Theranostics,
Год журнала:
2024,
Номер
14(11), С. 4411 - 4437
Опубликована: Янв. 1, 2024
In
recent
years,
gene
therapy
has
been
made
possible
with
the
success
of
nucleic
acid
drugs
against
sepsis
and
its
related
organ
dysfunction.Therapeutics
based
on
acids
such
as
small
interfering
RNAs
(siRNAs),
microRNAs
(miRNAs),
messenger
(mRNAs),
plasmid
DNAs
(pDNAs)
guarantee
to
treat
previously
undruggable
diseases.The
advantage
acid-based
lies
in
development
nanocarriers,
achieving
targeted
controlled
delivery
for
improved
efficacy
minimal
adverse
effects.Entrapment
into
nanocarriers
also
ameliorates
poor
cellular
uptake
naked
acids.In
this
study,
we
discuss
current
state
art
nanoparticles
hyperinflammation
apoptosis
associated
sepsis.The
optimized
design
through
physicochemical
property
modification
ligand
conjugation
can
target
specific
organs-such
lung,
heart,
kidney,
liver-to
mitigate
multiple
sepsis-associated
injuries.This
review
highlights
nanomaterials
designed
fabricating
anti-sepsis
nanosystems,
their
characterization,
mechanisms
working
sepsis,
potential
promoting
therapeutic
efficiency
acids.The
investigations
nanoparticulate
application
management
are
summarized
paper.Noteworthily,
nanotherapeutic
allows
a
novel
strategy
sepsis.Further
clinical
studies
required
confirm
findings
cell-and
animal-based
experiments.The
capability
large-scale
production
reproducibility
nanoparticle
products
critical
commercialization.It
is
expected
that
numerous
possibilities
will
be
investigated
nanotherapeutics
future.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
174, С. 116543 - 116543
Опубликована: Апрель 11, 2024
In
recent
years,
there
has
been
an
increasing
number
of
related
studies
on
exosomes.
Most
have
focused
exosomes
derived
from
mammals,
confirming
the
important
role
that
play
in
cell
communication.
Plants,
as
a
natural
ingredient,
plant-derived
confirmed
to
similar
structures
and
functions
mammalian-derived
Plant-derived
exosome-like
nanoparticles
(PELNs)
are
lipid
bilayer
membrane
nanovesicles
containing
bioactive
constituents
such
miRNA,
mRNA,
protein,
lipids
obtained
plant
cells,
can
participate
intercellular
communication
mediate
transboundary
communication,
high
bioavailability
low
immunogenicity,
relatively
safe,
shown
maintaining
homeostasis
preventing,
treating
variety
diseases.
this
review,
we
describe
biogenesis,
isolation
purification
methods,
structural
composition,
stability,
safety,
function
PELNs
challenges.
The
anti-inflammatory,
antioxidant,
antitumor
drug
delivery
mainly
described,
status
research
exosome
Chinese
herbal
medicines
is
outlined.
Overall,
summarized
importance
latest
results
field
provided
theoretical
basis
for
future
clinical
application
PELNs.
Theranostics,
Год журнала:
2024,
Номер
14(12), С. 4598 - 4621
Опубликована: Янв. 1, 2024
Over
the
past
ten
years,
significant
advancements
have
been
made
in
exploring
plant-derived
exosome-like
nanoparticles
(PELNs)
for
disease
therapeutics
and
drug
delivery.
PELNs,
as
inherent
nanoscale
particles
comprised
of
proteins,
lipids,
nucleic
acids,
secondary
metabolites,
exhibit
capacity
cellular
uptake
by
human
cells.
This
intercellular
interaction
transcends
biological
boundaries,
effectively
influencing
functions
animals.
PELNs
outstanding
biocompatibility,
low
immunogenicity,
enhanced
safety,
environmentally
friendly
sustainability.
article
summarized
preparation
methods
characteristics
PELNs.
It
provided
a
systematic
review
varied
roles
derived
from
fruits,
vegetables,
herbs
The
challenges
their
production
application
were
discussed,
future
prospects
this
rapidly
evolving
field
explored.
Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Июнь 22, 2024
Heart
transplantation
offers
life-saving
treatment
for
patients
with
end-stage
heart
failure;
however,
ischemia-reperfusion
injury
(IRI)
and
subsequent
immune
responses
remain
significant
challenges.
