) synergistically enhance maturation dendritic cells, promote expansion T lymphocytes, induce central memory cells. Moreover, R848 domesticates macrophages anti‐tumor phenotype. effectively eradicates metastases, completely inhibits ascites production, significantly prolongs mice lifespan. As such, provides promising approach managing PM patients without indications.
Язык: Английский
Процитировано
22
Bioactive Materials, Год журнала: 2024, Номер 39, С. 336 - 353
Опубликована: Май 25, 2024
While mild hyperthermia holds great potential in the treatment of solid tumors, thermal stress-triggered self-repairing autophagy significantly compromises its efficacy. To circumvent this obstacle, an injectable hydrogel (NO-Gel) composed thermosensitive poly(ethylene glycol)-polypeptide copolymers modified with abundant NO donors on their side chains is developed. Meanwhile, ferrimagnetic Zn
Язык: Английский
Процитировано
8