Molecular Imprinting: Green Perspectives and Strategies

Advanced Materials, Год журнала: 2021, Номер 33(30)

Опубликована: Июнь 18, 2021

Abstract Advances in revolutionary technologies pose new challenges for human life; response to them, global responsibility is pushing modern toward greener pathways. Molecular imprinting technology (MIT) a multidisciplinary mimic simulating the specific binding principle of enzymes substrates or antigens antibodies; along with its rapid progress and wide applications, MIT faces challenge complying green sustainable development requirements. With identification environmental risks associated unsustainable MIT, aspect termed has emerged developed. However, so far, no clear definition been provided appraise MIT. Herein, implementation process chemistry demonstrated mnemonic device form an acronym, GREENIFICATION, proposed present principles. The entire greenificated surveyed, including element choice, polymerization implementation, energy input, strategies, waste treatment, recovery, as well impacts these processes on operator health environment. Moreover, assistance upgraded instrumentation deploying goals considered. Finally, future perspectives are presented provide more complete picture road map pave way further development.

Язык: Английский

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Greenificated Molecularly Imprinted Materials for Advanced Applications

Advanced Materials, Год журнала: 2022, Номер 34(42)

Опубликована: Июнь 23, 2022

Abstract Molecular imprinting technology (MIT) produces artificial binding sites with precise complementarity to substrates and thereby is capable of exquisite molecular recognition. Over five decades evolution, it predicted that the resulting host imprinted materials will overtake natural receptors for research application purposes, but in practice, this has not yet been realized due unsustainability their life cycles (i.e., precursors, creation, use, recycling, end‐of‐life). To address issue, greenificated molecularly polymers (GMIPs) are a new class plastic antibodies have approached sustainability by following one or more greenification principles, while also demonstrating far‐reaching applications compared counterparts. In review, most recent developments delicate design advanced GMIPs six fast‐growing emerging fields surveyed, namely biomedicine/therapy, catalysis, energy harvesting/storage, nanoparticle detection, gas sensing/adsorption, environmental remediation. addition, distinct features highlighted, optimal means utilize these attaining incredibly discussed. Importantly, obscure technical challenges MIT revealed, conceivable solutions offered. Lastly, several perspectives on future directions proposed.

Язык: Английский

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Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Сен. 30, 2022

Abstract Chiral discrimination is critical in environmental and life sciences. However, an ideal chiral strategy has not yet been developed because of the inevitable nonspecific binding entity wrong enantiomers or insufficient intrinsic optical activities molecules. Here, we propose “inspector” recognition mechanism (IRM), which implemented on a imprinted polydopamine (PDA) layer coated surface-enhanced Raman scattering (SERS) tag layer. The IRM works based permeability change PDA after scrutiny by inspector molecule. Good enantiomer can specifically recognize fully fill cavities, whereas cannot. Then linear shape aminothiol molecule, as status introduced, only percolate through vacant nonspecifically occupied inducing SERS signal to decrease. Accordingly, chirality information exclusively stems from good specific binding, while curbed. benefits sensitivity versatility, enabling absolute wide variety molecules regardless size, functional groups, polarities, activities, scattering, number centers.

Язык: Английский

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Technical Challenges of Molecular-Imprinting-Based Optical Sensors for Environmental Pollutants

Langmuir, Год журнала: 2022, Номер 38(19), С. 5963 - 5967

Опубликована: Май 5, 2022

Combating environmental pollution constantly requires new affinity tools to selectively recognize and sensitively detect them. Molecularly imprinted polymers (MIPs) are plastic antibodies that have exhibited great potential as recognition units in optical sensing platforms monitor wide varieties of pollutants, including ionic species, organic compounds, gases, even manufactured nanoparticles. The construction, strategies, applications molecular-imprinting-based sensors (MI-OSs) been discussed recent reviews, thus we deliberately set them aside. This Perspective elaborates on unanswered questions main approaches being taken address the challenges MI-OS technologies, which less considered until now. Specifically, highlight obscure technical aspects fabrication validation impact their practical importantly offer conceivable solutions related problems bridge research gap.

