Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress DOI Creative Commons

Hurmat Malik,

Muhammad Usman, Mehreen Arif

и другие.

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Авг. 16, 2023

Introduction: Post-traumatic stress disorder (PTSD) is a chronic mental illness triggered by traumatic experiences such as wars, natural disasters, or catastrophes, and it characterized anxiety, depression cognitive impairment. Diosgenin steroidal sapogenin with known neuroprotective antioxidant properties. This study aimed to assess the pharmacological potential of diosgenin in single prolonged (SPS) model PTSD, plus other behavioral models along any consequent alterations brain neurochemistry male mice. Methodology: SPS was induced restraining animals for 2 h, followed 20 min forced swim, recuperation 15 min, finally, exposure ether induce anesthesia. The SPS-exposed were treated (20, 40, 60 mg/kg) compared positive controls, fluoxetine donepezil, then they observed changes anxiety/depression-like behaviors, After screening, postmortem serotonin, noradrenaline, dopamine, vitamin C, adenosine its metabolites inosine hypoxanthine quantified frontal cortex, hippocampus, striatum high-performance liquid chromatography. Additionally, animal serum screened corticosterone levels. Results: results showed that reversed anxiety- depression-like ameliorated impairment dose-dependent manner. restored monoamine C levels dose-dependently modulated regions. also reinstated otherwise increased Conclusion: findings suggest may be candidate improving symptoms PTSD.

Язык: Английский

Oxidative stress in Alzheimer’s disease: current knowledge of signaling pathways and therapeutics DOI

Rishika Dhapola,

Samir Kumar Beura,

Prajjwal Sharma

и другие.

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Янв. 2, 2024

Язык: Английский

Процитировано

64
Antioxidant and anti-inflammation effects of dietary phytochemicals: The Nrf2/NF-κB signalling pathway and upstream factors of Nrf2 DOI
Shujian Wu,

Xiyu Liao,

Zhenjun Zhu

и другие.

Phytochemistry, Год журнала: 2022, Номер 204, С. 113429 - 113429

Опубликована: Сен. 9, 2022

Язык: Английский

Процитировано

53
Oxygen metabolism abnormality and Alzheimer's disease: An update DOI Creative Commons
Guangdong Liu, Cui Yang,

Xin Wang

и другие.

Redox Biology, Год журнала: 2023, Номер 68, С. 102955 - 102955

Опубликована: Ноя. 8, 2023

Oxygen metabolism abnormality plays a crucial role in the pathogenesis of Alzheimer's disease (AD) via several mechanisms, including hypoxia, oxidative stress, and mitochondrial dysfunction. Hypoxia condition usually results from living high-altitude habitat, cardiovascular cerebrovascular diseases, chronic obstructive sleep apnea. Chronic hypoxia has been identified as significant risk factor for AD, showing an aggravation various pathological components such amyloid β-protein (Aβ) metabolism, tau phosphorylation, dysfunction, neuroinflammation. It is known that excessive hyperoxia can both result stress Oxidative dysfunction increase Aβ proteins lead to redox imbalance, thus forming vicious cycle exacerbating AD pathology. Hyperbaric oxygen therapy (HBOT) non-invasive intervention its capacity significantly enhance cerebral oxygenation levels, which attenuate aggregation, However, further investigation imperative determine optimal pressure, duration exposure, frequency HBOT sessions. In this review, we explore prospects with aim enhancing our understanding underlying molecular mechanisms AD. Current research aimed at attenuating abnormalities holds promise providing novel therapeutic approaches

Язык: Английский

Процитировано

26
Unveiling the impact of aging on BBB and Alzheimer's disease: Factors and therapeutic implications DOI
Niraj Kumar Jha, Niraj Kumar Jha, Mohana Vamsi Nuli

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102224 - 102224

Опубликована: Фев. 10, 2024

Язык: Английский

Процитировано

14
Injectable Hydrogel To Deliver Bone Mesenchymal Stem Cells Preloaded with Azithromycin To Promote Spinal Cord Repair DOI

Yujie Wan,

Yan Lin,

Tan Xie

и другие.

ACS Nano, Год журнала: 2024, Номер 18(12), С. 8934 - 8951

Опубликована: Март 14, 2024

Spinal cord injury is a disease that causes severe damage to the central nervous system. Currently, there no cure for spinal injury. Azithromycin commonly used as an antibiotic, but it can also exert anti-inflammatory effects by down-regulating M1-type macrophage genes and up-regulating M2-type genes, which may make effective treating Bone mesenchymal stem cells possess tissue regenerative capabilities help promote repair of injured cord. In this study, our objective was explore potential promoting in delivering bone had internalized nanoparticles preloaded with azithromycin. To achieve objective, we formulated azithromycin into along trans-activating transcriptional activator, should enhance nanoparticle uptake cells. These were then incorporated injectable hydrogel. The therapeutic formulation analyzed vitro using mouse microglial cell line human neuroblastoma line, well vivo rat model results showed exhibited neuroprotective vivo. highlight hydrogel containing activator mitigate repair.

