International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 828 - 828
Published: Jan. 19, 2025
With
the
widespread
use
of
lidocaine
for
pain
control
in
cancer
therapy,
its
antitumor
activity
has
attracted
considerable
attention
recent
years.
This
paper
provides
a
simple
strategy
combining
with
chemotherapy
drugs
aiming
to
relieve
chemotherapy-induced
and
achieve
stronger
efficacy.
However,
there
is
still
lack
substantial
pre-clinical
evidence
efficacy
related
mechanisms
such
combinations,
obstructing
their
potential
clinical
application.
In
this
study,
we
propose
intraperitoneal
(IPC)
against
gastric
(GC)
as
an
ideal
scenario
evaluate
lidocaine/paclitaxel
combination.
Firstly,
used
human
GC
cells
MKN-45-luc
investigate
combination
vitro.
Then,
C57BL/6
mice
drug
suffusion
suppress
paclitaxel-induced
hyperalgesia
mechanisms.
Lastly,
BALB/c
tumor-bearing
nude
evaluated
synergistic
pain-relieving
effect
Our
results
showed
enhanced
combination,
which
induced
apoptosis,
inhibited
migration,
invasion
manner.
animal
models,
effectively
growth
peritoneal
metastasis
tumor,
resulting
prolonged
survival
time.
Meanwhile,
anti-inflammatory
alongside
anesthetic
effect,
which,
relieved
by
paclitaxel.
These
suggested
that
could
be
pain-free
IPC
formulation
activity,
provide
promising
treatment
metastasis.
Small,
Journal Year:
2023,
Volume and Issue:
20(5)
Published: Sept. 26, 2023
Abstract
Microbial
infections
based
on
drug‐resistant
pathogenic
organisms
following
surgery
or
trauma
and
uncontrolled
bleeding
are
the
main
causes
of
increased
mortality
from
worldwide.
The
prevalence
pathogens
has
led
to
a
significant
increase
in
medical
costs
poses
great
threat
normal
life
people.
This
is
an
important
issue
field
biomedicine,
emergence
new
antimicrobial
materials
hydrogels
holds
promise
for
solving
this
problem.
Hydrogel
material
with
good
biocompatibility,
water
absorption,
oxygen
permeability,
adhesion,
degradation,
self‐healing,
corrosion
resistance,
controlled
release
drugs
as
well
structural
diversity.
Bacteria‐disturbing
have
applications
direction
surgical
treatment,
wound
dressing,
device
coating,
tissue
engineering.
paper
reviews
classification
hydrogels,
current
status
research,
potential
one
application
analyzes
research
biomedical
five
aspects:
metal‐loaded
drug‐loaded
carbon‐material‐loaded
fixed
activity
biological
provides
outlook
high
activity,
biodegradability,
injectability,
clinical
applicability
future
development
prospects
field.
Biomaterials,
Journal Year:
2024,
Volume and Issue:
312, P. 122718 - 122718
Published: July 27, 2024
Functional
hydrogels
are
used
for
numerous
biomedical
applications
such
as
tissue
engineering,
wound
dressings,
lubricants,
contact
lenses
and
advanced
drug
delivery
systems.
Most
of
them
based
on
synthetic
or
natural
polymers
forming
a
three-dimensional
network
that
contains
aqueous
media.
Among
polymers,
poly(meth)acrylates,
polyethyleneglycols,
poly(vinylalcohols),
poly(vinylpyrrolidones),
PLGA
poly(urethanes)
high
relevance,
whereas
mainly
polysaccharides
hyaluronic
acid,
alginate
chitosan
proteins
albumin,
collagen
elastin.
In
contrast
to
most
biodegradable.
Both
often
chemically
modified
in
order
improve
induce
favorable
properties
functions
like
mechanical
strength,
stiffness,
elasticity,
porosity,
adhesive
properties,
situ
gelling
water
binding
capacity
release
controlling
properties.
Within
this
review
we
provide
an
overview
about
the
broad
spectrum
functional
hydrogels,
summarize
innovative
approaches,
discuss
concept
relevant
clinical
trials
highlight
products
examples
successful
developments.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
37, P. 206 - 221
Published: March 21, 2024
With
the
development
of
nanomedicine,
nanomaterials
have
been
widely
used,
offering
specific
drug
delivery
to
target
sites,
minimal
side
effects,
and
significant
therapeutic
effects.
