International Journal of Pharmaceutics X,
Journal Year:
2024,
Volume and Issue:
8, P. 100265 - 100265
Published: June 26, 2024
Cancer
remains
a
major
global
health
challenge,
and
despite
available
treatments,
its
prognosis
poor.
Recently,
researchers
have
turned
their
attention
to
intelligent
nanofibers
for
cancer
drug
delivery.
These
exhibit
remarkable
capabilities
in
targeted
controlled
release.
Their
inherent
characteristics,
such
as
high
surface
area-to-volume
ratio,
make
them
attractive
candidates
delivery
applications.
Smart
can
release
drugs
response
specific
stimuli,
including
pH,
temperature,
magnetic
fields,
light.
This
unique
feature
not
only
reduces
side
effects
but
also
enhances
the
overall
efficiency
of
systems.
Electrospinning,
widely
used
method,
allows
precision
fabrication
smart
nanofibers.
Its
advantages
include
efficiency,
user-friendliness,
ability
control
various
manufacturing
parameters.
In
this
review,
we
explore
latest
developments
producing
electrospun
treatment.
Additionally,
discuss
materials
these
critical
parameters
involved
electrospinning
process.
Journal of Functional Foods,
Journal Year:
2023,
Volume and Issue:
110, P. 105862 - 105862
Published: Oct. 21, 2023
Caffeic
acid
(CA)
and
its
derivatives,
caffeic
phenyl
ethyl
amide
(CAPA)
ester
(CAPE),
were
shown
to
have
anti-oxidant,
anti-inflammatory,
anti-diabetic
effects.
Therefore,
in
this
systematic
review,
a
literature
search
was
conducted
from
inception
until
June
2023
on
major
electronic
databases
(ISI
Web
of
Science,
MEDLINE/PubMed,
Scopus,
Cochrane
Library,
Google
Scholar)
find
studies
evaluating
the
impacts
CA
common
derivatives
diabetes
complications
different
cellular,
animal,
clinical
studies.
therapy
mitigated
levels
blood
glucose,
oxidative
stress
markers,
inflammatory
cytokines
while
increasing
anti-oxidative
markers
cellular
animal
models
diabetes.
Furthermore,
they
remarkably
propagated
insulin
secretion
ameliorated
resistance.
also
revealed
protective
effects
against
complications,
such
as
diabetic-induced
hepatic
damage,
cardiomyopathy,
endothelial
dysfunction,
retinopathy,
cognitive
deficit,
nephropathy,
neuropathy.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 116079 - 116079
Published: Dec. 26, 2023
Heart
failure
(HF)
is
a
prevalent
long-term
complication
of
myocardial
infarction
(MI).
The
incidence
post-MI
HF
high,
and
patients
with
the
condition
have
poor
prognosis.
Accurate
identification
individuals
at
high
risk
for
crucial
implementation
protective
ideally
personalized
strategy
to
prevent
fatal
events.
Post-MI
characterized
by
adverse
cardiac
remodeling,
which
results
from
metabolic
changes
in
response
ischemia.
Moreover,
various
factors,
including
genetics,
diet,
obesity,
can
influence
pathways
patients.
This
review
focuses
on
signatures
that
could
serve
as
non-invasive
biomarkers
early
high-risk
populations.
We
also
explore
how
metabolism
participates
pathophysiology
HF.
Furthermore,
we
discuss
potential
metabolites
novel
targets
treatment
prognostic
evaluation.
It
expected
provide
valuable
suggestions
clinical
prevention
perspective.
ABSTRACT
Diabetic
cardiomyopathy
(DCM)
is
one
of
the
leading
causes
mortality
among
diabetic
patients.
Flavonoid
are
most
abundant
group
phytochemicals
in
fruits
and
vegetables,
have
received
increasing
interest
as
potential
chemopreventive
antidiabetic
agents.
Flavonoids
might
contribute
to
prevent
or
delay
DCM
by
regulating
cardiac
metabolism,
insulin
signaling,
oxidative
stress,
apoptosis,
autophagy,
inflammation.
Among
other
effects,
flavonoids
been
proved
enhance
glucose
uptake,
decrease
cellular
lipid
accumulation,
suppress
stress.
However,
mechanistic
basis
these
effects
not
fully
understood,
many
points
remain
be
clarified.
This
review
provides
insight
into
molecular
mechanisms
flavonoid
activity
summarizing
cell
culture
animal
model
studies.
Journal of Advanced Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
While
metformin
has
been
shown
to
alleviate
dextran
sulfate
sodium
(DSS)-induced
colitis
in
murine
models,
the
mechanisms
underlying
its
anti-inflammatory
and
barrier-restorative
effects
remain
poorly
defined.
This
study
investigates
role
of
acetyl
coenzyme
A
(acetyl-CoA)-dependent
STAT3
acetylation
mediating
metformin's
therapeutic
actions,
with
goal
identifying
novel
molecular
targets
for
ulcerative
(UC)
treatment.
Acute
was
induced
wild-type
C57BL/6J
mice
via
oral
DSS
administration,
followed
by
daily
intraperitoneal
Intestinal
inflammation,
barrier
integrity,
signaling
were
assessed
using
histopathology,
western
blotting,
transmission
electron
microscopy.
To
validate
STAT3's
critical
pathogenesis,
intestinal
epithelium-specific
knockout
employed,
enabling
targeted
investigation
regulation
metformin.
Metformin
attenuated
DSS-induced
suppressing
pro-inflammatory
cytokines
(TNF-α,
IL-6,
IL-1β),
reducing
epithelial
apoptosis,
restoring
tight
junction
proteins
(ZO-1,
E-cadherin,
Occludin).
Mechanistically,
reduced
acetyl-CoA
levels,
thereby
inhibiting
downstream
pathway
activation.
The
pivotal
progression
confirmed
mice,
as
significantly
diminished
absence
STAT3-mediated
inflammatory
signaling.
identifies
acetyl-CoA-dependent
a
mechanism
through
which
ameliorates
inflammation
dysfunction.
These
findings
not
only
advance
our
understanding
immunomodulatory
properties
but
also
highlight
potential
targeting
metabolism
UC.
