Emergent Materials, Год журнала: 2024, Номер unknown
Опубликована: Март 15, 2024
Язык: Английский
Gels, Год журнала: 2024, Номер 10(4), С. 262 - 262
Опубликована: Апрель 13, 2024
Hydrogels, with their distinctive three-dimensional networks of hydrophilic polymers, drive innovations across various biomedical applications. The ability hydrogels to absorb and retain significant volumes water, coupled structural integrity responsiveness environmental stimuli, renders them ideal for drug delivery, tissue engineering, wound healing. This review delves into the classification based on cross-linking methods, providing insights synthesis, properties, We further discuss recent advancements in hydrogel-based delivery systems, including oral, injectable, topical, ocular approaches, highlighting significance enhancing therapeutic outcomes. Additionally, we address challenges faced clinical translation propose future directions leveraging potential personalized medicine regenerative healthcare solutions.
Язык: Английский
Процитировано
45
Nanomaterials, Год журнала: 2024, Номер 14(6), С. 531 - 531
Опубликована: Март 16, 2024
Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic adds complexity to traditional cell cultivation methods. most commonly used technique involves cultivating cells on flat surface in two-dimensional format due its simplicity. A three-dimensional (3D) provide microenvironment for surrounding cells. There two main techniques obtaining 3D structures based the presence scaffolding. Scaffold-free consist spheroid technologies. Meanwhile, scaffold contain organoids all constructs that various types scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels one extensively studied forms potential culture up 4D bioprinted biomaterials. bioprinting is important create scaffolds. versatility this allows many different inks, mainly hydrogels, as well inorganic substances. Increasing amounts data evidence vast usage engineering personalized medicine, with area application being regeneration skin musculoskeletal systems. Recent papers also indicate increasing vivo tests products which further strengthen importance branch emphasize need extensive research safe humansbiomimetic tissues organs. In review article, we recent advancements field preceded by an overview technologies led development complex type culture.
Язык: Английский
Процитировано
20
Gels, Год журнала: 2024, Номер 10(2), С. 147 - 147
Опубликована: Фев. 14, 2024
Wound healing is a physiological process occurring after the onset of skin lesion aiming to reconstruct dermal barrier between external environment and body. Depending on nature duration process, wounds are classified as acute (e.g., trauma, surgical wounds) chronic diabetic ulcers) wounds. The latter take several months heal or do not (non-healing wounds), usually prone microbial infection represent an important source morbidity since they affect millions people worldwide. Typical wound treatments comprise debridement, grafts/flaps) non-surgical topical formulations, dressings) methods. Modern experimental approaches include among others three dimensional (3D)-(bio)printed dressings. present paper reviews recently developed 3D (bio)printed hydrogels for applications, especially focusing results their in vitro vivo assessment. advanced hydrogel constructs were printed using different types bioinks natural and/or synthetic polymers mixtures with biological materials) printing methods extrusion, digital light processing, coaxial microfluidic bioprinting, etc.) incorporated various bioactive agents growth factors, antibiotics, antibacterial agents, nanoparticles, cells fibroblasts, keratinocytes, mesenchymal stem cells, endothelial etc.).
Язык: Английский
Процитировано
17
Gels, Год журнала: 2024, Номер 10(9), С. 547 - 547
Опубликована: Авг. 23, 2024
Regenerative hydrogels from natural polymers have come forth as auspicious materials for use in regenerative medicine, with interest attributed to their intrinsic biodegradability, biocompatibility, and ability reassemble the extracellular matrix. This review covers latest advances used wound healing, focusing on chemical composition, cross-linking mechanisms, functional properties. Key carbohydrate polymers, including alginate, chitosan, hyaluronic acid, polysaccharide gums, agarose, carrageenan, xanthan gum, are discussed terms of sources, structures specific properties suitable applications. The further explores categorization based ionic charge, response physiological stimuli (i.e., pH, temperature) particularized roles tissue self-healing. Various methods enhance mechanical biological performance these also examined. By highlighting recent innovations ongoing challenges, this article intends give a detailed understanding potential revolutionize medicine improve patient healing outcomes.
Язык: Английский
Процитировано
17
Gels, Год журнала: 2023, Номер 9(12), С. 960 - 960
Опубликована: Дек. 7, 2023
Hydrogels have emerged as a versatile and promising class of materials in the field 3D printing, offering unique properties suitable for various applications. This review delves into intersection hydrogels exploring current research, technological advancements, future directions. It starts with an overview hydrogel basics, including composition properties, details used printing. The explores diverse printing methods hydrogels, discussing their advantages limitations. emphasizes integration 3D-printed biomedical engineering, showcasing its role tissue regenerative medicine, drug delivery. Beyond healthcare, it also examines applications food, cosmetics, electronics industries. Challenges like resolution limitations scalability are addressed. predicts trends material development, techniques, novel
Язык: Английский
Процитировано
27
Macromolecular Rapid Communications, Год журнала: 2024, Номер 45(7)
Опубликована: Янв. 25, 2024
Photocuring 3D printing of hydrogels, with sophisticated, delicate structures and biocompatibility, attracts significant attention by researchers possesses promising application in the fields tissue engineering flexible devices. After years development, photocuring technologies hydrogel inks make great progress. Herein, techniques including direct ink writing (DIW), stereolithography (SLA), digital light processing (DLP), continuous liquid interface production (CLIP), volumetric additive manufacturing (VAM), two photon polymerization (TPP) are reviewed. Further, raw materials for (photocurable polymers, monomers, photoinitiators, additives) applications devices also At last, current challenges future perspectives hydrogels discussed.
Язык: Английский
Процитировано
13
Bioprinting, Год журнала: 2024, Номер 38, С. e00335 - e00335
Опубликована: Фев. 1, 2024
Язык: Английский
Процитировано
10
AAPS PharmSciTech, Год журнала: 2024, Номер 25(5)
Опубликована: Май 10, 2024
Язык: Английский
Процитировано
10
Bioactive Materials, Год журнала: 2025, Номер 48, С. 273 - 293
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
1
Engineered Regeneration, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1