The
kidneys
filtration
reabsorption
functions,
with
various
potential
cell
types
a
complex
structural
environment,
making
strategies
for
kidney
function
protection
recovery
after
injury
complex.
This
also
lays
foundation
application
nanomedicine
in
diseases.
Currently,
evidence
preclinical
clinical
settings
supports
feasibility
targeted
therapy
diseases
using
based
on
nanomaterials.
prerequisite
treating
is
use
carriers
good
biocompatibility,
including
nanoparticles,
hydrogels,
liposomes,
micelles,
dendrimer
polymers,
adenoviruses,
lysozymes,
elastin-like
polypeptides.
These
precise
renal
uptake,
longer
half-life,
organ
distribution,
protecting
improving
efficacy
drugs
they
carry.
Additionally,
attention
should
be
paid
toxicity
solubility
carriers.
While
mentioned
above
used
studies
both
vivo
vitro,
extensive
trials
are
still
needed
ensure
short-term
long-term
effects
nano
human
body.
review
will
discuss
advantages
limitations
nanoscale
carrier
materials
diseases,
provide
more
comprehensive
catalog
nanocarrier
materials,
offer
prospects
their
drug-loading
applications.
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
31, P. 315 - 332
Published: Aug. 22, 2023
Surgical
resection
remains
the
prefer
option
for
bladder
cancer
treatment.
However,
effectiveness
of
surgery
is
usually
limited
high
recurrence
rate
and
poor
prognosis.
Consequently,
intravesical
chemotherapy
synergize
with
immunotherapy
in
situ
an
attractive
way
to
improve
therapeutic
effect.
Herein,
a
combined
strategy
based
on
thermo-sensitive
PLEL
hydrogel
drug
delivery
system
was
developed.
GEM
loaded
instilled
kill
tumor
cells
directly,
then
incorporated
CpG
injected
into
both
groins
subcutaneously
promote
immune
responses
GEM.
The
results
demonstrated
that
had
sol-gel
phase
transition
behavior
response
physiological
temperature
presented
sustained
release,
PLEL-assisted
combination
therapy
could
have
better
suppression
effect
stronger
immunostimulating
vivo.
Hence,
this
treatment
has
great
potential
suggests
clinically-relevant
valuable
cancer.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(3), P. 100911 - 100911
Published: April 14, 2024
Precision
therapy
has
become
the
preferred
choice
attributed
to
optimal
drug
concentration
in
target
sites,
increased
therapeutic
efficacy,
and
reduced
adverse
effects.
Over
past
few
years,
sprayable
or
injectable
thermosensitive
hydrogels
have
exhibited
high
potential.
These
can
be
applied
as
cell-growing
scaffolds
drug-releasing
reservoirs
by
simply
mixing
a
free-flowing
sol
phase
at
room
temperature.
Inspired
their
unique
properties,
been
widely
delivery
treatment
platforms
for
precision
medicine.
In
this
review,
state-of-the-art
developments
are
investigated,
which
covers
from
thermo-gelling
mechanisms
main
components
biomedical
applications,
including
wound
healing,
anti-tumor
activity,
osteogenesis,
periodontal,
sinonasal
ophthalmic
diseases.
The
most
promising
applications
trends
of
also
discussed
light
features.
The
severe
side
effects
of
systemic
chemotherapy
for
cervical
cancer
encourage
the
use
topical
intravaginal
drug
delivery
systems.
5-fluorouracil,
5-FU,
is
an
anticancer
accepted
in
clinical
therapy
colorectal,
gastric,
and
hepatocellular
carcinoma.
However,
it
shows
low
activity
against
cells
(HeLa)
thus
requires
usage
additional
drugs
to
support
therapy,
which
associated
with
effects.
We
report
on
polyglycidol/polyacrylamide-based
hydrogel
carrier
providing
effective
monotherapy
cells,
HeLa
along
a
neutral
effect
normal
HMEC-1.
hyperbranched
polyglycidol
modified
aryl
groups,
i.e.,
phenylurethane,
1,4-biphenylurethane,
benzoyl
ester,
respectively,
enhance
solubility
5-FU
aqueous
medium
ensured
drug's
efficacy
selectivity
Hela
after
48
h
at
dose.