Current
therapies
primarily
target
adaptive
immunity,
limited
options
available
addressing
IRI
innate
activation.
Although
plant-derived
vesicle-like
nanoparticles
show
promise
in
managing
diseases,
their
application
organ
complications
is
unexplored.
Here,
this
work
develops
a
novel
reactive
oxygen
species
(ROS)-responsive
multifunctional
fusion
extracellular
nanovesicles
carrying
rapamycin
(FNVs@RAPA)
to
address
early
Ly6C
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 911 - 911
Опубликована: Янв. 22, 2025
Exposure
to
air
pollution,
especially
fine
particulate
matter
(PM2.5),
is
closely
linked
various
adverse
health
effects,
particularly
in
the
respiratory
system.
The
present
study
was
designed
investigate
lncRNA–mRNA
interactions
PM2.5-induced
lung
cell
injury
using
weighted
gene
co-expression
network
analysis
(WGCNA).
We
downloaded
expression
data
of
GSE138870
from
Gene
Expression
Omnibus
(GEO)
database
and
screened
for
differentially
expressed
lncRNAs
mRNAs.
constructed
modules
with
WGCNA.
Furthermore,
functional
enrichment
also
performed.
networks
lncRNA–mRNA-pathway
identify
key
regulatory
relationships.
results
revealed
several
significantly
correlated
injury,
such
as
turquoise
blue
modules.
Genes
within
these
were
enriched
pathways
related
signal
transduction,
metabolism,
cancer.
Hub
module,
including
LOC100129034
CROCCP2,
found
be
co-expressed
mRNAs
involved
apoptosis
proliferation
regulation.
In
lnc-CLVS2-2
GARS1-DT
connected
genes
migration,
invasion,
injury.
These
findings
contribute
novel
perspectives
molecular
mechanisms
suggest
that
WGCNA
could
a
valuable
tool
predicting
understanding
this
disease
process.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 14, 2025
There
are
abundant
natural
products
resources
and
extensive
clinical
use
experience
in
China.
However,
the
active
components
of
generally
have
problems
such
as
poor
water
solubility
low
bioavailability,
which
limit
their
druggability.
Carrier-free
nanoparticles,
nanocrystals,
self-assembled
extracellular
vesicles
derived
from
both
animal
plant
sources,
great
application
potential
improving
safety
efficacy
drugs
due
to
simple
flexible
preparation
methods,
high
drug
loading
capacity
delivery
efficiency,
well
long
half-life
blood
circulation.
It
has
been
widely
used
biomedical
fields
anti-tumor,
anti-bacterial,
anti-inflammatory
anti-oxidation.
Therefore,
based
on
that
clinic,
this
review
focuses
advantages
carrier-free
nanoparticles
delivering
compounds,
order
improve
process
vivo
draggability.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Март 19, 2025
Exosomes
are
nanoscale
particles
with
a
lipid
bilayer
membrane
that
were
first
identified
in
mammalian
cells.
Plant-derived
exosome-like
nanoparticles
(PELNs)
share
structural
and
molecular
similarities
exosomes,
including
lipids,
proteins,
microRNA
(miRNA),
plant-derived
metabolites.
Owing
to
their
unique
characteristics,
such
as
outstanding
stability,
low
immunogenicity,
high
biocompatibility,
sustainability,
PELNs
have
emerged
promising
natural
bioactive
agents
the
capacity
for
cross-kingdom
cellular
regulation.
Dietary
supplementation
PELNs,
particularly
from
fruits
vegetables,
has
demonstrated
health
benefits.
An
increasing
number
of
studies
indicated
beneficial
effects
on
colon
health.
This
review
summarizes
isolation
characterization
uptake,
distribution
after
oral
ingestion.
Furthermore,
this
emphasizes
interactions
between
gut
microbiota,
immune
system,
uptake
by
modulation
bacteria
metabolism,
responses
PELNs.
Additionally,
applications
components
drug
carriers
targeting
reviewed.
In
summary,
represent
versatile
approach
improve
health,
potential
both
therapeutic
preventive
healthcare
strategies.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 24, 2023
Abstract
Tissue
damage
and
aging
lead
to
dysfunction,
disfigurement,
trauma,
posing
significant
global
challenges.
