T cells in health and disease

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Июнь 19, 2023

T cells are crucial for immune functions to maintain health and prevent disease. cell development occurs in a stepwise process the thymus mainly generates CD4

Язык: Английский

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Dynamics and specificities of T cells in cancer immunotherapy

Nature reviews. Cancer, Год журнала: 2023, Номер 23(5), С. 295 - 316

Опубликована: Апрель 12, 2023

Язык: Английский

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CD8+ T cells in the cancer-immunity cycle

Immunity, Год журнала: 2023, Номер 56(10), С. 2231 - 2253

Опубликована: Окт. 1, 2023

Язык: Английский

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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Язык: Английский

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Tumour-infiltrating lymphocyte therapy for patients with advanced-stage melanoma

Nature Reviews Clinical Oncology, Год журнала: 2024, Номер 21(3), С. 173 - 184

Опубликована: Янв. 8, 2024

Язык: Английский

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Immunotherapy and Cancer: The Multi-Omics Perspective

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3563 - 3563

Опубликована: Март 21, 2024

Immunotherapies have revolutionized cancer treatment approaches. Because not all patients respond positively to immune therapeutic agents, it represents a challenge for scientists who strive understand the mechanisms behind such resistance. In-depth exploration of tumor biology, using novel technologies as omics science, can help decode role microenvironment (TIME) in producing response blockade strategies. It also identify biomarkers patient stratification and personalized treatment. This review aims explore these new models highlight their possible pivotal changing clinical practice.

Язык: Английский

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Novel Strategies for Preventing Fungal Infections—Outline

Pathogens, Год журнала: 2025, Номер 14(2), С. 126 - 126

Опубликована: Фев. 1, 2025

Fungal infections are a significant global health challenge, causing approximately 3.8 million deaths annually, with immunocompromised populations particularly at risk. Traditional antifungal therapies, including azoles, echinocandins, and polyenes, face limitations due to rising resistance, toxicity, inadequate treatment options. This review explores innovative strategies for preventing managing fungal infections, such as vaccines, peptides, nanotechnology, probiotics, immunotherapy. Vaccines offer promising avenues long-term protection, despite difficulties in their development complexity immune evasion mechanisms. Antifungal peptides provide novel class of agents broad-spectrum activity reduced resistance risk, whilst nanotechnology enables targeted, effective drug delivery systems. Probiotics show potential vulvovaginal candidiasis, by maintaining microbial balance. Immunotherapy leverages system modulation enhance defenses, omics technologies deliver comprehensive insights into biology, paving the way therapeutic vaccine targets. While these approaches hold immense promise, challenges cost, accessibility, translational barriers remain. A coordinated effort among researchers, clinicians, policymakers is critical advancing addressing burden effectively.

Язык: Английский

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Single-Cell Profiling of CD8+ T Cells in Acute Myeloid Leukemia Reveals a Continuous Spectrum of Differentiation and Clonal Hyperexpansion

Cancer Immunology Research, Год журнала: 2023, Номер 11(7), С. 1011 - 1028

Опубликована: Май 10, 2023

Comprehensive investigation of CD8+ T cells in acute myeloid leukemia (AML) is essential for developing immunotherapeutic strategies beyond immune checkpoint blockade. Herein, we performed single-cell RNA profiling from 3 healthy bone marrow donors and 23 newly diagnosed (NewlyDx) 8 relapsed/refractory (RelRef) AML patients. Cells co-expressing canonical exhaustion markers formed a cluster constituting <1% all cells. We identified two effector cell subsets characterized by distinct cytokine metabolic profiles that were differentially enriched NewlyDx RelRef refined 25-gene CD8-derived signature correlating with therapy resistance, including genes associated activation, chemoresistance, terminal differentiation. Pseudotemporal trajectory analysis supported enrichment terminally differentiated state high expression at relapse or refractory disease. Higher the CD8 correlated poorer outcomes previously untreated patients, suggesting bona fide their degree differentiation are clinically relevant. Immune clonotype tracking revealed more phenotypic transitions clonotypes than Furthermore, patients had higher clonal hyperexpansion expression. Clonotype-derived antigen prediction most unreported patient-specific, significant heterogeneity immunogenicity. Thus, immunologic reconstitution likely to be successful earlier disease stages when less have greater capacity transitions.

Язык: Английский

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Tumor neoantigens: Novel strategies for application of cancer immunotherapy

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Год журнала: 2023, Номер 31(4), С. 437 - 448

Опубликована: Янв. 1, 2023

Neoantigen-targeted immunotherapy is a rapidly advancing field that holds great promise for treating cancer. The recognition of antigens by immune cells crucial step in tumor-specific killing, and neoantigens generated mutations cancer possess high immunogenicity are selectively expressed tumor cells, making them an attractive therapeutic target. Currently, find utility various domains, primarily the realm neoantigen vaccines such as DC vaccines, nucleic acid synthetic long peptide vaccines. Additionally, they hold adoptive cell therapy, encompassing tumor-infiltrating T receptors, chimeric antigen receptors which genetically modified cells. In this review, we summarized recent progress clinical use therapy targeting neoantigens, discussed potential burden checkpoint settings. With aid state-of-the-art sequencing bioinformatics technologies, together with significant advancements artificial intelligence, anticipated will be fully exploited personalized immunotherapy, from screening to application.

Язык: Английский

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Global trends in tumor microenvironment-related research on tumor vaccine: a review and bibliometric analysis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 6, 2024

Tumor vaccines have become crucial in cancer immunotherapy, but, only a limited number of phase III clinical trials demonstrated efficacy. The crux this issue is the inability tumor to effectively harmonize microenvironment with its intricate interplay. One factor that can hinder effectiveness natural immunosuppressive element present microenvironment. This lead low rates T-cell response specific antigens and development acquired resistance. Conversely, anticancer alter conflicting manners, inducing both immune activation immunological evasion. Hence, comprehending correlation between would establish foundation for forthcoming treatment.

Язык: Английский

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