Crucially,
cross-linking
drug-loaded
aryl-enriched
acrylamide
copolymer
bearing
2-acrylamidephenylboronic
acid
induced
anticervical
reducing
time
required
complete
cell
death
24
h.
An
vitro
study
showed
that
boronic
moieties
are
responsible
promotion
5-FU.
Reported
hydrogels'
structure
based
reversibly
cross-linked
HbPGLs
provides
self-healing
properties
network
crucial
formation
continuous
layer
formulation
ensuring
afflicted
area
covered
tissue.
Among
tested
hydrogels,
system
constructed
from
HbPGL
linear
constitutional
units
were
ester
or
phenylurethane
approximately
45
mol
%
highest
permeability
through
STRAT-M
model
membrane.
This
demonstrates
direction
synthetic
design
assuring
safe
avoiding
typical
combinatory
therapies.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(35)
Published: Oct. 24, 2023
Abstract
Patients
with
colorectal
cancer
(CRC)
and
diffuse
peritoneal
metastasis
(PM)
are
not
eligible
for
surgical
intervention.
Thus,
palliative
treatment
remains
the
standard
of
care
in
clinical
practice.
Systemic
chemotherapy
fails
to
cause
drug
accumulation
at
lesion
sites,
while
intraperitoneal
(IPC)
is
limited
by
high
clearance
rates
associated
complications.
Given
poor
prognosis,
a
customized
OxP/R848@PLEL
hydrogel
delivery
system
has
been
devised
improve
benefit
advanced
CRC
PM.
This
distinguished
its
simplicity,
security,
efficiency.
Specifically,
PLEL
exhibits
excellent
injectability
thermosensitivity,
enabling
formation
depots
within
abdominal
cavity,
rendering
it
an
optimal
carrier
IPC.
Oxaliplatin
(OxP),
first‐line
CRC,
cytotoxic
enhances
immunogenicity
tumors
inducing
immunogenic
cell
death.
Furthermore,
OxP
resiquimod
(R848)
synergistically
enhance
maturation
dendritic
cells,
promote
expansion
T
lymphocytes,
induce
central
memory
cells.
Moreover,
R848
domesticates
macrophages
anti‐tumor
phenotype.
effectively
eradicates
metastases,
completely
inhibits
ascites
production,
significantly
prolongs
mice
lifespan.
As
such,
provides
promising
approach
managing
PM
patients
without
indications.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(6)
Published: Dec. 1, 2023
Abstract
The
endometrium
is
a
unique
human
tissue
with
an
extraordinary
ability
to
undergo
hormone‐regulated
cycle
encompassing
shedding,
bleeding,
scarless
repair,
and
regeneration
throughout
the
female
reproductive
cycle.
cyclical
repair
of
manifest
as
changes
in
endometrial
epithelialization,
glandular
regeneration,
vascularization.
mechanisms
encompass
inflammation,
coagulation,
fibrinolytic
system
balance.
However,
specific
conditions
such
endometriosis
or
TCRA
treatment
can
disrupt
process
regeneration.
There
uncertainty
about
traditional
clinical
treatments'
efficacy
side
effects,
finding
new
therapeutic
interventions
essential.
Researchers
have
made
substantial
progress
perspective
regenerative
medicine
toward
maintaining
recent
years.
Such
encompasses
integration
biomaterials,
tissue‐engineered
scaffolds,
stem
cell
therapies,
3D
printing.
This
review
analyzes
mechanisms,
diseases,
associated
discusses
advantages
disadvantages
currently
employed
practice.
Additionally,
it
highlights
significant
this
domain.
Finally,
we
cells
biologics
among
available
medicine,
providing
insights
into
future
strategies.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
39, P. 336 - 353
Published: May 25, 2024
While
mild
hyperthermia
holds
great
potential
in
the
treatment
of
solid
tumors,
thermal
stress-triggered
self-repairing
autophagy
significantly
compromises
its
efficacy.
To
circumvent
this
obstacle,
an
injectable
hydrogel
(NO-Gel)
composed
thermosensitive
poly(ethylene
glycol)-polypeptide
copolymers
modified
with
abundant
NO
donors
on
their
side
chains
is
developed.
Meanwhile,
ferrimagnetic
Zn