Creating
a
regenerative
microenvironment
resist
external
stimuli
induce
stem
cell
differentiation
is
essential.
Plant-derived
nanovesicles
(PDNVs)
are
naturally
bioactive
lipid
bilayer
that
contain
proteins,
lipids,
ribonucleic
acid,
metabolites.
They
have
shown
potential
in
promoting
growth,
migration,
into
various
types
of
tissues.
With
immunomodulatory,
microbiota
regulatory,
antioxidant,
anti-aging
bioactivities,
PDNVs
valuable
resisting
facilitating
tissue
repair.
The
unique
structure
provides
an
optimal
platform
for
drug
encapsulation,
surface
modifications
enhance
their
stability
specificity.
Moreover,
by
employing
synergistic
administration
strategies,
can
maximize
therapeutic
potential.
This
review
summarized
the
progress
prospects
as
tools,
provided
insights
selection
repair
activities
based
on
existing
studies,
considered
key
challenge
clinical
application,
anticipated
continued
prominent
role
field
biomedicine.
Graphical
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
169, С. 115904 - 115904
Опубликована: Ноя. 18, 2023
Plant-derived
extracellular
vesicles
(PDEVs)
have
shown
remarkable
potential
as
sustainable,
green,
and
efficient
drug
delivery
nanocarriers.
As
natural
nanoparticles
containing
lipids,
protein,
nucleic
acids
secondary
metabolites,
they
received
widespread
attention
a
replacement
for
mammalian
exosomes
in
recent
years.
In
this
review,
the
advances
isolation,
identification,
composition,
therapeutic
effect,
clinical
application
prospect
were
comprehensively
reviewed,
respectively.
addition,
specific
modification
strategies
been
listed
focusing
on
inherent
drawbacks
of
raw
PDEVs
like
low
targeting
efficiency
poor
homogeneity.
With
emphasis
their
biology
mechanism
terms
immune
regulation,
regulating
oxidative
stress
promoting
regeneration
anti-inflammatory
field
value
demonstrated
by
citing
some
typical
examples,
review
about
would
provide
broad
fundamental
vision
in-depth
exploration
development
plant-derived
in-vivo
anti-inflammation
even
other
biomedical
applications.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 1097 - 1108
Опубликована: Фев. 1, 2024
Introduction:
Osteosarcoma
is
a
prevalent
and
highly
malignant
primary
bone
tumor.
However,
current
clinical
therapeutic
drugs
for
osteosarcoma
are
not
suitable
long-term
use
due
to
significant
side
effects.
Therefore,
there
an
urgent
need
develop
new
with
fewer
Dipsacus
asperoides
C.
Y.
Cheng
et
T.
M.
Ai,
traditional
Chinese
medicine,
commonly
used
its
anti-inflammatory,
anti-pain,
fracture
healing,
anti-tumor
In
this
study,
we
investigated
the
effects
of
exosome-like
nanoparticles
derived
from
(DAELNs)
on
cells
in
vitro
vivo.
Methods:
DAELNs
were
isolated
purified
their
physical
chemical
properties
characterized
using
transmission
electron
microscopy
(TEM)
nanoparticle
tracking
analysis
(NTA).
The
cellular
uptake
was
analyzed
by
PKH26
staining.
proliferation,
invasion,
migration,
apoptosis
assessed
CCK8
assay,
EdU
colony-formation
transwell
wound
healing
mitochondrial
membrane
potential
measurement,
respectively.
regulatory
mechanism
inhibiting
progression
via
activating
P38/JNK
signaling
pathway
Western
blotting
immunohistochemistry.
Moreover,
evaluated
vivo
small
animal
imaging
HE
staining,
Results:
Our
results
showed
that
inhibited
fostered
suppressed
tumor
growth
xenograft
nude
mouse
model.
Furthermore,
bio-distribution
DiD-labeled
preferential
targeting
tumors
excellent
biosafety
histological
liver
kidney.
Mechanistically,
activated
pathway-induced
apoptosis.
Conclusion:
Taken
together,
novel,
natural,
osteosarcoma-targeted
agents
can
serve
as
safe
effective
approaches
treatment
osteosarcoma.
Keywords:
osteosarcoma,
asperoides-derived
exosomes-like
nanoparticles,