Язык: Английский

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Environmental impact of greenness assessment tools in liquid chromatography – A review

Microchemical Journal, Год журнала: 2021, Номер 170, С. 106685 - 106685

Опубликована: Июль 27, 2021

Язык: Английский

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Recent advances of Au@Ag core–shell SERS‐based biosensors

Exploration, Год журнала: 2023, Номер 3(1)

Опубликована: Фев. 1, 2023

The methodological advancements in surface-enhanced Raman scattering (SERS) technique with nanoscale materials based on noble metals, Au, Ag, and their bimetallic alloy Au-Ag, has enabled the highly efficient sensing of chemical biological molecules at very low concentration values. By employing innovative various type Ag nanoparticles especially, high efficiency Au@Ag nanomaterials as substrate SERS biosensors have revolutionized detection components including; proteins, antigens antibodies complex, circulating tumor cells, DNA, RNA (miRNA), etc. This review is about SERS-based Au/Ag enhanced activity by focusing different factors related to them. emphasis this research describe recent developments field conceptual behind Furthermore, article we apex understanding impact variation basic features like effects size, shape varying lengths, thickness core-shell influence large-scale magnitude morphology. Moreover, detailed information applications these importantly receptor binding domain (RBD) protein COVID-19 provided.

Язык: Английский

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SERS sensing for cancer biomarker: Approaches and directions

Bioactive Materials, Год журнала: 2023, Номер 34, С. 248 - 268

Опубликована: Дек. 31, 2023

These days, cancer is thought to be more than just one illness, with several complex subtypes that require different screening approaches. can distinguished by the distinct markings left metabolites, proteins, miRNA, and DNA. Personalized illness management may possible if categorized according its biomarkers. In order stop from spreading posing a significant risk patient survival, early detection prompt treatment are essential. Traditional techniques tedious, time-consuming, expert personnel for analysis. This has led scientists reevaluate methodologies make use of emerging technologies achieve better results. Using time money saving techniques, these integrate procedures sample preparation in small devices high accuracy sensitivity. With proven potential biomedical use, surface-enhanced Raman scattering (SERS) been widely used biosensing applications, particularly biomarker identification. Consideration was given especially SERS as portable clinical diagnostic tool. The approaches SERS-based sensing both invasive non-invasive samples reviewed this article, along obstacles. Aside constraints approach review also takes into account complexity biological fluids, availability biomarkers, their sensitivity selectivity, which generally lowered. Massive ways maintain capabilities being developed recently get over restriction. known reliable method judgments. Nonetheless, there still room advancement terms portability, creation apps, interdisciplinary AI-based applications. Therefore, we will outline current state technological maturity article. meet demand reviewing various types (invasive non-invasive) biomarkers using SERS. It shed light on growing body research methods application quick detection.

Язык: Английский

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Novel Ag-coated nanofibers prepared by electrospraying as a SERS platform for ultrasensitive and selective detection of nitrite in food

Food Chemistry, Год журнала: 2023, Номер 412, С. 135563 - 135563

Опубликована: Янв. 27, 2023

Язык: Английский

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Molecular Imprinting-Based SERS Detection Strategy for the Large-Size Protein Quantitation and Curbing Non-Specific Recognition

Analytical Chemistry, Год журнала: 2024, Номер 96(16), С. 6417 - 6425

Опубликована: Апрель 12, 2024

Molecular imprinting-based surface-enhanced Raman scattering (MI-SERS) sensors have shown remarkable potential from an academic standpoint. However, their practical applications, especially in the detection of large-size protein (≥10 nm), face challenges due to lack versatile sensing strategies and nonspecific fouling matrix species. Herein, we propose a reporter inspector mechanism (RRIM) implemented on protein-imprinted polydopamine (PDA) layer coated SERS active substrate. In RRIM, after recognition, permeability PDA imprinted cavities undergoes changes that are scrutinized by molecules. Target proteins can specifically bind fully occupy cavities, whereas species cannot. Then, molecules with suitable size introduced serve as both inspectors recognition status inducers signal, which only penetrate through vacant nonspecifically filled cavities. Consequently, signal exclusively originate specific binding target proteins, while is curbed. The RRIM enables reproducible quantitation cyanobacteria-specific model phycocyanin, at level down 2.6 × 10

Язык: Английский

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The metal- and covalent-organic frameworks-based molecularly imprinted polymer composites for sample pretreatment

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 178, С. 117830 - 117830

Опубликована: Июнь 24, 2024

Язык: Английский

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