Smart Medicine,
Journal Year:
2025,
Volume and Issue:
4(2)
Published: May 19, 2025
ABSTRACT
The
research
of
primary
urological
cancers,
including
bladder
cancer
(BCa),
prostate
(PCa),
and
renal
(RCa),
has
developed
rapidly.
Microfluidic
technology
provides
a
good
variety
benefits
compared
to
the
heterogeneity
animal
models
potential
ethical
issues
human
study.
its
application
with
cell
culture
(e.g.,
organ‐on‐a‐chip,
OOC)
are
extensively
used
in
studies
preclinical
clinical
settings.
provided
diagnostic
therapeutic
for
patients
diseases,
especially
by
evaluating
biomarkers
urinary
malignancies.
In
this
review,
we
go
through
applications
OOC
BCa,
Pca
Rca,
discuss
prospects
reducing
cost
improving
repeatability
amicability
intelligent
integration
system
organ
chips.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(26)
Published: Jan. 12, 2023
Abstract
Cartilage
degeneration
is
among
the
fundamental
reasons
behind
disability
and
pain
across
globe.
Numerous
approaches
have
been
employed
to
treat
cartilage
diseases.
Nevertheless,
none
shown
acceptable
outcomes
in
long
run.
In
this
regard,
convergence
of
tissue
engineering
microfabrication
principles
can
allow
developing
more
advanced
microfluidic
technologies,
thus
offering
attractive
alternatives
current
treatments
traditional
constructs
used
applications.
Herein,
developments
involving
hydrogel‐based
scaffolds,
promising
structures
for
regeneration,
ranging
from
hydrogels
with
channels
prepared
by
devices,
that
enable
therapeutic
delivery
cells,
drugs,
growth
factors,
as
well
cartilage‐related
organ‐on‐chips
are
reviewed.
Thereafter,
anatomy
types
damages,
present
treatment
options
briefly
overviewed.
Various
introduced,
advantages
scaffolds
over
thoroughly
discussed.
Furthermore,
available
technologies
fabricating
chips
presented.
The
preclinical
clinical
applications
regeneration
development
time
further
explained.
developments,
recent
key
challenges,
prospects
should
be
considered
so
develop
systems
repair
highlighted.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(13), P. 4526 - 4558
Published: Jan. 1, 2023
Drug
evaluation
has
always
been
an
important
area
of
research
in
the
pharmaceutical
industry.
However,
animal
welfare
protection
and
other
shortcomings
traditional
drug
development
models
pose
obstacles
challenges
to
evaluation.
Organ-on-a-chip
(OoC)
technology,
which
simulates
human
organs
on
a
chip
physiological
environment
functionality,
with
high
fidelity
reproduction
organ-level
physiology
or
pathophysiology,
exhibits
great
promise
for
innovating
pipeline.
Meanwhile,
advancement
artificial
intelligence
(AI)
provides
more
improvements
design
data
processing
OoCs.
Here,
we
review
current
progress
that
made
generate
OoC
platforms,
how
single
multi-OoCs
have
used
applications,
including
testing,
disease
modeling,
personalized
medicine.
Moreover,
discuss
issues
facing
field,
such
as
large
reproducibility,
point
integration
OoCs
AI
analysis
automation,
is
benefit
future
Finally,
look
forward
opportunities
faced
by
coupling
AI.
In
summary,
advancements
development,
combinations
AI,
will
eventually
break
state
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(1), P. 100003 - 100003
Published: March 21, 2024
Organ-on-a-chip
(OOC)
facilitates
precise
manipulation
of
fluids
in
microfluidic
chips
and
simulation
the
physiological,
chemical,
mechanical
characteristics
tissues,
thus
providing
a
promising
tool
for
vitro
drug
screening
physiological
modeling.
In
recent
decades,
this
technology
has
advanced
rapidly
because
development
various
three-dimensional
(3D)
printing
techniques.
3D
can
not
only
fabricate
using
materials
such
as
resins
polydimethylsiloxane
but
also
construct
biomimetic
tissues
bioinks
cell-loaded
hydrogels.
review,
advances
3D-printing-based
OOC
are
systematically
summarized
based
on
used
direct
or
indirect
OOC,
techniques
construction
applications
models
heart,
blood
vessels,
intestines,
liver,
kidney.
addition,
future
perspectives
challenges
area
envisioned
to
inspire
researchers
employ
accelerate
development.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
42, P. 140 - 164
Published: Aug. 30, 2024
As
a
powerful
paradigm,
artificial
intelligence
(AI)
is
rapidly
impacting
every
aspect
of
our
day-to-day
life
and
scientific
research
through
interdisciplinary
transformations.
