Journal of Controlled Release, Год журнала: 2024, Номер 367, С. 441 - 469
Опубликована: Фев. 2, 2024
Язык: Английский
Smart Medicine, Год журнала: 2023, Номер 2(3)
Опубликована: Фев. 19, 2023
Abstract Wound infections continuously impose a huge economic and social burden on public healthcare. Despite the effective treatment of bacteria‐infected wounds after using traditional antibiotics, misuse antibiotics usually causes spread bacterial resistance decreases therapeutic outcomes. Therefore, development efficient antibacterial agents is urgently needed. Nanozymes, as new generation artificial enzymes, combine intrinsic abilities nanomaterials natural enzymes. Recently, nanozymes has been widely developed to kill bacteria treat wound by catalyzing various reactive oxygen species. Thus, this concept “antibacterial nanozymes” will promote further advances connecting elimination. To highlight these achievements, we summarize different types for healing. It believed that such promising strategy developing make great contribution in field skin regeneration. We expect play significant roles both basic research clinical applications.
Язык: Английский
Процитировано
82
Lab on a Chip, Год журнала: 2023, Номер 23(5), С. 869 - 887
Опубликована: Янв. 1, 2023
This review summarizes state-of-the-art microneedle-based detection and sensing systems, highlighting the objective significance, principles, systematic construction, validation models of these microneedles.
Язык: Английский
Процитировано
71
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 195, С. 114753 - 114753
Опубликована: Фев. 23, 2023
Язык: Английский
Процитировано
65
Engineering, Год журнала: 2023, Номер unknown
Опубликована: Июнь 1, 2023
Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to site lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are different kinds (e.g., small molecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) treating various disorders, including superficial tumors, wounds, infections, inflammatory diseases, abnormal appearance. The improved by integrating advantages multiple perform combination therapy. Through careful designing, further modified with biomimetic structures responsive drug release from internal external stimuli enhance transdermal delivery efficiency robust outcomes. Some studies have proposed use drug-free a promising mechanotherapeutic strategy promote wound healing, scar removal, hair regeneration via mechanical communication pathway. Although several advantages, practical application suffers problems related industrial manufacture clinical evaluation, making it difficult translation. In this study, we summarized applications, emerging challenges, developmental prospects provide information on ways advance
Язык: Английский
Процитировано
48
Colloids and Surfaces B Biointerfaces, Год журнала: 2023, Номер 226, С. 113302 - 113302
Опубликована: Апрель 8, 2023
Язык: Английский
Процитировано
46
Nano-Micro Letters, Год журнала: 2024, Номер 16(1)
Опубликована: Фев. 6, 2024
Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.
Язык: Английский
Процитировано
41
Advanced Materials, Год журнала: 2024, Номер 36(33)
Опубликована: Июнь 14, 2024
Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.
Язык: Английский
Процитировано
20
iScience, Год журнала: 2025, Номер 28(2), С. 111763 - 111763
Опубликована: Янв. 7, 2025
Recent years have witnessed tremendous advances in wearable sensors, which play an essential role personalized healthcare for their ability real-time sensing and detection of human health information. Nanozymes, capable mimicking the functions natural enzymes addressing limitations, possess unique advantages such as structural stability, low cost, ease mass production, making them particularly beneficial constructing recognition units biosensors. In this review, we aim to delineate latest advancements nanozymes development biosensors, focusing on key developments nanozyme immobilization strategies, technologies, biomedical applications. The review also highlights current challenges future perspectives. Ultimately, it aims provide insights research endeavors rapidly evolving area.
Язык: Английский
Процитировано
4
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(13), С. 2830 - 2851
Опубликована: Янв. 1, 2023
Diagram of the Smart Wound Management Microneedle Patch. microneedle patches combine treatment and monitoring for real-time diagnosis.
Язык: Английский
Процитировано
39
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Июнь 6, 2023
Microneedle patches have been extensively employed for wound healing, while the lack of rapid hemostasis efficiency and multiple tissue-repair properties restrict their values in hemorrhagic applications. Herein, we propose a Yunnan Baiyao-loaded multifunctional microneedle patch, namely (BY + EGF)@MN, with deep tissue penetration, regenerative healing. The EGF)@MNs are designed BY-loaded Bletilla striata polysaccharide (BSP) base epidermal growth factor (EGF)-loaded GelMA tips subsequent As BSP can be fastly dissolved completely release BY 6 min to promote platelet adhesion activate coagulation system, EGF achieve controlled sustained behavior 7 days gradual degradation tips, exhibit strong pro-coagulability satisfactory hemostatic effect rat hepatic hemorrhage model. Based on characteristics, verified that when applied cutaneous wounds, proposed MNs accelerate healing process by enhancing neovascularization, fibroblast density, collagen deposition. Thus, believe such promising candidates diverse
Язык: Английский
Процитировано
39