Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

Advanced Materials, Год журнала: 2023, Номер 35(26)

Опубликована: Янв. 12, 2023

Abstract Cartilage degeneration is among the fundamental reasons behind disability and pain across globe. Numerous approaches have been employed to treat cartilage diseases. Nevertheless, none shown acceptable outcomes in long run. In this regard, convergence of tissue engineering microfabrication principles can allow developing more advanced microfluidic technologies, thus offering attractive alternatives current treatments traditional constructs used applications. Herein, developments involving hydrogel‐based scaffolds, promising structures for regeneration, ranging from hydrogels with channels prepared by devices, that enable therapeutic delivery cells, drugs, growth factors, as well cartilage‐related organ‐on‐chips are reviewed. Thereafter, anatomy types damages, present treatment options briefly overviewed. Various introduced, advantages scaffolds over thoroughly discussed. Furthermore, available technologies fabricating chips presented. The preclinical clinical applications regeneration development time further explained. developments, recent key challenges, prospects should be considered so develop systems repair highlighted.

Язык: Английский

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Organ-on-a-chip meets artificial intelligence in drug evaluation

Theranostics, Год журнала: 2023, Номер 13(13), С. 4526 - 4558

Опубликована: Янв. 1, 2023

Drug evaluation has always been an important area of research in the pharmaceutical industry. However, animal welfare protection and other shortcomings traditional drug development models pose obstacles challenges to evaluation. Organ-on-a-chip (OoC) technology, which simulates human organs on a chip physiological environment functionality, with high fidelity reproduction organ-level physiology or pathophysiology, exhibits great promise for innovating pipeline. Meanwhile, advancement artificial intelligence (AI) provides more improvements design data processing OoCs. Here, we review current progress that made generate OoC platforms, how single multi-OoCs have used applications, including testing, disease modeling, personalized medicine. Moreover, discuss issues facing field, such as large reproducibility, point integration OoCs AI analysis automation, is benefit future Finally, look forward opportunities faced by coupling AI. In summary, advancements development, combinations AI, will eventually break state

Язык: Английский

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Proteomics-on-a-Chip – Microfluidics Meets Proteomics

Biosensors and Bioelectronics, Год журнала: 2025, Номер 273, С. 117122 - 117122

Опубликована: Янв. 9, 2025

Язык: Английский

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Intestinal Peyer’s Patches: Structure, Function, and In Vitro Modeling

Tissue Engineering and Regenerative Medicine, Год журнала: 2023, Номер 20(3), С. 341 - 353

Опубликована: Апрель 20, 2023

Язык: Английский

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Recent advances in 3D-printing-based organ-on-a-chip

Deleted Journal, Год журнала: 2024, Номер 1(1), С. 100003 - 100003

Опубликована: Март 21, 2024

Organ-on-a-chip (OOC) facilitates precise manipulation of fluids in microfluidic chips and simulation the physiological, chemical, mechanical characteristics tissues, thus providing a promising tool for vitro drug screening physiological modeling. In recent decades, this technology has advanced rapidly because development various three-dimensional (3D) printing techniques. 3D can not only fabricate using materials such as resins polydimethylsiloxane but also construct biomimetic tissues bioinks cell-loaded hydrogels. review, advances 3D-printing-based OOC are systematically summarized based on used direct or indirect OOC, techniques construction applications models heart, blood vessels, intestines, liver, kidney. addition, future perspectives challenges area envisioned to inspire researchers employ accelerate development.

Язык: Английский

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Harnessing the power of artificial intelligence for human living organoid research

Bioactive Materials, Год журнала: 2024, Номер 42, С. 140 - 164

Опубликована: Авг. 30, 2024

As a powerful paradigm, artificial intelligence (AI) is rapidly impacting every aspect of our day-to-day life and scientific research through interdisciplinary transformations. Living human organoids (LOs) have great potential for

Язык: Английский

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Bioprinting on Organ-on-Chip: Development and Applications

Biosensors, Год журнала: 2022, Номер 12(12), С. 1135 - 1135

Опубликована: Дек. 6, 2022

Organs-on-chips (OoCs) are microfluidic devices that contain bioengineered tissues or parts of natural organs and can mimic the crucial structures functions living organisms. They designed to control maintain cell- tissue-specific microenvironment while also providing detailed feedback about activities taking place. Bioprinting is an emerging technology for constructing artificial organ constructs by combining state-of-the-art 3D printing methods with biomaterials. The utilization bioprinting cells patterning in OoC technologies reinforces creation more complex imitate a organism precise way. Here, we summarize current techniques focus on advantages compared traditional cell seeding addition methods, materials, applications development microsystems.

Язык: Английский

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Vascularized organoid-on-a-chip: design, imaging, and analysis

Angiogenesis, Год журнала: 2024, Номер 27(2), С. 147 - 172

Опубликована: Фев. 26, 2024

Язык: Английский

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Advances in the Model Structure of In Vitro Vascularized Organ-on-a-Chip

Cyborg and Bionic Systems, Год журнала: 2024, Номер 5

Опубликована: Янв. 1, 2024

Microvasculature plays a crucial role in human physiology and is closely related to various diseases. Building vitro vascular networks essential for studying tissue behavior with repeatable morphology signaling conditions. Engineered 3D microvascular network models, developed through advanced microfluidic-based techniques, provide accurate reproducible platforms the microvasculature vitro, an component designing organ-on-chips achieve greater biological relevance. By optimizing microstructure of microfluidic devices mimic vivo microenvironment, organ-specific models healthy pathological tissues can be created. This review summarizes recent advancements strategies constructing devices. It discusses static vascularization chips’ classification, structural characteristics, techniques used build them: growing blood vessels on chips either or dynamic, grown microchannels, elastic membranes, hydrogels. Finally, paper application scenarios key technical issues existing chips. also explores potential novel organoid chip approach that combines organoids organ generate better

Язык: Английский

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Engineering Innervated Musculoskeletal Tissues for Regenerative Orthopedics and Disease Modeling

Small, Год журнала: 2024, Номер 20(23)

Опубликована: Янв. 10, 2024

Abstract Musculoskeletal (MSK) disorders significantly burden patients and society, resulting in high healthcare costs productivity loss. These are the leading cause of physical disability, their prevalence is expected to increase as sedentary lifestyles become common global population elderly increases. Proper innervation critical maintaining MSK function, nerve damage or dysfunction underlies various disorders, underscoring potential restoring function disorder treatment. However, most tissue engineering strategies have overlooked significance innervation. This review first expounds upon system its importance homeostasis functions. will be followed by for tissues that induce post‐implantation situ pre‐innervated. Subsequently, research progress modeling using innervated organoids organs‐on‐chips (OoCs) analyzed. Finally, future development treat recapitulate disease mechanisms discussed. provides valuable insights into underlying principles, methods, applications tissues, paving way targeted, efficacious therapies conditions.

Язык: Английский

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