Living
human
organoids
(LOs)
have
great
potential
for
Colloids and Surfaces B Biointerfaces,
Journal Year:
2025,
Volume and Issue:
249, P. 114507 - 114507
Published: Jan. 8, 2025
Organ-on-a-chip
systems,
also
referred
to
as
microphysiological
systems
(MPS),
represent
an
advance
in
bioengineering
microsystems
designed
mimic
key
aspects
of
human
organ
physiology
and
function.
Drawing
inspiration
from
the
intricate
hierarchical
architecture
body,
these
innovative
platforms
have
emerged
invaluable
vitro
tools
with
wide-ranging
applications
drug
discovery
development,
well
enhancing
our
understanding
disease
physiology.
The
facility
replicate
tissues
within
physiologically
relevant
three-dimensional
multicellular
environments
empowers
organ-on-a-chip
versatility
throughout
different
stages
development
process.
Moreover,
can
be
tailored
specific
states,
facilitating
investigation
progression,
responses,
potential
therapeutic
interventions.
In
particular,
they
demonstrate,
early-phase
pre-clinical
studies,
safety
toxicity
profiles
compounds.
Furthermore,
play
a
pivotal
role
evaluation
efficacy
modeling
diseases.
One
most
promising
prospects
technology
is
simulate
pathophysiology
subpopulations
even
individual
patients,
thereby
being
used
personalized
medicine.
By
mimicking
physiological
responses
diverse
patient
groups,
hold
promise
revolutionizing
strategies,
guiding
them
towards
intervention
unique
needs
each
patient.
This
review
presents
status
evolution
microfluidic
that
facilitated
transition
cells
organs
recreated
on
chips
some
opportunities
offered
by
technology.
Additionally,
current
future
perspectives
challenges
this
still
faces
are
discussed.
Biosensors,
Journal Year:
2022,
Volume and Issue:
12(12), P. 1135 - 1135
Published: Dec. 6, 2022
Organs-on-chips
(OoCs)
are
microfluidic
devices
that
contain
bioengineered
tissues
or
parts
of
natural
organs
and
can
mimic
the
crucial
structures
functions
living
organisms.
They
designed
to
control
maintain
cell-
tissue-specific
microenvironment
while
also
providing
detailed
feedback
about
activities
taking
place.
Bioprinting
is
an
emerging
technology
for
constructing
artificial
organ
constructs
by
combining
state-of-the-art
3D
printing
methods
with
biomaterials.
The
utilization
bioprinting
cells
patterning
in
OoC
technologies
reinforces
creation
more
complex
imitate
a
organism
precise
way.
Here,
we
summarize
current
techniques
focus
on
advantages
compared
traditional
cell
seeding
addition
methods,
materials,
applications
development
microsystems.
Small,
Journal Year:
2024,
Volume and Issue:
20(23)
Published: Jan. 10, 2024
Abstract
Musculoskeletal
(MSK)
disorders
significantly
burden
patients
and
society,
resulting
in
high
healthcare
costs
productivity
loss.
These
are
the
leading
cause
of
physical
disability,
their
prevalence
is
expected
to
increase
as
sedentary
lifestyles
become
common
global
population
elderly
increases.
Proper
innervation
critical
maintaining
MSK
function,
nerve
damage
or
dysfunction
underlies
various
disorders,
underscoring
potential
restoring
function
disorder
treatment.
However,
most
tissue
engineering
strategies
have
overlooked
significance
innervation.
This
review
first
expounds
upon
system
its
importance
homeostasis
functions.
will
be
followed
by
for
tissues
that
induce
post‐implantation
situ
pre‐innervated.
Subsequently,
research
progress
modeling
using
innervated
organoids
organs‐on‐chips
(OoCs)
analyzed.
Finally,
future
development
treat
recapitulate
disease
mechanisms
discussed.
provides
valuable
insights
into
underlying
principles,
methods,
applications
tissues,
paving
way
targeted,
efficacious
therapies
conditions.