Язык: Английский

Процитировано

12
The Effect of a Tribulus-Based Formulation in Alleviating Cholinergic System Impairment and Scopolamine-Induced Memory Loss in Zebrafish (Danio rerio): Insights from Molecular Docking and In Vitro/In Vivo Approaches DOI Creative Commons
Salwa Bouabdallah, Ion Brinza, Răzvan Ştefan Boiangiu

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(2), С. 200 - 200

Опубликована: Фев. 2, 2024

Tribulus terrestris L. (Tt) has been recently gaining attention for its pharmacological value, including neuroprotective activities. In this study, we explore the effects of a extract in zebrafish (Danio rerio) model scopolamine (SCOP)-induced memory impairment and brain oxidative stress. SCOP, an anticholinergic drug, was employed to replicate fundamental aspects Alzheimer’s disease (AD) animal models. The fish were treated with ethanolic leaf (ELE) from Tt (1, 3, 6 mg/L) 15 days. SCOP (100 µM) administered 30 min before behavioral tests conducted. Molecular interactions major compounds identified via UPLC-PDA/MS fractions active site acetylcholinesterase (AChE) explored molecular docking analyses. Terrestrosin C, protodioscin, rutin, saponin C exhibited most stable binding. spatial performance assessed using Y-maze test, recognition examined novel object (NOR) test. treatment reversed altered locomotion patterns that caused by administration. Biochemical analyses also verified Tt’s role inhibiting AChE, improving antioxidant enzyme activities, reducing stress markers. present findings pave way future application as natural alternative treat cognitive disorders.

Язык: Английский

Процитировано

11
A network pharmacology approach to reveal the key ingredients in Scrophulariae Radix (SR) and their effects against Alzheimer's disease DOI Creative Commons
Yingying Shi, Zhongqiang Chen,

Lixia Huang

и другие.

Heliyon, Год журнала: 2024, Номер 10(3), С. e24785 - e24785

Опубликована: Янв. 20, 2024

BackgroundScrophulariae Radix (SR) is a commonly used medicinal plant. Alzheimer's disease (AD) neurodegenerative for which there no effective treatment. This study aims to initially clarify the potential mechanism of SR in treatment AD based on network pharmacology and molecular docking techniques.MethodsThe principal components corresponding protein targets were conducted by HPLC analysis searched TCMSP. DrugBank, Chemogenomics, TTD, OMIM GeneCards databases. The compound-target was constructed Cytoscape3.8.2. intersection compound target obtained coincidence imported into STRING database construct PPI network. We further performed GO KEGG enrichment targets. Meanwhile, cell experiments approved core active compound.ResultsThrough multidatabase retrieval integration, it found that 17 could exert anti-AD effects against 40 indicated (hsa05010) one most significant signalling pathways. Combined with gene expression profile information AlzData database, 15 be associated tau or beta-amyloid (Aβ). primary functions neurotransmitter receptor activity (GO:0007268), postsynaptic (GO:0070997), acetylcholine (GO:0050435). Moreover, we explored extract ursolic acid (UA) using SH-SY5Y cells. Treatment cells 20 μM UA significantly reduced oxidative damage these neuronal cells.ConclusionThis reveals ingredients AD, provides theoretical basis basic research clinical application.

Язык: Английский

Процитировано

6
Borneol-Modified Schisandrin B Micelles Cross the Blood–Brain Barrier To Treat Alzheimer’s Disease in Aged Mice DOI

Feng-rui Li,

Yang Yu,

Yu-meng Du

и другие.

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(3), С. 593 - 607

Опубликована: Янв. 12, 2024

Objective: Schisandrin B (Sch B) is a bioactive dibenzocyclooctadiene derizative that prevalent in the fruit of Schisandra chinensis. Numerous studies have demonstrated Sch has neuroprotective action by reducing oxidative stress and effectively preventing inflammation. It follows potential treatment for Alzheimer's disease (AD). However, drug's solubility, bioavailability, lower permeability blood–brain barrier (BBB) can all reduce its efficacy during therapy process. Therefore, this study constructed borneol-modified schisandrin micelles (Bor-Sch B-Ms), which increase brain targeting accurately delivering medications to brain, improving bioavailability. High therapeutic been achieved at pathological site. Methods: Bor-Sch B-Ms were prepared using thin film dispersion approach article. On one hand, observe effect borneol, we model vitro studied ability cross BBB. other distribution micelle drugs their related pharmacological effects on neuroinflammation, stress, neuronal damage through vivo administration mice. Results: In drug uptake bEnd.3 cells was increased borneol alteration surface nano micelles, implying promote N2a cells. This could result more medicines entering addition, revealed circulation time tissue significantly higher than those groups, making it suitable central nervous system diseases. Conclusion: As novel nanodrug delivery system, modified promising research prospects disease.

Язык: Английский

Процитировано

5
Sennoside A restrains TRAF6 level to modulate ferroptosis, inflammation and cognitive impairment in aging mice with Alzheimer's Disease DOI

Xiaojia Li,

Xiaoping Wang,

Bin Huang

и другие.

International Immunopharmacology, Год журнала: 2023, Номер 120, С. 110290 - 110290

Опубликована: Май 20, 2023

Язык: Английский

Процитировано

12
The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges DOI Open Access
Jiaxuan He, Fan Liu, Ting Xu

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115807 - 115807

Опубликована: Окт. 30, 2023

Alzheimer's disease (AD) is a progressive neurodegenerative disorder predominantly affecting the elderly. While conventional pharmacological therapies remain primary treatment for AD, their efficacy limited effectiveness and often associated with significant side effects. This underscores urgent need to explore alternative, non-pharmacological interventions. Oxidative stress has been identified as central player in AD pathology, influencing various aspects including amyloid-beta metabolism, tau phosphorylation, autophagy, neuroinflammation, mitochondrial dysfunction, synaptic dysfunction. Among emerging non-drug approaches, hydrogen therapy garnered attention its potential mitigating these pathological conditions. review provides comprehensively overview of therapeutic AD. We delve into mechanisms action, administration routes, discuss current challenges future prospects, aim providing valuable insights facilitate clinical application hydrogen-based management.

Язык: Английский

Процитировано

12