Heliyon, Год журнала: 2024, Номер 10(22), С. e40127 - e40127
Опубликована: Ноя. 1, 2024
Язык: Английский
Theranostics, Год журнала: 2024, Номер 14(12), С. 4598 - 4621
Опубликована: Янв. 1, 2024
Over the past ten years, significant advancements have been made in exploring plant-derived exosome-like nanoparticles (PELNs) for disease therapeutics and drug delivery. PELNs, as inherent nanoscale particles comprised of proteins, lipids, nucleic acids, secondary metabolites, exhibit capacity cellular uptake by human cells. This intercellular interaction transcends biological boundaries, effectively influencing functions animals. PELNs outstanding biocompatibility, low immunogenicity, enhanced safety, environmentally friendly sustainability. article summarized preparation methods characteristics PELNs. It provided a systematic review varied roles derived from fruits, vegetables, herbs The challenges their production application were discussed, future prospects this rapidly evolving field explored.
Язык: Английский
Процитировано
14
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Ноя. 1, 2024
Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from tissues and can be classified into primary secondary types. Due the specificity of microenvironment, results traditional means treating tumors often unsatisfactory, so there is an urgent need develop new treatments for malignant tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis treatment. Nanoparticles (NPs) gained significant attention due their versatility, making them highly suitable applications tissue engineering, advanced imaging techniques, targeted drug delivery. For diagnosis, NPs enhance contrast sensitivity by integrating targeting ligands, significantly improve specific recognition localization tumor cells early detection. treatment, enable delivery, increasing accumulation at sites while reducing systemic toxicity. In conclusion, understanding microenvironment using unique properties holds promise improving disease management, enhancing treatment outcomes, ultimately quality life patients Further research development will undoubtedly contribute advancement personalized medicine field oncology.
Язык: Английский
Процитировано
12
Life Sciences, Год журнала: 2025, Номер unknown, С. 123472 - 123472
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1711 - 1711
Опубликована: Дек. 18, 2024
Nanotechnology has revolutionised biomedical research, offering innovative healthcare solutions. Plant-based nanotechnology is emerging as a sustainable alternative, minimising environmental impacts and enhancing therapeutic effectiveness. This paper explores the potential of plant-derived nanoparticles (PNPs) in medicine, highlighting their biocompatibility, multifunctionality, eco-friendliness. PNPs, synthesised through green methods, have demonstrated promising applications drug delivery, cancer therapy, antimicrobial treatments, tissue regeneration. Their unique properties, such high surface area bioactive components, enable improved targeting, controlled release, reducing side effects treatment efficacy. Additionally, compounds’ inherent antioxidant retained within platinum (PNPs), present opportunities for combating resistance promoting wound healing. Despite potential, challenges remain standardising PNP synthesis, ensuring consistency, scaling up production industrial applications. review emphasises need further research on toxicity, regulatory frameworks to fully harness capabilities clinical commercial represents promising, greener alternative advancing solutions, aligning with global sustainability goals.
Язык: Английский
Процитировано
6
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract Bone fractures, especially large and complex defects, continue to pose significant challenges in the medical field. Current treatments often rely on autografts or allografts for structural support, which can lead problems such as reduced bioactivity, infection risks, potential pathogen transmission. Nature herbal medicine (NHM), including herbs extracts, offers a promising alternative by effectively modulating inflammatory responses, enhancing osteoblast function, inhibiting bone resorption, thereby facilitating fracture repair. However, traditional drug delivery methods NHM encounter interactions, poor tissue distribution, patient compliance. Biomaterials, engineered interact with biological systems, play essential roles repair, mechanical delivery. When used carriers, biomaterials be combined form stable systems that further promote regeneration. Here applications of are reviewed, hydrogels, extracellular vesicles, cement, conjunction regulating homeostasis aiming provide valuable insights guidance future research therapeutic strategies.
Язык: Английский
Процитировано
0
Frontiers in Nutrition, Год журнала: 2025, Номер 12
Опубликована: Март 5, 2025
Plant-derived exosome-like nanoparticles (PDENs), emerging as novel bioactive agents, exhibit significant potential in food science and nutritional health. These nanoparticles, enriched with plant-specific biomolecules such proteins, lipids, nucleic acids, secondary metabolites, demonstrate unique cross-species regulatory capabilities, enabling interactions mammalian cells gut microbiota. PDENs enhance nutrient bioavailability by protecting sensitive compounds during digestion, modulate metabolic pathways through miRNA-mediated gene regulation, anti-inflammatory antioxidant properties. For instance, grape-derived reduce plasma triglycerides high-fat diets, while ginger-derived alleviate colitis downregulating pro-inflammatory cytokines. Additionally, serve natural drug carriers, applications delivering therapeutic agents like doxorubicin paclitaxel. Despite these advancements, challenges remain standardizing extraction methods (ultracentrifugation, immunoaffinity), ensuring stability processing storage, evaluating long-term safety. Current research highlights the need for optimizing lyophilization techniques understanding between matrices. Furthermore, show promise functional development—such fortified beverages probiotic formulations—their clinical translation requires rigorous pharmacokinetic studies clarity. This review synthesizes existing knowledge on PDENs’ composition, biological activities, applications, identifying gaps scalability, stability, safety assessments. Future directions emphasize interdisciplinary collaboration to harness combating disorders, enhancing functionality, advancing personalized nutrition strategies.
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106474 - 106474
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Апрель 11, 2025
Exosomes are tiny vesicles secreted by the vast majority of cells and play an important role in physiological as well pathological processes body. Circulating exosomes Lung Transplant Recipients (LTxR) undergoing rejection contain mismatched Human Leukocyte Antigens (HLA) lung-associated autoantigens (e.g., K-alpha1 microtubule protein collagen V), which may induce autoantibodies, circulating trigger immune response that results lung transplant recipient. This article discusses transplantation from three perspectives: a biomarker for after transplantation; mechanism exosome-mediated activation response; potential therapeutic strategy.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12092 - 12092
Опубликована: Ноя. 11, 2024
Plant-derived exosome-like nanoparticles (PELNs) are a type of membranous vesicle isolated from plant tissues. They contain proteins, lipids, nucleic acids, and other components. PELNs involved in the defensive response to pathogen attacks by exerting anti-inflammatory, antiviral, antifibrotic, antitumor effects through substances they contain. Most edible can be used as carriers for delivering specific drugs without toxicity side effects, making them hot topic research. Sources abundantly, produced high yields, with low risk developing immunogenicity vivo. This paper summarizes formation, isolation, purification methods; physical properties; composition comprehensive literature search. It also analyzes biomedical applications PELNs, well future research directions. provides new ideas methods on PELNs.
Язык: Английский
Процитировано
4
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Nonalcoholic fatty liver disease (NAFLD) represents an increasing public health concern. The underlying pathophysiological mechanisms of NAFLD remains unclear, and as a result, there is currently no specific therapy for this condition. However, recent studies focus on extracellular vesicles (EVs) novelty in their role cellular communication. An imbalance the gut microbiota composition may contribute to progression NAFLD, making gut-liver axis promising target therapeutic strategies. This review aims provide comprehensive overview EVs NAFLD. Additionally, exosome-like nanovesicles derived from plants (PELNs) probiotics-derived (postbiotics) have demonstrated potential re-establish intestinal equilibrium modulate microbiota, thus offering alleviate via axis. Further research needed using multiple omics approaches comprehensively characterize cargo including protein, metabolites, genetic material packaged, biological activities diverse microbes plants.
Язык: Английский
Процитировано
0