International Journal of Biological Macromolecules, Год журнала: 2022, Номер 225, С. 526 - 543
Опубликована: Ноя. 14, 2022
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2023, Номер 13(1)
Опубликована: Сен. 13, 2023
Abstract The healing of diabetic wounds is hindered by various factors, including bacterial infection, macrophage dysfunction, excess proinflammatory cytokines, high levels reactive oxygen species, and sustained hypoxia. These factors collectively impede cellular behaviors the process. Consequently, this review presents intelligent hydrogels equipped with multifunctional capacities, which enable them to dynamically respond microenvironment accelerate wound in ways, stimuli ‐responsiveness, injectable self‐healing, shape ‐memory, conductive real‐time monitoring properties. relationship between multiple functions also discussed. Based on wounds, antibacterial, anti‐inflammatory, immunomodulatory, antioxidant, pro‐angiogenic strategies are combined hydrogels. application repair systematically discussed, aiming provide guidelines for fabricating exploring role therapeutic processes.
Язык: Английский
Процитировано
108
Antioxidants, Год журнала: 2023, Номер 12(4), С. 787 - 787
Опубликована: Март 23, 2023
Natural-based biomaterials play an important role in developing new products for medical applications, primarily cutaneous injuries. A large panel of with antioxidant properties has revealed advancement supporting and expediting tissue regeneration. However, their low bioavailability preventing cellular oxidative stress through the delivery system limits therapeutic activity at injury site. The integration compounds implanted biomaterial should be able to maintain while facilitating skin recovery. This review summarises recent literature that reported natural antioxidant-incorporated promoting wound healing regeneration, which is supported by evidence from vitro, vivo, clinical studies. Antioxidant-based therapies have shown promising numerous animal studies, even though studies remain very limited. We also described underlying mechanism reactive oxygen species (ROS) generation provided a comprehensive ROS-scavenging found last six years.
Язык: Английский
Процитировано
69
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 127331 - 127331
Опубликована: Окт. 10, 2023
Язык: Английский
Процитировано
57
Pharmaceuticals, Год журнала: 2022, Номер 15(5), С. 602 - 602
Опубликована: Май 14, 2022
Materials derived from natural plants and animals have great potential for transdermal drug delivery. Polysaccharides are widely marine, herbal, microbial sources. Compared with synthetic polymers, polysaccharides the advantages of non-toxicity biodegradability, ease modification, biocompatibility, targeting, antibacterial properties. Currently, polysaccharide-based delivery vehicles, such as hydrogel, film, microneedle (MN), tissue scaffolds being developed. The addition allows these vehicles to exhibit better-swelling properties, mechanical strength, tensile etc. Due stratum corneum's resistance, system cannot deliver drugs efficiently desired. charge hydration allow them react skin promote penetration. In addition, nanotechnology enhances utilization efficiency. Various diseases currently treated by devices promising futures. most current knowledge on excellent materials will be thoroughly discussed reviewing strategies.
Язык: Английский
Процитировано
44
Carbohydrate Polymers, Год журнала: 2022, Номер 308, С. 120448 - 120448
Опубликована: Дек. 13, 2022
Язык: Английский
Процитировано
40
Carbohydrate Polymers, Год журнала: 2023, Номер 312, С. 120823 - 120823
Опубликована: Март 20, 2023
Язык: Английский
Процитировано
33
Carbohydrate Polymers, Год журнала: 2023, Номер 324, С. 121533 - 121533
Опубликована: Окт. 26, 2023
Язык: Английский
Процитировано
32
Materials Advances, Год журнала: 2023, Номер 5(4), С. 1364 - 1394
Опубликована: Дек. 20, 2023
This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.
Язык: Английский
Процитировано
32
Biomaterials Research, Год журнала: 2023, Номер 27(1)
Опубликована: Фев. 9, 2023
Diabetic ulcers (DUs) are one of the most serious complications diabetes mellitus. The application a functional dressing is crucial step in DU treatment and associated with patient's recovery prognosis. However, traditional dressings simple structure single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer hydrogels solve therapeutic bottleneck treatment. Hydrogels class gels three-dimensional network that good moisturizing properties permeability promote autolytic debridement material exchange. Moreover, mimic natural environment extracellular matrix, providing suitable surroundings for cell proliferation. Thus, different mechanical strengths biological been extensively explored as platforms. In this review, we define types elaborate mechanisms by which they repair DUs. summarize pathological process DUs review various additives used Finally, examine limitations obstacles exist development clinically relevant applications these appealing technologies. This defines carefully diabetic (DUs), summarizes DUs, reviews bioactivators
Язык: Английский
Процитировано
31
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 245, С. 125528 - 125528
Опубликована: Июнь 28, 2023
Язык: Английский
Процитировано
31